HIV Target gene Detail Information

> UPF3B Gene Search Result

Gene Information

Gene Name	UPF3B
Gene ID	65109
Gene Full Name	UPF3B, regulator of nonsense mediated mRNA decay
Gene Alias	MRX62; UPF3X; HUPF3B; MRXS14; RENT3B; UPF3BP1; UPF3BP2; UPF3BP3; Upf3p-X
Transcripts	ENSG00000125351
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoli;Nucleoplasm;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q9BZI7
HGNC ID	HGNC:20439
VEGA ID	OTTHUMG00000022282
OMIM ID	300298
String ID	9606.ENSP00000276201
PharmGKB ID	PA128394708

Target gene [UPF3B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4006585	chrX	14	8	2	24	View
4006586	chrX	14	8	2	24	View
4006587	chrX	14	8	2	24	View
4006588	chrX	14	8	2	24	View
4006589	chrX	14	8	2	24	View
4006590	chrX	14	8	2	24	View
4006591	chrX	14	8	2	24	View
4006592	chrX	14	8	2	24	View
4006593	chrX	14	8	2	24	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of UPF3B expression and immune infiltrating cell level correlation result in HIV+ samples
UPF3B expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of UPF3B expression and immune infiltrating cell level correlation result in HIV+ samples
UPF3B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).