Evidence Details for Vegfa
PMID Title Journal Year Abstract
24290795 Primo vascular system floating in lymph ducts of rats. J Acupunct Meridian Stud. 2013 Dec;6(6):306-18. doi: 10.1016/j.jams.2013.09.001. Epub 2013 Sep 21. 2013 Dec An epoch-making development in the gross anatomy of the lymph system has emerged: the observation of the primo vascular system (PVS), which is a threadlike structure floating in lymph ducts. The PVS, which was proposed as the conduit for the acupuncture Qi, is a complex network distributed throughout an animal's body. The lymph-PVS, which is a subsystem of the PVS, is one of the most convincing visual demonstrations of the PVS. Because its existence is not easily demonstrated, even with a microscope, due to its transparency, in current anatomy its existence is largely unknown despite its potential significance in physiology and medicine. The lymph-PVS has been observed in rabbits, rats, and mice by several independent teams. Because the involved techniques are rather complicated, we provide detailed protocols for surgery, for injection of the staining dye, and for detection, extraction, and identification of the PVS in a rat."

Evidence Sentence: The discovery of the specific marker LYVE-1 [1] was the culmination of a series of investigations on lymphatic endothelial cells that had been triggered by the discovery of vascular endothelial growth factors [2,3].
Evidence Sentence: PVS specimens for molecular-level investigations to find vascular endothelial growth factors and specific markers for the PVS.
Evidence Sentence: First, finding the vascular endothelial growth factors and the specific markers corresponding to LYVE-1 will be a milestone for molecular-level research on the PVS