HTLV1 Target gene Detail Information

> SYT6 Gene Search Result

Gene Information

Gene Name	SYT6
Gene ID	148281
Gene Full Name	synaptotagmin 6
Gene Alias	sytVI
Transcripts	ENSG00000134207
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q5T7P8
HGNC ID	HGNC:18638
VEGA ID	OTTHUMG00000011755
OMIM ID	607718
String ID	9606.ENSP00000477344
PharmGKB ID	PA38614

Target gene [SYT6] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002841	chr1	131	20	54	205	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SYT6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SYT6 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SYT6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SYT6 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of SYT6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SYT6 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).