Evidence Details for PDGFB
PMID Title Journal Year Abstract
25558226 Electroacupuncture upregulated platelet derived growth factor expression in spared dorsal root ganglion of cats. Neural Regen Res. 2012 Sep 25;7(27):2131-5. doi: 10.3969/j.issn.1673-5374.2012.27.007. 2012 Sep 25 A bilateral spared dorsal root ganglion model was established in healthy adult cats by bilateral resection of L1-5 and L7-S2 dorsal root ganglia. L6 dorsal root ganglia were spared. Zusanli (ST36) and Xuanzhong (BL39) or Futu (ST32) and Sanyinjiao (SP6) were alternatively electro-stimulated on the right leg. Immunohistochemical staining of anti-serum platelet-derived growth factor demonstrated that the number of total neurons and medium-small sized platelet-derived growth factor positive neurons was significantly decreased on the 7(th) day following injury. After 7 days of acupuncture, the total number of positive and large neurons staining for platelet-derived growth factor on the acupuncture side significantly increased compared to the non-acupuncture side. After acupuncture for 14 days, the total positive and medium-small sized neurons significantly increased compared with the non-acupuncture side. Results indicate that acupuncture promoted the synthesis of platelet-derived growth factor in spared dorsal root ganglia."

Evidence Sentence: PDGF expression in L6 DRG after bilateral dorsal root rhizotomy
Evidence Sentence: PDGF was mainly expressed in small-to medium-sized neurons in L6 DRG in each group.
Evidence Sentence: PDGF positive immunoreactive products were present mainly in the cytoplasm, and in the partial fibers, without pronounced satellite cell staining (Figure 1, Table 1).
Evidence Sentence: PDGF expression in spared DRG after partial dorsal root rhizotomy and acupuncture
Evidence Sentence: PDGF was expressed in neurons in spared DRG.
Evidence Sentence: The number of PDGF positive neurons and small-to-medium-sized neurons on both sides of the model group decreased significantly as compared with that in control DRG at 7 days (P < 0.05).
Evidence Sentence: After the application of acupuncture, however, there were overall more PDGF positive neurons, particularly large neurons, than those on the non-electroacupuncture side on the 7th day (P < 0.05).
Evidence Sentence: Furthermore, there were more PDGF positive neurons and small-to-medium-sized neurons than those on the non-electroacupuncture side on the 14th day (P < 0.05).
Evidence Sentence: Immunohistochemical staining of anti-serum platelet-derived growth factor demonstrated that the number of total neurons and medium-small sized platelet-derived growth factor positive neurons was significantly decreased on the 7th day following injury.
Evidence Sentence: After 7 days of acupuncture, the total number of positive and large neurons staining for platelet-derived growth factor on the acupuncture side significantly increased compared to the non-acupuncture side.
Evidence Sentence: Results indicate that acupuncture promoted the synthesis of platelet-derived growth factor in spared dorsal root ganglia.