Evidence Details for Zusanli
PMID Title Journal Year Abstract
18830456 Mechanism of reflex regulation of the gastroduodenal function by acupuncture. Evid Based Complement Alternat Med. 2008 Sep;5(3):251-6. doi: 10.1093/ecam/nem077. 2008 Sep Many clinical studies focus on the effects of acupuncture on digestive disorders. However, few studies describe the mechanism by which these effects are produced. We present some recent experimental work on the mechanism of acupuncture for reflex regulation of gastroduodenal function in anesthetized rats. In anesthetized rats, it has been proven that acupuncture to the abdomen excites sympathetic nerves via spinal reflexes causing inhibition of motilities while acupuncture of limbs excites vagus nerves via supraspinal reflexes causing an increase in the motilities. It has also been shown that in order to inhibit gastric motilities, acupuncture stimulation of the abdomen must be strong enough to excite group VI fibers of the afferent intercostal nerves. To increase gastric motilities, acupuncture stimulation to hind limbs must be strong enough to excite the high-threshold group III fibers of tibial nerves. It has also been shown that the neural mechanism of duodenal motility stimulation by acupuncture involves the same body regions and intensity of stimulation as that of gastric motilities. Theories regarding the underlying mechanism have proposed somato-autonomic reflexes and responses via endogenous opioids, etc., but without definitive conclusions."

Evidence Sentence: electro-acupuncture of the hind paw of the anesthetized rats at acupuncture point S-36 Excitatory response of gastric acid secretion with electro-acupuncture disappeared after vagotomy