HIV Target gene Detail Information

> SYMPK Gene Search Result

Gene Information

Gene Name	SYMPK
Gene ID	8189
Gene Full Name	symplekin
Gene Alias	SPK; SYM
Transcripts	ENSG00000125755
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;Plasma membrane;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q92797
HGNC ID	HGNC:22935
VEGA ID	OTTHUMG00000150151
OMIM ID	602388
String ID	9606.ENSP00000245934
PharmGKB ID	PA134896920

Target gene [SYMPK] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001111	chr19	6	204	4	214	View
4010797	chr19	6	2		8	View
4014615	chr19	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SYMPK expression and immune infiltrating cell level correlation result in HIV+ samples
SYMPK expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SYMPK expression and immune infiltrating cell level correlation result in HIV+ samples
SYMPK expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).