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HIV Target gene Detail Information

> STK17B Gene Search Result


Gene Information
Gene Name STK17B
Gene ID 9262
Gene Full Name serine/threonine kinase 17b
Gene Alias DRAK2
Transcripts ENSG00000081320
Virus HIV
Gene Type protein coding
HPA Location Info Cytosol;Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID O94768
HGNC ID HGNC:11396
VEGA ID OTTHUMG00000132735
OMIM ID 604727
String ID 9606.ENSP00000263955
Drugbank ID BE0004328
PharmGKB ID PA36204
Target gene [STK17B] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4002376 chr2 35 11 51 97 View
4002377 chr2 63 16 18 97 View
4002585 chr2 55 15 18 88 View
4014009 chr2 3 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of STK17B expression and immune infiltrating cell level correlation result in HIV+ samples
STK17B expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of STK17B expression and immune infiltrating cell level correlation result in HIV+ samples
STK17B expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).