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HBV Target gene Detail Information

> PRPF6 Gene Search Result


Gene Information
Gene Name PRPF6
Gene ID 24148
Gene Full Name pre-mRNA processing factor 6
Gene Alias TOM; ANT1; Prp6; RP60; ANT-1; hPrp6; U5-102K; C20orf14; SNRNP102
Transcripts ENSG00000101161
Virus HBV
Gene Type protein coding
HPA Location Info Nuclear speckles;
HPA Protein Class Info Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID O94906
HGNC ID HGNC:15860
VEGA ID OTTHUMG00000033018
OMIM ID 613979
String ID 9606.ENSP00000266079
PharmGKB ID PA25682
Target gene [PRPF6] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1006372 chr20 32 5 2 39 View
1006753 chr20 32 2 34 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of PRPF6 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
PRPF6 expression: Low -> High
Lollipop of PRPF6 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of PRPF6 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of PRPF6 expression and immune infiltrating cell level correlation result in HBV+ samples
PRPF6 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).