Gene symbol: Atp5mc2

Also known as: Atp5g2

Organism: Rattus norvegicus

Summary: Enables ligand-gated channel activity. Involved in pore complex assembly; response to 3,3',5-triiodo-L-thyronine; and response to ethanol. Part of cation channel complex. Human ortholog(s) of this gene implicated in renal cell carcinoma and urinary bladder cancer. Orthologous to human ATP5MC2 (ATP synthase membrane subunit c locus 2). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 171082 Ensembl:ENSRNOG00000015320 AllianceGenome:RGD:620051


GO Annotation


Category Term ID Term description
Process GO:0001101 Response to acid chemical
Process GO:0006139 Nucleobase-containing compound metabolic process
Process GO:0006163 Purine nucleotide metabolic process
Process GO:0006164 Purine nucleotide biosynthetic process
Process GO:0006725 Cellular aromatic compound metabolic process
Process GO:0006753 Nucleoside phosphate metabolic process
Process GO:0006754 ATP biosynthetic process
Process GO:0006793 Phosphorus metabolic process
Process GO:0006796 Phosphate-containing compound metabolic process
Process GO:0006807 Nitrogen compound metabolic process
Process GO:0006810 Transport
Process GO:0006811 Ion transport
Process GO:0006812 Cation transport
Process GO:0008152 Metabolic process
Process GO:0009058 Biosynthetic process
Process GO:0009117 Nucleotide metabolic process
Process GO:0009141 Nucleoside triphosphate metabolic process
Process GO:0009142 Nucleoside triphosphate biosynthetic process
Process GO:0009144 Purine nucleoside triphosphate metabolic process
Process GO:0009145 Purine nucleoside triphosphate biosynthetic process
Process GO:0009150 Purine ribonucleotide metabolic process
Process GO:0009152 Purine ribonucleotide biosynthetic process
Process GO:0009165 Nucleotide biosynthetic process
Process GO:0009199 Ribonucleoside triphosphate metabolic process
Process GO:0009201 Ribonucleoside triphosphate biosynthetic process
Process GO:0009205 Purine ribonucleoside triphosphate metabolic process
Process GO:0009206 Purine ribonucleoside triphosphate biosynthetic process
Process GO:0009259 Ribonucleotide metabolic process
Process GO:0009260 Ribonucleotide biosynthetic process
Process GO:0009987 Cellular process
Process GO:0010033 Response to organic substance
Process GO:0010243 Response to organonitrogen compound
Process GO:0014070 Response to organic cyclic compound
Process GO:0015986 Proton motive force-driven ATP synthesis
Process GO:0016043 Cellular component organization
Process GO:0018130 Heterocycle biosynthetic process
Process GO:0019438 Aromatic compound biosynthetic process
Process GO:0019637 Organophosphate metabolic process
Process GO:0019693 Ribose phosphate metabolic process
Process GO:0022607 Cellular component assembly
Process GO:0034220 Ion transmembrane transport
Process GO:0034641 Cellular nitrogen compound metabolic process
Process GO:0034654 Nucleobase-containing compound biosynthetic process
Process GO:0042221 Response to chemical
Process GO:0043200 Response to amino acid
Process GO:0043933 Protein-containing complex organization
Process GO:0044085 Cellular component biogenesis
Process GO:0044237 Cellular metabolic process
Process GO:0044238 Primary metabolic process
Process GO:0044249 Cellular biosynthetic process
Process GO:0044271 Cellular nitrogen compound biosynthetic process
Process GO:0044281 Small molecule metabolic process
Process GO:0045471 Response to ethanol
Process GO:0046034 ATP metabolic process
Process GO:0046390 Ribose phosphate biosynthetic process
Process GO:0046483 Heterocycle metabolic process
Process GO:0046931 Pore complex assembly
Process GO:0050896 Response to stimulus
Process GO:0051179 Localization
Process GO:0051234 Establishment of localization
Process GO:0055085 Transmembrane transport
Process GO:0055086 Nucleobase-containing small molecule metabolic process
Process GO:0065003 Protein-containing complex assembly
Process GO:0071704 Organic substance metabolic process
Process GO:0071840 Cellular component organization or biogenesis
Process GO:0072521 Purine-containing compound metabolic process
Process GO:0072522 Purine-containing compound biosynthetic process
Process GO:0090407 Organophosphate biosynthetic process
Process GO:0097305 Response to alcohol
Process GO:0098655 Cation transmembrane transport
Process GO:0098660 Inorganic ion transmembrane transport
Process GO:0098662 Inorganic cation transmembrane transport
Process GO:1901135 Carbohydrate derivative metabolic process
Process GO:1901137 Carbohydrate derivative biosynthetic process
Process GO:1901293 Nucleoside phosphate biosynthetic process
Process GO:1901360 Organic cyclic compound metabolic process
Process GO:1901362 Organic cyclic compound biosynthetic process
Process GO:1901564 Organonitrogen compound metabolic process
Process GO:1901566 Organonitrogen compound biosynthetic process
Process GO:1901576 Organic substance biosynthetic process
Process GO:1901698 Response to nitrogen compound
Process GO:1901700 Response to oxygen-containing compound
Process GO:1902600 Proton transmembrane transport
Process GO:1905242 Response to 3,3,5-triiodo-L-thyronine
Component GO:0000276 Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
Component GO:0005622 Intracellular anatomical structure
Component GO:0005737 Cytoplasm
Component GO:0005739 Mitochondrion
Component GO:0005740 Mitochondrial envelope
Component GO:0005743 Mitochondrial inner membrane
Component GO:0005753 Mitochondrial proton-transporting ATP synthase complex
Component GO:0016020 Membrane
Component GO:0016021 Integral component of membrane
Component GO:0016469 Proton-transporting two-sector ATPase complex
Component GO:0019866 Organelle inner membrane
Component GO:0031090 Organelle membrane
Component GO:0031224 Intrinsic component of membrane
Component GO:0031966 Mitochondrial membrane
Component GO:0031967 Organelle envelope
Component GO:0031975 Envelope
Component GO:0032991 Protein-containing complex
Component GO:0033177 Proton-transporting two-sector ATPase complex, proton-transporting domain
Component GO:0034702 Ion channel complex
Component GO:0034703 Cation channel complex
Component GO:0043226 Organelle
Component GO:0043227 Membrane-bounded organelle
Component GO:0043229 Intracellular organelle
Component GO:0043231 Intracellular membrane-bounded organelle
Component GO:0045259 Proton-transporting ATP synthase complex
Component GO:0045263 Proton-transporting ATP synthase complex, coupling factor F(o)
Component GO:0098796 Membrane protein complex
Component GO:0098798 Mitochondrial protein-containing complex
Component GO:0098800 Inner mitochondrial membrane protein complex
Component GO:0110165 Cellular anatomical entity
Component GO:1902495 Transmembrane transporter complex
Component GO:1990351 Transporter complex
Function GO:0005215 Transporter activity
Function GO:0005488 Binding
Function GO:0008289 Lipid binding
Function GO:0008324 Cation transmembrane transporter activity
Function GO:0015075 Ion transmembrane transporter activity
Function GO:0015078 Proton transmembrane transporter activity
Function GO:0015267 Channel activity
Function GO:0015318 Inorganic molecular entity transmembrane transporter activity
Function GO:0022803 Passive transmembrane transporter activity
Function GO:0022834 Ligand-gated channel activity
Function GO:0022836 Gated channel activity
Function GO:0022857 Transmembrane transporter activity
Function GO:0022890 Inorganic cation transmembrane transporter activity

Pathway annotation


Category Term ID Term description
RCTM RNO-1428517 The citric acid (TCA) cycle and respiratory electron transport
RCTM RNO-1430728 Metabolism
RCTM RNO-1592230 Mitochondrial biogenesis
RCTM RNO-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
RCTM RNO-163210 Formation of ATP by chemiosmotic coupling
RCTM RNO-1852241 Organelle biogenesis and maintenance
RCTM RNO-8949613 Cristae formation
KEGG rno00190 Oxidative phosphorylation
KEGG rno01100 Metabolic pathways
KEGG rno04714 Thermogenesis
KEGG rno05010 Alzheimer disease
KEGG rno05012 Parkinson disease
KEGG rno05014 Amyotrophic lateral sclerosis
KEGG rno05016 Huntington disease
KEGG rno05020 Prion disease
KEGG rno05022 Pathways of neurodegeneration - multiple diseases
KEGG rno05208 Chemical carcinogenesis - reactive oxygen species
KEGG rno05415 Diabetic cardiomyopathy

Expression profile of Atp5mc2 in omics data



ID GSE143895
Title GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4276356 dhsc01 strain: Sprague Dawley tissue: DHSC treatment: CCI 191.916
GSM4276357 dhsc03 strain: Sprague Dawley tissue: DHSC treatment: CCI 192.081
GSM4276358 dhsc05 strain: Sprague Dawley tissue: DHSC treatment: CCI 175.658
GSM4276359 dhsc13 strain: Sprague Dawley tissue: DHSC treatment: SHAM 181.526
GSM4276360 dhsc15 strain: Sprague Dawley tissue: DHSC treatment: SHAM 236.708

ID GSE244436
Title Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7816143 Liver, Control for SevoAnes tissue: liver genotype: wild type treatment: Control for SevoAnes 188.528763
GSM7816144 Liver, Anesthetized with sevoflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with sevoflurane for 6 h 198.959808
GSM7816145 Liver, Control for DesAnes tissue: liver genotype: wild type treatment: Control for DesAnes 171.790939
GSM7816146 Liver, Anesthetized with desflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with desflurane for 6 h 183.441895