Gene symbol: Rorc

Organism: Rattus norvegicus

Summary: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; oxysterol binding activity; and transcription coactivator binding activity. Involved in circadian rhythm. Predicted to be located in external side of plasma membrane and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related orphan receptor C). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 368158 EnsemblRapid:ENSRNOG00000020836 AllianceGenome:RGD:1595785


GO Annotation


Category Term ID Term description
Process GO:0000122 Negative regulation of transcription by RNA polymerase II
Process GO:0001775 Cell activation
Process GO:0002250 Adaptive immune response
Process GO:0002252 Immune effector process
Process GO:0002263 Cell activation involved in immune response
Process GO:0002285 Lymphocyte activation involved in immune response
Process GO:0002286 T cell activation involved in immune response
Process GO:0002287 Alpha-beta T cell activation involved in immune response
Process GO:0002292 T cell differentiation involved in immune response
Process GO:0002293 Alpha-beta T cell differentiation involved in immune response
Process GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response
Process GO:0002366 Leukocyte activation involved in immune response
Process GO:0002376 Immune system process
Process GO:0002460 Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Process GO:0002520 Immune system development
Process GO:0002521 Leukocyte differentiation
Process GO:0002682 Regulation of immune system process
Process GO:0002694 Regulation of leukocyte activation
Process GO:0006109 Regulation of carbohydrate metabolic process
Process GO:0006355 Regulation of transcription, DNA-templated
Process GO:0006357 Regulation of transcription by RNA polymerase II
Process GO:0006468 Protein phosphorylation
Process GO:0006793 Phosphorus metabolic process
Process GO:0006796 Phosphate-containing compound metabolic process
Process GO:0006805 Xenobiotic metabolic process
Process GO:0006807 Nitrogen compound metabolic process
Process GO:0006955 Immune response
Process GO:0007154 Cell communication
Process GO:0007165 Signal transduction
Process GO:0007275 Multicellular organism development
Process GO:0007623 Circadian rhythm
Process GO:0008152 Metabolic process
Process GO:0009410 Response to xenobiotic stimulus
Process GO:0009888 Tissue development
Process GO:0009889 Regulation of biosynthetic process
Process GO:0009890 Negative regulation of biosynthetic process
Process GO:0009891 Positive regulation of biosynthetic process
Process GO:0009892 Negative regulation of metabolic process
Process GO:0009893 Positive regulation of metabolic process
Process GO:0009987 Cellular process
Process GO:0010033 Response to organic substance
Process GO:0010468 Regulation of gene expression
Process GO:0010556 Regulation of macromolecule biosynthetic process
Process GO:0010557 Positive regulation of macromolecule biosynthetic process
Process GO:0010558 Negative regulation of macromolecule biosynthetic process
Process GO:0010604 Positive regulation of macromolecule metabolic process
Process GO:0010605 Negative regulation of macromolecule metabolic process
Process GO:0010675 Regulation of cellular carbohydrate metabolic process
Process GO:0010906 Regulation of glucose metabolic process
Process GO:0010941 Regulation of cell death
Process GO:0014070 Response to organic cyclic compound
Process GO:0016310 Phosphorylation
Process GO:0019216 Regulation of lipid metabolic process
Process GO:0019218 Regulation of steroid metabolic process
Process GO:0019219 Regulation of nucleobase-containing compound metabolic process
Process GO:0019222 Regulation of metabolic process
Process GO:0019538 Protein metabolic process
Process GO:0023052 Signaling
Process GO:0030097 Hemopoiesis
Process GO:0030098 Lymphocyte differentiation
Process GO:0030154 Cell differentiation
Process GO:0030217 T cell differentiation
Process GO:0030522 Intracellular receptor signaling pathway
Process GO:0031323 Regulation of cellular metabolic process
Process GO:0031324 Negative regulation of cellular metabolic process
Process GO:0031325 Positive regulation of cellular metabolic process
Process GO:0031326 Regulation of cellular biosynthetic process
Process GO:0031327 Negative regulation of cellular biosynthetic process
Process GO:0031328 Positive regulation of cellular biosynthetic process
Process GO:0032501 Multicellular organismal process
Process GO:0032502 Developmental process
Process GO:0032922 Circadian regulation of gene expression
Process GO:0033077 T cell differentiation in thymus
Process GO:0033993 Response to lipid
Process GO:0035710 CD4-positive, alpha-beta T cell activation
Process GO:0036211 Protein modification process
Process GO:0036314 Response to sterol
Process GO:0036315 Cellular response to sterol
Process GO:0042093 T-helper cell differentiation
Process GO:0042110 T cell activation
Process GO:0042221 Response to chemical
Process GO:0042752 Regulation of circadian rhythm
Process GO:0042753 Positive regulation of circadian rhythm
Process GO:0042981 Regulation of apoptotic process
Process GO:0043066 Negative regulation of apoptotic process
Process GO:0043067 Regulation of programmed cell death
Process GO:0043069 Negative regulation of programmed cell death
Process GO:0043170 Macromolecule metabolic process
Process GO:0043367 CD4-positive, alpha-beta T cell differentiation
Process GO:0043412 Macromolecule modification
Process GO:0044237 Cellular metabolic process
Process GO:0044238 Primary metabolic process
Process GO:0045321 Leukocyte activation
Process GO:0045580 Regulation of T cell differentiation
Process GO:0045586 Regulation of gamma-delta T cell differentiation
Process GO:0045595 Regulation of cell differentiation
Process GO:0045598 Regulation of fat cell differentiation
Process GO:0045619 Regulation of lymphocyte differentiation
Process GO:0045892 Negative regulation of transcription, DNA-templated
Process GO:0045893 Positive regulation of transcription, DNA-templated
Process GO:0045934 Negative regulation of nucleobase-containing compound metabolic process
Process GO:0045935 Positive regulation of nucleobase-containing compound metabolic process
Process GO:0046631 Alpha-beta T cell activation
Process GO:0046632 Alpha-beta T cell differentiation
Process GO:0046643 Regulation of gamma-delta T cell activation
Process GO:0046649 Lymphocyte activation
Process GO:0048511 Rhythmic process
Process GO:0048513 Animal organ development
Process GO:0048518 Positive regulation of biological process
Process GO:0048519 Negative regulation of biological process
Process GO:0048522 Positive regulation of cellular process
Process GO:0048523 Negative regulation of cellular process
Process GO:0048534 Hematopoietic or lymphoid organ development
Process GO:0048535 Lymph node development
Process GO:0048537 Mucosa-associated lymphoid tissue development
Process GO:0048541 Peyers patch development
Process GO:0048731 System development
Process GO:0048856 Anatomical structure development
Process GO:0048869 Cellular developmental process
Process GO:0050789 Regulation of biological process
Process GO:0050793 Regulation of developmental process
Process GO:0050794 Regulation of cellular process
Process GO:0050863 Regulation of T cell activation
Process GO:0050865 Regulation of cell activation
Process GO:0050896 Response to stimulus
Process GO:0051171 Regulation of nitrogen compound metabolic process
Process GO:0051172 Negative regulation of nitrogen compound metabolic process
Process GO:0051173 Positive regulation of nitrogen compound metabolic process
Process GO:0051239 Regulation of multicellular organismal process
Process GO:0051249 Regulation of lymphocyte activation
Process GO:0051252 Regulation of RNA metabolic process
Process GO:0051253 Negative regulation of RNA metabolic process
Process GO:0051254 Positive regulation of RNA metabolic process
Process GO:0051716 Cellular response to stimulus
Process GO:0060255 Regulation of macromolecule metabolic process
Process GO:0060548 Negative regulation of cell death
Process GO:0060612 Adipose tissue development
Process GO:0061448 Connective tissue development
Process GO:0062012 Regulation of small molecule metabolic process
Process GO:0065007 Biological regulation
Process GO:0070228 Regulation of lymphocyte apoptotic process
Process GO:0070229 Negative regulation of lymphocyte apoptotic process
Process GO:0070232 Regulation of T cell apoptotic process
Process GO:0070233 Negative regulation of T cell apoptotic process
Process GO:0070243 Regulation of thymocyte apoptotic process
Process GO:0070244 Negative regulation of thymocyte apoptotic process
Process GO:0070887 Cellular response to chemical stimulus
Process GO:0071310 Cellular response to organic substance
Process GO:0071396 Cellular response to lipid
Process GO:0071407 Cellular response to organic cyclic compound
Process GO:0071466 Cellular response to xenobiotic stimulus
Process GO:0071704 Organic substance metabolic process
Process GO:0072538 T-helper 17 type immune response
Process GO:0072539 T-helper 17 cell differentiation
Process GO:0080090 Regulation of primary metabolic process
Process GO:1901564 Organonitrogen compound metabolic process
Process GO:1901700 Response to oxygen-containing compound
Process GO:1901701 Cellular response to oxygen-containing compound
Process GO:1902105 Regulation of leukocyte differentiation
Process GO:1902679 Negative regulation of RNA biosynthetic process
Process GO:1902680 Positive regulation of RNA biosynthetic process
Process GO:1903131 Mononuclear cell differentiation
Process GO:1903506 Regulation of nucleic acid-templated transcription
Process GO:1903507 Negative regulation of nucleic acid-templated transcription
Process GO:1903508 Positive regulation of nucleic acid-templated transcription
Process GO:1903706 Regulation of hemopoiesis
Process GO:2000026 Regulation of multicellular organismal development
Process GO:2000106 Regulation of leukocyte apoptotic process
Process GO:2000107 Negative regulation of leukocyte apoptotic process
Process GO:2001141 Regulation of RNA biosynthetic process
Component GO:0005622 Intracellular anatomical structure
Component GO:0005634 Nucleus
Component GO:0005886 Plasma membrane
Component GO:0009897 External side of plasma membrane
Component GO:0009986 Cell surface
Component GO:0016020 Membrane
Component GO:0043226 Organelle
Component GO:0043227 Membrane-bounded organelle
Component GO:0043229 Intracellular organelle
Component GO:0043231 Intracellular membrane-bounded organelle
Component GO:0071944 Cell periphery
Component GO:0098552 Side of membrane
Component GO:0110165 Cellular anatomical entity
Function GO:0000976 Transcription cis-regulatory region binding
Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Function GO:0000987 Cis-regulatory region sequence-specific DNA binding
Function GO:0001067 Transcription regulatory region nucleic acid binding
Function GO:0001217 DNA-binding transcription repressor activity
Function GO:0001221 Transcription coregulator binding
Function GO:0001223 Transcription coactivator binding
Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Function GO:0003676 Nucleic acid binding
Function GO:0003677 DNA binding
Function GO:0003690 Double-stranded DNA binding
Function GO:0003700 DNA-binding transcription factor activity
Function GO:0004879 Nuclear receptor activity
Function GO:0005488 Binding
Function GO:0005496 Steroid binding
Function GO:0005515 Protein binding
Function GO:0008134 Transcription factor binding
Function GO:0008142 Oxysterol binding
Function GO:0008270 Zinc ion binding
Function GO:0008289 Lipid binding
Function GO:0032934 Sterol binding
Function GO:0038023 Signaling receptor activity
Function GO:0043167 Ion binding
Function GO:0043169 Cation binding
Function GO:0043565 Sequence-specific DNA binding
Function GO:0046872 Metal ion binding
Function GO:0046914 Transition metal ion binding
Function GO:0060089 Molecular transducer activity
Function GO:0097159 Organic cyclic compound binding
Function GO:0098531 Ligand-activated transcription factor activity
Function GO:0140110 Transcription regulator activity
Function GO:1901363 Heterocyclic compound binding
Function GO:1990837 Sequence-specific double-stranded DNA binding

Pathway annotation


Category Term ID Term description
RCTM RNO-212436 Generic Transcription Pathway
RCTM RNO-383280 Nuclear Receptor transcription pathway
RCTM RNO-73857 RNA Polymerase II Transcription
RCTM RNO-74160 Gene expression (Transcription)
WikiPathways WP217 Nuclear receptors