HTLV1 Target gene Detail Information

> S100A8 Gene Search Result

Gene Information

Gene Name	S100A8
Gene ID	6279
Gene Full Name	S100 calcium binding protein A8
Gene Alias	P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG
Transcripts	ENSG00000143546
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Intermediate filaments;Cytosol;Predicted to be secreted;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Gene Function	Oncogene
Uniport_ID	P05109
HGNC ID	HGNC:10498
VEGA ID	OTTHUMG00000013124
OMIM ID	123885
String ID	9606.ENSP00000357722
Drugbank ID	BE0008880
PharmGKB ID	PA34910

Target gene [S100A8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6007644	chr1	42	11		53	View
6018053	chr1	9			9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of S100A8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
S100A8 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of S100A8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
S100A8 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of S100A8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
S100A8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).