HTLV1 Target gene Detail Information

> SPTBN4 Gene Search Result

Gene Information

Gene Name	SPTBN4
Gene ID	57731
Gene Full Name	spectrin beta, non-erythrocytic 4
Gene Alias	QV; CMND; SPNB4; NEDHND; SPTBN3
Transcripts	ENSG00000160460
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoli;Nucleoplasm;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q9H254
HGNC ID	HGNC:14896
VEGA ID	OTTHUMG00000182592
OMIM ID	606214
String ID	9606.ENSP00000263373
PharmGKB ID	PA37918

Target gene [SPTBN4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6001071	chr19	16	414	173	603	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SPTBN4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SPTBN4 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SPTBN4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SPTBN4 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of SPTBN4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SPTBN4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).