Evidence Details for Hspa1a
PMID Title Journal Year Abstract
26237832 Effect of electro-acupuncture on gene expression in heart of rats with stress-induced pre-hypertension based on gene chip technology. J Tradit Chin Med. 2015 Jun;35(3):285-94. doi: 10.1016/s0254-6272(15)30099-6. 2015 Jun OBJECTIVE: To explore electro-acupuncture's (EA's) effect on gene expression in heart of rats with stress-induced pre-hypertension and try to reveal its biological mechanism based on gene chip technology. METHODS: Twenty-seven Wistar male rats were randomly divided into 3 groups. The stress-induced hypertensive rat model was prepared by electric foot-shocks combined with generated noise. Molding cycle lasted for 14 days and EA intervene was applied,on rats in model + EA group during model preparation. Rat Gene 2.0 Sense Target Array technology was used for the determination of gene expression profiles and the screened key genes were verified by real-time quantitative polymerase chain reaction (RT-PCR) method. RESULTS: Compared with blank control group, 390 genes were changed in model group; compared with model control group, 330 genes were changed in model+EA group. Significance analysis of gene function showed that the differentially expressed genes are those involved in biological process, molecular function and cellular components. RT-PCR result of the screened key genes is consistent with that of gene chip test. CONCLUTION: EA could significantly lower blood pressure of stress-induced pre-hypertension rats and affect its gene expression profile in heart. Genes that related to the contraction of vascular smooth muscle may be involved in EA's anti-hypertensive mechanism."

Evidence Sentence: The expression of heat shock 70 kDa protein (HSPA1A) (P < 0.01), heat shock protein beta-1 (HSPB1) (P < 0.01), oxidized low-density lipoprotein receptor 1 (OLR1) (P = 0.035), phospholipase A2 (PLA2G4A) (P < 0.01) and prostaglandin-endoperoxide synthase 2 (PTGS2) (P = 0.041) was significantly higher in model control group compared to blank control group.
Evidence Sentence: HSPA1A (P < 0.01), HSPB1 (P < 0.01), OLR1 (P < 0.01), PLA2G4A (P < 0.01) and PTGS2 (P = 0.015) expression was significantly lower in model + EA group when compared to model control group.
Evidence Sentence: Altered genes including PLA2G4A (FC = 1.70934), HSPB1 (FC = 1.88297), HSPA1A (FC = 1.70622), PTGS2 (FC = 2.24993), OLR1 (FC = 2.11512), which are related to the cytoskeleton and the contraction of vascular smooth muscle, up-regulated in model control group when compared with blank control group, but down-regulated in model + EA group, PLA2G4A (FC = - 1.54617), HSPB1 (FC = -2.52067), HSPA1A (FC = -1.92875), PTGS2 (FC = - 1.85358), OLR1 (FC = - 2.29848), when compared with model control.
Evidence Sentence: HSPA1A, also called HSP70. HSPB1 and HSPA1A proteins belong to the HSP family
Evidence Sentence: In recent years many researches also focus on the HSPA1A.
Evidence Sentence: Reports showed that the increased amount of serum HSPA1A antibody is positively correlated to the elevation of blood pressure, indicating that HSPA1A gene is closely related to hypertension.
Evidence Sentence: In our study, the elevated expression of HSPB1 and HSPA1A gene indicates that endogenous protection of the cardiovascular system has been activated by stress, HSPB1 and HSPA1A are involved in the development of hypertension, which is consistent with previous researches.