Evidence Details for Cdh1
| PMID | Title | Journal | Year | Abstract |
|---|---|---|---|---|
| 25983633 | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | 2015 Mar | Parkinson's disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transcript array in the SN region related to the inhibitory effects of acupuncture in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonism model. In this model, acupuncture stimulation at GB34 and LR3 attenuated the decrease in tyrosine hydroxylase in the SN region; stimulation at non-acupoints did not suppress this decrease. Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation. In addition, 17 (two annotated genes: 4921530L21Rik and Gm13931) probes that were down-regulated in MPTP animals compared to controls were exclusively up-regulated by acupuncture stimulation. These findings indicate that the 39 probes (12 annotated genes) affected by MPTP and acupuncture may be responsible for the inhibitory effects of acupuncture on degeneration-related gene expression in the SN following damage induced by MPTP intoxication." |
| Evidence Sentence: | Cadherin 1 (Cdh1) is a classic member of the cadherin superfamily that is thought to contribute to the control of synapse formation and synaptic transmission and plasticity. |
| Evidence Sentence: | Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation. |
| Evidence Sentence: | Cadherin 1 (Cdh1) is a classic member of the cadherin superfamily that is thought to contribute to the control of synapse formation and synaptic transmission and plasticity. |
| Evidence Sentence: | In the current study, Cdh1 was up-regulated in the MPTP group compared to controls. |
| Evidence Sentence: | However, acupuncture stimulation at GB34 and LR3 maintained Cdh1 expression similar to levels in control animals, suggesting that the down-regulation of Cdh1 expression by acupuncture may have a neuroprotective effect. |
| Evidence Sentence: | Cdh1, which is down-up regulated by MPTP and acupuncture stimulation at acupoints, was involved in thyroid, endometrial, bladder cancer, bacterial invasion of epithelial cells, and melanoma at significant levels according to the over-representation analysis (ORA). |
| Evidence Sentence: | These findings demonstrate that both MPTP and acupuncture at acupoints influence Cdh1, Tph2, Slc6a4, Serping1, Slc6a13, and Gm13931 expression in the indicated pathways in the SN region. |
| Evidence Sentence: | Cdh1 signaling is an important component of the regulation of GABAergic synapses in brain neurons; indeed, elevated GABA levels have been detected in PD. |