HTLV1 Target gene Detail Information

> SLC12A1 Gene Search Result

Gene Information

Gene Name	SLC12A1
Gene ID	6557
Gene Full Name	solute carrier family 12 member 1
Gene Alias	BSC1; NKCC2
Transcripts	ENSG00000074803
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, FDA approved drug targets, Predicted membrane proteins, Transporters
Uniport_ID	Q13621
HGNC ID	HGNC:10910
VEGA ID	OTTHUMG00000131495
OMIM ID	600839
String ID	9606.ENSP00000379822
Drugbank ID	BE0000502
PharmGKB ID	PA320

Target gene [SLC12A1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000737	chr15	169	430	310	909	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SLC12A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SLC12A1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SLC12A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SLC12A1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of SLC12A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SLC12A1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).