GO Annotation
| Category | Term ID | Term description |
|---|---|---|
| Process | GO:0000122 | Negative regulation of transcription by RNA polymerase II |
| Process | GO:0000165 | MAPK cascade |
| Process | GO:0001501 | Skeletal system development |
| Process | GO:0001503 | Ossification |
| Process | GO:0001894 | Tissue homeostasis |
| Process | GO:0001932 | Regulation of protein phosphorylation |
| Process | GO:0001934 | Positive regulation of protein phosphorylation |
| Process | GO:0002158 | Osteoclast proliferation |
| Process | GO:0002376 | Immune system process |
| Process | GO:0002520 | Immune system development |
| Process | GO:0002521 | Leukocyte differentiation |
| Process | GO:0002548 | Monocyte chemotaxis |
| Process | GO:0002573 | Myeloid leukocyte differentiation |
| Process | GO:0002673 | Regulation of acute inflammatory response |
| Process | GO:0002675 | Positive regulation of acute inflammatory response |
| Process | GO:0002682 | Regulation of immune system process |
| Process | GO:0002684 | Positive regulation of immune system process |
| Process | GO:0002694 | Regulation of leukocyte activation |
| Process | GO:0002696 | Positive regulation of leukocyte activation |
| Process | GO:0002761 | Regulation of myeloid leukocyte differentiation |
| Process | GO:0002763 | Positive regulation of myeloid leukocyte differentiation |
| Process | GO:0002791 | Regulation of peptide secretion |
| Process | GO:0002793 | Positive regulation of peptide secretion |
| Process | GO:0006355 | Regulation of transcription, DNA-templated |
| Process | GO:0006357 | Regulation of transcription by RNA polymerase II |
| Process | GO:0006935 | Chemotaxis |
| Process | GO:0006950 | Response to stress |
| Process | GO:0006955 | Immune response |
| Process | GO:0007154 | Cell communication |
| Process | GO:0007165 | Signal transduction |
| Process | GO:0007166 | Cell surface receptor signaling pathway |
| Process | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| Process | GO:0007254 | JNK cascade |
| Process | GO:0007267 | Cell-cell signaling |
| Process | GO:0007275 | Multicellular organism development |
| Process | GO:0008283 | Cell population proliferation |
| Process | GO:0009605 | Response to external stimulus |
| Process | GO:0009653 | Anatomical structure morphogenesis |
| Process | GO:0009887 | Animal organ morphogenesis |
| Process | GO:0009888 | Tissue development |
| Process | GO:0009889 | Regulation of biosynthetic process |
| Process | GO:0009890 | Negative regulation of biosynthetic process |
| Process | GO:0009891 | Positive regulation of biosynthetic process |
| Process | GO:0009892 | Negative regulation of metabolic process |
| Process | GO:0009893 | Positive regulation of metabolic process |
| Process | GO:0009966 | Regulation of signal transduction |
| Process | GO:0009967 | Positive regulation of signal transduction |
| Process | GO:0009987 | Cellular process |
| Process | GO:0010033 | Response to organic substance |
| Process | GO:0010468 | Regulation of gene expression |
| Process | GO:0010556 | Regulation of macromolecule biosynthetic process |
| Process | GO:0010557 | Positive regulation of macromolecule biosynthetic process |
| Process | GO:0010558 | Negative regulation of macromolecule biosynthetic process |
| Process | GO:0010562 | Positive regulation of phosphorus metabolic process |
| Process | GO:0010604 | Positive regulation of macromolecule metabolic process |
| Process | GO:0010605 | Negative regulation of macromolecule metabolic process |
| Process | GO:0010628 | Positive regulation of gene expression |
| Process | GO:0010646 | Regulation of cell communication |
| Process | GO:0010647 | Positive regulation of cell communication |
| Process | GO:0010720 | Positive regulation of cell development |
| Process | GO:0010817 | Regulation of hormone levels |
| Process | GO:0016477 | Cell migration |
| Process | GO:0019219 | Regulation of nucleobase-containing compound metabolic process |
| Process | GO:0019220 | Regulation of phosphate metabolic process |
| Process | GO:0019221 | Cytokine-mediated signaling pathway |
| Process | GO:0019222 | Regulation of metabolic process |
| Process | GO:0019722 | Calcium-mediated signaling |
| Process | GO:0019932 | Second-messenger-mediated signaling |
| Process | GO:0022407 | Regulation of cell-cell adhesion |
| Process | GO:0022409 | Positive regulation of cell-cell adhesion |
| Process | GO:0023051 | Regulation of signaling |
| Process | GO:0023052 | Signaling |
| Process | GO:0023056 | Positive regulation of signaling |
| Process | GO:0030097 | Hemopoiesis |
| Process | GO:0030099 | Myeloid cell differentiation |
| Process | GO:0030154 | Cell differentiation |
| Process | GO:0030155 | Regulation of cell adhesion |
| Process | GO:0030316 | Osteoclast differentiation |
| Process | GO:0030595 | Leukocyte chemotaxis |
| Process | GO:0030879 | Mammary gland development |
| Process | GO:0031098 | Stress-activated protein kinase signaling cascade |
| Process | GO:0031323 | Regulation of cellular metabolic process |
| Process | GO:0031324 | Negative regulation of cellular metabolic process |
| Process | GO:0031325 | Positive regulation of cellular metabolic process |
| Process | GO:0031326 | Regulation of cellular biosynthetic process |
| Process | GO:0031327 | Negative regulation of cellular biosynthetic process |
| Process | GO:0031328 | Positive regulation of cellular biosynthetic process |
| Process | GO:0031347 | Regulation of defense response |
| Process | GO:0031349 | Positive regulation of defense response |
| Process | GO:0031399 | Regulation of protein modification process |
| Process | GO:0031401 | Positive regulation of protein modification process |
| Process | GO:0031620 | Regulation of fever generation |
| Process | GO:0031622 | Positive regulation of fever generation |
| Process | GO:0031650 | Regulation of heat generation |
| Process | GO:0031652 | Positive regulation of heat generation |
| Process | GO:0032101 | Regulation of response to external stimulus |
| Process | GO:0032103 | Positive regulation of response to external stimulus |
| Process | GO:0032303 | Regulation of icosanoid secretion |
| Process | GO:0032305 | Positive regulation of icosanoid secretion |
| Process | GO:0032306 | Regulation of prostaglandin secretion |
| Process | GO:0032308 | Positive regulation of prostaglandin secretion |
| Process | GO:0032368 | Regulation of lipid transport |
| Process | GO:0032370 | Positive regulation of lipid transport |
| Process | GO:0032501 | Multicellular organismal process |
| Process | GO:0032502 | Developmental process |
| Process | GO:0032872 | Regulation of stress-activated MAPK cascade |
| Process | GO:0032874 | Positive regulation of stress-activated MAPK cascade |
| Process | GO:0032879 | Regulation of localization |
| Process | GO:0032890 | Regulation of organic acid transport |
| Process | GO:0032892 | Positive regulation of organic acid transport |
| Process | GO:0033209 | Tumor necrosis factor-mediated signaling pathway |
| Process | GO:0033554 | Cellular response to stress |
| Process | GO:0033598 | Mammary gland epithelial cell proliferation |
| Process | GO:0033674 | Positive regulation of kinase activity |
| Process | GO:0034097 | Response to cytokine |
| Process | GO:0034103 | Regulation of tissue remodeling |
| Process | GO:0034110 | Regulation of homotypic cell-cell adhesion |
| Process | GO:0034112 | Positive regulation of homotypic cell-cell adhesion |
| Process | GO:0034612 | Response to tumor necrosis factor |
| Process | GO:0035556 | Intracellular signal transduction |
| Process | GO:0036035 | Osteoclast development |
| Process | GO:0038001 | Paracrine signaling |
| Process | GO:0040011 | Locomotion |
| Process | GO:0042221 | Response to chemical |
| Process | GO:0042325 | Regulation of phosphorylation |
| Process | GO:0042327 | Positive regulation of phosphorylation |
| Process | GO:0042330 | Taxis |
| Process | GO:0042476 | Odontogenesis |
| Process | GO:0042592 | Homeostatic process |
| Process | GO:0043085 | Positive regulation of catalytic activity |
| Process | GO:0043122 | Regulation of I-kappaB kinase/NF-kappaB signaling |
| Process | GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling |
| Process | GO:0043269 | Regulation of ion transport |
| Process | GO:0043270 | Positive regulation of ion transport |
| Process | GO:0043393 | Regulation of protein binding |
| Process | GO:0043397 | Regulation of corticotropin-releasing hormone secretion |
| Process | GO:0043405 | Regulation of MAP kinase activity |
| Process | GO:0043406 | Positive regulation of MAP kinase activity |
| Process | GO:0043408 | Regulation of MAPK cascade |
| Process | GO:0043410 | Positive regulation of MAPK cascade |
| Process | GO:0043491 | Protein kinase B signaling |
| Process | GO:0043549 | Regulation of kinase activity |
| Process | GO:0044070 | Regulation of anion transport |
| Process | GO:0044093 | Positive regulation of molecular function |
| Process | GO:0044691 | Tooth eruption |
| Process | GO:0045124 | Regulation of bone resorption |
| Process | GO:0045453 | Bone resorption |
| Process | GO:0045595 | Regulation of cell differentiation |
| Process | GO:0045597 | Positive regulation of cell differentiation |
| Process | GO:0045637 | Regulation of myeloid cell differentiation |
| Process | GO:0045639 | Positive regulation of myeloid cell differentiation |
| Process | GO:0045670 | Regulation of osteoclast differentiation |
| Process | GO:0045672 | Positive regulation of osteoclast differentiation |
| Process | GO:0045780 | Positive regulation of bone resorption |
| Process | GO:0045785 | Positive regulation of cell adhesion |
| Process | GO:0045859 | Regulation of protein kinase activity |
| Process | GO:0045860 | Positive regulation of protein kinase activity |
| Process | GO:0045892 | Negative regulation of transcription, DNA-templated |
| Process | GO:0045893 | Positive regulation of transcription, DNA-templated |
| Process | GO:0045934 | Negative regulation of nucleobase-containing compound metabolic process |
| Process | GO:0045935 | Positive regulation of nucleobase-containing compound metabolic process |
| Process | GO:0045937 | Positive regulation of phosphate metabolic process |
| Process | GO:0045944 | Positive regulation of transcription by RNA polymerase II |
| Process | GO:0046328 | Regulation of JNK cascade |
| Process | GO:0046330 | Positive regulation of JNK cascade |
| Process | GO:0046849 | Bone remodeling |
| Process | GO:0046850 | Regulation of bone remodeling |
| Process | GO:0046883 | Regulation of hormone secretion |
| Process | GO:0046887 | Positive regulation of hormone secretion |
| Process | GO:0048468 | Cell development |
| Process | GO:0048513 | Animal organ development |
| Process | GO:0048518 | Positive regulation of biological process |
| Process | GO:0048519 | Negative regulation of biological process |
| Process | GO:0048522 | Positive regulation of cellular process |
| Process | GO:0048523 | Negative regulation of cellular process |
| Process | GO:0048534 | Hematopoietic or lymphoid organ development |
| Process | GO:0048583 | Regulation of response to stimulus |
| Process | GO:0048584 | Positive regulation of response to stimulus |
| Process | GO:0048731 | System development |
| Process | GO:0048732 | Gland development |
| Process | GO:0048771 | Tissue remodeling |
| Process | GO:0048856 | Anatomical structure development |
| Process | GO:0048869 | Cellular developmental process |
| Process | GO:0048870 | Cell motility |
| Process | GO:0048871 | Multicellular organismal homeostasis |
| Process | GO:0048878 | Chemical homeostasis |
| Process | GO:0050673 | Epithelial cell proliferation |
| Process | GO:0050727 | Regulation of inflammatory response |
| Process | GO:0050729 | Positive regulation of inflammatory response |
| Process | GO:0050789 | Regulation of biological process |
| Process | GO:0050790 | Regulation of catalytic activity |
| Process | GO:0050793 | Regulation of developmental process |
| Process | GO:0050794 | Regulation of cellular process |
| Process | GO:0050801 | Ion homeostasis |
| Process | GO:0050863 | Regulation of T cell activation |
| Process | GO:0050865 | Regulation of cell activation |
| Process | GO:0050867 | Positive regulation of cell activation |
| Process | GO:0050870 | Positive regulation of T cell activation |
| Process | GO:0050896 | Response to stimulus |
| Process | GO:0050900 | Leukocyte migration |
| Process | GO:0051046 | Regulation of secretion |
| Process | GO:0051047 | Positive regulation of secretion |
| Process | GO:0051049 | Regulation of transport |
| Process | GO:0051050 | Positive regulation of transport |
| Process | GO:0051090 | Regulation of DNA-binding transcription factor activity |
| Process | GO:0051091 | Positive regulation of DNA-binding transcription factor activity |
| Process | GO:0051092 | Positive regulation of NF-kappaB transcription factor activity |
| Process | GO:0051094 | Positive regulation of developmental process |
| Process | GO:0051098 | Regulation of binding |
| Process | GO:0051171 | Regulation of nitrogen compound metabolic process |
| Process | GO:0051172 | Negative regulation of nitrogen compound metabolic process |
| Process | GO:0051173 | Positive regulation of nitrogen compound metabolic process |
| Process | GO:0051174 | Regulation of phosphorus metabolic process |
| Process | GO:0051239 | Regulation of multicellular organismal process |
| Process | GO:0051240 | Positive regulation of multicellular organismal process |
| Process | GO:0051246 | Regulation of protein metabolic process |
| Process | GO:0051247 | Positive regulation of protein metabolic process |
| Process | GO:0051249 | Regulation of lymphocyte activation |
| Process | GO:0051251 | Positive regulation of lymphocyte activation |
| Process | GO:0051252 | Regulation of RNA metabolic process |
| Process | GO:0051253 | Negative regulation of RNA metabolic process |
| Process | GO:0051254 | Positive regulation of RNA metabolic process |
| Process | GO:0051338 | Regulation of transferase activity |
| Process | GO:0051347 | Positive regulation of transferase activity |
| Process | GO:0051403 | Stress-activated MAPK cascade |
| Process | GO:0051716 | Cellular response to stimulus |
| Process | GO:0051896 | Regulation of protein kinase B signaling |
| Process | GO:0051897 | Positive regulation of protein kinase B signaling |
| Process | GO:0055065 | Metal ion homeostasis |
| Process | GO:0055074 | Calcium ion homeostasis |
| Process | GO:0055080 | Cation homeostasis |
| Process | GO:0060249 | Anatomical structure homeostasis |
| Process | GO:0060255 | Regulation of macromolecule metabolic process |
| Process | GO:0060284 | Regulation of cell development |
| Process | GO:0060326 | Cell chemotaxis |
| Process | GO:0060348 | Bone development |
| Process | GO:0060429 | Epithelium development |
| Process | GO:0060749 | Mammary gland alveolus development |
| Process | GO:0061180 | Mammary gland epithelium development |
| Process | GO:0061377 | Mammary gland lobule development |
| Process | GO:0061515 | Myeloid cell development |
| Process | GO:0065007 | Biological regulation |
| Process | GO:0065008 | Regulation of biological quality |
| Process | GO:0065009 | Regulation of molecular function |
| Process | GO:0070302 | Regulation of stress-activated protein kinase signaling cascade |
| Process | GO:0070304 | Positive regulation of stress-activated protein kinase signaling cascade |
| Process | GO:0070371 | ERK1 and ERK2 cascade |
| Process | GO:0070372 | Regulation of ERK1 and ERK2 cascade |
| Process | GO:0070374 | Positive regulation of ERK1 and ERK2 cascade |
| Process | GO:0070661 | Leukocyte proliferation |
| Process | GO:0070887 | Cellular response to chemical stimulus |
| Process | GO:0071310 | Cellular response to organic substance |
| Process | GO:0071345 | Cellular response to cytokine stimulus |
| Process | GO:0071356 | Cellular response to tumor necrosis factor |
| Process | GO:0071674 | Mononuclear cell migration |
| Process | GO:0071812 | Positive regulation of fever generation by positive regulation of prostaglandin secretion |
| Process | GO:0071847 | TNFSF11-mediated signaling pathway |
| Process | GO:0071848 | Positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling |
| Process | GO:0071900 | Regulation of protein serine/threonine kinase activity |
| Process | GO:0071902 | Positive regulation of protein serine/threonine kinase activity |
| Process | GO:0072507 | Divalent inorganic cation homeostasis |
| Process | GO:0080090 | Regulation of primary metabolic process |
| Process | GO:0080134 | Regulation of response to stress |
| Process | GO:0080135 | Regulation of cellular response to stress |
| Process | GO:0090087 | Regulation of peptide transport |
| Process | GO:0090276 | Regulation of peptide hormone secretion |
| Process | GO:0090277 | Positive regulation of peptide hormone secretion |
| Process | GO:0097529 | Myeloid leukocyte migration |
| Process | GO:0098751 | Bone cell development |
| Process | GO:0098771 | Inorganic ion homeostasis |
| Process | GO:1902105 | Regulation of leukocyte differentiation |
| Process | GO:1902107 | Positive regulation of leukocyte differentiation |
| Process | GO:1902531 | Regulation of intracellular signal transduction |
| Process | GO:1902533 | Positive regulation of intracellular signal transduction |
| Process | GO:1902679 | Negative regulation of RNA biosynthetic process |
| Process | GO:1902680 | Positive regulation of RNA biosynthetic process |
| Process | GO:1903037 | Regulation of leukocyte cell-cell adhesion |
| Process | GO:1903039 | Positive regulation of leukocyte cell-cell adhesion |
| Process | GO:1903506 | Regulation of nucleic acid-templated transcription |
| Process | GO:1903507 | Negative regulation of nucleic acid-templated transcription |
| Process | GO:1903508 | Positive regulation of nucleic acid-templated transcription |
| Process | GO:1903530 | Regulation of secretion by cell |
| Process | GO:1903532 | Positive regulation of secretion by cell |
| Process | GO:1903706 | Regulation of hemopoiesis |
| Process | GO:1903708 | Positive regulation of hemopoiesis |
| Process | GO:1903793 | Positive regulation of anion transport |
| Process | GO:1904616 | Regulation of actin binding |
| Process | GO:1905952 | Regulation of lipid localization |
| Process | GO:1905954 | Positive regulation of lipid localization |
| Process | GO:1990823 | Response to leukemia inhibitory factor |
| Process | GO:1990830 | Cellular response to leukemia inhibitory factor |
| Process | GO:2000026 | Regulation of multicellular organismal development |
| Process | GO:2000191 | Regulation of fatty acid transport |
| Process | GO:2000193 | Positive regulation of fatty acid transport |
| Process | GO:2001141 | Regulation of RNA biosynthetic process |
| Process | GO:2001204 | Regulation of osteoclast development |
| Process | GO:2001206 | Positive regulation of osteoclast development |
| Process | GO:0051466 | Positive regulation of corticotropin-releasing hormone secretion |
| Component | GO:0005576 | Extracellular region |
| Component | GO:0005615 | Extracellular space |
| Component | GO:0005886 | Plasma membrane |
| Component | GO:0016020 | Membrane |
| Component | GO:0016021 | Integral component of membrane |
| Component | GO:0031224 | Intrinsic component of membrane |
| Component | GO:0071944 | Cell periphery |
| Component | GO:0110165 | Cellular anatomical entity |
| Function | GO:0005102 | Signaling receptor binding |
| Function | GO:0005125 | Cytokine activity |
| Function | GO:0005126 | Cytokine receptor binding |
| Function | GO:0005164 | Tumor necrosis factor receptor binding |
| Function | GO:0005488 | Binding |
| Function | GO:0005515 | Protein binding |
| Function | GO:0030545 | Signaling receptor regulator activity |
| Function | GO:0030546 | Signaling receptor activator activity |
| Function | GO:0032813 | Tumor necrosis factor receptor superfamily binding |
| Function | GO:0042802 | Identical protein binding |
| Function | GO:0048018 | Receptor ligand activity |
| Function | GO:0098772 | Molecular function regulator activity |
Pathway annotation
| Category | Term ID | Term description |
|---|---|---|
| RCTM | MAP-1280215 | Cytokine Signaling in Immune system |
| RCTM | MAP-168256 | Immune System |
| RCTM | MAP-5668541 | TNFR2 non-canonical NF-kB pathway |
| RCTM | MAP-5669034 | TNFs bind their physiological receptors |
| RCTM | MAP-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |