Evidence Details for Fosb
PMID Title Journal Year Abstract
22132113 Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease. PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. 2011 Parkinson's disease (PD) is caused by the selective loss of dopaminergic neurons in the substantia nigra (SN) and the depletion of striatal dopamine (DA). Acupuncture, as an alternative therapy for PD, has beneficial effects in both PD patients and PD animal models, although the underlying mechanisms therein remain uncertain. The present study investigated whether acupuncture treatment affected dopamine neurotransmission in a PD mouse model using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We found that acupuncture treatment at acupoint GB34 improved motor function with accompanying dopaminergic neuron protection against MPTP but did not restore striatal dopamine depletion. Instead, acupuncture treatment increased dopamine release that in turn, may lead to the enhancement of dopamine availability in the synaptic cleft. Moreover, acupuncture treatment mitigated MPTP-induced abnormal postsynaptic changes, suggesting that acupuncture treatment may increase postsynaptic dopamine neurotransmission and facilitate the normalization of basal ganglia activity. These results suggest that the acupuncture-induced enhancement of synaptic dopamine availability may play a critical role in motor function improvement against MPTP."

Evidence Sentence: Because MPTP administration is known to upregulate expression of immediate early gene, FosB, we also examined changes of FosB expression in the striatum.
Evidence Sentence: Consistent with previous reports, MPTP administration induced a significant increase in FosB expression in the MPTP group (130.7+-11.2% of Control group) in comparison to the Control group (100.0+-4.1% of Control group, P<0.05).
Evidence Sentence: Acupuncture treatment at GB34 significantly reduced the MPTP-induced increase of FosB expression in the MPTP+AP group (83.2+-8.3% of Control group, P<0.001, Figs.
Evidence Sentence: These results demonstrate that MPTP-induced increases in the phosphorylation of DARPP-32 and the expression of FosB were mitigated by acupuncture treatment at GB34, suggesting that the acupuncture treatment may normalize MPTP-induced abnormal postsynaptic changes.