| Evidence Sentence: |
To examine the possible correlation of aberrant Wnt signaling and pathological changes in Alzheimer's disease, we established a rat model of Alzheimer's disease and measured axin and beta-catenin expression in the hippocampus. |
| Evidence Sentence: |
Axin expression was lower, beta-catenin expression was greater, and neuronal cytoplasmic edema was visibly prevented in the rats that had received the pretreatments. |
| Evidence Sentence: |
Our results suggest that the mechanism underlying the neuroprotective effect of acupuncture and moxibustion in Alzheimer's disease is associated with axin and beta-catenin expression in the Wnt signal transduction pathway. |
| Evidence Sentence: |
Effects of acupuncture and moxibustion pretreatment on axin and beta-catenin protein expression in the hippocampus of Alzheimer's disease rats |
| Evidence Sentence: |
The western blot (Figure 2) revealed a low level of axin protein expression, but a high level of beta-catenin expression, in control and sham-operated rats. |
| Evidence Sentence: |
The model group had significantly higher axin expression (P < 0.01), but lower beta-catenin expression (P < 0.01) than the control group (Table 1). |
| Evidence Sentence: |
Compared with the model group, axin protein expression was lower (P < 0.01), but beta-catenin protein expression was higher (P < 0.01) in the electroacupuncture, moxibustion, and electroacupuncture + moxibustion groups (Figure 2, Table 1). |
