HPV Target gene Detail Information

> PDGFRL Gene Search Result

Gene Information

Gene Name	PDGFRL
Gene ID	5157
Gene Full Name	platelet derived growth factor receptor like
Gene Alias	PDGRL; PRLTS
Transcripts	ENSG00000104213
Virus	HPV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Nucleoli;Nucleoplasm;Predicted to be secreted;
HPA Protein Class Info	Disease related genes, Predicted secreted proteins
Gene Function	Suppressor gene
Uniport_ID	Q15198
HGNC ID	HGNC:8805
VEGA ID	OTTHUMG00000130818
OMIM ID	604584
String ID	9606.ENSP00000444211
PharmGKB ID	PA33149

Target gene [PDGFRL] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5003028	chr8	5	1		6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of PDGFRL expression and immune infiltrating cell level correlation result in HPV+ samples
PDGFRL expression: Low -> High

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of PDGFRL expression and immune infiltrating cell level correlation result in HPV+ samples
PDGFRL expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of PDGFRL expression and immune infiltrating cell level correlation result in HPV+ samples
PDGFRL expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of PDGFRL expression and immune infiltrating cell level correlation result in HPV+ samples
PDGFRL expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of PDGFRL expression and immune infiltrating cell level correlation result in HPV+ samples
PDGFRL expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of PDGFRL expression and immune infiltrating cell level correlation result in HPV+ samples
PDGFRL expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of PDGFRL expression and immune infiltrating cell level correlation result in HPV+ samples
PDGFRL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662