HBV Target gene Detail Information

> RUNX3 Gene Search Result

Gene Information

Gene Name	RUNX3
Gene ID	864
Gene Full Name	runt related transcription factor 3
Gene Alias	AML2; CBFA3; PEBP2aC
Transcripts	ENSG00000020633
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Vesicles;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene & Oncogene
Uniport_ID	Q13761
HGNC ID	HGNC:10473
VEGA ID	OTTHUMG00000003316
OMIM ID	600210
String ID	9606.ENSP00000382800
PharmGKB ID	PA34886

Target gene [RUNX3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1002205	chr1	170	43	104	317	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of RUNX3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
RUNX3 expression: Low -> High
Lollipop of RUNX3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of RUNX3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of RUNX3 expression and immune infiltrating cell level correlation result in HBV+ samples
RUNX3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).