Evidence Details for P2rx4
PMID Title Journal Year Abstract
25206515 Electroacupuncture at He-Mu points reduces P2X4 receptor expression in visceral hypersensitivity. Neural Regen Res. 2013 Aug 5;8(22):2069-77. doi: 10.3969/j.issn.1673-5374.2013.22.006. 2013 Aug 5 Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats. Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome. Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X4 receptor immureactivity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X4 receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X4 receptor immunoreactivity in the colon and spinal cord."

Evidence Sentence: Electroacupuncture at He-Mu points reduces P2X4 receptor expression in visceral hypersensitivity
Evidence Sentence: Simultaneously, P2X4 receptor immureactivity significantly increased in the colon and spinal cord.
Evidence Sentence: Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X4 receptor immunoreactivity in the colon and spinal cord.
Evidence Sentence: These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X4 receptor immunoreactivity in the colon and spinal cord.
Evidence Sentence: Electroacupuncture at He-Mu points diminished P2X4 receptor immunoreactivity in the colon of rats with chronic visceral hypersensitivity
Evidence Sentence: Immunohistochemistry revealed that P2X4 receptor immunoreactivity was increased in the colon of rats with irritable bowel syndrome (P < 0.01).
Evidence Sentence: Compared with the model group, P2X4 receptor immunoreactivity was significantly lower in the electroacupuncture and pinaverium bromide groups (P < 0.01; Figure 2).
Evidence Sentence: Electroacupuncture at He-Mu points diminished P2X4 receptor immunoreactivity in spinal cord tissue of rats with chronic visceral hypersensitivity
Evidence Sentence: Immunohistochemistry revealed that P2X4 receptor immunoreactivity was increased in the spinal cord of rats with irritable bowel syndrome (P < 0.01).
Evidence Sentence: Compared with the model group, P2X4 receptor immunoreactivity was significantly lower in the electroacupuncture and pinaverium bromide groups (P < 0.01; Figure 3).