HTLV1 Target gene Detail Information

> PLA1A Gene Search Result

Gene Information

Gene Name	PLA1A
Gene ID	51365
Gene Full Name	phospholipase A1 member A
Gene Alias	PSPLA1; PS-PLA1
Transcripts	ENSG00000144837
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytoplasmic bodies;Nuclear speckles;Nucleoplasm;Predicted to be secreted;
HPA Protein Class Info	Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins
Uniport_ID	Q53H76
HGNC ID	HGNC:17661
VEGA ID	OTTHUMG00000159425
OMIM ID	607460
String ID	9606.ENSP00000273371
PharmGKB ID	PA134955851

Target gene [PLA1A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6003617	chr3	70	42	38	150	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PLA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLA1A expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PLA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLA1A expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PLA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
PLA1A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).