Evidence Details for Ccl3
PMID Title Journal Year Abstract
34564665 Bee Venom Alleviated Edema and Pain in Monosodium Urate Crystals-Induced Gouty Arthritis in Rat by Inhibiting Inflammation. Toxins (Basel). 2021 Sep 16;13(9):661. doi: 10.3390/toxins13090661. 2021 Sep 16 Bee venom (BV) acupuncture has anti-inflammatory and analgesic effects; therefore, it was used as a traditional Korean medicine for various musculoskeletal disorders, especially arthritis. In this study, we investigated the effect of BV on monosodium urate (MSU) crystal-induced acute gouty rats. An intra-articular injection of MSU crystal suspension (1.25 mg/site) was administered to the tibiotarsal joint of the hind paw of Sprague Dawley rats to induce MSU crystal-induced gouty arthritis. Colchicine (30 mg/kg) was orally administered 1 h before MSU crystal injection as a positive control, and BV (0.5 mg/kg) was injected into the tibiotarsal joint immediately after MSU crystal injection. The ankle thickness, mechanical allodynia, and expression of proinflammatory cytokines (TNF-alpha, IL-1beta, IL6, COX2 and iNOS) and chemokines (MIP-1alpha, MIP-1beta, MCP-1, GRO-alpha, MIP-2alpha) were then evaluated. BV reduced the expression of proinflammatory cytokines and chemokines, which are important mediators of MSU crystal-induced inflammatory responses. This anti-inflammatory effect was also confirmed histologically to attenuate synovitis and neutrophil infiltration. We demonstrated that BV markedly ameliorated ankle edema and mechanical allodynia in gouty rats. These results suggest that BV acupuncture is a potential clinical therapy for acute gouty management."

Evidence Sentence: The expression of chemokines such as GRO-alpha (growth-regulated oncogene-alpha; CXCL1), MCP1 (monocyte chemoattractant protein-1; CCL2), and MIP-1alpha (macrophage inflammatory protein-1alpha; CCL3) is known to induce the infiltration of blood cells, thereby facilitating inflammatory responses.
Evidence Sentence: The expression of chemokines such as GRO-alpha (growth-regulated oncogene-alpha; CXCL1), MCP1 (monocyte chemoattractant protein-1; CCL2), and MIP-1alpha (macrophage inflammatory protein-1alpha; CCL3) is known to induce the infiltration of blood cells, thereby facilitating inflammatory responses.
Evidence Sentence: The ankle thickness, mechanical allodynia, and expression of proinflammatory cytokines (TNF-alpha, IL-1beta, IL6, COX2 and iNOS) and chemokines (MIP-1alpha, MIP-1beta, MCP-1, GRO-alpha, MIP-2alpha) were then evaluated.
Evidence Sentence: The expression of chemokines such as GRO-alpha (growth-regulated oncogene-alpha; CXCL1), MCP1 (monocyte chemoattractant protein-1; CCL2), and MIP-1alpha (macrophage inflammatory protein-1alpha; CCL3) is known to induce the infiltration of blood cells, thereby facilitating inflammatory responses.
Evidence Sentence: Thus, we examined the effect of BV on the expression of chemokines such as MIP-1alpha, MIP-1beta (CCL4), MCP-1, GRO-alpha, and MIP-2alpha (CXCL2) by reverse transcriptase-PCR (n = 3).
Evidence Sentence: As shown in Figure 4A,C, the MIP-1alpha, MIP-1beta, MCP-1, GRO-alpha, and MIP-2alpha messenger RNAs increased at 24 h after MSU injection.
Evidence Sentence: Furthermore, messenger RNA expression of MIP-1alpha, MIP-1beta, MCP-1, GRO-alpha, and MIP-2alpha at 24 h after MSU injection was significantly inhibited by BV and Col treatment.