HPV Target gene Detail Information

> RP2 Gene Search Result

Gene Information

Gene Name	RP2
Gene ID	6102
Gene Full Name	RP2, ARL3 GTPase activating protein
Gene Alias	XRP2; NME10; TBCCD2; NM23-H10; DELXp11.3
Transcripts	ENSG00000102218
Virus	HPV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Plasma membrane;Nuclear bodies;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	O75695
HGNC ID	HGNC:10274
VEGA ID	OTTHUMG00000021430
OMIM ID	300757
String ID	9606.ENSP00000218340
PharmGKB ID	PA34641

Target gene [RP2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5002653	chr2	7	2		9	View
5200698	chr2		2		2	View
5201210	chr2	49	14	14	77	View
5201407	chr13	6	7	4	17	View
5201449	chr2	16			16	View
5402380	chr2	59	4	1	64	View
5402574	chrX	1	1		2	View
5403559	chr2	27	4	2	33	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO)	Head and neck squamous cell carcinoma	134	Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of RP2 expression and immune infiltrating cell level correlation result in HPV+ samples
RP2 expression: Low -> High

> Dataset: GSE40774
HeatMap of cell type fractions in all samples	Lollipop of RP2 expression and immune infiltrating cell level correlation result in HPV+ samples
RP2 expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of RP2 expression and immune infiltrating cell level correlation result in HPV+ samples
RP2 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of RP2 expression and immune infiltrating cell level correlation result in HPV+ samples
RP2 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of RP2 expression and immune infiltrating cell level correlation result in HPV+ samples
RP2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE65858