HTLV1 Target gene Detail Information

> SACS Gene Search Result

Gene Information

Gene Name	SACS
Gene ID	26278
Gene Full Name	sacsin molecular chaperone
Gene Alias	SPAX6; ARSACS; DNAJC29; PPP1R138
Transcripts	ENSG00000151835
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q9NZJ4
HGNC ID	HGNC:10519
VEGA ID	OTTHUMG00000016562
OMIM ID	604490
String ID	9606.ENSP00000371735
PharmGKB ID	PA34927

Target gene [SACS] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004581	chr13	90	18	3	111	View
6010936	chr13	22	4	2	28	View
6013575	chr13	6	7	6	19	View
6014429	chr13	15		1	16	View
6014961	chr13	15			15	View
6016437	chr13	11	1		12	View
6024671	chr13		3		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SACS expression and immune infiltrating cell level correlation result in HTLV1+ samples
SACS expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SACS expression and immune infiltrating cell level correlation result in HTLV1+ samples
SACS expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of SACS expression and immune infiltrating cell level correlation result in HTLV1+ samples
SACS expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).