| Evidence Sentence: |
In the current study, the expression level of PCNA, Ag-NORs, EGF and VEGF in gastric mucosal cells of CAG rats were determined by ELISA methods. |
| Evidence Sentence: |
In the EA group, significant decreases in the expression of PCNA, Ag-NORs, EGF and VEGF were observed compared to the CAG group, which indicated reduced expression of cell proliferation factor and further restraining the trends to malignant proliferation of gastric mucosal cells. |
| Evidence Sentence: |
PCNA, Ag-NORs, EGF and VEGF) were selected to observe the cellular proliferation in gastric mucosa based to published literatures as their expressions are sensitive to CAG-induced gastric mucosal lesions. |
| Evidence Sentence: |
The elevation of serum lipid levels were correlated with enhanced EGF expression in CAG rats shown in Fig. |
| Evidence Sentence: |
reported a positive correlation between circulating EGF level and LDL levels. |
| Evidence Sentence: |
Electro-acupuncture treatment was found to inhibit EGF activation (Fig. |
| Evidence Sentence: |
EGFR has been verified to play a regulatory role in hepatocyte proliferation and plasma lipid metabolism in adult male mice. |
| Evidence Sentence: |
The livers of Dsk5 mice, an animal model with gain of function in EGFR, exhibited decreased hepatic LDL receptor (LDLR) expression as well as fatty acid synthase (FAS) expression, providing metabolic mechanism for the elevated plasma LDL. |
| Evidence Sentence: |
EGFR is a member of the receptor tyrosine kinases (RTK) ErbB family and has been found to be overexpressed in various cancers, including non-small cell lung cancer, colorectal cancer, pancreatic cancer, and gastric cancer. |
| Evidence Sentence: |
High expression level of EGFR is associated with an increased risk of invasion or metastasis; while the inhibition of EGFR level leads to decreased cancer cell division, migration, angiogenesis and apoptosis in solid tumors. |
| Evidence Sentence: |
It is known that activation of EGFR can subsequently activate Ras/Raf/MEK as well as its downstream protein kinase ERK1/2. |
| Evidence Sentence: |
The regulation of several intracellular signaling pathways is believed to correlate with the over proliferation process where epidermal growth factor receptor (EGFR) is one of the critical pathways. |
| Evidence Sentence: |
The data indicated that the cellular over-proliferation in gastric mucosa during the progression of CAG increased the activation of the EGFR signaling pathways, leading to upregulation the lipid metabolism. |
| Evidence Sentence: |
EGFR is a member of the receptor tyrosine kinases (RTK) ErbB family and has been found to be overexpressed in various cancers, including non-small cell lung cancer, colorectal cancer, pancreatic cancer, and gastric cancer. |
| Evidence Sentence: |
VEGF is a potent angiogenic cytokine that induces a highly specific mitogen for endothelial cell and promotes the formation of neovascular. |
| Evidence Sentence: |
Pathogenesis of cancer has been reported to be directly related to VEGF level. |
| Evidence Sentence: |
In the current study, the expression level of PCNA, Ag-NORs, EGF and VEGF in gastric mucosal cells of CAG rats were determined by ELISA methods. |
| Evidence Sentence: |
In the EA group, significant decreases in the expression of PCNA, Ag-NORs, EGF and VEGF were observed compared to the CAG group, which indicated reduced expression of cell proliferation factor and further restraining the trends to malignant proliferation of gastric mucosal cells. |
| Evidence Sentence: |
PCNA, Ag-NORs, EGF and VEGF) were selected to observe the cellular proliferation in gastric mucosa based to published literatures as their expressions are sensitive to CAG-induced gastric mucosal lesions. |
