Evidence Details for Tgfb1
PMID Title Journal Year Abstract
27630692 Mechanisms of electroacupuncture effects on acute cerebral ischemia/reperfusion injury: possible association with upregulation of transforming growth factor beta 1. Neural Regen Res. 2016 Jul;11(7):1099-101. doi: 10.4103/1673-5374.187042. 2016 Jul Electroacupuncture at the head acupoints Baihui (GV20) and Shuigou (GV26) improves recovery of neurological function following ischemic cerebrovascular events, but its mechanism remains incompletely understood. We hypothesized that the action of electroacupuncture at these acupoints is associated with elevated serum levels of transforming growth factor beta 1 (TGF-beta1). To test this, we established a rat model of cerebral ischemia by middle cerebral artery occlusion. Electroacupuncture was performed at Baihui and Shuigou with a ""disperse-dense"" wave at an alternating frequency of 2 and 150 Hz, and at a constant intensity of 3 mA. Each electroacupuncture session lasted 30 minutes and was performed every 12 hours for 3 days. Neurological severity scores were lower in injured rats after acupuncture than in those not subjected to treatment. Furthermore, serum level of TGF-beta1 was greater after electroacupuncture than after no treatment. Our results indicate that electroacupuncture at Baihui and Shuigou increases the serum level of TGF-beta1 in rats with acute cerebral ischemia/reperfusion injury, and exerts neuroprotective effects."

Evidence Sentence: We hypothesized that the action of electroacupuncture at these acupoints is associated with elevated serum levels of transforming growth factor beta 1 (TGF-beta1).
Evidence Sentence: Furthermore, serum level of TGF-beta1 was greater after electroacupuncture than after no treatment.
Evidence Sentence: Our results indicate that electroacupuncture at Baihui and Shuigou increases the serum level of TGF-beta1 in rats with acute cerebral ischemia/reperfusion injury, and exerts neuroprotective effects.
Evidence Sentence: Electroacupuncture increased serum TGF-beta1 level in rats with acute cerebral ischemia/reperfusion injury
Evidence Sentence: Serum level of TGF-beta1 in the model and electroacupuncture groups was greater than in the sham-operated group 12, 24, 48 and 72 hours after cerebral ischemia/reperfusion (P < 0.05).
Evidence Sentence: TGF-beta1 level in the model group was significantly elevated after cerebral ischemia/reperfusion at all time points examined, increasing between 12 and 48 hours, and decreasing at 72 hours.
Evidence Sentence: In the electroacupuncture group, TGF-beta1 level was higher than in the model group at all time points (P < 0.05; Table 1).