Evidence Details for Syp
PMID Title Journal Year Abstract
29623942 Combined acupuncture and HuangDiSan treatment affects behavior and synaptophysin levels in the hippocampus of senescence-accelerated mouse prone 8 after neural stem cell transplantation. Neural Regen Res. 2018 Mar;13(3):541-548. doi: 10.4103/1673-5374.228760. 2018 Mar Sanjiao acupuncture and HuangDiSan can promote the proliferation, migration and differentiation of exogenous neural stem cells in senescence-accelerated mouse prone 8 (SAMP8) mice and can improve learning and memory impairment and behavioral function in dementia-model mice. Thus, we sought to determine whether Sanjiao acupuncture and HuangDiSan can elevate the effect of neural stem cell transplantation in Alzheimer's disease model mice. Sanjiao acupuncture was used to stimulate Danzhong (CV17), Zhongwan (CV12), Qihai (CV6), bilateral Xuehai (SP10) and bilateral Zusanli (ST36) 15 days before and after implantation of neural stem cells (5 x 10(5)) into the hippocampal dentate gyrus of SAMP8 mice. Simultaneously, 0.2 mL HuangDiSan, containing Rehmannia Root and Chinese Angelica, was intragastrically administered. Our results demonstrated that compared with mice undergoing neural stem cell transplantation alone, learning ability was significantly improved and synaptophysin mRNA and protein levels were greatly increased in the hippocampus of mice undergoing both Sanjiao acupuncture and intragastric administration of HuangDiSan. We conclude that the combination of Sanjiao acupuncture and HuangDiSan can effectively improve dementia symptoms in mice, and the mechanism of this action might be related to the regulation of synaptophysin expression."

Evidence Sentence: Combined acupuncture and HuangDiSan treatment affects behavior and synaptophysin levels in the hippocampus of senescence-accelerated mouse prone 8 after neural stem cell transplantation
Evidence Sentence: Our results demonstrated that compared with mice undergoing neural stem cell transplantation alone, learning ability was significantly improved and synaptophysin mRNA and protein levels were greatly increased in the hippocampus of mice undergoing both Sanjiao acupuncture and intragastric administration of HuangDiSan.
Evidence Sentence: We conclude that the combination of Sanjiao acupuncture and HuangDiSan can effectively improve dementia symptoms in mice, and the mechanism of this action might be related to the regulation of synaptophysin expression.
Evidence Sentence: Protein levels of synaptophysin in the hippocampus of SAMP8 mice
Evidence Sentence: Compared with the RC group, the levels of synaptophysin in the PC, PT, PTA, PTD and PTC groups were significantly reduced (P < 0.05).
Evidence Sentence: Compared with the PC group, synaptophysin levels in the PTC group were significantly increased (P < 0.05).
Evidence Sentence: Compared with the PT group, synaptophysin levels in the PTA, PTD and PTC groups were not changed significantly (P > 0.05).
Evidence Sentence: Compared with the PTA group, synaptophysin levels in the PTD and PTC groups were not significantly different (P > 0.05; Figure 2).
Evidence Sentence: Gene expression of synaptophysin in the hippocampus of SAMP8 mice
Evidence Sentence: Compared with the RC group, synaptophysin mRNA levels in the PC, PT, PTA, PTD and PTC groups were significantly decreased (P < 0.05).
Evidence Sentence: Meanwhile, synaptophysin mRNA levels in the PTC group were significantly increased compared with the PC group (P < 0.05).
Evidence Sentence: Compared with the PT, PTA, and PTD groups, synaptophysin mRNA levels in the PTC group were significantly increased (P < 0.05; Figure 3).