Home
Virus
Gene
Disease
Dataset
Download
Help
 
HBV Target gene Detail Information

> RAPGEF6 Gene Search Result


Gene Information
Gene Name RAPGEF6
Gene ID 51735
Gene Full Name Rap guanine nucleotide exchange factor 6
Gene Alias RAGEF2; PDZGEF2; KIA001LB; PDZ-GEF2; RA-GEF-2
Transcripts ENSG00000158987
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Centrosome;
HPA Protein Class Info Predicted intracellular proteins
Uniport_ID Q8TEU7
HGNC ID HGNC:20655
VEGA ID OTTHUMG00000162683
OMIM ID 610499
String ID 9606.ENSP00000296859
PharmGKB ID PA134885793
Target gene [RAPGEF6] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1005675 chr5 31 18 49 View
1005690 chr5 31 18 49 View
1400575 chr5 31 18 49 View
1403456 chr5 31 18 49 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of RAPGEF6 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
RAPGEF6 expression: Low -> High
Lollipop of RAPGEF6 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of RAPGEF6 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of RAPGEF6 expression and immune infiltrating cell level correlation result in HBV+ samples
RAPGEF6 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).