HIV Target gene Detail Information

> PXN Gene Search Result

Gene Information

Gene Name	PXN
Gene ID	5829
Gene Full Name	paxillin
Transcripts	ENSG00000089159
Virus	HIV
Gene Type	protein coding
HPA Location Info	Focal adhesion sites;Centrosome;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	P49023
HGNC ID	HGNC:9718
VEGA ID	OTTHUMG00000169169
OMIM ID	602505
String ID	9606.ENSP00000267257
PharmGKB ID	PA34062

Target gene [PXN] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002621	chr12	85	1		86	View
4005812	chr11	4	24	1	29	View
4006274	chr11	4	7	15	26	View
4011963	chr12	1	5		6	View
4015586	chr11		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PXN expression and immune infiltrating cell level correlation result in HIV+ samples
PXN expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PXN expression and immune infiltrating cell level correlation result in HIV+ samples
PXN expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).