Detail information
ID ENCL000145
Year 2001
Disease Heart Septal Defects, Atrial
Surgery Atrial Septal Defect Repair
Acupoint
Acupoint Code
Neiguan PC6
Lieque LU7
Yunmen LU2
Side
Description
Experimental Description Thirty patients with atrial septal defect were divided into 3 groups, the general anesthesia group (A), the acupuncture anesthesia group (B) and the general anesthesia combined EA group (C).
Sample Count 30
Age 19-55
Control
Std
general anesthesia group(A)(n=10)
Experiment the acupuncture anesthesia group (B) (n=10) and the general anesthesia combined EA group (C) (n=10).
Indicator Plasma β-endorphin Adrenocorticotropic Hormone(ACTH) Cortisol(Cor) Blood glucose
Auxiliary Medication Fluphenazine;Fentanyl;Lidocaine
Stimulation Method EA
Anesthesia Method
AA
AAA
Clinical Trial Type
Contraindications There are no obvious infections, malignant lesions, endocrine or immunological diseases, etc
Effector Plasma beta-endorphin, ACTH and serum cortisol increased significantly in Group A and B 30 min after CPB but without significant change in Group C. Blood glucose increased in all the 3 groups 30 min after CPB but the increment in Group C was the lowest. Group A and B showed no significant inhibitory effect on HPA axis response and glucose metabolism in open-heart surgery patients undergoing CPB, but Group C could obviously inhibit those responses. Assessment from the viewpoint of stress, the general anesthesia combined with EA is the better approach for anesthesia in open-heart surgery with CPB.
Positive
Literature
PMID 12575601
Title [Effect of combined drug-acupuncture anesthesia on hypothalamo-pituitary-adrenocortical axis response and glucose metabolism in open-heart surgery patients].
Abstract OBJECTIVE: To study and evaluate the effect of electroacupuncture (EA) on hypothalamo-pituitary-adrenocortical (HPA) axis response and glucose metabolism in open-heart surgery patients undergoing cardiopulmonary bypass (CPB). METHODS: Thirty patients with atrial septal defect were divided into 3 groups, the general anesthesia group (A), the acupuncture anesthesia group (B) and the general anesthesia combined EA group (C). Peripheral blood samples were collected at the time before anesthesia, before CPB and 30 min after CPB to determine plasma beta-endorphin, adrenocorticotropic hormone (ACTH), serum cortisol and blood glucose. RESULTS: Plasma beta-endorphin, ACTH and serum cortisol increased significantly in Group A and B 30 min after CPB but without significant change in Group C. Blood glucose increased in all the 3 groups 30 min after CPB but the increment in Group C was the lowest. CONCLUSION: Group A and B showed no significant inhibitory effect on HPA axis response and glucose metabolism in open-heart surgery patients undergoing CPB, but Group C could obviously inhibit those responses. Assessment from the viewpoint of stress, the general anesthesia combined with EA is the better approach for anesthesia in open-heart surgery with CPB."
Souce Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Oct;21(10):729-31.