| Evidence Sentence: |
The result shows that TLR2, IRAK1, and IKK-b mRNA and protein levels in the colonic mucosa were significantly higher in the UC rats than in the control rats. |
| Evidence Sentence: |
Herb-partitioned moxibustion reduced the expression of TLR2, IRAK1, and IKK-b mRNA and proteins in the UC rats. |
| Evidence Sentence: |
TLR2 mRNA and Protein Expression in Rat Colonic Mucosa |
| Evidence Sentence: |
As shown in Figure 3, TLR2 mRNA level in the colonic mucosa was significantly higher in the UC rats than in the control rats (P < 0.01). |
| Evidence Sentence: |
Both herb-partitioned moxibustion and SASP treatments significantly reduced TLR2 mRNA expression in the colonic mucosa of UC rats (P < 0.01). |
| Evidence Sentence: |
TLR2 protein expression was determined using immunohistochemistry and quantified by the total area of staining and the integrated optical density. |
| Evidence Sentence: |
As shown in Figures 4 and 5, TLR2 protein levels in the colonic mucosa were higher in UC rats than in control rats, as indicated by both of these measurements (P < 0.01). |
| Evidence Sentence: |
The total area of TLR2 staining was significantly lower in both the herb-partitioned moxibustion and SASP treated groups than in the UC group (P < 0.01, P < 0.05). |
| Evidence Sentence: |
TLR2 protein levels were slightly lower in the herb-partitioned moxibustion group than in the SASP group, but the difference was not statistically significant (P > 0.05). |
| Evidence Sentence: |
It indicates that herb-partitioned moxibustion can inhibit the expression of multiple signaling molecules of the TLR2 pathway effectively, and it may modulate the excessive local immune response by inhibiting TLR2 signaling, thereby promoting the repair of damaged colonic mucosa. |
| Evidence Sentence: |
Herb-Partitioned Moxibustion Regulates the TLR2/NF-kappaB Signaling Pathway in a Rat Model of Ulcerative Colitis |
| Evidence Sentence: |
The TLR2/NF-kappaB signaling pathway plays an important role in the pathomechanism of ulcerative colitis (UC); acupuncture and moxibustion can improve the damage in colonic tissues of UC, but the regulatory mechanism remains unknown. |
| Evidence Sentence: |
This study observed the effect of moxibustion on the TLR2/NF-kappaB signaling pathway at the Tianshu (ST25) and Qihai (CV6) acupuncture points in the UC rat. |
