Evidence Details for Rdh9
PMID Title Journal Year Abstract
25983633 Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis. Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. 2015 Mar Parkinson's disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transcript array in the SN region related to the inhibitory effects of acupuncture in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonism model. In this model, acupuncture stimulation at GB34 and LR3 attenuated the decrease in tyrosine hydroxylase in the SN region; stimulation at non-acupoints did not suppress this decrease. Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation. In addition, 17 (two annotated genes: 4921530L21Rik and Gm13931) probes that were down-regulated in MPTP animals compared to controls were exclusively up-regulated by acupuncture stimulation. These findings indicate that the 39 probes (12 annotated genes) affected by MPTP and acupuncture may be responsible for the inhibitory effects of acupuncture on degeneration-related gene expression in the SN following damage induced by MPTP intoxication."

Evidence Sentence: Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation.
Evidence Sentence: Retinol dehydrogenase 9 (Rdh9) is a short-chain dehydrogenase/reductase and converts 9-cis-retinol into 9-cis-retinal and 3alpha-androstanediol into dihydrotestosterone.
Evidence Sentence: Widespread Rdh9 function in steroid or retinoid metabolism begins mid-embryogenesis, and may be an important link between neuroactive steroids and neurodegenerative disorders.
Evidence Sentence: The up-regulation of Rdh9 in the MPTP-treated group relative to the control group is thought to be one aspect of this consequence.
Evidence Sentence: However, further evidence is needed to confirm this, and the maintenance of Rdh9 expression following acupuncture may have neuro-protective effects.
Evidence Sentence: Expression levels of Rdh9, Slc6a4, Tph2 and Ucma, which were up-down regulated in the microarray analysis, also showed up-down regulation in real time RT-PCR (Figure 3).