HIV Target gene Detail Information

> PPP3CA Gene Search Result

Gene Information

Gene Name	PPP3CA
Gene ID	5530
Gene Full Name	protein phosphatase 3 catalytic subunit alpha
Gene Alias	CALN; CCN1; CNA1; CALNA; IECEE; PPP2B; CALNA1; IECEE1
Transcripts	ENSG00000138814
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q08209
HGNC ID	HGNC:9314
VEGA ID	OTTHUMG00000133839
OMIM ID	114105
String ID	9606.ENSP00000378323
Drugbank ID	BE0004238
PharmGKB ID	PA33678

Target gene [PPP3CA] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4016023	chr4				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PPP3CA expression and immune infiltrating cell level correlation result in HIV+ samples
PPP3CA expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PPP3CA expression and immune infiltrating cell level correlation result in HIV+ samples
PPP3CA expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).