Ninety patients undergoing IVF-EF oocyte retrieval were randomly divided into three groups: an acupuncture group with needles inserted into bilateral Hegu (LI 4) points, a placebo group given placebo needles, and a control group with routine oocyte retrieval. Each group had an indometacin enema 30 min before the operation.
Sample Count
90
Age
25-40
Control
Std
Placebo
placebo group(n=30);control group(n=30)
Experiment
acupuncture group(n=30)
Indicator
SF-MPQPain-rated index(PRI)Visual analog scale(VAS)Present pain intensity(PPI)NPY level of the follicular fluid
Auxiliary Medication
Thirty minutes before the operation, a 0.1 g indometacin enema (produced by Shanghai Modern Pharmaceutical Limited Company with batch number H31020401, Shanghai, China) was given to the patients in the three groups.
Stimulation Method
MS
Induction Method
Electroacupuncture Instrument Model
Manufacturer
Frequency
Waveform
Strength
Induction Time
-
-
-
-
-
Fifteen minutes before the operation,until the end of the operation
Acupuncture_Needle
Needle_Manufacturer
Needle_Depth
0.3×50 mm
-
-
Description Fifteen minutes before the operation, needles were inserted into bilateral Hegu (LI 4) points of the patients in the acupuncture group with the uniform reinforcing-reducing method and remained there until the end of the operation. Hegu (LI 4) points of the patients in the placebo group were tapped with placebo needles (15 mm was cut off from 25 mm filiform needle, the section was ground round and smooth and the needle was inserted into a slice of rubber) without pricking the epidermis, making the patient think that the filiform needle had been inserted into their skin. The rubber slice was fixed with adhesive plaster to fix the needle in place.
Anesthesia Method
AAA
Clinical Trial Type
randomly
Contraindications
Allergies or were uncooperative
Effector
PRI, VAS, and PPI after operation and 1 h after operation in the acupuncture group were significantly lower than those in the control group (P< 0.01). No obvious difference (P>0.05) was observed in PRI, VAS, and PPI after operation and 1 h after operation between the placebo group and the control group. The NPY level of the follicular fluid in the acupuncture group was significantly higher than that in the control group (P<0.01). No obvious difference (P>0.05) was observed in the NPY level of the follicular fluid between the placebo group and the control group. The analgesic effect of acupuncture at Hegu in transvaginal oocyte retrieval using ultra- sonography may be related to the increase in the NPY level of the follicular fluid.
Analgesic effect of acupuncture at hegu (LI 4) on transvaginal oocyte retrieval with ultrasonography.
Abstract
OBJECTIVE: To observe the analgesic effect of acupuncture at Hegu (LI 4) in vitro fertilization-embryo transfer (IVF-ET) transvaginal oocyte retrieval using ultrasonography and explore its mechanism. METHODS: Ninety patients undergoing IVF-EF oocyte retrieval were randomly divided into three groups: an acupuncture group with needles inserted into bilateral Hegu (LI 4) points, a placebo group given placebo needles, and a control group with routine oocyte retrieval. Each group had an indometacin enema 30 min before the operation. We compared the pain-rated index (PRI), visual analogy scale (VAS), and present pain intensity (PPI) immediately after operation and 1 h after operation. We also determined the neuropeptide Y (NPY) level of the follicular fluid. RESULTS: PRI, VAS, and PPI after operation and 1 h after operation in the acupuncture group were significantly lower than those in the control group (P < 0.01). No obvious difference (P > 0.05) was observed in PRI, VAS, and PPI after operation and 1 h after operation between the placebo group and the control group. The NPY level of the follicular fluid in the acupuncture group was significantly higher than that in the control group (P < 0.01). No obvious difference (P > 0.05) was observed in the NPY level of the follicular fluid between the placebo group and the control group. CONCLUSION: The analgesic effect of acupuncture at Hegu in transvaginal oocyte retrieval using ultrasonography may be related to the increase in the NPY level of the follicular fluid."
