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HIV Target gene Detail Information

> RAC1 Gene Search Result


Gene Information
Gene Name RAC1
Gene ID 5879
Gene Full Name Rac family small GTPase 1
Gene Alias MIG5; MRD48; Rac-1; TC-25; p21-Rac1
Transcripts ENSG00000136238
Virus HIV
Gene Type protein coding
HPA Location Info Cytosol;Nucleoplasm;Nucleoli;
HPA Protein Class Info Cancer-related genes, Predicted intracellular proteins, RAS pathway related proteins
Gene Function Oncogene
Uniport_ID P63000
HGNC ID HGNC:9801
VEGA ID OTTHUMG00000023540
OMIM ID 602048
String ID 9606.ENSP00000348461
Drugbank ID BE0001109; BE0004904
PharmGKB ID PA34162
Target gene [RAC1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4004249 chr7 6 41 47 View
4005075 chr6 30 6 36 View
4011279 chr7 6 1 7 View
4015556 chr6 1 1 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of RAC1 expression and immune infiltrating cell level correlation result in HIV+ samples
RAC1 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of RAC1 expression and immune infiltrating cell level correlation result in HIV+ samples
RAC1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).