Evidence Details for Ngf
PMID Title Journal Year Abstract
34393735 Acupuncture Treatment for Social Defeat Stress. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. 2021 Depression is a mood disorder characterized by disordered affect, thoughts, cognition, and behavior. Antidepressant therapy is often the primary treatment for depression. However, antidepressant therapy may cause unwanted side effects, and its effects are slow. Therefore, some patients are seeking alternative treatments for depression, such as acupuncture. However, there are many unclear points regarding the mechanism of the effect of acupuncture on depression. In recent years, we have reported that acupuncture improves the symptoms of mild depression induced by water-immersion stress in a rat model and depression induced by forced swimming in a mouse model. In this study, we examined the effect of acupuncture on the symptoms of social defeat stress (SDS)-induced depression in mice that most closely resemble human symptoms. In this study, we investigated the preventive and therapeutic effects of acupuncture as part of GV20 ""Bai-Hui"" and Ex-HN3 ""Yintang"" on model mice with depression induced by SDS. To examine the mechanism of the preventive and therapeutic effects of acupuncture on depression model mice, we examined the expression of neurotrophic factors in the brains of SDS mice. Two weeks of simultaneous acupuncture stimulation as part of GV20 and Ex-HN3 restored SDS-reduced brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3, and NT-4/5 expression, which was not observed with antidepressants. In contrast, acupuncture stimulation suppressed nerve growth factor (NGF) expression induced by SDS. These results suggest that acupuncture treatment could be effective in correcting the imbalance in the expression of neurotrophic factors. Furthermore, the effects of acupuncture on the expression of neurotrophic factors appear earlier than those of antidepressants, suggesting that it may be a useful treatment for depression."

Evidence Sentence: In contrast, acupuncture stimulation suppressed nerve growth factor (NGF) expression induced by SDS.
Evidence Sentence: In the SDS group, mRNA expression of NGF was higher than that in the control group [F(3, 28) = 6.113497, p = 0.0025] (Control vs.
Evidence Sentence: In the SDS+AP and SDS+ imipramine groups, the mRNA expression of NGF was lower than that in the SDS group (SDS vs.
Evidence Sentence: Contrary to NGF expression, mRNA expression of BDNF [F(3, 28) = 5.740770, p = 0.0034] (Control vs.
Evidence Sentence: As with the study of preventive effects, NGF was significantly enhanced in the brain of SDS mice [F(3, 28) = 7.016273, p = 0.0012] (Control vs.
Evidence Sentence: Enhanced mRNA expression of NGF by SDS was reduced by acupuncture (SDS vs.
Evidence Sentence: In the brain of SDS mice with ongoing symptoms of depression, NGF protein levels were significantly enhanced [F(3, 28) = 4.619710, p = 0.0095] (Control vs.
Evidence Sentence: SDS-enhanced NGF protein was suppressed by acupuncture (SDS vs.
Evidence Sentence: As with mRNA expression analysis, NGF protein was significantly enhanced [F(3, 28) = 5.583477, p = 0.0039] (Control vs.
Evidence Sentence: Similar to the study investigating preventive effects, acupuncture and imipramine suppressed SDS-enhanced NGF protein (SDS vs.