Detail information
ID ENCL000050
Year 2015
Disease Coronary Artery Disease
Surgery Percutaneous Coronary Intervention
Acupoint
Acupoint Code
Neiguan PC6
Ximen PC4
Side bilaterally
Description Neiguan (PC6) and Ximen (PC4) acupoints in the forearm bilaterally
Experimental Description 388 patients (≥ 18 years old) with CAD, undergoing elective PCI were enrolled and randomized, out of those 204 went through the whole trial. EAP was conducted by 30-minute electrical stimulation through 4 electrodes attached to the Antiguan (PC6) and Ximen (PC4) acupoints in the forearm bilaterally 1-2 h prior to PCI. The control group had sham electrodes but no electrical stimulation.
Sample Count 388
Age ≥18
Control
Placebo
control group(n=195)
Experiment EAP group(n=193)
Indicator Myocardial infarction type 4a(MI4a) Post-procedural cardiac function Major adverse cardiac/cerebrovascular event(MACCE) rate Echocardiography C-reactive protein(CRP) TNF-α IL-6 IL-10 High mobility group box 1(HMGB1) PET/CT imaging
Stimulation Method EA
Induction Method
Electroacupuncture Instrument Model Manufacturer Frequency Waveform Strength Induction Time
- - - - - 30 min

Acupuncture_Needle Needle_Manufacturer Needle_Depth
- - -

Description EAP protocol utilized was 30-minute electrical stimulation through 4 electrodes attached to the Neiguan (PC6) and Ximen (PC4) acupoints in the forearm bilaterally 1-2 h prior to PCI.
Anesthesia Method
GA
Clinical Trial Type randomly
Effector EAP prior to PCI significantly reduced the incidence of MI4a (serum cTnI ≥ 0.20 ng/mL) 24 h post-PCI compared to the control group (P = 0.004). The echocardiography at 6 months after PCI revealed significant improvement in cardiac function in the EAP group compared with the control group. The MACCE rate was significantly decreased in the EAP group at 24 month follow-up compared to the control group (P = 0.0157). Moreover, multivariate logistic regression analysis showed that EAP was associated with decreased likelihood of MACCE (odds ratio 0.327, 95% CI 0.140-0.767, P = 0.010). EAP prior to PCI significantly reduced cTnI release and protected patients with CAD from subsequent myocardial injury after PCI procedure.
Literature
PMID 26011261
Title Efficacy of electroacupuncture pretreatment for myocardial injury in patients undergoing percutaneous coronary intervention: A randomized clinical trial with a 2-year follow-up.
Abstract Electroacupuncture pretreatment (EAP) safely protects the heart from ischemic injury, however, the efficacy of EAP for periprocedural myocardial injury after percutaneous coronary intervention (PCI) remains unclear. Our aim was to investigate whether EAP prior to PCI reduces post-PCI myocardial injury in patients with coronary artery disease (CAD). 388 patients (>/= 18 years old) with CAD, undergoing elective PCI were enrolled and randomized, out of those 204 went through the whole trial. EAP was conducted by 30-minute electrical stimulation through 4 electrodes attached to the Antiguan (PC6) and Ximen (PC4) acupoints in the forearm bilaterally 1-2h prior to PCI. The control group had sham electrodes but no electrical stimulation. The primary end point was the incidence of myocardial infarction type 4a (MI4a) based on serum cTnI values at 24h after PCI. The secondary end points included post-procedural cardiac function and the major adverse cardiac/cerebrovascular event (MACCE) rate. EAP prior to PCI significantly reduced the incidence of MI4a (serum cTnI>/=0.20 ng/mL) 24h post-PCI compared to the control group (P=0.004). The echocardiography at 6 months after PCI revealed significant improvement in cardiac function in the EAP group compared with the control group. The MACCE rate was significantly decreased in the EAP group at 24 month follow-up compared to the control group (P=0.0157). Moreover, multivariate logistic regression analysis showed that EAP was associated with decreased likelihood of MACCE (odds ratio 0.327, 95% CI 0.140-0.767, P=0.010). EAP prior to PCI significantly reduced cTnI release and protected patients with CAD from subsequent myocardial injury after PCI procedure."
Souce Int J Cardiol. 2015 Sep 1;194:28-35. doi: 10.1016/j.ijcard.2015.05.043. Epub 2015 May 13.