Evidence Details for Egfr
PMID Title Journal Year Abstract
28358020 NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats. Sci Rep. 2017 Mar 30;7:45580. doi: 10.1038/srep45580. 2017 Mar 30 Chronic atrophic gastritis (CAG) is a common gastrointestinal disease which has been considered as precancerous lesions of gastric carcinoma. Previously, electro-acupuncture stimulation has been shown to be effective in ameliorating symptoms of CAG. However the underlying mechanism of this beneficial treatment is yet to be established. In the present study, an integrated histopathological examination along with molecular biological assay, as well as (1)H NMR analysis of multiple biological samples (urine, serum, stomach, cortex and medulla) were employed to systematically assess the pathology of CAG and therapeutic effect of electro-acupuncture stimulation at Sibai (ST 2), Liangmen (ST 21), and Zusanli (ST 36) acupoints located in the stomach meridian using a rat model of CAG. The current results showed that CAG caused comprehensive metabolic alterations including the TCA cycle, glycolysis, membrane metabolism and catabolism, gut microbiota-related metabolism. On the other hand, electro-acupuncture treatment was found able to normalize a number of CAG-induced metabolomics changes by alleviating membrane catabolism, restoring function of neurotransmitter in brain and partially reverse the CAG-induced perturbation in gut microbiota metabolism. These findings provided new insights into the biochemistry of CAG and mechanism of the therapeutic effect of electro-acupuncture stimulations."

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Evidence Sentence: The data indicated that the cellular over-proliferation in gastric mucosa during the progression of CAG increased the activation of the EGFR signaling pathways, leading to upregulation the lipid metabolism.
Evidence Sentence: EGFR is a member of the receptor tyrosine kinases (RTK) ErbB family and has been found to be overexpressed in various cancers, including non-small cell lung cancer, colorectal cancer, pancreatic cancer, and gastric cancer.