Detail information
ID ENCL000078
Year 2012
Acupoint
Acupoint Code
Shenting GV24
Yintang GV29
Side
Description GV24 and EX–HN3 (Yintang)
Experimental Description Orotracheally intubated patients undergoing mechanical ventilation were randomly assigned into three groups (groups A, B and C). All patients were given an intravenous infusion of midazolam. Patients in group A received no additional treatment. Patients in group B were given acupuncture without electrical stimulation at acupuncture points GV24 and EX-HN3 (Yintang) for 6 h simultaneously, and patients in group C were given electroacupuncture to the same points as in group B.
Sample Count 45
Age ＞18
Control
Std
midazolam group(n=15)
Experiment acupuncture group(n=15);electroacupuncture group(n=15)
Indicator Bispectral index(BIS) Liver function Renal function Adverse reactions associated with anesthesia Cost of midazolam Respiratory depression Hypotension Abdominal distension Postoperative Nausea and Vomiting(PONV) Delayed bowel movement Rash Hallucinations Headache Thrombophlebitis Ataxia
Auxiliary Medication Midazolam
Stimulation Method EA
Induction Method
Electroacupuncture Instrument Model Manufacturer Frequency Waveform Strength Induction Time
HANS LH-202 - 2/100 Hz alternating wave 10-15 mA 6 h

Acupuncture_Needle Needle_Manufacturer Needle_Depth
0.25×40 mm Ace Acupuncture Supplies, China Town, New York, USA 0.5-1.0 inches

Description The parameters of electroacupuncture stimulation were as follows: 3-s bursts alternating between 2 Hz and 100 Hz, at 10~15 mA intensity inducing no discomfort, without muscle contraction. Electrical stimulation was maintained for 30 min alternating with periods of rest for 30 min, repeated six times until the end of the experiment.
Clinical Trial Type random
Contraindications No obvious rash, hallucination, headache, thrombophlebitis or ataxia occurred in any group. In addition, after the acupuncture needles were removed, there was no obvious bleeding at the acupuncture points
Effector Maintaining the BIS between 60 and 80, the hourly mean one dose of midazolam within the first 6 h after sedation in group C was 0.05 (±0.02 mg/kg per hour), which was significantly lower than both group A (0.08±0.03 mg/kg per hour, p<0.001) and group B (0.07±0.01 mg/kg per hour, p<0.021). The doses in groups A and B showed no significant difference. Between-group comparison analysis of hepatic and renal function and severe adverse reactions all showed no significant difference between the three groups. Electroacupuncture appears to reduce markedly the dose of sedative drug required in critically ill patients with mechanical ventilation monitored by BIS, without any obvious severe adverse action, and larger studies to confirm the effect are justified.
Literature
PMID 22459647
Title Electroacupuncture reduces the dose of midazolam monitored by the bispectral index in critically ill patients with mechanical ventilation: an exploratory study.
Abstract OBJECTIVE: Electroacupuncture, a modern variation on a traditional Chinese treatment, might be useful for sedation and analgesia. This study aims to investigate whether electroacupuncture can modify the dose of midazolam monitored by the bispectral index (BIS) in critically ill patients with mechanical ventilation. METHODS: Orotracheally intubated patients undergoing mechanical ventilation were randomly assigned into three groups (groups A, B and C). All patients were given an intravenous infusion of midazolam. Patients in group A received no additional treatment. Patients in group B were given acupuncture without electrical stimulation at acupuncture points GV24 and EX-HN3 (Yintang) for 6 h simultaneously, and patients in group C were given electroacupuncture to the same points as in group B. RESULTS: Maintaining the BIS between 60 and 80, the hourly mean one dose of midazolam within the first 6 h after sedation in group C was 0.05 (+/-0.02 mg/kg per hour), which was significantly lower than both group A (0.08 +/- 0.03 mg/kg per hour, p<0.001) and group B (0.07 +/- 0.01 mg/kg per hour, p<0.021). The doses in groups A and B showed no significant difference. Between-group comparison analysis of hepatic and renal function and severe adverse reactions all showed no significant difference between the three groups. CONCLUSIONS: Electroacupuncture appears to reduce markedly the dose of sedative drug required in critically ill patients with mechanical ventilation monitored by BIS, without any obvious severe adverse action, and larger studies to confirm the effect are justified."
Souce Acupunct Med. 2012 Jun;30(2):78-84. doi: 10.1136/acupmed-2011-010095. Epub 2012 Mar 29.