Evidence Details for Tnf
PMID Title Journal Year Abstract
25302705 Electro-acupuncture at Neiguan pretreatment alters genome-wide gene expressions and protects rat myocardium against ischemia-reperfusion. Molecules. 2014 Oct 9;19(10):16158-78. doi: 10.3390/molecules191016158. 2014 Oct 9 This study investigated genome-wide gene expressions and the cardioprotective effects of electro-acupuncture pretreatment at the PC6 Neiguan acupoint on myocardial ischemia reperfusion (I/R) injury. Male SD rats were randomly divided into four groups: sham operation (SO), I/R, electro-acupuncture at the PC6 Neiguan acupoint pretreatment (EA) and electro-acupuncture at non-acupoint pretreatment (NA). Compared with the I/R group, the survival rate of the EA group was significantly increased, the arrhythmia score, infarction area, serum concentrations of CK, LDH and CK-Mb and plasma level of cTnT were significantly decreased. RNA-seq results showed that 725 genes were up-regulated and 861 genes were down-regulated under I/R conditions compared to the SO group; both EA and NA reversed some of these gene expression levels (592 in EA and 238 in NA group). KEGG pathway analysis indicated that these genes were involved in multiple pathways, including ECM, MAPK signaling, apoptosis, cytokine and leukocyte pathways. In addition, some pathways were uniquely regulated by EA, but not NA pretreatment, such as oxidative stress, cardiac muscle contraction, gap junction, vascular smooth muscle contraction, hypertrophic, NOD-like receptor, and P53 and B-cell receptor pathways. This study was first to reveal the gene expression signatures of acute myocardial I/R injury and electro-acupuncture pretreatment in rats."

Evidence Sentence: This gene encodes a 14-kDa protein (Fn14, TNFrsf12a or Tweakr), which had been shown to play a critical role in cardiac remodeling.
Evidence Sentence: A study by Chorianopoulos and colleagues has identified the expression and regulation of Fn14 in cardiomyocytes and in experimental myocardial infarction.
Evidence Sentence: Recent study showed that TNF-alpha secretion was enhanced in SR-A-/-mice, and could be responsible for the increased MMP activity and augmented risk of MI; SR-A has a role in the induction of innate immunity and plays a central role in cerebral ischemia/reperfusion injury.
Evidence Sentence: Tnfrsf12a, a member of TNF family was up-regulated considerably with 2.67 of FC (Log2) by I/R in our study and largely reversed by EA but not NA (Table 2A).
Evidence Sentence: This gene encodes a 14-kDa protein (Fn14, TNFrsf12a or Tweakr), which had been shown to play a critical role in cardiac remodeling.
Evidence Sentence: Another study also provided evidence, by using an ischemia-reperfusion injury model through hemorrhage and a supraceliac cross-clamp followed by 6h resuscitation, that Tnfrsf12a was involved in apoptosis/cell death and angiogenesis/vascular development.
Evidence Sentence: Our results showed a marked down-regulation of Tnfrsf12a gene with a FC (Log2) of -2.39 in the EA group (Table 2A) but no change in the NA group.
Evidence Sentence: Tnfsf10, Xiap, IL1rap, Pik3r1 were involved in both EA and NA, but Chuk was only involved in EA.