Evidence Details for Ucma
PMID Title Journal Year Abstract
25983633 Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis. Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. 2015 Mar Parkinson's disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transcript array in the SN region related to the inhibitory effects of acupuncture in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonism model. In this model, acupuncture stimulation at GB34 and LR3 attenuated the decrease in tyrosine hydroxylase in the SN region; stimulation at non-acupoints did not suppress this decrease. Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation. In addition, 17 (two annotated genes: 4921530L21Rik and Gm13931) probes that were down-regulated in MPTP animals compared to controls were exclusively up-regulated by acupuncture stimulation. These findings indicate that the 39 probes (12 annotated genes) affected by MPTP and acupuncture may be responsible for the inhibitory effects of acupuncture on degeneration-related gene expression in the SN following damage induced by MPTP intoxication."

Evidence Sentence: Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation.
Evidence Sentence: Upper zone of growth plate and cartilage matrix associated (Ucma) is a highly conserved tyrosine-sulphated secreted protein with a molecular weight of 17 kDa that is expressed by juvenile chondrocytes.
Evidence Sentence: Ucma may be involved in the negative control of the osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface .
Evidence Sentence: In the current study, Ucma expression was up-regulated in the MPTP group compared to the control group, and acupuncture stimulation at GB34 and LR3 maintained Ucma expression at levels similar to those in control animals.
Evidence Sentence: Expression levels of Rdh9, Slc6a4, Tph2 and Ucma, which were up-down regulated in the microarray analysis, also showed up-down regulation in real time RT-PCR (Figure 3).
Evidence Sentence: PD patients have been reported to have a significantly increased risk of fracture, which may be caused by an imbalance in Ucma expression.