HIV Target gene Detail Information

> TNFSF10 Gene Search Result

Gene Information

Gene Name	TNFSF10
Gene ID	8743
Gene Full Name	TNF superfamily member 10
Gene Alias	TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A
Transcripts	ENSG00000121858
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	P50591
HGNC ID	HGNC:11925
VEGA ID	OTTHUMG00000156917
OMIM ID	603598
String ID	9606.ENSP00000241261
PharmGKB ID	PA36618

Target gene [TNFSF10] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003580	chr3	55	3		58	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TNFSF10 expression and immune infiltrating cell level correlation result in HIV+ samples
TNFSF10 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TNFSF10 expression and immune infiltrating cell level correlation result in HIV+ samples
TNFSF10 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).