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HTLV1 Target gene Detail Information

> RET Gene Search Result


Gene Information
Gene Name RET
Gene ID 5979
Gene Full Name ret proto-oncogene
Gene Alias PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1
Transcripts ENSG00000165731
Virus HTLV1
Gene Type protein coding
HPA Location Info Cytosol;Golgi apparatus;Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Gene Function Oncogene
Uniport_ID P07949
HGNC ID HGNC:9967
VEGA ID OTTHUMG00000018024
OMIM ID 164761
String ID 9606.ENSP00000347942
Drugbank ID BE0001104; BE0002411
PharmGKB ID PA34335
FDA Approved Drug Cabozantinib;Pralsetinib;Selpercatinib
Target gene [RET] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6016661 chr10 10 1 1 12 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of RET expression and immune infiltrating cell level correlation result in HTLV1+ samples
RET expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of RET expression and immune infiltrating cell level correlation result in HTLV1+ samples
RET expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of RET expression and immune infiltrating cell level correlation result in HTLV1+ samples
RET expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).