In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.

           
Lower Incidence of Side Effects
Toxic Side Effects
Acupuncture anesthesia can help reduce the toxic side effects of certain medications used in surgery, minimizing harm to the patient's body.
Hypothermia
Acupuncture anesthesia can aid in maintaining normal body temperature during surgery, reducing the risk of hypothermia.
Stress Response
Acupuncture anesthesia can mitigate the body's stress response to surgery, promoting a more relaxed and stable physiological state.
Nausea and Vomiting
Acupuncture anesthesia has antiemetic properties, effectively preventing postoperative nausea and vomiting.
Adverse Reactions
Acupuncture anesthesia can minimize adverse reactions to anesthesia drugs, enhancing patient safety during surgical procedures.
Side Effects
Acupuncture anesthesia's minimal side effects make it a safer alternative to traditional anesthesia methods.
Insomnia
Acupuncture anesthesia can improve sleep quality by reducing postoperative pain and discomfort.
Urinary Retention
Acupuncture anesthesia can help prevent urinary retention, ensuring proper urinary function post-surgery.
Sleep Quality
Acupuncture anesthesia contributes to better sleep quality by alleviating pain and promoting relaxation.
Urinary Incontinence
Acupuncture anesthesia can address urinary incontinence issues, improving bladder control post-surgery.

Acupuncture anesthesia for Lower Incidence of Side Effects-Adverse Reactions


PMID Evidence Source Keyword Type
1091133 Adverse reactions, contraindications and complications of acupuncture and moxibustion. Am J Chin Med (Gard City N Y). 1975 Jan;3(1):35-46. doi: 10.1142/s0192415x75000050. Adverse Reactions Review
1091133 This article discusses the various adverse reactions, contraindications and complications of employing acupuncture and moxibustion in therapy. Am J Chin Med (Gard City N Y). 1975 Jan;3(1):35-46. doi: 10.1142/s0192415x75000050. Adverse Reactions Review
11710415 After introducing acupuncture from historical and technique viewpoints, preliminary studies of the effects of acupuncture on strength, aerobic conditioning, flexibility, and sport performance are discussed, as well as concerns regarding the direction of research investigating the potential benefit and/ or adverse effects of this practice. J Strength Cond Res. 2001 May;15(2):266-71. Adverse Reactions Review
15253851 This paper also examines conclusions from the same international reviews on the safety and adverse effects of acupuncture. J Altern Complement Med. 2004 Jun;10(3):468-80. doi: 10.1089/1075553041323894. Adverse Reactions Review
15846693 OBJECTIVES: To examine the efficacy and adverse effects of acupuncture for depression. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004046. doi: 10.1002/14651858.CD004046.pub2. Adverse Reactions Depression Review
16235404 BACKGROUND: Acupuncture has been shown to be a relatively safe health care intervention with few adverse effects. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD005475. doi: 10.1002/14651858.CD005475. Adverse Reactions Review
17264833 It seems, however, that acupuncture has a positive effect and no adverse effects on pregnancy outcome. Acupunct Med. 2006 Dec;24(4):157-63. doi: 10.1136/aim.24.4.157. Adverse Reactions Review
18630550 Acupuncture is a medical technique with national and cultural characteristics in traditional Chinese medicine with a less adverse reaction and obvious therapeutic effect. Zhongguo Zhen Jiu. 2008 Jun;28(6):463-7. Adverse Reactions Review
19568718 While acupuncture procedures should not be taken for granted as safe, complications causing harm are usually, according to the authors, the result of negligence, and should be differentiated from other adverse effects. Chin J Integr Med. 2009 Jun;15(3):229-32. doi: 10.1007/s11655-009-0229-2. Epub 2009 Jul 2. Adverse Reactions Review
19568718 In a study of acupuncture complications and adverse effects in 2000 procedures conducted by experienced professional acupuncturists in a research institution, it was found that complications did not occur, and adverse events happened infrequently. Chin J Integr Med. 2009 Jun;15(3):229-32. doi: 10.1007/s11655-009-0229-2. Epub 2009 Jul 2. Adverse Reactions Review
19568718 Now that acupuncture is being widely incorporated into medical practice, a good understanding of adverse effects and complications would be necessary and helpful. Chin J Integr Med. 2009 Jun;15(3):229-32. doi: 10.1007/s11655-009-0229-2. Epub 2009 Jul 2. Adverse Reactions Review
19887992 Several studies have demonstrated the efficacy of acupuncture, with fewer adverse effects than analgesic drugs, in the treatment of painful diabetic and human immunodeficiency virus-related neuropathy. Am J Clin Oncol. 2009 Jun;32(3):319-25. doi: 10.1097/COC.0b013e318173a520. Immunity Adverse Reactions Review
20091556 OBJECTIVES: To examine the effectiveness and adverse effects of acupuncture in the treatment for depression. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD004046. doi: 10.1002/14651858.CD004046.pub3. Adverse Reactions Depression Review
20230329 CONCLUSION: Acupuncture is a safe and effective treatment to PCOS as the adverse effects of pharmacologic interventions are not expected by women with PCOS. Gynecol Endocrinol. 2010 Jun;26(6):473-8. doi: 10.3109/09513591003686304. Adverse Reactions Review
20496745 This paper is intended to explain that because of its safety, effectiveness, less adverse reactions, and not involving stimulants, acupuncture has great potential to protect against exercise-induced fatigue. Zhongguo Zhen Jiu. 2010 Mar;30(3):261-4. Adverse Reactions Review
21280460 Adverse effects of acupuncture, which were reported in three studies, were mild. Altern Ther Health Med. 2010 Nov-Dec;16(6):30-5. Adverse Reactions Review
21280460 CONCLUSION: The evidence reviewed previously suggests that acupuncture is of similar efficacy as CBZ but with fewer adverse effects in treatment of TN. Altern Ther Health Med. 2010 Nov-Dec;16(6):30-5. Adverse Reactions Review
21563159 No adverse effects of acupuncture were reported in any of the studies. Cochrane Database Syst Rev. 2011 May 11;(5):CD007700. doi: 10.1002/14651858.CD007700.pub2. Adverse Reactions Review
21894716 Analysis on the situation of adverse reaction to acupuncture and acupuncture risk. Zhongguo Zhen Jiu. 2011 Aug;31(8):764-8. Adverse Reactions Review
21894716 The Medline database system and the CNKI literature database were used to evaluate the publications in acupuncture in recent years, using the key words: ""acupuncture"" ""adverse reaction"" and ""risk"". Zhongguo Zhen Jiu. 2011 Aug;31(8):764-8. Adverse Reactions Review
21894716 The analysis of the publications shows that various causes lead to adverse reactions to acupuncture. Zhongguo Zhen Jiu. 2011 Aug;31(8):764-8. Adverse Reactions Review
23418645 No adverse effects of acupuncture were reported in any of the studies. Cochrane Database Syst Rev. 2012;12:CD007700. doi: 10.1002/14651858.CD007700.pub2. Adverse Reactions Review
23543554 No adverse effects of acupuncture were reported in any of the studies. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD007700. doi: 10.1002/14651858.CD007700.pub3. Adverse Reactions Review
23650807 A lot of findings of researches demonstrated that acupuncture therapy is effective in reducing postoperative pain and adverse reactions as nausea, vomiting, etc. Zhen Ci Yan Jiu. 2013 Feb;38(1):83-7. Adverse Reactions Nausea and Vomiting Review
23945980 The limited observational studies to date suggest acupuncture for induction of labour appears safe, has no known adverse effects to the fetus, and may be effective. Cochrane Database Syst Rev. 2013 Aug 15;(8):CD002962. doi: 10.1002/14651858.CD002962.pub3. Adverse Reactions Review
24150042 Acupuncture and related techniques (acustimulation) are often suggested to be adequate treatments with low cost and minimal adverse effects. Curr Opin Anaesthesiol. 2013 Dec;26(6):661-8. doi: 10.1097/ACO.0000000000000017. Adverse Reactions Review
26021961 In this study, we demonstrated that acupuncture can enhance recovery in gynaecological surgery without adverse effects and thus should be considered in ERAS. Forsch Komplementmed. 2015;22(2):111-6. doi: 10.1159/000381360. Epub 2015 Apr 22. Adverse Reactions ERAS(Enhanced Recovery After Surgery) Review
26484723 No major adverse effects of perioperative acupuncture were reported in the enrolled studies. Laryngoscope. 2016 Mar;126(3):608-15. doi: 10.1002/lary.25721. Epub 2015 Oct 20. Adverse Reactions Review
26880252 The meta-analysis also demonstrated that acupuncture produced small-to-large effects on adverse symptoms including pain, fatigue, sleep disturbance, and some gastrointestinal discomfort; however, no significant effect was found on the frequency of hot flashes (Cohen's d = -0.02; 95% CI = -1.49 to 1.45; P = 0.97; I(2) = 36%) and mood distress (P > 0.05). J Pain Symptom Manage. 2016 Apr;51(4):728-747. doi: 10.1016/j.jpainsymman.2015.11.027. Epub 2016 Feb 12. Adverse Reactions Insomnia Mood Review
27145001 Whether subsequent repeated sessions would be successful was not examined by investigators in our primary studies.Acupuncture appears to be a safe treatment modality, as adverse effects are minor. Cochrane Database Syst Rev. 2016 May 4;(5):CD004870. doi: 10.1002/14651858.CD004870.pub4. Adverse Reactions Review
27145001 These studies reported no life-threatening adverse effects and found that acupuncture treatments were cost-effective.Since the time of our previous review, the quality of RCTs has improved, and we have assessed many of them as having low risk of bias. Cochrane Database Syst Rev. 2016 May 4;(5):CD004870. doi: 10.1002/14651858.CD004870.pub4. Adverse Reactions Review
28377250 BACKGROUND: Spinal acupuncture is a relatively safe and common analgesic treatment, but it may be complicated by serious adverse effects, such as direct spinal cord and nerve root injury, subdural empyema, and epidural abscesses. World Neurosurg. 2017 Jun;102:695.e11-695.e14. doi: 10.1016/j.wneu.2017.03.125. Epub 2017 Apr 2. Adverse Reactions Review
28748654 Where measured, acupuncture appears to be associated with improved patient satisfaction, lower cost and a low adverse effects profile. Emerg Med Australas. 2017 Oct;29(5):490-498. doi: 10.1111/1742-6723.12832. Epub 2017 Jul 26. Adverse Reactions Review
29180347 In the safety evaluation, it was found that acupuncture combined with Madopar was associated with significantly fewer adverse effects including gastrointestinal reactions (RR=0.38, 95% CI 0.23 to 0.65, P<0.001), on-off phenomena (RR=0.27, 95% CI 0.11 to 0.66, P=0.004) and mental disorders (RR=0.24, 95% CI 0.06 to 0.92, P=0.04) but did not significantly reduce dyskinesia (RR=0.64, 95% CI 0.35 to 1.16, P=0.14). Acupunct Med. 2017 Dec;35(6):404-412. doi: 10.1136/acupmed-2016-011342. Epub 2017 Nov 27. Adverse Reactions Review
29354943 Analysis on the concepts related to adverse events and adverse reactions of acupuncture. Zhongguo Zhen Jiu. 2018 Jan 12;38(1):87-90. doi: 10.13703/j.0255-2930.2018.01.023. Adverse Reactions Review
29354943 The ""adverse events of acupuncture"" and ""adverse reactions of acupuncture"" are the common concepts in the research of acupuncture safety. Zhongguo Zhen Jiu. 2018 Jan 12;38(1):87-90. doi: 10.13703/j.0255-2930.2018.01.023. Adverse Reactions Review
29354943 In the paper, on the basis of the conceptual characteristics of ""adverse events"" and ""adverse reactions"" and in combination with the particular characteristics of acupuncture itself, the connation and features of the concepts of the ""adverse events of acupuncture"" and ""adverse reactions of acupuncture"" are analyzed. Zhongguo Zhen Jiu. 2018 Jan 12;38(1):87-90. doi: 10.13703/j.0255-2930.2018.01.023. Adverse Reactions Review
29354943 Both ""adverse events of acupuncture"" and ""adverse reactions of acupuncture"" are in the category of adverse medical events. Zhongguo Zhen Jiu. 2018 Jan 12;38(1):87-90. doi: 10.13703/j.0255-2930.2018.01.023. Adverse Reactions Review
29354943 The ""adverse reactions of acupuncture"" refers to the adverse outcomes induced by acupuncture therapy specially. Zhongguo Zhen Jiu. 2018 Jan 12;38(1):87-90. doi: 10.13703/j.0255-2930.2018.01.023. Adverse Reactions Review
29354943 Hence, the application of ""adverse reactions of acupuncture"" is more objective and accurate in the assessment of acupuncture safety. Zhongguo Zhen Jiu. 2018 Jan 12;38(1):87-90. doi: 10.13703/j.0255-2930.2018.01.023. Adverse Reactions Review
29705474 Clinical research studies render acupuncture as a valid treatment therapy for anxiety disorders without significant adverse effects. Complement Ther Clin Pract. 2018 May;31:31-37. doi: 10.1016/j.ctcp.2018.01.008. Epub 2018 Jan 31. Adverse Reactions Anxiety Review
33131633 With many pharmacologic interventions noted to have adverse effects, many patients are turning to alternative therapies, including acupuncture and acupressure. Nurs Clin North Am. 2020 Dec;55(4):571-580. doi: 10.1016/j.cnur.2020.07.001. Epub 2020 Oct 14. Adverse Reactions Review
33197658 Common adverse effects reported with topical capsaicin included mild burning sensations (50.0-88.2 %) or erythema (6.7-22.7%) while that of acupuncture included soreness (7.5 %), bleeding (6.0-7.5%) and hematoma (1.9 %). Complement Ther Med. 2021 Jan;56:102609. doi: 10.1016/j.ctim.2020.102609. Epub 2020 Nov 5. Adverse Reactions Bleeding Review
33350223 As for the occurrence of adverse reactions, the adverse reactions reported in the acupuncture group included in the study were all mild adverse reactions, like drowsiness, subcutaneous bleeding, local pain, subcutaneous hematoma and dizziness needle. Zhongguo Zhong Yao Za Zhi. 2020 Nov;45(21):5083-5092. doi: 10.19540/j.cnki.cjcmm.20200521.502. Adverse Reactions Bleeding Review
33522192 CONCLUSION: The therapeutic effects of acupuncture combined with Western Medicine on post-stroke depression are often better than those of Western Medicine alone, and fewer adverse reactions occur. J Tradit Chin Med. 2021 Feb;41(1):6-16. doi: 10.19852/j.cnki.jtcm.2021.01.002. Adverse Reactions Depression Review
33788440 The summarized findings showed that acupuncture anesthesia has a better analgesic effect in thyroid surgery, which can reduce the occurrence of stress reactions, adverse reactions and complications, and is conducive to postoperative recovery. Zhen Ci Yan Jiu. 2021 Feb 25;46(2):168-71. doi: 10.13702/j.1000-0607.200283. Analgesic Effect Adverse Reactions Stress Response Review
33907909 Integrative medicine techniques, such as acupuncture, are a promising approach to control peri-operative symptoms without the associated adverse effects of more conventional pharmacologic interventions. Curr Oncol Rep. 2021 Apr 28;23(6):73. doi: 10.1007/s11912-021-01051-9. Adverse Reactions Review
34623754 Clinical studies have shown that acupuncture is an effective therapy without obvious side effects compared to limited efficacy and adverse reactions of drug therapy, cognitive behavioral therapy, and neuromodulation technology in treating depression. Anat Rec (Hoboken). 2021 Nov;304(11):2436-2453. doi: 10.1002/ar.24783. Epub 2021 Oct 8. Side Effects Adverse Reactions Depression Review
35013031 Acupuncture and electroacupuncture have definite efficacy in the treatment of postmenopausal symptoms with few adverse effects, so they are a reasonable option as an alternative therapy for high-risk women. Biosci Trends. 2022 Mar 11;16(1):46-57. doi: 10.5582/bst.2021.01418. Epub 2022 Jan 10. Adverse Reactions Review
35439704 Common adverse reactions associated with acupressure included intradialytic hypotension (20.4%) and dizziness (11.1%) while that of acupuncture included elbow soreness (7.5%) and bleeding (7.5%). Complement Ther Clin Pract. 2022 Aug;48:101593. doi: 10.1016/j.ctcp.2022.101593. Epub 2022 Apr 15. Adverse Reactions Bleeding Review
35595611 OBJECTIVE: This review aims to provide evidence on whether acupuncture can enhance the therapeutic effectiveness of antidepressants for treating depression, and explore whether acupuncture can reduce the adverse reactions associated with antidepressants. J Integr Med. 2022 Jul;20(4):305-320. doi: 10.1016/j.joim.2022.05.002. Epub 2022 May 6. Adverse Reactions Depression Review
35963138 Our meta-analysis demonstrated that in terms of changes in systolic blood pressure (MD 3.62 mmHg; 95% CI, 1.34 to 5.90; I(2) = 56%), diastolic blood pressure (MD 3.12 mmHg; 95% CI, 1.03 to 5.20; I(2) = 77%), and treatment efficacy (RR 2.12; 95% CI, 1.38 to 3.26; I(2) = 93%), acupuncture is more effective in treating grade 1 hypertension than a placebo, no treatment at all, or interventions that improve lifestyle alone, with a low incidence of adverse effects. Complement Ther Clin Pract. 2022 Nov;49:101649. doi: 10.1016/j.ctcp.2022.101649. Epub 2022 Aug 7. Adverse Reactions Blood Pressure Review
36549277 Furthermore, high-quality evidence showed that acupuncture led to fewer adverse effects than antidepressants. Neuropsychobiology. 2023;82(1):1-13. doi: 10.1159/000527903. Epub 2022 Dec 22. Adverse Reactions Review
37159979 Compared with carbamazepine, acupuncture led to improvements in pain scores (15 RCTs, mean difference (MD) - 1.40, 95% confidence interval (CI)-1.82 to -0.98 [95% prediction interval, -3.137,0.343], p < 0.00001, low certainty of evidence (CoE)), response rates (29 RCTs, risk ratio (RR) 1.20, 95% CI 1.15 to 1.25 [95% prediction interval, 1.067, 1.346], p < 0.00001, low CoE), frequency of pain attacks (2 RCTs, MD -2.53, 95% CI -4.11 to -0.96, P = 0.002, low CoE), and adverse effects (13 RCTs, risk difference (RD) -0.15, 95% CI -0.19 to -0.11 [95% prediction interval, -0.193, -0.108], P < 0.00001, very low CoE). Complement Ther Clin Pract. 2023 Aug;52:101763. doi: 10.1016/j.ctcp.2023.101763. Epub 2023 May 2. Adverse Reactions Review
9211472 Life-threatening adverse reactions after acupuncture? A systematic review. Pain. 1997 Jun;71(2):123-6. doi: 10.1016/s0304-3959(97)03368-x. Adverse Reactions Review
24206922 No adverse effect was found in acupuncture group, while in cisapride and mosapride group, some mild side effects such as dry mouth, dizziness, diarrhea, debilitation, erythra were observed. BMC Complement Altern Med. 2013 Nov 9;13:311. doi: 10.1186/1472-6882-13-311. Side Effects Adverse Reactions Review
24716183 The safety issues concerning oncology acupuncture practice have become imperative, since cancer patients usually have a more complicated medical status and are at higher risk of developing adverse reactions from acupuncture. J Tradit Complement Med. 2013 Oct;3(4):234-9. doi: 10.4103/2225-4110.119733. Adverse Reactions Review
24716183 Severe adverse effects of acupuncture are rare and easily handled, such as a small hemorrhage, fainting, or syncope, bruising, dizziness, needle breakage, pneumothorax, or nerve damage. J Tradit Complement Med. 2013 Oct;3(4):234-9. doi: 10.4103/2225-4110.119733. Adverse Reactions Bleeding Review
25132858 Adverse events were reported in only 4 studies, in which the frequency of adverse effects that occurred due to WAA was lower than western medication but equal to sham acupuncture. Evid Based Complement Alternat Med. 2014;2014:261709. doi: 10.1155/2014/261709. Epub 2014 Jul 15. Adverse Reactions Review
25379462 ADVERSE EFFECTS OF ACUPUNCTURE (針灸 ZHĒN JIŬ) J Tradit Complement Med. 2014 Oct;4(4):218-23. doi: 10.4103/2225-4110.139113. Adverse Reactions Review
25379462 There have been numerous reports of adverse effects following acupuncture (針灸 Zhēn Jiǔ). J Tradit Complement Med. 2014 Oct;4(4):218-23. doi: 10.4103/2225-4110.139113. Adverse Reactions Review
25614752 Acupuncture has long been used for the management of numerous disorders in particular pain and visceral pain, characterized by the high therapeutic benefits and low adverse effects. Evid Based Complement Alternat Med. 2014;2014:609594. doi: 10.1155/2014/609594. Epub 2014 Dec 29. Visceral Pain Adverse Reactions Review
25886561 The pooled outcomes of number of awakenings, sleep onset latency and adverse effects also revealed a better therapeutic effect of auricular acupuncture, statistically. BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. Adverse Reactions Review
25886561 These are internationally accepted indexes of sleep evaluation and particularly the former three are objective sleep parameters; the adverse effects from the auricular acupuncture VS medications comparison have complemented the assessment from another point of view. BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. Adverse Reactions Review
26039131 Adverse reactions related to acupuncture were also investigated. Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. Adverse Reactions Review
26039131 Out of 141 clinical trials, 2 trials reported the incidence of adverse reactions related to acupuncture. Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. Adverse Reactions Review
26039131 Seven out of 3416 patients had adverse reactions related to acupuncture during or after treatment; the reactions were described as tolerable and not severe. Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. Adverse Reactions Review
26039131 However, 2 trials ineligible for included in meta-analysis reported the incidence of adverse reactions related to acupuncture. Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. Adverse Reactions Review
26039131 None of the remaining clinical trials reported any adverse reactions related to acupuncture. Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. Adverse Reactions Review
26039131 Adverse reactions related to acupuncture occurred in only 7 cases, in which the reactions were described as tolerable and not severe; none of the other studies mentioned any adverse reactions related to acupuncture. Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. Adverse Reactions Review
26345336 The total number of adverse reactions after acupuncture was low in two systematic reviews by Sun et al. Evid Based Complement Alternat Med. 2015;2015:793649. doi: 10.1155/2015/793649. Epub 2015 Aug 5. Adverse Reactions Review
26345336 And various causes lead to adverse reactions to acupuncture. Evid Based Complement Alternat Med. 2015;2015:793649. doi: 10.1155/2015/793649. Epub 2015 Aug 5. Adverse Reactions Review
26557088 Acupuncture, stimulating the special body points by the thin needles, is one of the most frequently used remedies, and effective for various adverse reactions resulting from chemotherapy or radiation therapy. Front Pharmacol. 2015 Oct 23;6:234. doi: 10.3389/fphar.2015.00234. eCollection 2015. Adverse Reactions Review
26608664 Adverse effects of acupuncture and related therapies Sci Rep. 2015 Nov 26;5:16776. doi: 10.1038/srep16776. Adverse Reactions Review
26608664 No serious adverse effects were reported in the included studies, consistent with the results of previous SRs that concluded that acupuncture is a relatively safe treatment option. Sci Rep. 2015 Nov 26;5:16776. doi: 10.1038/srep16776. Adverse Reactions Review
26816742 Thus recent discoveries and better understanding of the penile anatomy had been meaningful in the development and improvement of specific nerve blockade techniques for penile surgeries in particularly adding up with acupuncture techniques, while minimizing anesthetic adverse effects and resulting in a rapid return to daily activity with minimal complications. Transl Androl Urol. 2013 Dec;2(4):291-300. doi: 10.3978/j.issn.2223-4683.2013.12.02. Adverse Reactions Review
26945382 The following data were extracted from each included RCT: characteristics of the study, including first author's name, year of publication, country in which the trial was conducted, eligibility criteria, and sample size; details on patient characteristics, acupuncture and related therapies, and control interventions and outcomes; effect on each interested outcomes and adverse effects related to acupuncture and related therapies; and information on risk of bias. Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. Adverse Reactions Review
26977172 However, as compared with the drug therapy alone, acupuncture plus drug therapy resulted in increased pain remission rate, shorter onset time of pain relief, longer pain-free duration, and better quality of life without serious adverse effects. Evid Based Complement Alternat Med. 2016;2016:1720239. doi: 10.1155/2016/1720239. Epub 2016 Feb 10. Pain Relief Adverse Reactions Review
26977172 Among a variety of CAM treatments, acupuncture is the most widely used intervention, which is used to treat many symptoms and conditions associated with cancer and adverse effects related to cancer treatments. Evid Based Complement Alternat Med. 2016;2016:1720239. doi: 10.1155/2016/1720239. Epub 2016 Feb 10. Adverse Reactions Review
26977172 It has been shown that acupuncture is safe and minimally invasive, with very few adverse effects. Evid Based Complement Alternat Med. 2016;2016:1720239. doi: 10.1155/2016/1720239. Epub 2016 Feb 10. Adverse Reactions Review
26977172 One trial reported adverse effects such as subcutaneous hemorrhage and fainting during acupuncture, with an incident rate of 8%. Evid Based Complement Alternat Med. 2016;2016:1720239. doi: 10.1155/2016/1720239. Epub 2016 Feb 10. Adverse Reactions Bleeding Review
26977172 Acupuncture plus drug therapy resulted in increased remission rate of pain, shorter onset time of pain relief, longer duration of analgesia time, and better quality of life without serious adverse effects, as compared with drug therapy alone. Evid Based Complement Alternat Med. 2016;2016:1720239. doi: 10.1155/2016/1720239. Epub 2016 Feb 10. Pain Relief Adverse Reactions Review
27471137 Adverse reactions to acupuncture were rarely observed. Sci Rep. 2016 Jul 29;6:30675. doi: 10.1038/srep30675. Adverse Reactions Review
27705610 Moreover, no adverse effects of acupuncture were reported in any of the clinical trials reviewed. Nutr Neurosci. 2018 Feb;21(2):79-91. doi: 10.1080/1028415X.2016.1236174. Epub 2016 Oct 5. Adverse Reactions Review
27885326 Clinical studies suggest that acupuncture and moxibustion therapy in ulcerative colitis (UC) can regulate bowel inflammation, and these treatments have the advantages of low rates of adverse reactions and recurrence as well as good long-term efficacy. Gastroenterol Res Pract. 2016;2016:9248589. doi: 10.1155/2016/9248589. Epub 2016 Nov 3. Adverse Reactions Review
28243308 It is reported that some single Chinese herbal medicines (CHMs) or bioactive ingredients, traditional Chinese patent medicines, and nondrug methods including acupuncture, Qigong, and Tai Chi Chuan can play active roles in the four principles of AF treatment, respectively, with low adverse reaction. Evid Based Complement Alternat Med. 2017;2017:1381732. doi: 10.1155/2017/1381732. Epub 2017 Jan 24. Adverse Reactions Review
28632194 A number of other articles have also shown some perceived pain relief without significant adverse effects due to acupuncture. Children (Basel). 2017 Jun 20;4(6):50. doi: 10.3390/children4060050. Pain Relief Adverse Reactions Review
28659989 reported no adverse effects in the acupuncture treatment group. Evid Based Complement Alternat Med. 2017;2017:7597363. doi: 10.1155/2017/7597363. Epub 2017 May 9. Adverse Reactions Review
28659989 The two other trials reported no adverse reactions in the acupuncture treatment group. Evid Based Complement Alternat Med. 2017;2017:7597363. doi: 10.1155/2017/7597363. Epub 2017 May 9. Adverse Reactions Review
28930208 Acupuncture-treated patients reported no adverse reactions, whereas drug-treated patients did report adverse side-effects in two trials. Medicines (Basel). 2015 Aug 4;2(3):212-219. doi: 10.3390/medicines2030212. Side Effects Adverse Reactions Review
28930222 For acupuncture and TCM, the areas of application are post-chemotherapy and post-surgical nausea and vomiting, pain in all of its phases, vasomotor disturbances of iatrogenic menopause and xerostomia; for homeopathy, the vasomotor disturbances of iatrogenic menopause and adverse effects of radiotherapy; for herbal medicine, cancer-related fatigue, nausea and vomiting, pain, mucositis, anxiety and depression. Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. Adverse Reactions Nausea and Vomiting Anxiety Depression Review
29465566 Only 15 of 794 OAB patients from the included studies reported mild adverse reactions related to EA, therefore, acupuncture is safe for treating OAB. Medicine (Baltimore). 2018 Feb;97(8):e9838. doi: 10.1097/MD.0000000000009838. Adverse Reactions Review
29465566 Nevertheless, acupuncture is comparatively with few adverse reactions and safe. Medicine (Baltimore). 2018 Feb;97(8):e9838. doi: 10.1097/MD.0000000000009838. Adverse Reactions Review
29729027 Additionally, a large UK survey of patients who received acupuncture treatment supports the notion that serious adverse effects of acupuncture are very rare, while minor side effects such as pain, nausea, or bruising at the site of needling may be experienced by up to 30% of patients. Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. Side Effects Adverse Reactions Nausea and Vomiting Review
29729027 To determine the benefits and potential adverse effects of needle acupuncture for OA of the hip, in comparison to sham acupuncture, other sham procedures, no (specific) treatment, and other active treatment, as well as the effects of acupuncture as an addition to another treatment. Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. Adverse Reactions Review
29729027 Because acupuncture has previously been documented to have a low risk of adverse effects, and because arthritis patients seem to be accepting of acupuncture, there seem to be few drawbacks to hip OA patients electing to receive acupuncture, other than the additional costs incurred. Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. Adverse Reactions Review
29941854 Acupuncture is recommended for patients with chronic LBP due to its cost-effectiveness and low adverse effects. Medicines (Basel). 2018 Jun 25;5(3):63. doi: 10.3390/medicines5030063. Adverse Reactions Review
30013603 A few participants developed minor inflammation and had mild tenderness at the acupuncture sites during the treatment in 1 record; no major adverse effects were seen during the study. Evid Based Complement Alternat Med. 2018 Jun 14;2018:6409389. doi: 10.1155/2018/6409389. eCollection 2018. Adverse Reactions Review
30050856 The potential adverse effects of acupuncture are low when performed correctly. Vet Med (Auckl). 2017 Aug 24;8:53-58. doi: 10.2147/VMRR.S125609. eCollection 2017. Adverse Reactions Review
30050856 Given the low risk of adverse effects and observed benefits for animal health and well-being, acupuncture should be considered as a potential tool in all veterinarian treatment strategies. Vet Med (Auckl). 2017 Aug 24;8:53-58. doi: 10.2147/VMRR.S125609. eCollection 2017. Adverse Reactions Review
30142834 No adverse effects about acupuncture were reported. Medicine (Baltimore). 2018 Aug;97(34):e11986. doi: 10.1097/MD.0000000000011986. Adverse Reactions Review
30142834 No adverse effects were reported in the acupuncture group. Medicine (Baltimore). 2018 Aug;97(34):e11986. doi: 10.1097/MD.0000000000011986. Adverse Reactions Review
30142834 Two trials reported stomach discomfort in the pharmacologic therapy group in 5 and 8 cases, respectively, and no trials reported the adverse effects of acupuncture. Medicine (Baltimore). 2018 Aug;97(34):e11986. doi: 10.1097/MD.0000000000011986. Adverse Reactions Review
30557963 With simple operation, low cost, and few adverse reactions, acupuncture therapy is very popular among Chinese people. Medicine (Baltimore). 2018 Dec;97(50):e13041. doi: 10.1097/MD.0000000000013041. Adverse Reactions Review
30622598 The objective of this study is to assess the efficacy of various modes of acupuncture in OUD through intensity of withdrawal syndrome; duration of treatment; urine examination; intensity of pain, anxiety, depression, insomnia, and other associated symptoms; retention of treatment; and nature and rate of adverse effect. Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. Adverse Reactions Insomnia Anxiety Depression Review
30762808 Although the mechanism of acupuncture as a non-drug therapy for the treatment of PDD is not yet clear, its curative effect has been proved, with few adverse reactions and almost no side effects. Medicine (Baltimore). 2019 Feb;98(7):e14574. doi: 10.1097/MD.0000000000014574. Side Effects Adverse Reactions Review
30834020 Acupuncture treatment increased the total efficacy and the rate of AF cardioversion to sinus rhythm (RR: 1.38; 95% CI: 1.25 to 1.53 vs RR: 1.40;95% CI: 1.16 to 1.69; each P < 0.05), and decreased the time of AF cardioversion to sinus rhythm, the heart rate and incidence of adverse effects (RR: -3.95; 95% CI: -4.98 to -2.91 vs RR: -14.54; 95% CI: -24.09 to -5.00 vs RR: 0.48; 95% CI: 0.21 to 1.11, each P < 0.05). Open Access Maced J Med Sci. 2019 Jan 26;7(3):461-466. doi: 10.3889/oamjms.2019.036. eCollection 2019 Feb 15. Heart Rate Adverse Reactions Review
30834020 In this study, two literature referred to the adverse effects of acupuncture in treating AF patients. Open Access Maced J Med Sci. 2019 Jan 26;7(3):461-466. doi: 10.3889/oamjms.2019.036. eCollection 2019 Feb 15. Adverse Reactions Review
30854010 As an economical medical technology without adverse effects, acupuncture could be used in obese patients who cannot tolerate exercise or drug therapy and could also be used for lots of metabolic disorders along with other therapies. Evid Based Complement Alternat Med. 2019 Feb 3;2019:5796381. doi: 10.1155/2019/5796381. eCollection 2019. Adverse Reactions Review
30855351 The combination of acupuncture and drugs could reduce the amounts of narcotic drugs, which in turn, could reduce the adverse reactions associated with narcotic drugs. Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. Adverse Reactions Review
30855351 In addition, acupuncture could prevent postoperative nausea and vomiting, which is the most common anesthetic-related adverse reaction. Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. Adverse Reactions Nausea and Vomiting Review
31110553 Typically, acupuncture contributes to achieving obvious and fast effect without causing adverse reaction; however, it is limited by its action area and span. Evid Based Complement Alternat Med. 2019 Apr 14;2019:7680963. doi: 10.1155/2019/7680963. eCollection 2019. Adverse Reactions Review
31305415 According to high-quality outcomes, acupuncture had more total effective rate, short-term effective rate, and less adverse reactions than western medicine in treating KOA. Medicine (Baltimore). 2019 Jul;98(28):e16301. doi: 10.1097/MD.0000000000016301. Adverse Reactions Review
31305415 The results of GRADE suggested that, acupuncture has more total effective rate, short-term effective rate, and less adverse reactions than western medicine as a treatment for KOA; the effectiveness of electroacupuncture is better than western medicine in terms of Lequesne index and LKSS score. Medicine (Baltimore). 2019 Jul;98(28):e16301. doi: 10.1097/MD.0000000000016301. Adverse Reactions Review
31305415 Firstly, this overview provides the latest evidence on acupuncture for KOA based on the findings of SRs, which indicated that acupuncture may have more total effective rate, short-term effective rate, and less adverse reactions in treating KOA than western medicine. Medicine (Baltimore). 2019 Jul;98(28):e16301. doi: 10.1097/MD.0000000000016301. Adverse Reactions Review
31379957 Furthermore, few adverse effects have been observed when acupuncture is performed correctly, even in children and pregnant women. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Adverse Reactions Review
31379957 In addition to medication, acupuncture has been reported to improve cognitive function and the global clinical status of patients with AD without causing major adverse effects. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Cognitive Function Adverse Reactions Review
31379957 Acupuncture induced autophagic clearance of α-syn, caused recovery of DA neurons in the SN, and improved motor function of an animal model without any notable adverse effect. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Adverse Reactions Motor Function Review
31438914 Results showed that acupuncture therapy clould be benificial in clinical effective rate, sleep duration, sleep efficiency and adverse effect, but the quality of evidence was low. BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. Adverse Reactions Review
31577726 Before the data extraction, a standard data extraction form with following information will be created: year of publication, general information, country, participant characteristics, inclusion and exclusion criteria, sample size, methods, randomization, blinding methods, type of acupuncture interventions, control, outcome measures, results, conflicts of interest, adverse reactions, ethical approval and other information. Medicine (Baltimore). 2019 Oct;98(40):e17320. doi: 10.1097/MD.0000000000017320. Adverse Reactions Review
31702639 This study will provide comprehensive evidence of high quality of acupuncture treatment for insomnia from ISI, PSQI, HAMD, SAS, and adverse reactions. Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. Adverse Reactions Insomnia Review
31702639 In addition, we will carefully observe the adverse reactions of patients during acupuncture. Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. Adverse Reactions Review
31802723 This systematic review supports that acupuncture is a safe intervention for people with dementia with few adverse effects and that participants often report high satisfaction with the treatments. West J Nurs Res. 2020 Oct;42(10):867-880. doi: 10.1177/0193945919890552. Epub 2019 Dec 5. Adverse Reactions Review
31855257 In all of the trials included, no dropouts were attributed to adverse effects associated with acupuncture treatment. JAMA Oncol. 2020 Feb 1;6(2):271-278. doi: 10.1001/jamaoncol.2019.5233. Adverse Reactions Review
31914030 At the same time, close attention should be paid to whether adverse reactions or adverse events occur during the experiment to comprehensively evaluate the clinical efficacy and safety of acupuncture in the treatment of angina pectoris. Medicine (Baltimore). 2020 Jan;99(2):e18548. doi: 10.1097/MD.0000000000018548. Adverse Reactions Review
32051687 The main adverse effects following acupuncture include subcutaneous bleeding and pain following the piercing. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Adverse Reactions Bleeding Review
32051687 It should, however, be noted that the risks associated with acupuncture could not be assessed with confidence as many of the RCTs in our study did not adequately report adverse effects of their interventions. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Adverse Reactions Review
32100220 Beneficial effects of acupuncture on obesity have been demonstrated at various levels in animals and clinical trials, with almost no adverse effect, even when combined with local electrical stimulation, i.e., electroacupuncture (EA), a way to potentiate the effects of acupuncture. Eat Weight Disord. 2021 Feb;26(1):61-74. doi: 10.1007/s40519-020-00864-0. Epub 2020 Feb 25. Adverse Reactions Review
32419803 The safety analysis showed that there were few related adverse events during acupuncture and that drug related adverse reactions could have also occurred in studies using drug interventions Evid Based Complement Alternat Med. 2020 Apr 28;2020:4243175. doi: 10.1155/2020/4243175. eCollection 2020. Adverse Reactions Review
32419803 The safety analysis showed that there had been a few related adverse events during acupuncture treatment and that drug related adverse reactions could have also occurred in studies using drug interventions. Evid Based Complement Alternat Med. 2020 Apr 28;2020:4243175. doi: 10.1155/2020/4243175. eCollection 2020. Adverse Reactions Review
32481324 In China, acupuncture can be used to safely treat the nausea and vomiting of patients, and there is basically no adverse effect. Medicine (Baltimore). 2020 May 22;99(21):e20343. doi: 10.1097/MD.0000000000020343. Adverse Reactions Nausea and Vomiting Review
32481324 Acupuncture offers a new option which makes adverse effects no longer such hard-to-tackle problems. Medicine (Baltimore). 2020 May 22;99(21):e20343. doi: 10.1097/MD.0000000000020343. Adverse Reactions Review
32493452 Since acupuncture can be considered as an alternative treatment method to avoid the adverse effects of typical medication using anti-inflammatory analgesics and anti-depressants, we believe that acupuncture can be an important treatment for occipital neuralgia. BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. Neuralgia Adverse Reactions Review
32493452 All other studies were judged to show unclear risk, since there were no reports regarding adverse effects of acupuncture used as the intervention or of drug treatment. BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. Adverse Reactions Review
32493452 In TOM, occipital neuralgia is treated using methods with few adverse effects, such as acupuncture, electroacupuncture, pharmacoacupuncture, moxibustion, and chuna manual therapy. BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. Neuralgia Adverse Reactions Review
32493452 Hence, in this study, in order to improve the level of evidence for acupuncture, which can be considered an effective treatment modality with few adverse effects, we conducted a systematic literature review and meta-analysis of studies investigating the effects of acupuncture on occipital neuralgia. BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. Neuralgia Adverse Reactions Review
32565846 reported that there were no adverse reactions in auricular acupuncture. Evid Based Complement Alternat Med. 2020 May 25;2020:1618767. doi: 10.1155/2020/1618767. eCollection 2020. Adverse Reactions Review
32590807 Many patients with POF choose acupuncture as a complementary therapy over HRT, due to possible adverse reactions. Medicine (Baltimore). 2020 Jun 26;99(26):e20958. doi: 10.1097/MD.0000000000020958. Adverse Reactions Review
32590807 Therefore, acupuncture could be effective for patients with POF, who are intolerant to the adverse effects of hormone replacement therapy or who would prefer non-drug therapies. Medicine (Baltimore). 2020 Jun 26;99(26):e20958. doi: 10.1097/MD.0000000000020958. Adverse Reactions Review
32630156 Acupuncture is generally a safe, easy to perform, and economical procedure that provides another choice for those who are concerned about the adverse effects of routine managements such as drug prescription. Int J Mol Sci. 2020 Jun 30;21(13):4693. doi: 10.3390/ijms21134693. Adverse Reactions Review
32714268 Improvement in visual analog scale (VAS) score was greater in the acupuncture group than in the sham acupuncture group (MD = −1.00, 95% CI [-1.27,−0.46], P < 0.00001; MD = −0.59, 95% CI [-0.81,−0.38], P < 0.00001), and their adverse reaction rate was lower than that of the medication group (RR = 0.16, 95% CI [0.05, 0.52], P = 0.002). Front Neurol. 2020 Jun 30;11:596. doi: 10.3389/fneur.2020.00596. eCollection 2020. Adverse Reactions Review
32714268 Compared with medication, acupuncture showed higher effectiveness with less adverse reactions and improved intracranial blood circulation. Front Neurol. 2020 Jun 30;11:596. doi: 10.3389/fneur.2020.00596. eCollection 2020. Adverse Reactions Circulation Review
32714268 Compared with the medication (medication group), acupuncture treatment is more effective and the incidence of adverse reactions is lower. Front Neurol. 2020 Jun 30;11:596. doi: 10.3389/fneur.2020.00596. eCollection 2020. Adverse Reactions Review
32714268 A meta-analysis of the adverse reaction rates in four medication studies was conducted (Figure 6); one study was excluded as it used sham acupuncture as the control group. Front Neurol. 2020 Jun 30;11:596. doi: 10.3389/fneur.2020.00596. eCollection 2020. Adverse Reactions Review
32714268 The meta-analysis of the four studies showed that 18 of 158 patients in the medication groups developed adverse reactions (11.39%), while only two of the 159 patients that received acupuncture developed adverse reactions (0.01%); these results indicate that the acupuncture therapy features relatively higher security than medication (RR: 0.16, 95% CI [0.05, −0.52], P = 0.002); the results showed no heterogeneity (I2 = 0%, P = 0.88). Front Neurol. 2020 Jun 30;11:596. doi: 10.3389/fneur.2020.00596. eCollection 2020. Adverse Reactions Review
32714268 When compared with the medication group, the acupuncture group showed higher treatment efficiency and fewer adverse reactions. Front Neurol. 2020 Jun 30;11:596. doi: 10.3389/fneur.2020.00596. eCollection 2020. Adverse Reactions Review
32714268 Further, compared with the medication group, the acupuncture group showed higher treatment efficiency and fewer adverse reactions. Front Neurol. 2020 Jun 30;11:596. doi: 10.3389/fneur.2020.00596. eCollection 2020. Adverse Reactions Review
32802133 (2) Adverse effects (relevant symptoms caused by acupuncture). Evid Based Complement Alternat Med. 2020 Jul 30;2020:7509481. doi: 10.1155/2020/7509481. eCollection 2020. Adverse Reactions Review
32996339 Among the 9 RCTs, 2 studies have reported the occurrence of minor adverse effects (spot bleeding and bruising) related to acupuncture treatment. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420949679. doi: 10.1177/1534735420949679. Adverse Reactions Bleeding Review
32996339 No serious adverse reactions related to acupuncture were reported. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420949679. doi: 10.1177/1534735420949679. Adverse Reactions Review
33005199 Two reviewers independently extracted data from the retrieved articles using a predefined template that included the author name, publication year, sample size, average age, time since onset, intervention types, methods of intervention including AT, SLT, and general management (GM), primary outcome, secondary outcomes, study results, characteristics of acupuncture manipulation, and adverse effects. Evid Based Complement Alternat Med. 2020 Sep 14;2020:4981945. doi: 10.1155/2020/4981945. eCollection 2020. Adverse Reactions Review
33005199 None of trials reported any adverse effects due to invasive acupuncture manipulations, such as strong stimulation or deep insertion. Evid Based Complement Alternat Med. 2020 Sep 14;2020:4981945. doi: 10.1155/2020/4981945. eCollection 2020. Adverse Reactions Review
33299403 The more adverse effect occurred in the acupuncture group when comparing with the dicetel group (RR = 11.86, 95% CI [1.58, 89.07]) and loperamide group (RR = 4.42, 95% CI [0.57, 33.97]), but most of the adverse reactions were mild hypodermic hemorrhage. Neural Plast. 2020 Nov 22;2020:8892184. doi: 10.1155/2020/8892184. eCollection 2020. Adverse Reactions Bleeding Review
33299403 The literature included in our study met the following requirements: (1) study type: clinical randomized controlled trials of acupuncture treatment for IBS-D or FD, blinded or nonblinded, written in Chinese or English, and available online before June 8, 2020; (2) intervention measures: the treatment group was treated with penetrating acupuncture, or combined with a control group, and the control group was treated with conventional medicine, sham acupuncture, or conventional acupuncture; (3) participants: patients aged 18 years and over, with unlimited gender and case source, who were definitively diagnosed with IBS-D or FD; and (4) outcome indicators: weekly defecation rate, patient drop off rate, Bristol stool form, total symptom score, IBS quality of life (IBS-QOL), total efficiency, recurrence rate, IBS Symptom Severity Scale (IBS-SSS) and adverse effect. Neural Plast. 2020 Nov 22;2020:8892184. doi: 10.1155/2020/8892184. eCollection 2020. Adverse Reactions Review
33498883 On the other hand, electroacupuncture, laser moxibustion and traditional Chinese medicine presented adverse effects, and kinesiology did not show effectiveness. Int J Environ Res Public Health. 2021 Jan 24;18(3):1017. doi: 10.3390/ijerph18031017. Adverse Reactions Review
33498883 Regarding the risks or adverse effects of CTs in cancer patients, the RCTs on electroacupuncture, laser moxibustion and traditional Chinese medicine described side effects, although they are listed as mild and rapidly resolving symptoms. Int J Environ Res Public Health. 2021 Jan 24;18(3):1017. doi: 10.3390/ijerph18031017. Side Effects Adverse Reactions Review
33498883 However, we found that some studies did not mention the risks or adverse effects in the use of certain therapies, such as electroacupuncture, PMR and guided imagery, yoga and phytotherapy. Int J Environ Res Public Health. 2021 Jan 24;18(3):1017. doi: 10.3390/ijerph18031017. Adverse Reactions Review
33511675 There is a need for further study of the pathogenesis of DPN, and for developing a unified standard for methods of acupuncture treatment, acupoint selection, and adverse reactions reporting. J Clin Pharm Ther. 2021 Jun;46(3):585-598. doi: 10.1111/jcpt.13351. Epub 2021 Jan 28. Adverse Reactions Review
33511675 In recent years, evidence has shown that acupuncture treatment, which is low cost and produces few adverse reactions, is effective for treating DPN, and can improve various clinical symptoms. J Clin Pharm Ther. 2021 Jun;46(3):585-598. doi: 10.1111/jcpt.13351. Epub 2021 Jan 28. Adverse Reactions Review
33511675 There is a need for further study of the pathogenesis of DPN, and for developing a unified standard for methods of acupuncture treatment, acupoint selection and adverse reactions reporting. J Clin Pharm Ther. 2021 Jun;46(3):585-598. doi: 10.1111/jcpt.13351. Epub 2021 Jan 28. Adverse Reactions Review
33531894 Taken together, the inhibition of neuroglial plasticity-mediated central sensitization is one of the critical mechanisms in acupuncture analgesia, contributing to the wider application of acupuncture, alone or in combination with pain medication, in the enhancement of treatment effectiveness and the lowering of pain medication dosages and decreasing the risk of debilitating adverse effects. Neural Plast. 2021 Jan 18;2021:8881557. doi: 10.1155/2021/8881557. eCollection 2021. Dosage of Medication Adverse Reactions Review
33680223 The results of our current systematic review and meta-analysis show that compared with drug treatment, single acupuncture treatment has the same effect in reducing pain and relieving symptoms of depression in patients with CPRD, but the incidence of adverse reactions of acupuncture treatment is smaller. Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. Adverse Reactions Depression Review
33794857 In our review, we prove that the combination of acupuncture and antidepressants has no significant effect on adverse events compared with antidepressants alone. BMC Complement Med Ther. 2021 Apr 1;21(1):109. doi: 10.1186/s12906-021-03277-3. Adverse Reactions Review
33859714 The safety issue of an automanipulation device for acupuncture operation in rats is feasible among real-time physiological functions and laboratory data, and no significant adverse effect was noted such as crippling and molting in the whole process. Evid Based Complement Alternat Med. 2021 Mar 31;2021:8883598. doi: 10.1155/2021/8883598. eCollection 2021. Adverse Reactions Review
33868443 Among the 14 studies, 6 mentioned no adverse reactions between the experimental group and the control group, and 3 mentioned adverse reactions: Yan acupuncture group: gastrointestinal reactions (2 cases), control group: liver function impairment (4 cases), renal function impairment (4 cases), routine blood abnormalities (2 cases), gastrointestinal reactions (6 cases), and hypersensitivity reactions (2 cases). Evid Based Complement Alternat Med. 2021 Apr 2;2021:6694936. doi: 10.1155/2021/6694936. eCollection 2021. Adverse Reactions Kidney Review
33868443 Li showed that the acupuncture plus Chinese medicine group (1 case) vs the Chinese medicine group (11 cases) showed fewer adverse reactions and higher safety in the treatment of CVA with acupuncture. Evid Based Complement Alternat Med. 2021 Apr 2;2021:6694936. doi: 10.1155/2021/6694936. eCollection 2021. Adverse Reactions Review
33868443 Safety analysis: 3 of the 11 studies mentioned adverse reactions of acupuncture, mainly manifesting as minor reactions such as gastrointestinal reactions and local skin redness. Evid Based Complement Alternat Med. 2021 Apr 2;2021:6694936. doi: 10.1155/2021/6694936. eCollection 2021. Adverse Reactions Review
33986818 The second aim of this systematic review was to investigate acupuncture as an adjuvant therapy to hypnotic drugs, whether acupuncture can further enhance the clinical efficacy and/or reduce the adverse reactions caused by these Western medications. Evid Based Complement Alternat Med. 2021 Apr 26;2021:5566742. doi: 10.1155/2021/5566742. eCollection 2021. Adverse Reactions Review
34054306 A recent review indicated that acupuncture, moxibustion, and herbal medicine have important analgesic effects and are safe to use, in contrast to drugs that have adverse effects, for the treatment of knee OA. J Pain Res. 2021 May 21;14:1345-1351. doi: 10.2147/JPR.S311557. eCollection 2021. Analgesic Effect Adverse Reactions Review
34055020 For example, some adverse reactions may occur in the process of acupuncture in clinical trials, such as pain, redness, hematoma, and nausea after acupuncture. Evid Based Complement Alternat Med. 2021 May 17;2021:6678398. doi: 10.1155/2021/6678398. eCollection 2021. Adverse Reactions Nausea and Vomiting Review
34093119 Pharmacological therapies show limited efficacy in relieving headache and are often accompanied by adverse effects, while the benefits of acupuncture, a non-pharmacological therapy, have been well-documented in both the treatment and prevention of acute migraine attacks. Front Neurosci. 2021 May 20;15:674852. doi: 10.3389/fnins.2021.674852. eCollection 2021. Adverse Reactions Review
34122180 The second aim of this systematic review was to investigate if acupuncture could further enhance the clinical efficacy and/or reduce the adverse reactions caused by these Western medications. Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. Adverse Reactions Review
34178633 As a complementary and alternative medicine, the mechanism of action of acupuncture is not clear, but it is thought to be useful in improving complications such as lymphedema and upper extremity impairment caused by modified radical mastectomy, hot flashes and arthralgias related to endocrine therapy, cancer-related fatigue, chemotherapy-related peripheral neuropathy and the QoL, with less adverse effects. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Endocrinology Adverse Reactions Review
34234358 Wong (2006) reported that no mortality, complications, or adverse effects occurred in either the EA or sham acupuncture groups. PLoS One. 2021 Jul 7;16(7):e0254093. doi: 10.1371/journal.pone.0254093. eCollection 2021. Adverse Reactions Review
34336626 In a study that investigated retrospective studies, case reports, and surveys of medical providers, they concluded the following to be the most common adverse effects of acupuncture: bruising, needle site bleeding, diarrhea, increased pain, nausea, vomiting, fainting, psychiatric disturbances, headaches, sweating, dizziness, and aggravation of symptoms. Anesth Pain Med. 2021 Apr 3;11(2):e113627. doi: 10.5812/aapm.113627. eCollection 2021 Apr. Adverse Reactions Bleeding Nausea and Vomiting Review
34336626 No adverse effects were reported after acupuncture treatment. Anesth Pain Med. 2021 Apr 3;11(2):e113627. doi: 10.5812/aapm.113627. eCollection 2021 Apr. Adverse Reactions Review
34349826 However, this review of acupuncture treatment of cancer pain with a large number of RCT experiments demonstrated that acupuncture treatment of cancer has fewer adverse reactions such as nausea and vomiting than analgesic drug treatment alone. Evid Based Complement Alternat Med. 2021 Jul 26;2021:5558590. doi: 10.1155/2021/5558590. eCollection 2021. Cancer Pain Adverse Reactions Nausea and Vomiting Review
34349826 Based on the meta-analysis of 19 studies, compared with the treatment of cancer pain with three-step analgesic drug treatment alone, the response rates of pain relief from acupuncture combined with three-step analgesic drug treatment were higher, the NRS scores were lower, the incidence of adverse reactions such as nausea and vomiting was less frequent, the incidence of times of burst pain was also less frequent, the onset time to analgesic effect was shorter, and the duration of pain response was longer. Evid Based Complement Alternat Med. 2021 Jul 26;2021:5558590. doi: 10.1155/2021/5558590. eCollection 2021. Analgesic Effect Cancer Pain Pain Relief Adverse Reactions Nausea and Vomiting Review
34367299 As for hydroacupuncture therapy, although its efficacy on HG has been demonstrated to some extent, further research is required because of its considerable stimulation, significant pain, unclear adverse effects, and action mechanism. Evid Based Complement Alternat Med. 2021 Jul 27;2021:2731446. doi: 10.1155/2021/2731446. eCollection 2021. Adverse Reactions Review
34397902 Only 1 study reported the safety profile of the intervention, and no acupuncture-related adverse reactions were reported. Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. Adverse Reactions Review
34408622 Evidence shows that acupuncture can be a low-cost, low-risk therapy with few and minor adverse effects and it can help in the management of diseases involving inflammatory pain and reduce reliance on analgesics, including morphine. Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. Adverse Reactions Inflammatory Pain Review
34437474 The application of acupuncture can produce curative effects with barely any adverse reactions. Vet Sci. 2021 Jul 30;8(8):149. doi: 10.3390/vetsci8080149. Adverse Reactions Review
34437474 Broad applications with a low risk of adverse reactions are the advantages of acupuncture, which are closely related to its characteristics. Vet Sci. 2021 Jul 30;8(8):149. doi: 10.3390/vetsci8080149. Adverse Reactions Review
34489268 Following the differentiation between AEs and adverse drug reactions defined by the International Conference on Harmonisation (ICH) of Good Clinical Practice, articles were classified into reports on AEs irrespective of their causal relationship to acupuncture and adverse reactions for which a causal relationship was a reasonable possibility. BMJ Open. 2021 Sep 6;11(9):e045961. doi: 10.1136/bmjopen-2020-045961. Adverse Reactions Review
34489268 Sensitivity analyses of trials reporting on adverse reactions only with a plausible relationship to acupuncture resulted in marginally lower overall AE risk estimates but reduced the SAE risk from one to 0.45 cases in 10 000 patients and from eight to five cases in one million treatments. BMJ Open. 2021 Sep 6;11(9):e045961. doi: 10.1136/bmjopen-2020-045961. Adverse Reactions Review
34489268 First, it is debatable whether studies should be summarised irrespective of whether AEs not necessarily related to acupuncture or adverse reactions likely caused by acupuncture were reported. BMJ Open. 2021 Sep 6;11(9):e045961. doi: 10.1136/bmjopen-2020-045961. Adverse Reactions Review
34526816 Acupuncture is an appropriate option for women to avoid pharmacological anesthesia, including GA, PCB, CSA, which mainly produces postoperative adverse effects and potential effects on oocytes or embryos. J Pain Res. 2021 Sep 9;14:2833-2849. doi: 10.2147/JPR.S319923. eCollection 2021. Adverse Reactions Review
34526816 Four studies included in this review indicated acupuncture combined with dolantin or propofol analgesia decreased adverse effects compared to using dolantin or propofol alone. J Pain Res. 2021 Sep 9;14:2833-2849. doi: 10.2147/JPR.S319923. eCollection 2021. Adverse Reactions Review
34630605 Finally, due to lack of reports on the adverse effects of acupuncture, the possible adverse reactions during implementation of acupuncture were not systematically evaluated. Evid Based Complement Alternat Med. 2021 Sep 29;2021:2500282. doi: 10.1155/2021/2500282. eCollection 2021. Adverse Reactions Review
34646653 Advantages to acupuncture include effectiveness, favorable safety profile, and few adverse effects as a non-drug therapy. Cureus. 2021 Aug 31;13(8):e17601. doi: 10.7759/cureus.17601. eCollection 2021 Aug. Adverse Reactions Review
34646653 A review from the Cochrane Institute showed that acupuncture in migraine is equally as effective or even more effective than preventive medication and has fewer adverse effects. Cureus. 2021 Aug 31;13(8):e17601. doi: 10.7759/cureus.17601. eCollection 2021 Aug. Adverse Reactions Review
34646653 Adverse Effects of Acupuncture and Manual Therapy Cureus. 2021 Aug 31;13(8):e17601. doi: 10.7759/cureus.17601. eCollection 2021 Aug. Adverse Reactions Review
34646653 Common adverse effects of acupuncture include bruises, pain, and localized edema at needle insertion sites. Cureus. 2021 Aug 31;13(8):e17601. doi: 10.7759/cureus.17601. eCollection 2021 Aug. Adverse Reactions Review
34646653 Overall, acupuncture seems to be a safe treatment in patients taking anticoagulants with self-limited adverse effects. Cureus. 2021 Aug 31;13(8):e17601. doi: 10.7759/cureus.17601. eCollection 2021 Aug. Adverse Reactions Review
34721179 Some meta-analyses showed that acupuncture is a safe and effective method for the treatment of depression (Li et al.,; Armour et al.,), with relatively few adverse effects (Smith et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Adverse Reactions Depression Review
34721179 Prenatal acupuncture reduced depression, stress, and pain and improved the quality of life without adverse reactions (Ormsby et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Adverse Reactions Depression Review
34760630 Omega-3 and zinc sulfate supplements with minimal adverse effects can be used first; external treatments without side effects, such as acupuncture, CHBT, and Chinese herbal-based cream, can then be considered. Tzu Chi Med J. 2020 Dec 24;33(4):350-358. doi: 10.4103/tcmj.tcmj_151_20. eCollection 2021 Oct-Dec. Side Effects Adverse Reactions Review
34840581 When the outcome indicators of adverse reactions are included, the safety of acupuncture combined with different physical therapies in the treatment of PSCI can be better compared. Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. Adverse Reactions Review
34889286 TCM combined with acupuncture did not increase adverse reactions in patients with CP, and the safety was relatively high, as shown in Figure 9. Medicine (Baltimore). 2021 Dec 10;100(49):e28163. doi: 10.1097/MD.0000000000028163. Adverse Reactions Review
34889286 The results showed that acupuncture combined with TCM can significantly improve the symptoms of urination, relieve pain, and improve the quality of life of patients with prostatitis, and it does not increase the incidence of adverse reactions. Medicine (Baltimore). 2021 Dec 10;100(49):e28163. doi: 10.1097/MD.0000000000028163. Adverse Reactions Review
34899943 The low adverse effects of acupuncture for primary dysmenorrhea (PD), known as one of the most commonly reported gynecological debilitating conditions affecting women's overall health, have been thus far confirmed. Evid Based Complement Alternat Med. 2021 Dec 3;2021:1907009. doi: 10.1155/2021/1907009. eCollection 2021. Adverse Reactions Review
34930039 Acupuncture is a traditional Chinese medicine (TCM) based approach for treating a wide variety of symptoms by triggering specific acupoints on the skin with needles, which has been observed to alleviate adverse effects of surgery or chemotherapy for cancer patients, including postoperative arm lymphedema, chemotherapy-induced nausea and vomiting, and chemotherapy-induced peripheral neuropathy and leukopenia. Integr Cancer Ther. 2021 Jan-Dec;20:15347354211063884. doi: 10.1177/15347354211063884. Adverse Reactions Nausea and Vomiting Review
35085351 In terms of adverse reactions, acupuncture and conventional drugs for the treatment of FGIDs were associated with few adverse reactions, and there was no significant difference between the two. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Adverse Reactions Review
35085351 Previous studies have also shown that acupuncture is associated with fewer adverse reactions than antidepressants. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Adverse Reactions Review
35168522 In a study, 58 participants with ischemic PSD received acupuncture and placebo starch tablets treatment or fluoxetine tablets add body acupuncture treatment during a 12-week intervention period, found that both acupuncture and fluoxetine could reduce the depressive scores, but the former had no obvious adverse reaction and side effects, indicating that the effects of acupuncture were comparable to first-line treatments in PSD patients Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Side Effects Adverse Reactions Review
35168522 Compared with pharmacological treatment, acupuncture may be reasonable to consider for women during pregnancy or postpartum due to fewer adverse effects. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Adverse Reactions Review
35310023 Relevant studies in recent years have shown that traditional acupuncture therapy has a positive role in the treatment of NAFLD, and its adverse reactions are mild, simple, and effectively treated. Evid Based Complement Alternat Med. 2022 Mar 11;2022:2447529. doi: 10.1155/2022/2447529. eCollection 2022. Adverse Reactions Review
35345621 The existing clinical trials have shown that acupuncture has more advantages than western medicine, with rapid effects, safety, and convenience and no obvious adverse reactions, which is more and more favored by insomnia patients and has become one of the effective ways to treat insomnia. Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. Adverse Reactions Insomnia Review
35360658 Previous reviews and meta-analyses have focused on the clinical efficacy and adverse reactions of comprehensive acupuncture for UC and confirmed the benign effect of acupuncture for UC, but none of them specifically studied the influence of acupuncture parameters on clinical efficacy, despite them playing an important role in clinical efficacy. Evid Based Complement Alternat Med. 2022 Mar 22;2022:8362892. doi: 10.1155/2022/8362892. eCollection 2022. Adverse Reactions Review
35360658 The following conditions were not eligible for inclusion: head needle, abdominal needle, ear needle, eye needle, and other non-traditional manual needle therapy; pregnant or lactating patients or those about to become pregnant; patients with mental illness; severe adverse effects of acupuncture (e.g., fear of acupuncture, fainting during acupuncture); animal experiments, case reports, review articles and repeated publications. Evid Based Complement Alternat Med. 2022 Mar 22;2022:8362892. doi: 10.1155/2022/8362892. eCollection 2022. Adverse Reactions Review
35366871 Acupuncture is considered to be a modality that is less invasive, more natural, and less liable to adverse effects than many conventional forms of treatment, and potentially cost-effective. BMC Complement Med Ther. 2022 Apr 2;22(1):97. doi: 10.1186/s12906-022-03537-w. Adverse Reactions Review
35366871 Acupuncture is considered less invasive, and less liable to adverse effects. BMC Complement Med Ther. 2022 Apr 2;22(1):97. doi: 10.1186/s12906-022-03537-w. Adverse Reactions Review
35380733 Two randomized trials found that acupuncture for acute pain in the ED performed better than titrated or intravenous morphine, with minimal adverse effects. Pain Med. 2022 Aug 31;23(9):1582-1612. doi: 10.1093/pm/pnac056. Adverse Reactions Review
35380733 Of the 300 participants, adverse effects were experienced by 89 (29.3%) patients: 85 (56.6%) in the morphine group and 4 (2.6%) in the acupuncture group. Pain Med. 2022 Aug 31;23(9):1582-1612. doi: 10.1093/pm/pnac056. Adverse Reactions Review
35399635 A large number of studies have shown that the use of CAM, including Chinese herbal medicine, acupuncture, moxibustion, psychotherapy, dietary supplements, and exercise therapy, can effectively treat POI (Table 1) with fewer adverse reactions. Evid Based Complement Alternat Med. 2022 Apr 1;2022:9053930. doi: 10.1155/2022/9053930. eCollection 2022. Adverse Reactions Review
35433299 Despite this scarce literature, a systematic review published identified common minor adverse effects and rare serious harms in pediatric acupuncture. World J Clin Pediatr. 2022 Mar 9;11(2):105-119. doi: 10.5409/wjcp.v11.i2.105. eCollection 2022 Mar 9. Adverse Reactions Review
35492706 The third purpose of this systematic review was to determine whether acupuncture could amplify the therapeutic effect and/or attenuate the adverse reactions caused by psychotropic substances. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Adverse Reactions Review
35619992 The intervention group received acupuncture treatment, including plum blossom acupuncture, fire acupuncture, electro-acupuncture, body acupuncture, manual acupuncture, warm acupuncture, or acupuncture therapy in combination with the treatments received by the control group; (4) Outcome indicators: Outcomes assessed in this overview include: Effective rate, 1-hour pad test, international consultation on incontinence questionnaire short form (ICIQ-SF) score, visual analog scale (VAS) score, and adverse reactions. Pain Res Manag. 2022 May 17;2022:5887862. doi: 10.1155/2022/5887862. eCollection 2022. Adverse Reactions Review
35664757 Although 13 studies had a total sample of 961 participants and were conducted in six countries, which included United States, China, South Korea, Denmark, Sweden, and Australia, acupuncture and AA with few adverse effects were poor persuasion for cancer survivors. Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. Adverse Reactions Review
35726681 Among the studies that reported adverse effects, they were mostly considered as direct risk, as 13% reported mainly bleeding and bruising upon acupuncture treatment, and dizziness with yoga treatment. Integr Cancer Ther. 2022 Jan-Dec;21:15347354221105563. doi: 10.1177/15347354221105563. Adverse Reactions Bleeding Review
35726681 No serious adverse effects were noted for acupuncture, yoga, and antioxidant supplements. Integr Cancer Ther. 2022 Jan-Dec;21:15347354221105563. doi: 10.1177/15347354221105563. Adverse Reactions Review
35726681 In contrast, other studies have reported that adverse effects in acupuncture and homeopathy are commonly reported. Integr Cancer Ther. 2022 Jan-Dec;21:15347354221105563. doi: 10.1177/15347354221105563. Adverse Reactions Review
35726681 The report of adverse effects among these modalities could be attributed to well-established reporting guidelines such as the Standard for Reporting Interventions in Controlled Trials of Acupuncture (STRICTA) guidelines and Consolidated Standards of Reporting Trials (CONSORT) for herbal medicine. Integr Cancer Ther. 2022 Jan-Dec;21:15347354221105563. doi: 10.1177/15347354221105563. Adverse Reactions Review
35832139 Overall, a meta-analysis of randomized control trials involving more than 1500 patients did not show any significant difference in treatment effects in the acupuncture group compared to controls receiving antidepressants such as Fluoxetine, Citalopram and Sertraline, however, lesser adverse effects were noted in the former. Psychol Res Behav Manag. 2022 Jul 7;15:1689-1706. doi: 10.2147/PRBM.S310207. eCollection 2022. Adverse Reactions Review
35875071 Compared with the control group, acupuncture interventions could alleviate some of the common adverse effects of antiemetic drugs. Front Oncol. 2022 Jul 8;12:888651. doi: 10.3389/fonc.2022.888651. eCollection 2022. Adverse Reactions Review
35884060 Acupuncture, when applied by a well-trained and board-certified acupuncturist, remains a safe therapeutic with few adverse effects. Children (Basel). 2022 Jul 19;9(7):1076. doi: 10.3390/children9071076. Adverse Reactions Review
35911171 The following information will be recorded: (1) general information (title, the first author's name, nationality, year of publication, and journal name); (2) study design (random sequence generation, allocation concealment method, blinding method, conflict of interest, sex ratio of treatment group, sex ratio of control group, age of treatment group, age of control group, and sample size); (3) intervention and comparator (type of acupuncture therapy, acupoints selection, stimulation duration, needle depths and frequency, treatment duration, follow-up duration, and details of the control group); (4) outcomes (different types of outcomes and related statistical results); (5) patients' adverse reactions; and (6) funding. Evid Based Complement Alternat Med. 2022 Jul 20;2022:1226702. doi: 10.1155/2022/1226702. eCollection 2022. Adverse Reactions Review
35978992 The adverse events reported by these studies were largely related to opioids' side effects, including nausea or vomiting, constipation, dizziness, itching, delirium, drowsiness, and abdominal distention, and there is no report about the adverse effects associated with acupuncture treatment. Front Pain Res (Lausanne). 2022 Aug 1;3:925013. doi: 10.3389/fpain.2022.925013. eCollection 2022. Side Effects Adverse Reactions Nausea and Vomiting Review
36011540 In general, acupuncture and scalp acupuncture showed to be effective in the treatment of fibromyalgia for reducing pain and disability in the short term if combined with other treatments, reducing the adverse effects and treatment costs. Int J Environ Res Public Health. 2022 Aug 11;19(16):9904. doi: 10.3390/ijerph19169904. Adverse Reactions Review
36017012 Several studies have shown that external therapy of TCM, such as acupuncture, moxibustion, and acupoint application, can be used to relieve symptoms and reduce the recurrence rate and adverse reactions associated with IBS-D. Front Med (Lausanne). 2022 Aug 9;9:940328. doi: 10.3389/fmed.2022.940328. eCollection 2022. Adverse Reactions Review
36203799 On the contrary, acupuncture is a relatively safe and well-tolerated treatment, with most patients experiencing no adverse effects at all. Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. Adverse Reactions Review
36268156 TCM characteristic therapy has been gradually paid attention and widely used in the treatment of insomnia, especially the traditional external treatment of TCM such as acupuncture and massage developed on the basis of the theory of meridians and viscera in TCM, which has the advantages of good clinical efficacy and less adverse reactions. Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. Adverse Reactions Insomnia Review
36276855 This study evaluated the effects of acupuncture-related therapies alone or in combination with Western medicine on pain scores, overall effectiveness, and adverse reaction rates in patients with PHN. Evid Based Complement Alternat Med. 2022 Oct 14;2022:3975389. doi: 10.1155/2022/3975389. eCollection 2022. Adverse Reactions Review
36276855 Evidence network diagram for adverse effects of reticulated meta-analysis of different acupuncture treatments for PHN. Evid Based Complement Alternat Med. 2022 Oct 14;2022:3975389. doi: 10.1155/2022/3975389. eCollection 2022. Adverse Reactions Review
36313493 Regarding the safety of acupuncture therapies, low-quality evidence showed that there was no difference in the incidence of adverse reactions between the 2 groups, and very-low quality evidence showed that acupuncture did not promote hemorrhagic conversion. Front Neurol. 2022 Oct 13;13:1005819. doi: 10.3389/fneur.2022.1005819. eCollection 2022. Adverse Reactions Review
36313493 Low-quality evidence and very low-quality evidence indicated that adjuvant acupuncture after thrombolysis might not increase the hemorrhagic conversion rate and incidence of other adverse reactions in patients within 48 h of AIS onset. Front Neurol. 2022 Oct 13;13:1005819. doi: 10.3389/fneur.2022.1005819. eCollection 2022. Adverse Reactions Review
36340786 Acupuncture, a widely used non-pharmacological therapy, offers the benefit of therapeutic results and few adverse effects in the prevention and treatment of migraines. Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. Adverse Reactions Review
36381700 Acupuncture was also shown to be well-tolerated and safe with no significant adverse reactions within the conducted trials. Cureus. 2022 Oct 5;14(10):e29963. doi: 10.7759/cureus.29963. eCollection 2022 Oct. Adverse Reactions Review
36388203 In conclusion, there were mild adverse reactions but no serious adverse reactions in the treatment of migraine by different acupuncture treatments. Front Neurol. 2022 Oct 26;13:1010410. doi: 10.3389/fneur.2022.1010410. eCollection 2022. Adverse Reactions Review
36408345 Acupuncture analgesia has a long history, and its effectiveness, simplicity, and few adverse reactions have been widely recognized at national and international levels. Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. Adverse Reactions Review
36408345 Acupuncture analgesia relieves patients' degree of pain and avoids addiction, immunosuppression, gastrointestinal injury, and other adverse reactions caused by taking analgesic drugs. Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. Immunity Adverse Reactions Review
36482537 Bleeding at the stimulated site during acupuncture therapy and slight contusion of the skin tissue during massage therapy are common adverse reactions. Medicine (Baltimore). 2022 Dec 2;101(48):e32058. doi: 10.1097/MD.0000000000032058. Adverse Reactions Bleeding Review
36532179 And the remaining eight cases had adverse effects such as subcutaneous bleeding, acupuncture pain, and insomnia. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Adverse Reactions Insomnia Bleeding Review
36532179 The intervention methods in Lan were all needling, and there were four cases of adverse reactions, one case of dizziness, and three cases of local bruising from acupuncture. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Adverse Reactions Review
36532179 There were no serious adverse events of acupuncture in all included studies, and the adverse reactions related to acupuncture were relieved by rest. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Adverse Reactions Review
36570846 Another RCT on the treatment of functional constipation found that electroacupuncture ST25, Fujie (SP14), and Shangjuxu (ST37) could increase the number of entirely spontaneous defecations in patients with functional constipation while decreasing the prevalence of adverse effects, but whether these effects are related to ANS regulation requires further exploration. Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. Adverse Reactions Review
36590284 The most common adverse effects of acupuncture in the included studies were pain, pruritus, bruising, and colds. Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. Adverse Reactions Review
36590284 In the subgroup analysis results showed that acupuncture or electroacupuncture had more positive efficacy and higher safety compared to drugs such as eszopiclone and gabapentin for the treatment of CRI, while some articles were less good and there were no good solutions mentioned in the text for these adverse reactions, which is something we need to improve in the future when using acupuncture therapy. Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. Adverse Reactions Review
36590284 Moreover, although acupuncture treatment has fewer side effects, there is no clear solution to these adverse effects, which is what we need to improve in the use of acupuncture in the future, such as pain, itching, bruising, colds, etc. Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. Side Effects Adverse Reactions Review
36590284 In terms of the safety of acupuncture efficacy, there is a need to further improve and ameliorate the adverse effects associated with acupuncture. Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. Adverse Reactions Review
36607887 Combined acupuncture-medicine anesthesia significantly increases the anesthesia significance rate, reduces the intraoperative heart rate, and blood pressure, and reduces the incidence of postoperative adverse reactions. Medicine (Baltimore). 2023 Jan 6;102(1):e32582. doi: 10.1097/MD.0000000000032582. Heart Rate Adverse Reactions Blood Pressure Review
36607887 Meta-analysis of the RCTs comparing adverse reactions between acupuncture group and control group. Medicine (Baltimore). 2023 Jan 6;102(1):e32582. doi: 10.1097/MD.0000000000032582. Adverse Reactions Review
36607887 Notably, unlike electroacupuncture, transcutaneous electrical acupoint stimulation should not implement the piercing of the needle into the body, which reduces pain, bleeding, needle breakage, and other adverse reactions. Medicine (Baltimore). 2023 Jan 6;102(1):e32582. doi: 10.1097/MD.0000000000032582. Adverse Reactions Bleeding Review
36620677 ; (2) Baseline data: age and course of patients in each group, before treatment data for each outcome indicator; (3) Interventions: type of acupuncture, frequency and period of treatment; (4) post-treatment data for each outcome indicator, and adverse effects; (5) risk bias-related factors: random sequence generation, allocation, blinding, etc. Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Adverse Reactions Review
36698826 Compared with conventional analgesic-based interventions, acupuncture can more efficiently relieve renal colic with fewer adverse effects. Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. Adverse Reactions Kidney Review
36698826 Objective outcome indicators, such as time to complete pain relief, episodes of renal colic during treatment and adverse effects as well as circulating prostaglandin E2 concentration, may be included in future studies to provide more accurate information for elucidating the beneficial effects of acupuncture in this clinical setting. Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. Pain Relief Adverse Reactions Kidney Circulation Review
36698826 The results of the current meta-analysis showed that the clinical efficacy of acupuncture for renal colic was superior to that of conventional analgesics with a rapid onset of analgesia and relatively few adverse effects. Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. Adverse Reactions Kidney Review
36704010 Acupuncture therapy, an essential part of traditional Chinese medicine, is valuable in pain management and has the advantages of quick effects and minimal adverse reactions. Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. Adverse Reactions Review
36704010 A systematic review by suggested that the efficacy of moxibustion was higher than that of control groups (pharmacological therapies, herbal medicine, or no treatment), despite the high heterogeneity of the included studies, and a systematic review by suggested that acupuncture is comparable to the effects of Western medicines, but with no reported adverse effects. Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. Adverse Reactions Review
36845439 The pooled results indicated a higher incidence rate of adverse effects in drug reactions compared with acupuncture (RR=0.19, 95%CI [0.08, 0.45]) (Figure 6). Front Neurosci. 2023 Feb 9;17:1097830. doi: 10.3389/fnins.2023.1097830. eCollection 2023. Adverse Reactions Review
36862907 Excel was used to extract the basic information of the incorporated articles, including; Basic information of the article (age, gender, course of disease, sample size, etc); Parameters of acupuncture (treatment frequency, course of treatment, needle retention time, etc); Intervention method, randomization plan, follow-up, adverse reactions, outcome indicators and other data. Medicine (Baltimore). 2023 Mar 3;102(9):e33006. doi: 10.1097/MD.0000000000033006. Adverse Reactions Review
36862907 In terms of safety, drug adverse reactions as dizziness, dry mouth, drowsiness, gastrointestinal symptoms, and adverse reactions of acupuncture for subcutaneous bleeding, strong sense of needle legacy, at the end of the withdrawal or acupuncture treatment can obviously relieve or disappear, never reported left side effects. Medicine (Baltimore). 2023 Mar 3;102(9):e33006. doi: 10.1097/MD.0000000000033006. Side Effects Adverse Reactions Bleeding Review
36862907 For example, the random-number table method should be used in grouping rather than the order of treatment, subjects and outcome evaluators were blinded, the adverse reactions of patients were observed, long-term follow-up was conducted to observe the after effect of acupuncture. Medicine (Baltimore). 2023 Mar 3;102(9):e33006. doi: 10.1097/MD.0000000000033006. Adverse Reactions Review
36862907 In conclusion, compared with drug treatment, acupuncture can reduce the VAS, PPI and PRI scores of patients with poststroke thalamic pain, and improve the effective rate, and no serious adverse reactions have been reported so far. Medicine (Baltimore). 2023 Mar 3;102(9):e33006. doi: 10.1097/MD.0000000000033006. Adverse Reactions Review
36864974 Moreover, as a non-pharmacological treatment, acupuncture has shown fewer adverse effects than pharmacological treatment. Cardiovasc Diagn Ther. 2023 Feb 28;13(1):67-82. doi: 10.21037/cdt-22-480. Epub 2022 Dec 15. Adverse Reactions Review
36864974 In comparison to medication therapies, acupuncture has less adverse effects as a nonpharmacological treatment. Cardiovasc Diagn Ther. 2023 Feb 28;13(1):67-82. doi: 10.21037/cdt-22-480. Epub 2022 Dec 15. Adverse Reactions Review
36864974 As a therapy for hypertension, acupuncture has various advantages, including effectiveness, long-lasting effects, fewer adverse effects, target organ protection, improved inpatient compliance, etc. Cardiovasc Diagn Ther. 2023 Feb 28;13(1):67-82. doi: 10.21037/cdt-22-480. Epub 2022 Dec 15. Adverse Reactions Organ Protection Review
36873742 They found that when compared to western medicine, acupuncture was more beneficial for global cognitive function, and there was no difference in adverse effects between the acupuncture and control groups. Front Aging. 2023 Feb 16;4:1143408. doi: 10.3389/fragi.2023.1143408. eCollection 2023. Cognitive Function Adverse Reactions Review
36950556 Therefore, he proposed an integrative medicine (TCIM) including acupuncture and massage, to alleviate cancer symptoms or treatment-related adverse reactions such as pain, insomnia and fatigue. Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. Adverse Reactions Insomnia Review
36950556 The Society for Integrative Oncology (SIO) developed an evidence-based guideline on the use of integrative therapy during and after breast cancer treatment, which recommends acupressure and acupuncture to manage adverse effects related to breast cancer treatment. Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. Adverse Reactions Review
36968499 Based on a meta-analysis of eight randomized controlled trials (RCTs) that compared acupuncture with sham therapy in patients with FD, acupuncture was found to significantly reduce symptoms and gastric emptying time, while having few adverse effects. Front Neurosci. 2023 Mar 8;17:1109510. doi: 10.3389/fnins.2023.1109510. eCollection 2023. Adverse Reactions Review
37034090 Acupuncture for PSD is effective and has few adverse effects. Front Neurol. 2023 Mar 23;14:979643. doi: 10.3389/fneur.2023.979643. eCollection 2023. Adverse Reactions Review
37034090 Acupuncture, as a characteristic therapy of Chinese medicine, has achieved positive results in the treatment of PSD with remarkable efficacy and low adverse effects. Front Neurol. 2023 Mar 23;14:979643. doi: 10.3389/fneur.2023.979643. eCollection 2023. Adverse Reactions Review
37038228 Adverse effects associated with acupuncture therapies: An evidence mapping from 535 systematic reviews Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 Considering that physicians and patients widely use acupuncture, it is necessary to explore its adverse effects during treatment. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 Herein, an evidence map was generated based on published studies to identify acupuncture-induced adverse effects and assess their severity, with the overarching goal of providing references for safe and effective implementation. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 This evidence mapping explores the adverse effects of acupuncture, showing that there are multiple types of adverse reactions to acupuncture, with milder symptoms. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 The study found that although acupuncture was effective in treating infertility, significant adverse reactions occurred in the treatment process. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 It is also worth noting that the values and preferences of patients are rarely taken into account in acupuncture guidelines, which further limits the effectiveness of acupuncture recommendations and may be a factor in the occurrence of potential adverse reactions. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 This study presents the current status of acupuncture-related adverse effects from the following aspects: (1) the distribution and quality of SRs and/or MAs that have reported the outcome of adverse reactions caused by acupuncture; (2) the main adverse reactions, types of needles used, and diseases associated with acupuncture; (3) whether the existence of adverse reactions is associated with the acupuncture therapist and the acupuncture techniques; and (4) whether there is a significant difference between acupuncture-related adverse effects and other interventions, such as exercise and drugs. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 Studies were considered eligible if they met the following criteria: (1) Participants were healthy or unhealthy; (2) Included any acupuncture technique, such as electroacupuncture, fire needle, dry needle, auricular acupuncture, acupoint catgut embedding, and acupoint injection; (3) Studies that reported adverse reactions associated with acupuncture; (4) For SRs of the same topic, we choose the updated system reviews; and (5) English language based SRs and/or MAs that were conducted according to the PRISMA guidelines. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 We generated a heatmap using GraphPad prism version 9.3 and a bubble plot using Microsoft Excel 2019 to visually display the information associated with adverse effects in the process of acupuncture therapy. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 On the other hand, the bubble plot summarized the quantity and quality of SRs of each identified acupuncture-induced adverse effect and the current situation of adverse effects caused by different acupuncture types. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 The X-axis on the bubble plot depicted the type of adverse effects in the acupuncture process, whereas the Y-axis illustrated the SRs and/or MAs included in each quality category, and presented the statistical effect of each adverse reaction in each quality. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 The number of bubbles showed the number of adverse effects reported in the included studies, the size represented the number of original studies included in each eligible systematic review, and the color indicated the different types of acupuncture. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 Distribution of Acupuncture-related Adverse Effect Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 Notably, only a few included studies reported adverse effects due to acupuncture therapists. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 This study found 50 SRs with statistically significant acupuncture-related adverse effects, ranging from high- to critically low-quality. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 Forty-three adverse effects were described in a high-quality study that compared acupuncture with other interventions. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 Acupuncture-related adverse effects Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 It was evident that improper acupuncture operation could lead to local chronic pain, chronic swelling pain, and other adverse reactions. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Inflammatory Pain Review
37038228 The reported tiredness (3.28%, 40 SRs), discomforts (2.54%, 31 SRs), and psychological disorder (2.46%, 30 SRs) adverse effects may be attributed to improvement of the viscera function after acupuncture, blood adjusting well, short fatigue and discomforts after constantly improved body function, improved metabolism, and improved immunity and physical fitness. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Immunity Adverse Reactions Review
37038228 Infection, one of the most common acupuncture adverse effects, was reported in 19 studies (1.56%). Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 This evidence map provides a broad overview of adverse effects associated with acupuncture based on 535 published SRs. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 This study has shown that many types and large numbers of adverse reactions are associated with acupuncture. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 Therefore, to avoid these adverse reactions, the needle quality should be strictly controlled, acupuncturists or other professional operators should receive strict and standardized training, and a pre-test (similar to a skin test before an antibiotic injection) should be performed to understand the patient's constitution before the acupuncture process. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 The study conducted a systematic and comprehensive literature search in four public databases to identify all published SRs and/or MAs regarding the adverse effects of acupuncture. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 This evidence map provides a comprehensive summary of acupuncture-related adverse effects as described in published SRs and/or MAs. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 Unfortunately, most of the included studies were of low- or critically low-quality and only qualitatively described the acupuncture-related adverse effects or did not analyze individual adverse effects. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37038228 This may be attributed to the fact that most primary studies did not provide adequate details of acupuncture-related adverse effects, thereby limiting the extent of conclusions drawn by the SRs. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Adverse Reactions Review
37046882 Wang reported that among participants who received electro-acupuncture and placebo pill, two cases of nausea (2/19, 10.5%), two cases of fatigue (2/19, 10.5%), and one case of itchiness (1/19, 5.3%) were reported as adverse reactions. Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. Adverse Reactions Nausea and Vomiting Review
37046882 Yang reported that among participants who received electro-acupuncture, bleeding and hematoma around the site of the needling occurred as adverse reactions in 12.5% (4/32) of cases. Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. Adverse Reactions Bleeding Review
37091130 Acupuncture has the characteristics of evident efficacy, low price, flexible use, and few adverse reactions. Behav Neurol. 2023 Apr 12;2023:9445381. doi: 10.1155/2023/9445381. eCollection 2023. Adverse Reactions Review
37226372 Twelve out of 38 studies mentioned adverse effects (AEs) of acupuncture, but the reporting of AEs was clear only in 10 (26%). Cancer Med. 2023 Jun;12(11):12504-12517. doi: 10.1002/cam4.5962. Epub 2023 May 24. Adverse Reactions Review
37229426 This research also found that acupuncture therapy has many characteristics, few side effects, relatively safe, and in the treatment of PD, it has a certain antagonistic effect on the adverse reactions caused by madopar or other dopaminergic drugs, such as nausea and vomiting, which are typical symptoms of the gastrointestinal adverse reactions. Front Neurosci. 2023 May 9;17:1125626. doi: 10.3389/fnins.2023.1125626. eCollection 2023. Side Effects Adverse Reactions Nausea and Vomiting Review
37256179 Most importantly, substantial evidence has shown that acupuncture and medication are indistinguishable in cancer pain management and also reduce the adverse effect compared to western medicine. Front Oncol. 2023 May 15;13:1169458. doi: 10.3389/fonc.2023.1169458. eCollection 2023. Cancer Pain Adverse Reactions Review
37260441 In women with PCOS and IR, acupuncture was superior to metformin in improving glucose metabolism and had a lower incidence of gastrointestinal adverse effects. Front Endocrinol (Lausanne). 2023 May 16;14:956772. doi: 10.3389/fendo.2023.956772. eCollection 2023. Adverse Reactions Review
37260441 The therapeutic effect is superior to that of Western medicine alone, and there are no adverse reactions, based on the research of Jo J et al.. Acupuncture combined with TCM could improve the endocrine level and IR of phlegm-dampness PCOS and reduce miR-29 expression and TCM symptom score. Front Endocrinol (Lausanne). 2023 May 16;14:956772. doi: 10.3389/fendo.2023.956772. eCollection 2023. Endocrinology Adverse Reactions Review
37289799 Except for syncope after acupuncture, all other adverse reactions were mild (Table 1). PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Adverse Reactions Review
37332744 Two studies noted that none of the patients receiving acupuncture experienced adverse reactions. Front Med (Lausanne). 2023 Jun 2;10:1114485. doi: 10.3389/fmed.2023.1114485. eCollection 2023. Adverse Reactions Review
37396891 Acupuncture combined with sedation reduces sedative consumption and wake-up time compared with sedation alone in gastrointestinal endoscopy; this combined approach allows patients to regain consciousness more quickly after examination and lower the risk of adverse effects. Front Med (Lausanne). 2023 Jun 16;10:1189429. doi: 10.3389/fmed.2023.1189429. eCollection 2023. Adverse Reactions Sedation Review
37396891 The overall incidence of adverse effects was lower in the group of acupuncture combined with sedation than in the control group, indicating the efficacy of acupuncture in improving the safety of sedated gastrointestinal endoscopy. Front Med (Lausanne). 2023 Jun 16;10:1189429. doi: 10.3389/fmed.2023.1189429. eCollection 2023. Adverse Reactions Sedation Review
37396891 More detailed documentation of acupuncture-related adverse effects is required. Front Med (Lausanne). 2023 Jun 16;10:1189429. doi: 10.3389/fmed.2023.1189429. eCollection 2023. Adverse Reactions Review
37396891 In view of all that has been mentioned so far, it may be supposed that acupuncture combined with sedation reduced sedative consumption and wake-up time compared with simple sedation in gastrointestinal endoscopy, which allows patients to regain consciousness more quickly after examination and overall reduces the risk of adverse effects. Front Med (Lausanne). 2023 Jun 16;10:1189429. doi: 10.3389/fmed.2023.1189429. eCollection 2023. Adverse Reactions Sedation Review
37417606 Moreover, safety was assessed by investigating the frequency of the adverse reactions, which were much less common in the group that received acupuncture combined with Chinese herbal medicine for the treatment of ODI compared to the control group. Medicine (Baltimore). 2023 Jul 7;102(27):e34310. doi: 10.1097/MD.0000000000034310. Adverse Reactions Review
37441610 In terms of safety, acupuncture did not cause serious adverse reactions, however, due to limited safety information, reliable safety conclusions cannot be drawn. Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. Adverse Reactions Review
37449100 Acupuncture and moxibustion, in particular, have demonstrated substantial effectiveness with minimal adverse reactions. Heliyon. 2023 Jul 4;9(7):e17805. doi: 10.1016/j.heliyon.2023.e17805. eCollection 2023 Jul. Adverse Reactions Review
37478233 In the long-term medical practice, Chinese medicine practitioners have gradually found that although both Chinese medicine prescriptions and acupuncture can produce therapeutic effects on TS, the effect of Chinese medicine combined with acupuncture on TS is more significant, and the adverse reactions are less. Medicine (Baltimore). 2023 Jul 21;102(29):e34268. doi: 10.1097/MD.0000000000034268. Adverse Reactions Review
37478233 In the above studies, there were no obvious adverse reactions in the process of taking traditional Chinese medicine preparations and acupuncture treatment of TS. Medicine (Baltimore). 2023 Jul 21;102(29):e34268. doi: 10.1097/MD.0000000000034268. Adverse Reactions Review
37505150 The observation group was treated with Bushen Zhichan Fang (Fructus Lycii, Radix Paeoniae Alba, Ramulus Uncariae cum Uncis, Herba Cistanches, Radix Rehmanniae, Carapax et Plastrum Testudinis, Radix Codonopsis, Fructus Cannabis, Radix Ophiopogonis, Carapax Trionycis, Rhizoma Gastrodiae, Colla Cornus cervi, Colla Corii Asini, Rhizoma Polygonati, Fructus Corni, and Radix Glycyrrhizae Preparata) and acupuncture (After treatment, the sleep quality [PD sleep scale, Pittsburgh sleep quality index], quality of life [PD quality of life scale 39], clinical efficacy of TCM, plasma glutamate and serum cystatin C levels before and after treatment, daily average dosage of madopar and adverse reactions were observed. Medicine (Baltimore). 2023 Jul 28;102(30):e34278. doi: 10.1097/MD.0000000000034278. Adverse Reactions Sleep Quality Review
37542321 As a supplementary therapy for migraine, acupuncture is well tolerated and has few adverse reactions, so it is widely used in clinical practice. BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. Adverse Reactions Review
37614513 Acupuncture also reduced the incidence of adverse effects (RR=0.43, 95% CI [0.23, 0.80], p = 0.008). Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Adverse Reactions Review
37614513 There were superior effectiveness and fewer adverse reactions to acupuncture compared to usual care. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Adverse Reactions Review
37655096 For each article, the following information was extracted: authors; country where the study was performed; gastrointestinal symptoms and other symptoms; surgical organs or systems; study design; sample size; treatment period; acupuncture protocols; acupuncture style; adverse effect; and significant results between the acupuncture and control groups. Front Oncol. 2023 Aug 15;13:1232754. doi: 10.3389/fonc.2023.1232754. eCollection 2023. Adverse Reactions Review
37675019 Some scholars believe that acupuncture combined with moxibustion reduces the adverse effects of hyperlipidemia and obesity better than acupuncture alone. Front Nephrol. 2022 Nov 9;2:1006506. doi: 10.3389/fneph.2022.1006506. eCollection 2022. Adverse Reactions Review
37675019 Various meta-analyses, which included thousands of patients each, suggested that acupuncture could improve the sleep quality of patients with primary insomnia and patients with insomnia-related primary diseases and conditions (stroke, ESRD, perimenopause, pregnancy, and mental illness) of all ages, with few and mild adverse reactions. Front Nephrol. 2022 Nov 9;2:1006506. doi: 10.3389/fneph.2022.1006506. eCollection 2022. Adverse Reactions Insomnia Sleep Quality Review
37732301 In a clinical context, acupuncture is a general term comprising many therapeutic procedures, including traditional human acupuncture, moxibustion, electric acupuncture, and laser acupuncture, among other techniques used in the analgesic treatment of clinically relevant acute and chronic pain diseases, such as an acute sprain, migraine, osteoarthritis, labor pain, cancer pain, etc.. A recent meta-analysis of randomized controlled clinical trials on the efficacy of acupuncture in treating IBS revealed that acupuncture significantly improves the severity of IBS symptoms (especially abdominal pain) while at the same time improving patient quality of life without any adverse effects. Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. Cancer Pain Adverse Reactions Review
37773829 Through a comprehensive comparison of 9 different acupuncture therapies, acupotomy was the optimal treatment to improve VAS pain scores and the time of incrustation; bloodletting, acupuncture, fire needle, and moxibustion could be effective intervention measures to improve the time of ceasing new blisters and decrustation and reduce the incidence of PHN; Western medicine was closely related to adverse reactions. Medicine (Baltimore). 2023 Sep 29;102(39):e34920. doi: 10.1097/MD.0000000000034920. Adverse Reactions Review
37773829 Overall, the number of cases of adverse reactions related to acupuncture therapies was lower than that of drug, and no serious adverse reactions were reported. Medicine (Baltimore). 2023 Sep 29;102(39):e34920. doi: 10.1097/MD.0000000000034920. Adverse Reactions Review
37773829 The analysis of the above outcome measures revealed that acupuncture-related therapies were superior to Western medicine in terms of improvement of pain, overall effective rate, the incidence of adverse reactions, and reduction of the disease course. Medicine (Baltimore). 2023 Sep 29;102(39):e34920. doi: 10.1097/MD.0000000000034920. Adverse Reactions Review
37773829 Secondly, we found no significant difference in the incidence of adverse reactions among different acupuncture treatment protocols. Medicine (Baltimore). 2023 Sep 29;102(39):e34920. doi: 10.1097/MD.0000000000034920. Adverse Reactions Review
37773829 In summary, through the comprehensive comparison of 9 different acupuncture therapies, acupotomy is the optimal treatment to improve the VAS pain score and the time of incrustation; bloodletting, acupuncture, fire needle, and moxibustion may be effective interventions to improve the time of ceasing new blisters and decrustation and reduce the incidence of PHN; Western medicine is closely related to adverse reactions. Medicine (Baltimore). 2023 Sep 29;102(39):e34920. doi: 10.1097/MD.0000000000034920. Adverse Reactions Review
37810054 On the contrary, acupuncture therapies, especially electroacupuncture, have fewer adverse effects and longer-term curative effects than medicines. Heliyon. 2023 Sep 1;9(9):e19732. doi: 10.1016/j.heliyon.2023.e19732. eCollection 2023 Sep. Adverse Reactions Review
37810368 The clinical practice guidelines for non-drug treatment and drug treatment of adult patients with major depression developed by the American College of Physicians in 2016 suggested that acupuncture treatment for major depression has fewer adverse reactions than drug treatment. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Adverse Reactions Depression Review
37849245 Recent investigations have demonstrated the pivotal role of acupuncture in managing postoperative pain, yielding notable reductions in postoperative pain levels and opioid consumption, thereby mitigating the occurrence of opioid-induced adverse effects, such as nausea and vomiting. Med Sci Monit. 2023 Oct 18;29:e941262. doi: 10.12659/MSM.941262. Adverse Reactions Nausea and Vomiting Review
37849245 In comparison with antiemetic drugs, acupuncture offers distinct advantages, including minimal physiological perturbation and a lower incidence of adverse effects. Med Sci Monit. 2023 Oct 18;29:e941262. doi: 10.12659/MSM.941262. Adverse Reactions Review
37861487 Acupuncture is a traditional Chinese medicine therapy, which has the advantages of safety, effectiveness, no adverse reactions, no dependence, no addiction, and withdrawal. Medicine (Baltimore). 2023 Oct 20;102(42):e35000. doi: 10.1097/MD.0000000000035000. Adverse Reactions Review
37861487 Acupuncture can enhance the efficacy of chemotherapy, strengthen immune function, reduce adverse reactions, and induce the apoptosis of tumor cells. Medicine (Baltimore). 2023 Oct 20;102(42):e35000. doi: 10.1097/MD.0000000000035000. Immunity Adverse Reactions Review
37861514 Studies have reported that the use of acupuncture and moxibustion in the treatment of insomnia has the advantages of accurate efficacy, simple operation, and fewer adverse reactions. Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. Adverse Reactions Insomnia Review
37942632 Adverse effects were reported in only 5 reviews, and the pooled results all suggested that the incidence of adverse events was lower in the intervention group (acupuncture plus drug therapy) than in the control group (drug therapy). Integr Cancer Ther. 2023 Jan-Dec;22:15347354231210288. doi: 10.1177/15347354231210288. Adverse Reactions Review
37954034 The results showed that acupuncture can improve the total effective rate [OR=3.43 (95% CI: 2.71, 4.35), moderate credibility], reduce the incidence of adverse reactions [OR=0.45 (95% CI: 0.32, 0.63), moderate credibility], reduce the TESS score (side effect scale) [MD=−1.83 (95% CI: −2.94, −0.71), very low credibility. Neuropsychiatr Dis Treat. 2023 Nov 7;19:2381-2400. doi: 10.2147/NDT.S428518. eCollection 2023. Side Effects Adverse Reactions Review
37954034 Existing evidence indicates that acupuncture as an adjunctive therapy can improve the total effective rate of SZ patients, reduce the incidence of adverse reactions, improve clinical symptoms, and alleviate depression and anxiety in SZ patients. Neuropsychiatr Dis Treat. 2023 Nov 7;19:2381-2400. doi: 10.2147/NDT.S428518. eCollection 2023. Adverse Reactions Anxiety Depression Review
37954034 As can be seen, acupuncture as an adjunctive therapy can effectively reduce adverse reactions in clinical practice. Neuropsychiatr Dis Treat. 2023 Nov 7;19:2381-2400. doi: 10.2147/NDT.S428518. eCollection 2023. Adverse Reactions Review
37954034 The results indicated that acupuncture, as an adjunctive therapy in conjunction with Western medicine or other therapies, could improve the overall effective rate of SZ patients (P<0.00001) while reducing the adverse reactions caused by medication. Neuropsychiatr Dis Treat. 2023 Nov 7;19:2381-2400. doi: 10.2147/NDT.S428518. eCollection 2023. Adverse Reactions Review
37954034 Existing evidence suggests that acupuncture, as an adjunctive therapy used in conjunction with Western medicine or other treatments, can improve the overall effectiveness in patients with SZ, reduce adverse reactions, and improve the mental condition, alleviating the severity of symptoms in SZ patients. Neuropsychiatr Dis Treat. 2023 Nov 7;19:2381-2400. doi: 10.2147/NDT.S428518. eCollection 2023. Adverse Reactions Review
37998449 reported no adverse effects in either the acupuncture treatment group or the control group. Healthcare (Basel). 2023 Nov 14;11(22):2957. doi: 10.3390/healthcare11222957. Adverse Reactions Review
37998449 Therefore, the adverse effects of auricular acupuncture and acupuncture for PTSD military personnel in distal acupoints are not fatal, and the side effects are within the controllable range of the operator. Healthcare (Basel). 2023 Nov 14;11(22):2957. doi: 10.3390/healthcare11222957. Side Effects Adverse Reactions Review
38046583 Although acupuncture is an invasive treatment, the incidence of acupuncture-induced adverse reactions is significantly lower than that of many drugs or other recognized medical interventions according to the consensus report for the NIH Conference. Front Neurol. 2023 Nov 17;14:1268626. doi: 10.3389/fneur.2023.1268626. eCollection 2023. Adverse Reactions Review
38046594 Recently, acupuncture therapies have gained global recognition as a complementary alternative medicine, and are considered safe and well tolerated with few reported adverse effects. Front Neurol. 2023 Nov 16;14:1281485. doi: 10.3389/fneur.2023.1281485. eCollection 2023. Adverse Reactions Review
38046594 Out of the 10 studies which mentioned adverse effects, only two trials reported a negative association with acupuncture therapy while the other eight trials reported none. Front Neurol. 2023 Nov 16;14:1281485. doi: 10.3389/fneur.2023.1281485. eCollection 2023. Adverse Reactions Review
38046594 A meta-analysis of acupuncture for neuropathic pain suggested that the adverse effects of acupuncture for neuropathic pain were mild and reversible. Front Neurol. 2023 Nov 16;14:1281485. doi: 10.3389/fneur.2023.1281485. eCollection 2023. Neuropathic Pain Adverse Reactions Review
38050318 Acupuncture combined with Chinese medicine treatment of obesity has prominent advantages in terms of clinical efficacy, and its clinical safety is higher, with fewer adverse reactions. Medicine (Baltimore). 2023 Dec 1;102(48):e36071. doi: 10.1097/MD.0000000000036071. Adverse Reactions Review
38075051 In the observation of adverse reactions, compared with clomiphene alone, Acupuncture & Moxibustion combined with Clomiphene can reduce the occurrence of Luteinized Unruptured Follicle Syndrome (LUFS) and Ovarian Hyperstimulation Syndrome (OHSS), and reduce the occurrence of physical adverse reactions such as nausea, vomiting, headache and dermatitis. Front Endocrinol (Lausanne). 2023 Nov 20;14:1261016. doi: 10.3389/fendo.2023.1261016. eCollection 2023. Adverse Reactions Nausea and Vomiting Review
38075051 The ovulation promoting effect of Acupuncture & Moxibustion or combined with Clomiphene is similar to that of Clomiphene alone, but Acupuncture & Moxibustion combined with Clomiphene has more advantages in improving the pregnancy rate of PCOS, and it also can reduce the adverse reactions of Clomiphene alone. Front Endocrinol (Lausanne). 2023 Nov 20;14:1261016. doi: 10.3389/fendo.2023.1261016. eCollection 2023. Adverse Reactions Review
38075051 Acupuncture & Moxibustion, as a non drug treatment method, has simple operation, high acceptance, and few adverse reactions. Front Endocrinol (Lausanne). 2023 Nov 20;14:1261016. doi: 10.3389/fendo.2023.1261016. eCollection 2023. Adverse Reactions Review
38075051 There are three studies to observe adverse reactions, including one study to observe the occurrence of LUFS, 1.7% in the Acupuncture & Moxibustion combined with Clomiphene group (1 case/60 cases), 15% in the Clomiphene group (9 cases/60 cases), and to observe the occurrence of OHSS, 3.3% in the Acupuncture & Moxibustion combined with Clomiphene group (2 cases/60 cases), and 16.7% in the Clomiphene group (10 cases/60 cases); One study observed the occurrence of adverse reactions such as nausea, vomiting, headache, and dermatitis, with a rate of 5% in the Electroacupuncture combined with Clomiphene group (2 cases/40 cases) and 25% in the clomiphene group (10 cases/40 cases); One study observed the occurrence of diarrhea, with 5% in the Electroacupuncture combined with Clomiphene or Placebo group (25 cases/500 cases), 1.6% in the sham Acupuncture combined with Clomiphene or Placebo group (8 cases/500 cases), and 7.4% in the Electroacupuncture combined with Clomiphene or Placebo group (37 cases/500 cases), and 1.8% in the sham Acupuncture combined with Clomiphene or Placebo group (9 cases/500 cases). Front Endocrinol (Lausanne). 2023 Nov 20;14:1261016. doi: 10.3389/fendo.2023.1261016. eCollection 2023. Adverse Reactions Nausea and Vomiting Review
38075051 For the analysis of adverse reactions, although only three studies were included, Acupuncture & Moxibustion combined with Clomiphene can reduce the incidence of LUFS and OHSS compared with the use of clomiphene alone, which is consistent with the analysis results of XJ. Front Endocrinol (Lausanne). 2023 Nov 20;14:1261016. doi: 10.3389/fendo.2023.1261016. eCollection 2023. Adverse Reactions Review
38075051 At the same time, the combination of Acupuncture & Moxibustion and Clomiphene can reduce the occurrence of physical adverse reactions such as nausea, vomiting, headache and dermatitis compared with the use of clomiphene alone. Front Endocrinol (Lausanne). 2023 Nov 20;14:1261016. doi: 10.3389/fendo.2023.1261016. eCollection 2023. Adverse Reactions Nausea and Vomiting Review
38075051 It shows that the combination of acupuncture & moxibustion can reduce the adverse reactions of Clomiphene alone. Front Endocrinol (Lausanne). 2023 Nov 20;14:1261016. doi: 10.3389/fendo.2023.1261016. eCollection 2023. Adverse Reactions Review
38078016 For example, acupuncture not only could significantly relieve joint pain associated with aromatase inhibitors among BC survivors, but it could also minimize the opioid dose and treat opioid-related adverse effects. J Pain Res. 2023 Dec 5;16:4165-4180. doi: 10.2147/JPR.S442151. eCollection 2023. Adverse Reactions Review
38162142 Generally speaking, serving as a non-pharmacological intervention, acupuncture has been used by clinicians to improve and treat a variety of cardiovascular diseases and also has the advantage of reducing treatment costs, adverse effects, and complications. Front Cardiovasc Med. 2023 Dec 14;10:1147135. doi: 10.3389/fcvm.2023.1147135. eCollection 2023. Cardiovascular Adverse Reactions Review
38162142 Therefore, based on our research, we recommend that elderly patients using antihypertensive medications, especially those who have responded poorly or have adverse effects to antihypertensive medications, also receive acupuncture treatment. Front Cardiovasc Med. 2023 Dec 14;10:1147135. doi: 10.3389/fcvm.2023.1147135. eCollection 2023. Adverse Reactions Review
38165870 Adverse reactions related to acupuncture and quality of life were less mentioned among included RCTs. PLoS One. 2024 Jan 2;19(1):e0291685. doi: 10.1371/journal.pone.0291685. eCollection 2024. Adverse Reactions Review
38165870 As a non-pharmacological treatment, acupuncture rarely causes adverse effects such as gastrointestinal discomfort, liver function damage, and kidney function damage because it does not involve pharmacological metabolism and other effects. PLoS One. 2024 Jan 2;19(1):e0291685. doi: 10.1371/journal.pone.0291685. eCollection 2024. Adverse Reactions Kidney Review
38165870 In order to improve the evidence strength of the conclusion, more high-quality, large-sample, multi-center clinical randomized controlled trials are needed to comprehensively report the improvement of clinical symptoms, adverse reactions, and immune function indicators of MG, so as to further to verify the efficacy and safety of acupuncture in the treatment of MG. PLoS One. 2024 Jan 2;19(1):e0291685. doi: 10.1371/journal.pone.0291685. eCollection 2024. Immunity Adverse Reactions Review
38215134 Studies have shown that acupuncture, moxibustion, and electroacupuncture all have good curative effects on RA without obvious adverse reactions. Medicine (Baltimore). 2024 Jan 12;103(2):e36875. doi: 10.1097/MD.0000000000036875. Adverse Reactions Review
22650136 In view of the characteristics of different analgesic methods applied to nasal operation, the principle of point selection in acupuncture anesthesia, the frequency of electroacupuncture and the assessment of operation, it was stated that the compound acupuncture anesthesia not only prevented from incomplete analgesia of local anesthesia, but also avoided the adverse reactions of general anesthesia in this paper. Zhongguo Zhen Jiu. 2012 May;32(5):448-50. Adverse Reactions Clinic
22712373 The dosage of liquids and adverse reaction of PCA pump in different time were recorded. Zhongguo Gu Shang. 2012 Mar;25(3):220-3. Adverse Reactions Clinic
23865512 OBJECTIVE: We examined whether auricular acupressure (AA) can alleviate postoperative pain and decrease narcotic consumption and its adverse effects for osteoarthritis patients after total knee arthroplasty (TKA). Pain Med. 2013 Oct;14(10):1608-13. doi: 10.1111/pme.12197. Epub 2013 Jul 18. Adverse Reactions Clinic
23865512 OUTCOME MEASURES: Visual analog scale (VAS), the consumption of analgesic via patient-controlled analgesia, the incidence of analgesia-related adverse effects, Hospital for Special Surgery scores (HSS), and range of motion (ROM) were recorded. Pain Med. 2013 Oct;14(10):1608-13. doi: 10.1111/pme.12197. Epub 2013 Jul 18. Adverse Reactions Clinic
23865512 The incidence of analgesia-related adverse effects in the AA group was lower than that in the control group (P < 0.05). Pain Med. 2013 Oct;14(10):1608-13. doi: 10.1111/pme.12197. Epub 2013 Jul 18. Adverse Reactions Clinic
23865512 CONCLUSIONS: Applying auricular acupoint acupressure in the perioperative period of TKA is favorable for alleviating postoperative pain, decreasing opioid consumption and its adverse effects, and promoting early rehabilitation. Pain Med. 2013 Oct;14(10):1608-13. doi: 10.1111/pme.12197. Epub 2013 Jul 18. Adverse Reactions Clinic
25851423 No adverse effects of acupuncture were reported. Laryngoscope. 2015 Aug;125(8):1972-8. doi: 10.1002/lary.25252. Epub 2015 Apr 7. Adverse Reactions Clinic
32188223 CONCLUSION: Both AA and CSEA were effective for labor pain relief, CSEA provided more effective pain relief, while AA was associated with a shorter duration of labor and fewer adverse effects.and each has its advantages and disadvantages. J Tradit Chin Med. 2017 Oct;37(5):629-635. Pain Relief Adverse Reactions Clinic
22459647 Between-group comparison analysis of hepatic and renal function and severe adverse reactions all showed no significant difference between the three groups. Acupunct Med. 2012 Jun;30(2):78-84. doi: 10.1136/acupmed-2011-010095. Epub 2012 Mar 29. Adverse Reactions Kidney Clinic
25158837 The amount of postoperative fentanyl required, the time to the first fentanyl request, pain intensity on a 100-mm visual analog scale, incidence of analgesia-related adverse effects, and success of patients' blinding were recorded. Reg Anesth Pain Med. 2015 Jan-Feb;40(1):31-6. doi: 10.1097/AAP.0000000000000138. Adverse Reactions Clinic
25158837 The incidence of analgesia-related adverse effects of nausea and vomiting was lower in the study group. Reg Anesth Pain Med. 2015 Jan-Feb;40(1):31-6. doi: 10.1097/AAP.0000000000000138. Adverse Reactions Nausea and Vomiting Clinic
19632409 No adverse effects due to acupuncture treatment were reported. Ann Thorac Surg. 2009 Aug;88(2):537-42. doi: 10.1016/j.athoracsur.2009.04.106. Adverse Reactions Clinic
19632409 CONCLUSIONS: A single preoperative acupuncture treatment decreased incidence and severity of PON in patients undergoing coronary artery bypass graft or cardiac valve surgery, or both, and caused no adverse effects. Ann Thorac Surg. 2009 Aug;88(2):537-42. doi: 10.1016/j.athoracsur.2009.04.106. Adverse Reactions Clinic
25661270 No adverse effects were recorded. Paediatr Anaesth. 2015 Jun;25(6):603-9. doi: 10.1111/pan.12621. Epub 2015 Feb 7. Adverse Reactions Clinic
19709377 Various medications have been investigated to alleviate the pain and agitation, which have been accompanied by high incidence of adverse effects. Paediatr Anaesth. 2009 Nov;19(11):1096-101. doi: 10.1111/j.1460-9592.2009.03129.x. Epub 2009 Aug 26. Adverse Reactions Clinic
19709377 No adverse effects related to acupuncture treatment were observed. Paediatr Anaesth. 2009 Nov;19(11):1096-101. doi: 10.1111/j.1460-9592.2009.03129.x. Epub 2009 Aug 26. Adverse Reactions Clinic
19709377 CONCLUSION: Our study suggests that acupuncture therapy may be effective in diminishing both pain and emergence agitation in children after BMT insertion without adverse effects. Paediatr Anaesth. 2009 Nov;19(11):1096-101. doi: 10.1111/j.1460-9592.2009.03129.x. Epub 2009 Aug 26. Adverse Reactions Clinic
28818674 The common EA-related adverse effects were minor, and did not require medical attention. Explore (NY). 2017 Sep-Oct;13(5):313-318. doi: 10.1016/j.explore.2017.06.002. Epub 2017 Jun 30. Adverse Reactions Clinic
24621826 Acupuncture, a therapeutic modality with few or no adverse effects, has been used in China and other Asian countries for thousands of years to treat a variety of conditions such as inflammatory disease and chronic pain. Med Sci Monit. 2014 Mar 12;20:406-12. doi: 10.12659/MSM.890111. Adverse Reactions Clinic
29391879 In terms of adverse reactions, there were no differences in nausea, vomiting, and hypoxemia between the two groups (P>0.05), but the incidence of delayed recovery and postoperative agitation were significantly lower in the experimental group compared with those in the control group (P<0.05). Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. Adverse Reactions Nausea and Vomiting Clinic
29391879 Adverse reactions, including nausea and vomiting, hypoxemia, delayed recovery, and postoperative agitation, we recorded. Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. Adverse Reactions Nausea and Vomiting Clinic
29391879 The analysis of adverse reactions after operation showed no obvious differences in nausea and vomiting, hypoxemia, and delayed recovery between the two groups. Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. Adverse Reactions Nausea and Vomiting Clinic
29391879 On achieving the same anesthetic effect, acupuncture anesthesia can considerably reduce the use of anesthetic drugs, lowering the incidence of adverse reactions. Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. Adverse Reactions Clinic
29391879 In conclusion, compared with simple general anesthesia, combined acupuncture and general anesthesia can stabilize the hemodynamic indexes in elderly patients undergoing subtotal gastrectomy, reduce adverse reactions after operation, and effectively improve immune function. Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. Immunity Adverse Reactions Clinic
35647012 The anesthesia effect, stress state, levels of inflammatory factors, T-lymphocyte subsets and adverse reactions were compared. Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. Adverse Reactions Acupuncture Anesthesia Effect Clinic
35647012 Moreover, it has high safety and can significantly reduce the occurrence of postoperative adverse reactions. Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. Adverse Reactions Clinic
35647012 Record the number of adverse reactions such as cognitive impairment, nausea, vomiting, intestinal obstruction, intestinal adhesion and so on. Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. Adverse Reactions Nausea and Vomiting Clinic
35647012 During this period, severe hemodynamic abnormalities, severe stress response, obvious postoperative anesthesia side effects and high incidence of adverse reactions easily occur. Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. Side Effects Adverse Reactions Stress Response Clinic
35647012 Compared with conventional acupuncture, EA is more effective and convenient, so EA is often used to assist anesthesia and analgesia in various surgical procedures.. It has been reported that in a variety of local anesthesia surgerys, EA can significantly enhance the perioperative analgesic effect, improve hemodynamic abnormalities, and reduce the incidence of adverse reactions after anesthesia. Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. Analgesic Effect Adverse Reactions Clinic
35647012 In this study, the adverse reactions of patients in the observation group were only manifested as nausea and vomiting, and no severe adverse reactions such as intestinal obstruction and cognitive impairment was observed. Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. Adverse Reactions Nausea and Vomiting Clinic
35647012 The total incidence of adverse reactions was significantly lower than that in the control group, which might be due to the efficacy of acupuncture in exciting the vgaus nerve, dilating blood vessels, and reducing myocardial oxygen consumption, in addition to inhibiting the excitement of the sympathetic nerve, thereby avoiding excessive disorder of body hemodynamics. Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. Hemodynamics Adverse Reactions Clinic
35647012 Moreover, it is highly safe and can significantly reduce the occurrence of postoperative adverse reactions. Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. Adverse Reactions Clinic
36034956 In recent years, in addition to drug analgesia, it has been reported that auricular point pressing bean as a nondrug intervention can reduce the dosage of early postoperative analgesics by stimulating the auricle acupoints, without vomiting, nausea, and other adverse reactions. Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. Adverse Reactions Nausea and Vomiting Clinic
36034956 In recent years, multimode analgesia has been clinically considered as an ideal analgesic method in the perioperative period, which can effectively shorten the length of hospital stay and reduce the adverse reactions such as vomiting and nausea caused by anesthesia, and is favored by the majority of doctors and patients. Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. Adverse Reactions Nausea and Vomiting Clinic
36034956 In addition, studies have reported that auricular acupoint therapy can reduce the dosage of postoperative analgesic drugs without occurrence of anesthesia-related adverse reactions. Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. Adverse Reactions Clinic
36034956 This study for the first time found that the first exhaust, get out of bed time, and hospital stay in the observation group were shorter than that of the control group (P < 0.05), indicating that multimodal analgesia combined with auricular application therapy could achieve good analgesia effect through a variety of analgesic effect mechanism and reduce the adverse effects of traumatic stimulation on patients' body and mind. Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. Analgesic Effect Adverse Reactions Clinic
30425466 Another mechanism is that anesthetics weaken BBB, and then surgery-induced inflammation may cross the damaged BBB and directly injure neurons, causing elevated biomarkers of neuronal injury and perhaps some of the long-term adverse effects of delirium. Clin Interv Aging. 2018 Oct 24;13:2127-2134. doi: 10.2147/CIA.S183698. eCollection 2018. Adverse Reactions Clinic
32062864 As an essential component of most ERAS pathways, multimodal pain management with nonopioid agents or techniques is established to minimize the use of perioperative opioids and to decrease opioidxe2x80x90related adverse effects (e.g. Thorac Cancer. 2020 Apr;11(4):928-934. doi: 10.1111/1759-7714.13343. Epub 2020 Feb 16. Adverse Reactions ERAS(Enhanced Recovery After Surgery) Clinic
32062864 We compared analgesiaxe2x80x90related adverse effects of nausea and vomiting between the groups. Thorac Cancer. 2020 Apr;11(4):928-934. doi: 10.1111/1759-7714.13343. Epub 2020 Feb 16. Adverse Reactions Nausea and Vomiting Clinic
32062864 Lung surgery guidelines strongly recommend opioidxe2x80x90sparing analgesia and nausea and vomiting control to improve the quality of ERAS.12 There is a dosexe2x80x90response relationship between opioid use and adverse effects.13 Our data showed that TEAS reduced the postoperative sufentanil consumption by almost 16%, suggesting that TEAS may exert an analgesic effect. Thorac Cancer. 2020 Apr;11(4):928-934. doi: 10.1111/1759-7714.13343. Epub 2020 Feb 16. Analgesic Effect Adverse Reactions Nausea and Vomiting ERAS(Enhanced Recovery After Surgery) Clinic
33154688 Postoperative sleep disturbances have serious adverse effects on postoperative outcomes. Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. Adverse Reactions Insomnia Clinic
33154688 Record the total number of PCA pump presses and appropriately treat the adverse reactions within 24 hours after surgery, such as hypotension, bradycardia, nausea and vomiting, and dizziness. Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. Adverse Reactions Nausea and Vomiting Clinic
33154688 Secondary Outcome: Comparison of Postoperative Pain and Adverse Effects Between the Two Groups Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. Adverse Reactions Clinic
33488793 However, opioid-induced immunosuppressive effects and adverse reactions including nausea, vomiting, sedation, dizziness and decreased gut motility may delay patient recovery, which limits the application of opioids. Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. Immunity Adverse Reactions Nausea and Vomiting Sedation Clinic
33488793 However, intractable opioid-induced adverse reactions, especially immunosuppression, could be easily overlooked. Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. Immunity Adverse Reactions Clinic
33488793 In addition, the incidences of nausea, vomiting and headache were lower in the TEAS group, which suggested that TEAS could attenuate the incidence of adverse effects. Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. Adverse Reactions Nausea and Vomiting Clinic
36098938 Considerable data have shown that TEAS reduces the incidence of adverse effects associated with general anesthesia and improves the quality of the patientxe2x80x99s postoperative recovery. Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. Adverse Reactions Clinic
36098938 Currently, opioids are the preferred choice for relieving postoperative pain in patients, but their use is associated with adverse effects such as PONV. Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. Adverse Reactions Clinic
36098938 However, TEAS may also cause some adverse effects such as allergy and ulceration at the acupoint. Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. Adverse Reactions Clinic
36098938 We all perform TAPB through a professional under ultrasound guidance, without adverse effects. Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. Adverse Reactions Clinic
36749304 The American Society of Anesthesiologists has recommended that multimodal pain management (administration of two or more drugs via the same route or different routes) should be implemented whenever possible to maximize the analgesia effect while minimize the potential adverse effects and reduce the consumption of opioids (American Management,). Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. Adverse Reactions Clinic
34622872 Plum blossom needle is an important acupuncture method in traditional Chinese medicine, and it has the advantages of low cost, high tolerance, convenience, and minimal adverse reactions. Medicine (Baltimore). 2021 Oct 8;100(40):e27461. doi: 10.1097/MD.0000000000027461. Adverse Reactions Clinic
29601832 Given the importance of depression and the adverse effects of conventional treatment, it is necessary to seek complementary therapies. Neurosci Lett. 2018 May 14;675:48-53. doi: 10.1016/j.neulet.2018.03.057. Epub 2018 Mar 27. Adverse Reactions Depression Mechanism
30030752 Although L-3,4-dihydroxyphenylalanine (L-DOPA) is currently the most effective medication for treating Parkinson's disease (PD) motor symptoms, its prolonged administration causes several adverse effects, including dyskinesia. Mol Neurobiol. 2019 Apr;56(4):2408-2423. doi: 10.1007/s12035-018-1194-6. Epub 2018 Jul 20. Adverse Reactions Mechanism
25139460 To avoid the adverse effect of PD98059, PD98059 was given in a dose of 0.3 mg/kg in this study. Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. Adverse Reactions Mechanism
34033703 The adverse effects on lung development have been widely addressed in previous studies . Pediatr Pulmonol. 2021 Aug;56(8):2537-2545. doi: 10.1002/ppul.25466. Epub 2021 May 25. Adverse Reactions Mechanism
35482778 Current pharmacotherapy treatment options are usually associated with adverse effects and withdrawal phenomena. PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. Adverse Reactions Mechanism
32249904 Conclusion: A combination of findings in the present study suggest that warm acupuncture treatment is efficacious in improving sleep by regulating the protein expression process in an experimental rat model and may be of potential benefit in treating insomnia patients with the added advantage with no adverse effects. Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. Adverse Reactions Insomnia Mechanism
21625423 Since all of our above tests show that 100 Hz EA stimulation had no adverse effect on normal mice and 0 Hz EA stimulation did not have an effect on MPTP treated mice, we abandoned the 100 Hz + NS and 0 Hz + MPTP groups in order to minimize the number of animals used in the following experiments. PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. Adverse Reactions Mechanism
26792101 Due to this fundamental difference, acupuncture may circumvent adverse effects of the rapamycin treatment. Sci Rep. 2016 Jan 21;6:19714. doi: 10.1038/srep19714. Adverse Reactions Mechanism
26792101 However, rapamycin is known to have various adverse effects since it broadly affects many aspects of metabolism. Sci Rep. 2016 Jan 21;6:19714. doi: 10.1038/srep19714. Adverse Reactions Mechanism
26792101 However, since rapamycin influences both upstream and downstream ALP, and broadly affects cell growth and metabolism, rapamycin-based treatments show adverse effects including dyslipidemias, anti-proliferative toxicity and renal dysfunction, which has intrigued intense interest in developing new drugs independent of mTOR or finding new therapeutic targets. Sci Rep. 2016 Jan 21;6:19714. doi: 10.1038/srep19714. Toxic Side Effects Adverse Reactions Kidney Mechanism
22132113 From a clinical point of view, one of the major issues in the treatment of PD is how to reduce the adverse effects of L-DOPA. PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. Adverse Reactions Mechanism
22132113 Indeed, various attempts have been made to find a new clinical therapy that can decrease the adverse effects of L-DOPA and increase its efficacy. PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. Adverse Reactions Mechanism
24321617 Unfortunately, there is not yet a perfectly effective clinical treatment for PD patients; despite promising laboratory data, dopamine agonist drugs engender tolerance and adverse effects. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
24321617 Notwithstanding its widespread use, l-dopa produces adverse effects, including hallucination, insomnia, nausea, and dyskinesia. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Insomnia Nausea and Vomiting Mechanism
24321617 The dose of l-dopa is still the most significant variable in the development of dyskinesia, and lowering the dose of l-dopa is the best strategy for avoiding l-dopa-induced adverse effects. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
24321617 There is growing evidence that the problems with l-dopa treatment, including adverse effects, originate from abnormal synaptic transmission and a dysregulated basal ganglia system. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
24321617 For testing adverse effects, we also assigned AIM scores after l-dopa injection. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
24321617 l-dopa shows great potential in the treatment of PD patients; however, it has serious adverse effects. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
24321617 In this study, we found acupuncture and l-dopa in combination can enhance the benefits of l-dopa and alleviate the adverse effects. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
24321617 Overall, we can conclude that acupuncture and l-dopa in combination reduce the effective dose of l-dopa, alleviating adverse effects and enhancing its benefits. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
24321617 4B), we could conclude that the combination treatment alleviates the adverse effects of l-dopa by modulating GABA in the SNr. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
24321617 The administration of low-dose l-dopa in conjunction with acupuncture potentiates motor function improvement without the onset of adverse effects such as LID. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Motor Function Mechanism
24321617 Moreover, adverse effects and tolerance of drug produce another problem to patients. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
24321617 In summary, we found that acupuncture and l-dopa combination therapy reduces the effective dose of l-dopa and alleviates LID, an adverse effect of l-dopa. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
24321617 Acupuncture modulates the basal ganglia system to enhance the benefits of l-dopa while mitigating its adverse effects. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
24321617 Following continued l-dopa therapy, the motor benefits and adverse effects from chronic treatment were evaluated with two behavioural tests on day 30: the cylinder test and AIM test. Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. Adverse Reactions Mechanism
19756387 On the other hand, high concentrations of DOR ligands, either SNC80, naloxone or naltrindole, may induce a complicated, even adverse effect on neurons because of the non-selective action on multiple membrane proteins. Cell Mol Life Sci. 2009 Nov;66(21):3505-16. doi: 10.1007/s00018-009-0136-x. Adverse Reactions Mechanism
21872220 Chemotherapy-induced peripheral neuropathy (CIPN) is the most common and serious adverse effect of effective chemotherapeutic agents. Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. Adverse Reactions Mechanism
29034548 It has been used in China and other Asian countries for thousands of years to treat pain, and has few or no adverse effects. Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. Adverse Reactions Mechanism
29034548 No adverse effect was observed following acupuncture treatment. Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. Adverse Reactions Mechanism
29034548 CIP is often difficult to manage; available treatment options rarely provide total relief and the current pharmacological therapy also produces many adverse effects. Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. Adverse Reactions Mechanism
36003380 Postoperative delirium, one of the perioperative neurocognitive disorders, is associated with adverse effects. Front Immunol. 2022 Aug 8;13:955581. doi: 10.3389/fimmu.2022.955581. eCollection 2022. Adverse Reactions Mechanism
38026466 Medicines like NSAIDs, opiate, and relaxants could alleviate CSR symptoms and restore neurological function, but being limited by adverse reactions or addiction. J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. Adverse Reactions Mechanism
38026466 Acupuncture shows rapid relief of pain and numbness, whole body regulation, and minor adverse reactions, generally using local acupoints as the main points, and distant acupoints as adjunct points. J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. Pain Relief Adverse Reactions Mechanism
36816326 In the present study, we similarly found that acupuncture treatment ameliorated VD-related memory and spatial learning deficits without any adverse effects, suggesting that this may be a safe and effective approach to VD treatment. Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. Adverse Reactions Mechanism
34630618 However, the gastrointestinal adverse effects of lactulose have limited its usage, and it is not recommended for long-term clinical application due to its potential toxicity and the development of drug-resistant strains. Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. Toxic Side Effects Adverse Reactions Mechanism
34646326 However, these are frequently associated with adverse effects such as addiction and constipation. Evid Based Complement Alternat Med. 2021 Oct 4;2021:5561999. doi: 10.1155/2021/5561999. eCollection 2021. Adverse Reactions Mechanism
30151295 Despite the significant progress in treating depression, novel treatments for depression with greater efficacy and fewer adverse effects are needed. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Adverse Reactions Depression Mechanism
26487031 Gold Bead Implantation in Acupoints for Coxofemoral Arthrosis in Dogs: Method Description and Adverse Effects Animals (Basel). 2012 Sep 4;2(3):426-36. doi: 10.3390/ani2030426. Adverse Reactions Mechanism
26487031 Adverse effects, measured as pain or discomfort, were seen for a period of up to four weeks in 15 of the dogs in the gold implantation group, compared to six dogs in the placebo group. Animals (Basel). 2012 Sep 4;2(3):426-36. doi: 10.3390/ani2030426. Adverse Reactions Mechanism
26487031 We could not find any detailed descriptions of the GBI technique or any report on subsequent adverse effects in the scientific literature. Animals (Basel). 2012 Sep 4;2(3):426-36. doi: 10.3390/ani2030426. Adverse Reactions Mechanism
26487031 A detailed description of any adverse effects of the treatment is also lacking. Animals (Basel). 2012 Sep 4;2(3):426-36. doi: 10.3390/ani2030426. Adverse Reactions Mechanism
25206697 Acupuncture is simple to perform, is not toxic, does not have adverse effects, and has been extensively used in the clinic. Neural Regen Res. 2013 Feb 25;8(6):540-9. doi: 10.3969/j.issn.1673-5374.2013.06.007. Toxic Side Effects Adverse Reactions Mechanism
34621320 For example, H. pylori eradication using antibiotics often produces gastrointestinal side effects such as diarrhea, nausea, taste distortion, stomatitis, and bloating, which reduce the tolerability of treatment and lead to treatment withdrawal; treatments using PPIs have been shown to potentially cause serious long-term adverse effects, such as pneumonia, C. difficile diarrhea, risk of fractures, and hypomagnesemia. Evid Based Complement Alternat Med. 2021 Sep 14;2021:2771094. doi: 10.1155/2021/2771094. eCollection 2021. Side Effects Adverse Reactions Nausea and Vomiting Mechanism
29853959 Pharmacological therapy for hypertension has some disadvantages, such as costs and adverse effects. Evid Based Complement Alternat Med. 2018 Apr 26;2018:5712857. doi: 10.1155/2018/5712857. eCollection 2018. Adverse Reactions Mechanism
25206545 Therefore, investigations into effective therapies for the treatment of neuropathic pain, with fewer adverse effects, are highly relevant. Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. Neuropathic Pain Adverse Reactions Mechanism
31775332 Paclitaxel-induced peripheral neuropathy is a common adverse effect during paclitaxel treatment resulting in sensory abnormalities and neuropathic pain during chemotherapy and in cancer survivors. Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. Neuropathic Pain Adverse Reactions Mechanism
31775332 Conventional therapies are usually ineffective and possess adverse effects. Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. Adverse Reactions Mechanism
31775332 Unfortunately, these treatment options usually have limited therapeutic effects and cause many adverse effects. Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. Adverse Reactions Mechanism
36819511 As a low-cost, well-tolerated therapy with few and minor adverse effects, acupuncture has a certain regulatory influence on systemic inflammation. Ann Transl Med. 2023 Jan 31;11(2):47. doi: 10.21037/atm-22-6082. Epub 2023 Jan 13. Adverse Reactions Mechanism
18830446 These results are promising for pharmacopuncture as an adjunct to hormonotherapy, reducing adverse effects of large doses of hormones, treatment costs, as well as less exposure of consumers to hormones. Evid Based Complement Alternat Med. 2008 Sep;5(3):267-72. doi: 10.1093/ecam/nel096. Adverse Reactions Mechanism
20981331 (−): The adverse effects of CC on reproduction. Evid Based Complement Alternat Med. 2011;2011:606514. doi: 10.1155/2011/606514. Epub 2010 Sep 30. Adverse Reactions Mechanism
35069759 As a nonpharmacologic intervention, acupuncture has been increasingly used for treatment of pain, including PD, and is recognized as an effective and safe therapy with little risk of serious adverse effects. Evid Based Complement Alternat Med. 2022 Jan 13;2022:4571981. doi: 10.1155/2022/4571981. eCollection 2022. Adverse Reactions Mechanism
37383281 Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia, and long-term use is prone to drug resistance and other adverse reactions. World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. Adverse Reactions Insomnia Mechanism
37383281 Western medicine mainly uses sedative and hypnotic drugs to treat insomnia, which easy to produce drug resistance and some adverse reactions. World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. Adverse Reactions Insomnia Mechanism
37383281 However, high drug dependence and a high incidence of adverse reactions limit their clinical application. World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. Adverse Reactions Mechanism
37383281 Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia, and long-term use is prone to drug resistance and other adverse reactions. World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. Adverse Reactions Insomnia Mechanism
37383281 Some Western drugs can improve insomnia symptoms, but their high drug dependence and adverse reactions limit their clinical application. World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. Adverse Reactions Insomnia Mechanism
34757591 Current therapeutic strategies to manage hyperglycemia do not halt (or reverse) disease progression and may even cause undesirable adverse effects and comorbidities on their own, while treatment with insulin, sulfonylureas, and glinides may lead to weight gain. Mol Neurobiol. 2022 Jan;59(1):703-716. doi: 10.1007/s12035-021-02609-1. Epub 2021 Nov 10. Adverse Reactions Mechanism
27127487 However, the adverse effects associated with these treatments are significant, such as diarrhea, nausea, vomiting, salivating, muscle twitching, and the treatments suffer from short effectiveness, difficult dosage control, strong dependence, and high cost (Rodnitzky and Goeken, 1982; Guo et al., 1999). Neural Regen Res. 2016 Mar;11(3):465-8. doi: 10.4103/1673-5374.179060. Adverse Reactions Nausea and Vomiting Mechanism
27127487 Compared with western medicine, Chinese medicinal herb treatments and acupuncture for treating MG have marked advantages, including few adverse effects and notably successful outcomes. Neural Regen Res. 2016 Mar;11(3):465-8. doi: 10.4103/1673-5374.179060. Adverse Reactions Mechanism
37303036 It is well known that this disease is mostly treated clinically with pharmacological ovulation promotion or Western medicine surgery, but there are many adverse effects, the disease reoccurs easily after discontinuation of medication or surgery, and the long-term outcome is poor. Biol Res. 2023 Jun 12;56(1):31. doi: 10.1186/s40659-023-00441-6. Adverse Reactions Mechanism
37303036 The disease is mostly treated clinically with pharmacological ovulation promotion or Western surgery, but there are many adverse effects, the disease reoccurs easily after discontinuation of medication or surgery, and the long-term outcome is poor. Biol Res. 2023 Jun 12;56(1):31. doi: 10.1186/s40659-023-00441-6. Adverse Reactions Mechanism
32967614 Compared with western medicine, specifically with applied pharmacological therapies, TCM provides effective treatment options with relatively mild adverse effects. J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. Adverse Reactions Mechanism
32042305 However, only half patients with CIBP gain temporary pain relief from conventional analgesics, and new and better therapies for CIBP alleviation with few adverse effects are urgently required. Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. Pain Relief Adverse Reactions Mechanism
27852302 Based on these results, we propose that TNF-α is produced by activated microglia and astrocytes after TBI, thus activating the neuronal apoptosis pathway, and that these adverse effects could be attenuated by EA treatment. BMC Complement Altern Med. 2016 Nov 16;16(1):470. doi: 10.1186/s12906-016-1457-6. Adverse Reactions Mechanism
34646336 Although there are many treatment methods for simple obesity, including diet, exercise, weight-loss drug therapies, and surgical removal of fat, these methods have different degrees of adverse effects. Comput Math Methods Med. 2021 Oct 4;2021:6730274. doi: 10.1155/2021/6730274. eCollection 2021. Adverse Reactions Mechanism
21799685 Acupuncture, a commonly used complementary therapy with few or no adverse effects, has been used in China for thousands of years to treat a variety of conditions, including pain. Evid Based Complement Alternat Med. 2011;2011:619650. doi: 10.1093/ecam/neq016. Epub 2011 Jan 9. Adverse Reactions Mechanism
21799673 Acupuncture, a therapeutic modality with few or no adverse effects, is a non-pharmacological therapy in which needles are inserted at specific cutaneous locations of the body, known as acupoints, for the treatment or prevention of several inflammatory diseases, including asthma, rhinitis, inflammatory bowel disease and rheumatoid arthritis. Evid Based Complement Alternat Med. 2011;2011:217946. doi: 10.1093/ecam/neq036. Epub 2011 Jun 5. Adverse Reactions Mechanism
34039946 Acupuncture, which has many good effects and few adverse effects, is widely recognized as an alternative therapy for depression in clinical practice. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Adverse Reactions Depression Mechanism
34039946 Most antidepressants, including fluoxetine, have severe adverse effects and low efficacy, and at least one-third of patients do not obtain a therapeutic effect. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Adverse Reactions Mechanism
34039946 Acupuncture is an alternative therapy for depression, with fewer adverse effects and good therapeutic efficacy, as well as a low financial burden. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Adverse Reactions Depression Mechanism
35478723 Compared to those who were taking flunarizine hydrochloride capsules, the treatment through the TCM has advantages of the lower rate of adverse reaction and the lower rate of recurrence. Front Surg. 2022 Apr 11;9:778608. doi: 10.3389/fsurg.2022.778608. eCollection 2022. Adverse Reactions Mechanism
29946236 EA has been used successfully to treat depression in China and several other countries worldwide for its efficiency and minimal adverse effects (Ulett et al.,; Kim et al.,; Guo et al.,; Schroeder et al.,). Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Adverse Reactions Depression Mechanism
25624811 However, the current study employed only two time points, which might not be able to determine if and when any plateau effect or adverse effect may be achieved. Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. Adverse Reactions Mechanism
31835339 Although several agents have shown some benefits for patients with NAFLD, even the most promising of such pharmacological agents are associated with significant adverse effects, and none have been approved by the Food and Drug Administration (FDA) for NAFLD therapy. Metabolites. 2019 Dec 9;9(12):299. doi: 10.3390/metabo9120299. Adverse Reactions Mechanism
30766475 Manual acupuncture (MA), which is one of the most important alternative complementary treatments for AD, has positive outcomes due to its economic efficiency, convenience, and low rate adverse effects. Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. Adverse Reactions Mechanism
30766475 Considering the other advantages of MA, including economic feasibility and low risk of adverse effects, additional studies of the effects of MA on AD should be encouraged. Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. Adverse Reactions Mechanism