Evidence Details for Folr1
| PMID | Title | Journal | Year | Abstract |
|---|---|---|---|---|
| 25206746 | Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints. | Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. | 2014 Jan 1 | Preliminary basic research and clinical findings have demonstrated that electroacupuncture therapy exhibits positive effects in ameliorating depression. However, most studies of the underlying mechanism are at the single gene level; there are few reports regarding the mechanism at the whole-genome level. Using a rat genomic gene-chip, we profiled hippocampal gene expression changes in rats after electroacupuncture therapy. Electroacupuncture therapy alleviated depression-related manifestations in the model rats. Using gene-chip analysis, we demonstrated that electroacupuncture at Baihui (DU20) and Yintang (EX-HN3) regulates the expression of 21 genes. Real-time PCR showed that the genes Vgf, Igf2, Tmp32, Loc500373, Hif1a, Folr1, Nmb, and Rtn were upregulated or downregulated in depression and that their expression tended to normalize after electroacupuncture therapy. These results indicate that electroacupuncture at Baihui and Yintang modulates depression by regulating the expression of particular genes." |
| Evidence Sentence: | Real-time PCR showed that the genes Vgf, Igf2, Tmp32, Loc500373, Hif1a, Folr1, Nmb, and Rtn were upregulated or downregulated in depression and that their expression tended to normalize after electroacupuncture therapy. |
| Evidence Sentence: | A total of 21 genes (Table 5), Trim32, Tm2d1, Sumo2, Spcs2, Serinc3, Rtn4, Rnf103, Loc500373, Rnf103, RGD1311493, Psmd4, Ppap2a, Vgf, Tmp32, Nmb, Lsm8, Igf2, Hif1a, H3f3b, Gpm6b, Gng10, Folr1, and XM_231625 were identified to be differentially expressed in the hippocampus of the depression model rats compared with control rats. |
| Evidence Sentence: | Among the 21 differentially expressed genes, RGD1311493, Nmb, Folr1, and Chmp4B were upregulated, i.e., gene expression in the model group was more than twice that in the control group. |
| Evidence Sentence: | The genes Vgf, Igf2, Tmp32, Loc500373, Hif1a, Folr1, Nmb, and Rtn4, were selected for PCR analysis. |