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HPV Target gene Detail Information

> PLOD3 Gene Search Result


Gene Information
Gene Name PLOD3
Gene ID 8985
Gene Full Name procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Gene Alias LH3
Transcripts ENSG00000106397
Virus HPV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID O60568
HGNC ID HGNC:9083
VEGA ID OTTHUMG00000157111
OMIM ID 603066
String ID 9606.ENSP00000223127
Drugbank ID BE0002195
PharmGKB ID PA33413
Target gene [PLOD3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5401242 chr7 4 4 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of PLOD3 expression and immune infiltrating cell level correlation result in HPV+ samples
PLOD3 expression: Low -> High

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of PLOD3 expression and immune infiltrating cell level correlation result in HPV+ samples
PLOD3 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of PLOD3 expression and immune infiltrating cell level correlation result in HPV+ samples
PLOD3 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of PLOD3 expression and immune infiltrating cell level correlation result in HPV+ samples
PLOD3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).