| Evidence Sentence: |
The result shows that the phosphorylation of the Ras, Raf-1, MEK-1, and ERK-1/2 proteins and the expression of the corresponding mRNAs in the colon tissue of CD rat were significantly higher than the normal control group. |
| Evidence Sentence: |
Both treatments with mild moxibustion and with herb-separated moxibustion significantly reduced the expression of the Ras, Raf-1, MEK-1, and ERK-1/2 proteins and Ras and Raf-1 mRNA. |
| Evidence Sentence: |
MEK-1 and ERK-1/2 mRNA expression in each treatment group showed a downward trend, and the ERK-1/2 mRNA levels were significantly lower in the mild moxibustion group. |
| Evidence Sentence: |
It indicates that Ras, Raf-1, MEK-1, and ERK-1/2 are involved in the process of intestinal fibrosis in CD rats. |
| Evidence Sentence: |
Moxibustion can downregulate the abnormal expression of colonic Ras, Raf-1, MEK-1, and ERK-1/2 protein and mRNA levels in CD intestinal fibrosis in rats. |
| Evidence Sentence: |
The MEK-1 Expression in the Colonic Mucosa of Rat |
| Evidence Sentence: |
As shown in Figures 9 and 10, the MEK-1 protein expression in the colonic tissue of the MC group was significantly higher than in NC rats (P < 0.01), and MEK-1 protein expression was significantly reduced in each group after acupuncture treatment (P < 0.01), although the levels were still higher than normal levels (P < 0.01). |
| Evidence Sentence: |
The results in Figure 11 show that the MEK-1 mRNA levels in the model group were significantly higher than those in the NC group (P < 0.01) and that MM, HSM, and EA treatment reduced MEK-1 mRNA levels, although there was no statistically significant difference between the treatment and no treatment groups or among the treatment groups. |
