- The advantages of acupuncture anesthesia in clinical practice
In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.
|
|
|
|
|
|
|
Pain Relief
- Cancer Pain
- Acupuncture anesthesia offers effective cancer pain relief, improving the quality of life for cancer patients.
- Pain Relief
- Acupuncture anesthesia provides robust pain relief, reducing the need for postoperative analgesics.
- Analgesic Effect
- Acupuncture anesthesia's analgesic effect offers profound pain relief, particularly beneficial for patients with chronic pain conditions.
- Visceral Pain
- Acupuncture anesthesia can address visceral pain, improving the surgical experience for patients.
- Neuralgia
- Acupuncture anesthesia offers relief from neuralgia, reducing pain and discomfort.
- Inflammatory Pain
- Acupuncture anesthesia's anti-inflammatory properties make it effective in managing inflammatory pain conditions.
Acupuncture anesthesia for Pain Relief-Analgesic Effect
| PMID | Evidence | Source | Keyword | Type |
|---|---|---|---|---|
| 11783823 | Although sham acupuncture may have analgesic effects, it was used as a control in many studies. | Clin J Pain. 2001 Dec;17(4 Suppl):S105-13. doi: 10.1097/00002508-200112001-00019. | Analgesic Effect | Review |
| 11822627 | A 1973 study, using volunteer medical students, looked into acupuncture's analgesic effect on experimentally induced pain and suggests that humoral factors may mediate acupuncture-induced analgesia. | J Altern Complement Med. 2001;7 Suppl 1:S121-7. doi: 10.1089/107555301753393896. | Analgesic Effect | Review |
| 11822627 | The analgesic effect was observed in the recipient rabbits, suggesting that acupuncture-induced analgesia may be mediated by substances released in the cerebrospinal fluid. | J Altern Complement Med. 2001;7 Suppl 1:S121-7. doi: 10.1089/107555301753393896. | Analgesic Effect | Review |
| 15449 | If we summate all the information available now, it is possible to suggest that enkephalin may be the product of the nervous system released by acupuncture stimulation to create an analgesic effect as well as suppress opiate withdrawal symptoms. | Am J Chin Med (Gard City N Y). 1977 Spring;5(1):25-30. doi: 10.1142/s0192415x77000038. | Analgesic Effect | Review |
| 15547526 | This systematic review aims to critically evaluate the evidence on analgesic effect of acupuncture during labor. | Am J Obstet Gynecol. 2004 Nov;191(5):1573-9. doi: 10.1016/j.ajog.2004.05.027. | Analgesic Effect | Review |
| 15846753 | Acupuncture to treat musculoskeletal pain is being used increasingly to confer an analgesic effect and to date its use in shoulder disorder has not been evaluated in a systematic review. | Cochrane Database Syst Rev. 2005 Apr 18;(2):CD005319. doi: 10.1002/14651858.CD005319. | Analgesic Effect | Review |
| 15979024 | CONCLUSIONS: The notion that acupuncture may be an effective analgesic adjunctive method for cancer patients is not supported by the data currently available from the majority of rigorous clinical trials. | Eur J Pain. 2005 Aug;9(4):437-44. doi: 10.1016/j.ejpain.2004.10.004. Epub 2004 Nov 11. | Analgesic Effect | Review |
| 16674603 | OBJECTIVES: Although acupuncture therapy has demonstrated itself to be effective in several clinical areas, the underlying mechanisms of acupuncture in general and the analgesic effect in particular are, however, still not clearly delineated. | Acta Neurol Scand. 2006 Jun;113(6):370-7. doi: 10.1111/j.1600-0404.2006.00600.x. | Analgesic Effect | Review |
| 16674603 | We, therefore, have studied acupuncture analgesic effect through fMRI and proposed a hypothesis, based on the obtained result, which will enlighten the central role of the brain in acupuncture therapy. | Acta Neurol Scand. 2006 Jun;113(6):370-7. doi: 10.1111/j.1600-0404.2006.00600.x. | Analgesic Effect | Review |
| 18404372 | It is universally accepted that acupuncture or acupoint stimulation can produce analgesic effect on patients with painful disorders. | Neurochem Res. 2008 Oct;33(10):1950-5. doi: 10.1007/s11064-008-9692-y. Epub 2008 Apr 11. | Analgesic Effect | Review |
| 20034438 | The consistent analgesic effect of acupuncture in this model has allowed us to pursue the underlying neural mechanisms. | Neurol Res. 2010 Feb;32 Suppl 1:10-7. doi: 10.1179/016164109X12537002793689. | Analgesic Effect | Review |
| 20100789 | CONCLUSION: A small analgesic effect of acupuncture was present, which, however, was not clearly distinguishable from bias. | Rheumatology (Oxford). 2010 Apr;49(4):778-88. doi: 10.1093/rheumatology/kep439. Epub 2010 Jan 25. | Analgesic Effect | Review |
| 20209979 | Results indicate that any anesthetic method has its own advantages and disadvantages, while compound acupuncture anesthesia for thyroid surgery is of prominent preponderance not only in the analgesic effect but also in fewer side-effects and less physiological interference. | Zhen Ci Yan Jiu. 2009 Dec;34(6):410-2, 420. | Analgesic Effect Side Effects | Review |
| 20399151 | In addition to the analgesic effect of acupuncture, an increasing number of studies have demonstrated that acupuncture treatment can control autonomic nerve system functions such as blood pressure regulation, sphincter Oddi relaxation, and immune modulation. | Auton Neurosci. 2010 Oct 28;157(1-2):38-41. doi: 10.1016/j.autneu.2010.03.010. Epub 2010 Apr 15. | Analgesic Effect Immunity Blood Pressure | Review |
| 20551730 | DISCUSSION: The results of this meta-analysis suggest that acupuncture is a reasonable adjunctive treatment for producing a short-term analgesic effect in patients with painful TMD symptoms. | Clin J Pain. 2010 Jul-Aug;26(6):541-50. doi: 10.1097/AJP.0b013e3181e2697e. | Analgesic Effect | Review |
| 21246860 | The relationship between effect of acupuncture analgesia and needling direction, angle as well as depth is initially optimized to enhance the analgesic effect. | Zhongguo Zhen Jiu. 2010 Nov;30(11):965-8. | Analgesic Effect | Review |
| 22494470 | Homeopathy is not an effective analgesic, while acupuncture has varied evidence and effectiveness. | Pain Med. 2012 May;13(5):711-27. doi: 10.1111/j.1526-4637.2012.01359.x. Epub 2012 Apr 11. | Analgesic Effect | Review |
| 22964986 | This brief overview describes the effects of analgesic acupuncture on the DMN architecture. | Forsch Komplementmed. 2012;19(4):197-201. doi: 10.1159/000341928. Epub 2012 Aug 3. | Analgesic Effect | Review |
| 23705162 | Acupuncture exerts diffuse analgesic effects through the release of endogenous opioids and other locally and centrally acting mediators. | Compend Contin Educ Vet. 2011 May;33(5):E1-11. | Analgesic Effect | Review |
| 25384448 | Analgesic effect of manual acupuncture and laser acupuncture for lateral epicondylalgia: a systematic review and meta-analysis. | Am J Chin Med. 2014;42(6):1301-14. doi: 10.1142/S0192415X14500815. | Analgesic Effect | Review |
| 25384448 | However, the analgesic effect of manual acupuncture and laser acupuncture on lateral epicondylalgia has rarely been explored. | Am J Chin Med. 2014;42(6):1301-14. doi: 10.1142/S0192415X14500815. | Analgesic Effect | Review |
| 25384448 | We conducted a systematic review and meta-analysis to compare the analgesic effect of laser acupuncture and manual acupuncture for the treatment of lateral epicondylalgia. | Am J Chin Med. 2014;42(6):1301-14. doi: 10.1142/S0192415X14500815. | Analgesic Effect | Review |
| 25384448 | We analyzed the meta-analysis results regarding the analgesic effect of the treatment, and observed substantial differences in 4 articles related to manual acupuncture. | Am J Chin Med. 2014;42(6):1301-14. doi: 10.1142/S0192415X14500815. | Analgesic Effect | Review |
| 25384448 | Manual acupuncture is effective in short-term pain relief for the treatment of lateral epicondylalgia; however, its long-term analgesic effect is unremarkable. | Am J Chin Med. 2014;42(6):1301-14. doi: 10.1142/S0192415X14500815. | Analgesic Effect Pain Relief | Review |
| 25384448 | Manual acupuncture applied on lateral epicondylalgia produced stronger evidence of an analgesic effect than did laser acupuncture, and further study on the analgesic effect of laser acupuncture is required. | Am J Chin Med. 2014;42(6):1301-14. doi: 10.1142/S0192415X14500815. | Analgesic Effect | Review |
| 25518120 | Research results of acupuncture analgesia revealed that the analgesic effect is closely related to its regulation on ""pain matrix"" brain regions and pain-related default mode network. | Zhen Ci Yan Jiu. 2014 Oct;39(5):418-21. | Analgesic Effect | Review |
| 26591694 | Researchers usually use PREPs to study the analgesic effect of acupuncture, observe influential factors, or for mechanistic exploration. | J Tradit Chin Med. 2015 Oct;35(5):606-12. doi: 10.1016/s0254-6272(15)30147-3. | Analgesic Effect | Review |
| 26849399 | In particular, we discuss potent analgesic effects of acupuncture via neural pain processes through inhibition of microglial activation. | Cell Transplant. 2016;25(4):621-8. doi: 10.3727/096368916X690872. Epub 2016 Feb 4. | Analgesic Effect | Review |
| 26967459 | CONCLUSIONS: The analysis suggests that the complementary use of acupuncture for craniotomy has additional analgesic effects, reduces the needed amount of volatile anesthetic, reduces the onset of postoperative nausea and vomiting, and might have protective effects on brain tissue. | J Neurosurg Anesthesiol. 2017 Jul;29(3):219-227. doi: 10.1097/ANA.0000000000000290. | Analgesic Effect Nausea and Vomiting | Review |
| 29071937 | Involvement of Central Neuroglia Cells in Analgesic Effect of Electroacupuncture Therapy for Neuropathic Pain. | Zhen Ci Yan Jiu. 2016 Aug 25;41(4):369-372. | Analgesic Effect Neuropathic Pain | Review |
| 29071952 | Acupuncture exerts anti-inflammatory and analgesic effects via elevating anti-inflammatory cytokine level and reducing pro-inflammatory cytokine level and regulating Th 1/Th 2 balance, which reflects the dual directional regulatory effect of acupuncture. | Zhen Ci Yan Jiu. 2016 Oct 25;41(5):469-73. | Analgesic Effect | Review |
| 30007828 | Acupuncture is used in the treatment and prevention of migraine for its analgesic effects. | J Integr Med. 2018 Sep;16(5):312-321. doi: 10.1016/j.joim.2018.06.002. Epub 2018 Jun 28. | Analgesic Effect | Review |
| 32138535 | Along with growing use and interest in acupuncture to treat pain, more attention has been paid to the mechanism underlying its analgesic effect, which is mainly associated with the changes of neurotransmitters. | Am J Chin Med. 2020;48(2):245-258. doi: 10.1142/S0192415X20500135. Epub 2020 Mar 5. | Analgesic Effect | Review |
| 32333543 | Existing evidence suggests that acupuncture has a multi-dimensional comprehensive regulatory effect on chronic pain, and the brain regions in the limbic system also mediate the analgesic effect of acupuncture. | Zhen Ci Yan Jiu. 2020 Apr 25;45(4):339-45. doi: 10.13702/j.1000-0607.180858. | Analgesic Effect | Review |
| 32420752 | Finally, the ""Acupuncture [Formula: see text]"" strategy is introduced to help clinicians achieve better analgesic effects, and a newly reported acupuncture method called acupoint catgut embedding, which injects sutures made of absorbable materials at acupoints to achieve long-term effects, is discussed. | Am J Chin Med. 2020;48(4):793-811. doi: 10.1142/S0192415X20500408. Epub 2020 May 15. | Analgesic Effect | Review |
| 32533885 | BACKGROUND AND OBJECTIVE: Critical clinical questions regarding how soon and how long the analgesic effect will be achieved by acupuncture, as well as who will be responsive to acupuncture, need further address. | Eur J Pain. 2020 Oct;24(9):1653-1665. doi: 10.1002/ejp.1617. Epub 2020 Jul 31. | Analgesic Effect | Review |
| 32533885 | The response-time analysis suggested that the treatment duration of acupuncture will be 5 weeks or more to achieve 80% of maximum analgesic effect. | Eur J Pain. 2020 Oct;24(9):1653-1665. doi: 10.1002/ejp.1617. Epub 2020 Jul 31. | Analgesic Effect | Review |
| 32533885 | The absolute maximum analgesic effects of sham acupuncture and conventional therapy were 22.6 and 15.8 points at a 0-100 NRS scale. | Eur J Pain. 2020 Oct;24(9):1653-1665. doi: 10.1002/ejp.1617. Epub 2020 Jul 31. | Analgesic Effect | Review |
| 32533885 | CONCLUSION: The treatment duration of acupuncture will not be less than 5 weeks to achieve 80% maximum analgesic effect. | Eur J Pain. 2020 Oct;24(9):1653-1665. doi: 10.1002/ejp.1617. Epub 2020 Jul 31. | Analgesic Effect | Review |
| 33788440 | The summarized findings showed that acupuncture anesthesia has a better analgesic effect in thyroid surgery, which can reduce the occurrence of stress reactions, adverse reactions and complications, and is conducive to postoperative recovery. | Zhen Ci Yan Jiu. 2021 Feb 25;46(2):168-71. doi: 10.13702/j.1000-0607.200283. | Analgesic Effect Adverse Reactions Stress Response | Review |
| 34152398 | OBJECTIVE: To identify the analgesic effectiveness of acupuncture after total knee replacement by systematic review. | Pain Med. 2021 Sep 8;22(9):2117-2127. doi: 10.1093/pm/pnab201. | Analgesic Effect | Review |
| 34152398 | The main acupuncture points that produced an analgesic effect when they were used after total knee replacement included the Xuehai, Liangqiu, Dubi, Neixiyan, Yanglingquan, and Zusanli points. | Pain Med. 2021 Sep 8;22(9):2117-2127. doi: 10.1093/pm/pnab201. | Analgesic Effect | Review |
| 35916732 | A single acupuncture treatment in rodents had an analgesic effect, which was more effective in inflammatory pain than in neuropathic pain in the early phase of treatment. | Pain Med. 2023 Jan 4;24(1):11-24. doi: 10.1093/pm/pnac115. | Analgesic Effect Neuropathic Pain Inflammatory Pain | Review |
| 35916732 | CONCLUSIONS: Acupuncture treatment improves analgesic effect in rodent pain conditions under the possible mechanism of glial inhibition. | Pain Med. 2023 Jan 4;24(1):11-24. doi: 10.1093/pm/pnac115. | Analgesic Effect | Review |
| 35998753 | CONCLUSIONS: This bibliometric study identifies six important research hot spots: Static brain functional connectivity analysis of acupuncture analgesic effects, key theories on the scientific problems of acupuncture, acupuncture analgesic effect of the placebo effect, the neuroimaging of acupoint ST-36, the value of acupuncture in regulating the autonomic nerves and acupuncture therapy as complementary medicine. | Complement Ther Med. 2022 Dec;71:102877. doi: 10.1016/j.ctim.2022.102877. Epub 2022 Aug 20. | Analgesic Effect | Review |
| 6314718 | Brief review of the mechanism of action of acupuncture stimulation in its analgesic effect. | Acta Belg Med Phys. 1983 Jan-Mar;6(1):11-9. | Analgesic Effect | Review |
| 8408602 | Although acupuncture has a long history of analgesic effects, the mechanisms underlying its effects are still unclear. | J Clin Neurophysiol. 1993 Jul;10(3):370-7. doi: 10.1097/00004691-199307000-00011. | Analgesic Effect | Review |
| 8408602 | Thus, acupuncture seems to have analgesic effects that are probably related to activation of the antinociceptive system, and application of the pain SEP methodology to the study of mechanisms of AA may be promising. | J Clin Neurophysiol. 1993 Jul;10(3):370-7. doi: 10.1097/00004691-199307000-00011. | Analgesic Effect | Review |
| 9387347 | Therefore, in order to guarantee EA analgesic effects, it is necessary that patients should take a rest and calm down before electroacupuncture. | Zhen Ci Yan Jiu. 1996;21(1):4-11. | Analgesic Effect | Review |
| 9388309 | As a result of the acupuncture anesthesia being applied widely in clinical operation, most of the studies were focused on the evoked potential of somatosensory cortex for elucidating the principle of the analgesic effect of acupuncture, while less observations were reported on the aspects of auditory and visual cortex. | Zhen Ci Yan Jiu. 1996;21(4):1-6. | Analgesic Effect | Review |
| 9646895 | Our studies showed that acupuncture produces analgesic effect and that electroacupuncture (EA) is more effective than manual acupuncture. | Biol Psychiatry. 1998 Jul 15;44(2):129-38. doi: 10.1016/s0006-3223(97)00394-6. | Analgesic Effect | Review |
| 9646895 | This notion was supported by cross-perfusion experiments in which acupuncture-induced analgesic effect was transferred from the donor rabbit to the recipient rabbit when the cerebrospinal fluid (CSF) was transferred. | Biol Psychiatry. 1998 Jul 15;44(2):129-38. doi: 10.1016/s0006-3223(97)00394-6. | Analgesic Effect | Review |
| 19174438 | Objectives To study the analgesic effect of acupuncture and placebo acupuncture and to explore whether the type of the placebo acupuncture is associated with the estimated effect of acupuncture. | BMJ. 2009 Jan 27;338:a3115. doi: 10.1136/bmj.a3115. | Analgesic Effect | Review |
| 19174438 | Conclusions A small analgesic effect of acupuncture was found, which seems to lack clinical relevance and cannot be clearly distinguished from bias. | BMJ. 2009 Jan 27;338:a3115. doi: 10.1136/bmj.a3115. | Analgesic Effect | Review |
| 19174438 | In 2005 two large, high quality trials in patients with headache found little difference between the effects of acupuncture and placebo acupuncture but a substantial difference between placebo acupuncture and no acupuncture.w1 w2 This result differed from that of a large systematic review comparing all placebo interventions with no treatment that found only a small to moderate analgesic effect of placebo, which could not be clearly distinguished from reporting bias owing to the inevitable lack of blinding of the no treatment groups. | BMJ. 2009 Jan 27;338:a3115. doi: 10.1136/bmj.a3115. | Analgesic Effect | Review |
| 19174438 | Our objectives were to study the analgesic effect of acupuncture and placebo acupuncture and to explore whether the type of placebo acupuncture is associated with the estimated effect of acupuncture. | BMJ. 2009 Jan 27;338:a3115. doi: 10.1136/bmj.a3115. | Analgesic Effect | Review |
| 19174438 | Our review is the first that identifies and analyses three armed trials of acupuncture for pain, thus providing an estimate of the general analgesic effect of acupuncture and its direct comparison with the analgesic effect of placebo acupuncture. | BMJ. 2009 Jan 27;338:a3115. doi: 10.1136/bmj.a3115. | Analgesic Effect | Review |
| 19174438 | However, our findings are similar to that of a randomised trial reporting no difference in analgesic effect between three types of placebo acupuncture: acupuncture considered specific for another disease, needle insertion at non-acupuncture points, and non-penetrative simulated acupuncture. | BMJ. 2009 Jan 27;338:a3115. doi: 10.1136/bmj.a3115. | Analgesic Effect | Review |
| 19174438 | Our finding of limited, at best, analgesic effects of acupuncture corresponds with the seven Cochrane reviews on acupuncture for various types of pain, which all concluded that no clear evidence existed of an analgesic effect of acupuncture. | BMJ. 2009 Jan 27;338:a3115. doi: 10.1136/bmj.a3115. | Analgesic Effect | Review |
| 19174438 | In some situations placebo acupuncture is associated with large analgesic effects, but in other situations similar procedures cause no, or only small, effects. | BMJ. 2009 Jan 27;338:a3115. doi: 10.1136/bmj.a3115. | Analgesic Effect | Review |
| 19174438 | We found a small analgesic effect of acupuncture that seems to lack clinical relevance and cannot be clearly distinguished from bias. | BMJ. 2009 Jan 27;338:a3115. doi: 10.1136/bmj.a3115. | Analgesic Effect | Review |
| 19174438 | The analgesic effect of acupuncture is small and cannot be distinguished from bias resulting from incomplete blinding | BMJ. 2009 Jan 27;338:a3115. doi: 10.1136/bmj.a3115. | Analgesic Effect | Review |
| 19174438 | The analgesic effect of placebo acupuncture is moderate but very variable as some large trials report substantial effects | BMJ. 2009 Jan 27;338:a3115. doi: 10.1136/bmj.a3115. | Analgesic Effect | Review |
| 23055010 | Many of the latest trials assessing the benefits of acupuncture in rheumatic diseases found that acupuncture was not better than sham acupuncture implying that the analgesic effects observed are related to a strong placebo response. | Curr Rheumatol Rep. 2012 Dec;14(6):589-97. doi: 10.1007/s11926-012-0295-x. | Analgesic Effect | Review |
| 23055010 | Analgesic effects of acupuncture | Curr Rheumatol Rep. 2012 Dec;14(6):589-97. doi: 10.1007/s11926-012-0295-x. | Analgesic Effect | Review |
| 23055010 | Different hypotheses have been proposed to explain the analgesic effects of acupuncture on the basis of animal and human studies. | Curr Rheumatol Rep. 2012 Dec;14(6):589-97. doi: 10.1007/s11926-012-0295-x. | Analgesic Effect | Review |
| 23055010 | compared the analgesic effects of verum and sham acupuncture in subjects conditioned to either positive or neutral expectations of analgesia. | Curr Rheumatol Rep. 2012 Dec;14(6):589-97. doi: 10.1007/s11926-012-0295-x. | Analgesic Effect | Review |
| 23055010 | Better quality RCTs including various control groups, and incorporating neurochemical and neurofunctional studies are needed to further elucidate and quantify the specific analgesic effects of acupuncture. | Curr Rheumatol Rep. 2012 Dec;14(6):589-97. doi: 10.1007/s11926-012-0295-x. | Analgesic Effect | Review |
| 23055010 | A small analgesic effect was found with acupuncture treatment but it was not maintained at follow up (on average at week 26). | Curr Rheumatol Rep. 2012 Dec;14(6):589-97. doi: 10.1007/s11926-012-0295-x. | Analgesic Effect | Review |
| 23055010 | With the evolving advances in neurosciences, well designed high quality RCTs including neurochemical and functional evaluations of the brain will be crucial in our understanding of whether the analgesic effects of acupuncture are specific to this treatment and not simply a placebo response enhanced by patients' expectations. | Curr Rheumatol Rep. 2012 Dec;14(6):589-97. doi: 10.1007/s11926-012-0295-x. | Analgesic Effect | Review |
| 35313481 | From the theory of traditional Chinese medicine (TCM), the blocked meridian is the main cause of pain, and effective acupuncture can play a positive analgesic effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Today, many types of research have confirmed that acupuncture has a positive analgesic effect in treating pain. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Acupuncture mainly exerts an analgesic effect by activating acupoints with special anatomical locations. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Many clinical pain studies on acupuncture have shown that the analgesic effect of the acupuncture group is superior to the standard control group. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | The analgesic effects of the acupuncture and the placebo groups are superior to those of the no acupuncture groups, but placebo analgesia has only a tiny to moderate effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Although the analgesic effect of the acupuncture group was superior to the control groups, it cannot be neglected that on the management of some pain (pain in labor, migraine, and neuropathic pain), low-quality evidence suggests that acupuncture does not differ much from usual care. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Neuropathic Pain | Review |
| 35313481 | Studies have shown that different acupuncture methods (actually stimulating acupoints but with different intensities) also have an analgesic effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Twist ankle acupuncture (WAA) and auricular acupuncture (AA) have curative effects on cancer pain, and the combination of different acupuncture methods has a better analgesic effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Cancer Pain | Review |
| 35313481 | The analgesic effect of acupuncture in certain pain disorders is as effective as NSAIDs, even has a faster and longer-lasting action in acute pain analgesia. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | divided 46 patients with postoperative swallowing pain into three groups, each receiving NSAIDs, and showed that the analgesic effect of the acupuncture group was better than that of the drug treatment group. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Interestingly, acupuncture may be the best option for pain relief when a patient cannot take NSAIDs or other analgesic medications, exerting analgesic effects even faster than medication. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Pain Relief | Review |
| 35313481 | found that the analgesic effect of acupuncture in urolithiasis-driven renal colic pain relief was superior to that of diclofenac and acetaminophen after ten minutes, and there was no significant difference in the analgesic effect of the three types of therapy after 120 minutes. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Pain Relief Kidney | Review |
| 35313481 | When combined with drugs to treat pain diseases, acupuncture can enhance the analgesic effect and reduce patients' dependence on drugs and even reduce the side effects of drugs. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Side Effects | Review |
| 35313481 | These studies clearly show that serotonin is involved in acupuncture analgesia, but the corresponding matching points should be selected for better analgesic effects. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Acupuncture can achieve an analgesic effect by downregulating glutamate in the ascending excitation pathway. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Although the acupuncture method is different, it seems to play the same analgesic effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | The modulation of glutamate and its receptor content by acupuncture is beneficial for optimizing the analgesic effect of acupuncture. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | The analgesic effect is closely related to the quantity of acupuncture stimulation. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | But the analgesic effect of acupuncture still has limitations, for instance, placebo as mentioned above effect and the inadequacy of RCTs design such as the design of an effective control group. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Heterogeneity among practitioners may bias the analgesic effect of acupuncture. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | In the formalin-induced pain rat model, acupunctures ST36, SP9, and BL60 had a better analgesic effect than the control group, and BL60 had the most significant effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | The use of acupuncture helps to increase the levels of neurotransmitters in the body, which can be targeted for the treatment of different pain disorders according to different activation mechanisms while maximizing the analgesic effect according to their quantity requirements. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | (b) Based on the superiority and safety of acupuncture, acupuncture is now also used extensively as an effective analgesic therapy for various diseases. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 24322588 | Electroacupuncture increased stepping force of the affected limb, and this analgesic effect was not blocked by systemic injection of the opioid antagonists naloxone or naltrexone. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Analgesic Effect | Review |
| 24716183 | The main mechanism of the analgesic effect of acupuncture may be related to its effect in decreased substance P and upregulating plasma β-endorphin levels. | J Tradit Complement Med. 2013 Oct;3(4):234-9. doi: 10.4103/2225-4110.119733. | Analgesic Effect | Review |
| 24809037 | Electroacupuncture (EA) takes advantage of a low frequency (1-15 Hz) electrical stimulation that elicits muscle contraction and augments the analgesic effects of acupuncture. | Transl Med UniSa. 2014 Apr 24;9:56-65. eCollection 2014 Apr. | Analgesic Effect | Review |
| 25097658 | The analgesic effect of acupuncture was mediated by inhibiting the production of superoxide anion (O2 â) and ROS-induced p38MAPK and extracellular signal-regulated kinase (ERK) activation in microglia of spinal cord injury rats. | Evid Based Complement Alternat Med. 2014;2014:483294. doi: 10.1155/2014/483294. Epub 2014 Jul 7. | Analgesic Effect | Review |
| 25132858 | Routine acupuncture incorporates wrist-ankle acupuncture (WAA) for its analgesic effect, but WAA is not widely used in clinics due to incomplete knowledge of its effectiveness and concerns about less clinical research and because less people know it. | Evid Based Complement Alternat Med. 2014;2014:261709. doi: 10.1155/2014/261709. Epub 2014 Jul 15. | Analgesic Effect | Review |
| 25614752 | In the past decades, a large number of studies have proved that acupuncture induces analgesic effects, known as acupuncture analgesia in both humans and animals. | Evid Based Complement Alternat Med. 2014;2014:609594. doi: 10.1155/2014/609594. Epub 2014 Dec 29. | Analgesic Effect | Review |
| 25614752 | To examine the role of neurotransmitters in this inhibitory effect, the cerebrospinal fluid from acupuncture-treated rabbits was infused into recipient rabbits and the analgesic effect reproduced in the latter as expected, indicating that acupuncture-induced analgesia might be mediated by some bioactive substances released in the cerebrospinal fluid. | Evid Based Complement Alternat Med. 2014;2014:609594. doi: 10.1155/2014/609594. Epub 2014 Dec 29. | Analgesic Effect | Review |
| 25614752 | Acupuncture achieves analgesic effects on visceral pain via multiple modes (signal interaction and integration at neurons, ion channels, activation of central descending inhibition pathways, gene regulation, etc.) | Evid Based Complement Alternat Med. 2014;2014:609594. doi: 10.1155/2014/609594. Epub 2014 Dec 29. | Analgesic Effect Visceral Pain | Review |
| 26945382 | Acupuncture and related therapies significantly reduced pain in cancer patients with a quicker analgesic effect and longer analgesic duration when compared with conventional medicine. | Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. | Analgesic Effect | Review |
| 26945382 | In conclusion, our meta-analyses demonstrated that acupuncture and related therapies showed a significant analgesic effect in terms of reducing pain score, providing quicker analgesic effect, and longer analgesic duration in cancer patients when compared with conventional medicine alone. | Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. | Analgesic Effect | Review |
| 26977172 | If acupuncture plus conventional drug therapies was compared with conventional drug therapies alone, the use of analgesic drug must be unchanged during the study period, so as to ensure the effect of acupuncture on cancer pain relief clearly, and (4) outcome measures: the primary outcome was the analgesic effect validated with a pain measurement, such as the Visual Analog Scale for Pain (VAS Pain), the Numeric Rating Scale for Pain (NRS Pain), or the McGill Pain Questionnaire. | Evid Based Complement Alternat Med. 2016;2016:1720239. doi: 10.1155/2016/1720239. Epub 2016 Feb 10. | Analgesic Effect Cancer Pain Pain Relief | Review |
| 26977172 | In addition, most of trails did not follow up patients after acupuncture treatment, and thus the long-term analgesic effect according to the duration and frequency of acupuncture was unclear. | Evid Based Complement Alternat Med. 2016;2016:1720239. doi: 10.1155/2016/1720239. Epub 2016 Feb 10. | Analgesic Effect | Review |
| 26977172 | Activity of copper-zinc superoxide dismutase (Cu/Zn-SOD) increased corresponding to increase in analgesic effects by acupuncture in the cancer patients, but the level was not as high as that in healthy volunteers. | Evid Based Complement Alternat Med. 2016;2016:1720239. doi: 10.1155/2016/1720239. Epub 2016 Feb 10. | Analgesic Effect | Review |
| 26977172 | Although it seems that acupuncture has certain therapeutic values for cancer pain, objective index to evaluate these analgesic effects is still inadequate. | Evid Based Complement Alternat Med. 2016;2016:1720239. doi: 10.1155/2016/1720239. Epub 2016 Feb 10. | Analgesic Effect Cancer Pain | Review |
| 27403201 | In particular, acupuncture treatment has been shown to have analgesic effects in patients with various pain conditions, such as low back pain, headaches, and osteoarthritis. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Analgesic Effect | Review |
| 27403201 | studied whether acupuncture-induced changes in local microcirculation could have a clinical influence and found that the repeated manipulation of LI4 enhanced local microcirculation and increased the analgesic effects compared with single manipulations or insertion-only. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Analgesic Effect Microcirculation | Review |
| 27403201 | Additionally, these two parameters were correlated, which indicates that local increases in microcirculation might influence the analgesic effects of acupuncture. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Analgesic Effect Microcirculation | Review |
| 27471137 | The aims of this systematic review were to study the analgesic effect of real acupuncture and to explore whether sham acupuncture (SA) type is related to the estimated effect of real acupuncture for musculoskeletal pain. | Sci Rep. 2016 Jul 29;6:30675. doi: 10.1038/srep30675. | Analgesic Effect | Review |
| 27471137 | Gate control theory and the release of endogenous opioids have been suggested as explanations for the apparent analgesic effect of acupuncture. | Sci Rep. 2016 Jul 29;6:30675. doi: 10.1038/srep30675. | Analgesic Effect | Review |
| 27471137 | Our objectives were to study the analgesic effect of real acupuncture and to explore whether SA type is related to the estimated effect of real acupuncture. | Sci Rep. 2016 Jul 29;6:30675. doi: 10.1038/srep30675. | Analgesic Effect | Review |
| 28632194 | Many researchers believe that acupuncture stimulates nerves and muscles located within the acupuncture points and trigger a release of neurochemicals endorphins such as serotonin, oxytocin, and endogenous opioid peptides and therefore result in an analgesic effect. | Children (Basel). 2017 Jun 20;4(6):50. doi: 10.3390/children4060050. | Analgesic Effect | Review |
| 29143805 | A systematic review and meta-analysis of randomized trials conducted in 2010 has indicated that acupuncture may be effective in improving post-stroke impairment, as measured by its analgesic effect, motor rehabilitation, increased perfusion within peri-infarcts and low perfusion zones in the affected lobe, and the stimulation of neuronal reorganization, amongst other findings. | Int J Mol Sci. 2017 Oct 28;18(11):2270. doi: 10.3390/ijms18112270. | Analgesic Effect | Review |
| 29234385 | The Immediate Analgesic Effect of Acupuncture for Pain: A Systematic Review and Meta-Analysis | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | Although acupuncture is gaining popularity for the treatment of nonspecific pain, the immediate analgesic effect of acupuncture has never been reviewed. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | The duration of acupuncture stimulation and acupuncture paradigm as well as the assessment of analgesic effect following acupuncture treatment in different clinical trials have been varied, and these time-dependent factors might be a crucial determinant in evaluating the analgesic effect of acupuncture. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | In fact, immediate analgesic effect could have clinical significance in determining the ultimate efficacy of acupuncture in pain management because of the following factors. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | (2) For many patients with acute postoperative pain and labor pain, the reported analgesic effect of acupuncture usually reflects the immediate effect. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | (3) The results of some fMRI studies have suggested that the immediate and cumulative acupuncture-induced analgesic effect elicit different temporal neural responses in a wide range of brain networks, suggesting there is specific underlying mechanisms for the immediate analgesic effect of acupuncture. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | To date, there is no published systematic review or meta-analysis of the immediate analgesic effect of acupuncture. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | This PRISMA-compliant (Table S1; see Table S1 in the Supplementary Material available online at https://doi.org/10.1155/2017/3837194) systematic review was conducted with the following aims: (1) to compare the immediate analgesic effect and safety of acupuncture in the treatment of disease-related pain with those of sham acupuncture and other active treatments; (2) to identify specific factors associated with positive results; and (3) to identify areas for future treatment and research. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | We performed the subgroup analysis of two clinical characteristics that might influence the immediate analgesic effect of acupuncture on pain: (1) the type of sham, penetrating or nonpenetrating; (2) the duration of pain, acute (â¤3 months) or chronic (>3 months). | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | Because of the exclusion or minimization of these variable factors, the evaluation of the immediate effect may closely reflect the actual analgesic effects of acupuncture stimulation. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | The results of our systematic review and meta-analysis indicate that acupuncture shows an immediate analgesic effect as the treatment of chronic pain. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | The duration of the analgesic effect following a single session of acupuncture is about 3 days, although this duration is not consistent. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | The apparent benefits of the immediate analgesic effect of acupuncture may entice patients to receive long-term acupuncture treatment willingly or open to other forms of acupuncture options. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | Our systematic review and meta-analysis study focuses on the immediate analgesic effect of acupuncture. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | The first question is whether the immediately analgesic effect following the first acupuncture treatment can be used as a predictor for the success of subsequent or long-term acupuncture treatment. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | Most clinical trials focused on analgesic effects after multiple acupuncture treatment. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | Few studies assessed analgesic effects after both immediate posttreatment and multiple acupuncture treatments. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | The second question is whether the immediate acupuncture analgesic effect and cumulative analgesic effects following repeated acupuncture treatments share common mechanisms. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | The cumulative analgesic effects following repeated acupuncture treatments on the brain differ from the immediate analgesic effect after one acupuncture treatment. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | The immediate analgesic effect of acupuncture was a result of an extensive brain activation at selective pain-related regions. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | Therefore, although acupuncture has both immediate and cumulative analgesic effects following repeated treatments, underlying mechanisms may be different. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | Local anesthesia at the needle-insertion sites completely blocks the immediate analgesic effect of acupuncture, indicating that these effects are dependent on intact neural conduction. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | Second, we assessed the differences in the immediate analgesic effect of acupuncture between real acupuncture and different types of controls. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | In conclusion, this review facilitates a better understanding of acupuncture stimulation and its immediate analgesic effect for disease-related pain. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | The results of our systematic review and meta-analysis suggest that evidence of the immediate analgesic effect of acupuncture is encouraging, but not convincing. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234385 | Further rigorous, high-quality, randomized controlled trials comparing acupuncture with nontreatment and sham acupuncture without skin penetration are required to evaluate the immediate analgesic effect of acupuncture. | Evid Based Complement Alternat Med. 2017;2017:3837194. doi: 10.1155/2017/3837194. Epub 2017 Oct 25. | Analgesic Effect | Review |
| 29234450 | The analgesic effect of acupuncture is widely known, and, by numerous studies conducted both in humans and in rodents, its effect has been proven. | Evid Based Complement Alternat Med. 2017;2017:9785345. doi: 10.1155/2017/9785345. Epub 2017 Oct 18. | Analgesic Effect | Review |
| 29234450 | LC, as the largest NE producing part in the CNS, was also suggested to be related to acupuncture mediated pain inhibition, as the acupuncture analgesic effect was blocked by α2-adrenergic receptors antagonist at the spinal level. | Evid Based Complement Alternat Med. 2017;2017:9785345. doi: 10.1155/2017/9785345. Epub 2017 Oct 18. | Analgesic Effect | Review |
| 29876878 | The analgesic effects of acupuncture may involve the release of endogenous opioids in the brain (Table 1). | Mol Neurobiol. 2019 Feb;56(2):1137-1166. doi: 10.1007/s12035-018-1130-9. Epub 2018 Jun 6. | Analgesic Effect | Review |
| 29941854 | The efforts to reveal the link between acupuncture points and anatomical features and the neurological mechanisms that lead to acupuncture-induced analgesic effect are reviewed. | Medicines (Basel). 2018 Jun 25;5(3):63. doi: 10.3390/medicines5030063. | Analgesic Effect | Review |
| 29941854 | This gave rise to many modern studies about pain management, such as nerve blocking and analgesic effect by acupuncture. | Medicines (Basel). 2018 Jun 25;5(3):63. doi: 10.3390/medicines5030063. | Analgesic Effect | Review |
| 29941854 | While Zhao suggested that stimulation by manual acupuncture (MA) and electroacupuncture (EA) activates Aδ and C fibres to produce an analgesic effect. | Medicines (Basel). 2018 Jun 25;5(3):63. doi: 10.3390/medicines5030063. | Analgesic Effect | Review |
| 29941854 | ATP is also involved in the process of muscle contraction and relaxation, inflammation and the analgesic effect of acupuncture, as explained below. | Medicines (Basel). 2018 Jun 25;5(3):63. doi: 10.3390/medicines5030063. | Analgesic Effect | Review |
| 29941854 | It is therefore plausible that many sham acupunctures, used as control procedures in acupuncture studies, activated this group of afferents and hence produced analgesic effects. | Medicines (Basel). 2018 Jun 25;5(3):63. doi: 10.3390/medicines5030063. | Analgesic Effect | Review |
| 29941854 | The study of acupuncture in pain management and its analgesic effects have been highlighted in the literature. | Medicines (Basel). 2018 Jun 25;5(3):63. doi: 10.3390/medicines5030063. | Analgesic Effect | Review |
| 29941854 | But the opposite is observed when an adenosine receptor antagonist, such as caffeine, is either taken orally or injected at the acupuncture points, which then interfere with the analgesic effect of acupuncture. | Medicines (Basel). 2018 Jun 25;5(3):63. doi: 10.3390/medicines5030063. | Analgesic Effect | Review |
| 29941854 | The high density of nerve endings under acupuncture points could be another reason that contributed to the acupuncture-induced analgesic effects, which yields better results in verum than in the sham acupuncture group. | Medicines (Basel). 2018 Jun 25;5(3):63. doi: 10.3390/medicines5030063. | Analgesic Effect | Review |
| 30050856 | In support of the analgesic effects of acupuncture, it has also been shown that naloxone can reverse the analgesic effects of acupuncture in nonhuman primates. | Vet Med (Auckl). 2017 Aug 24;8:53-58. doi: 10.2147/VMRR.S125609. eCollection 2017. | Analgesic Effect | Review |
| 30117343 | The analgesic effect of acupuncture on chronic neuropathic pain has been shown to be mediated by P2 X3 receptors of purinergic signaling and is identified with specific neurons that are activated via stimulation of ATP flux in the brains of rat animal models. | Integr Cancer Ther. 2018 Sep;17(3):602-618. doi: 10.1177/1534735418786801. | Analgesic Effect Neuropathic Pain | Review |
| 30298094 | Many different mechanisms may explain the analgesic effect of acupuncture. | Evid Based Complement Alternat Med. 2018 Sep 12;2018:8107508. doi: 10.1155/2018/8107508. eCollection 2018. | Analgesic Effect | Review |
| 30486810 | In one-third of fibromyalgia patients who have prominent soreness phenotypes, acupuncture usually has no analgesic effect and even worsens the soreness phenotypes. | J Biomed Sci. 2018 Nov 29;25(1):85. doi: 10.1186/s12929-018-0486-5. | Analgesic Effect | Review |
| 30855351 | Acupuncture is commonly perceived as a hallmark of traditional Chinese medicine (TCM) that can achieve analgesic effects by regulating the nervous system and the release of peptidyl neurotransmitters. | Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. | Analgesic Effect | Review |
| 30855351 | A meta-analysis showed that the perioperative use of acupuncture could reduce the pain on day 1 after surgery; the analgesic effect of acupuncture rendered the patients in the test group to need less postoperative analgesic drugs than those in the control group. | Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. | Analgesic Effect | Review |
| 30915143 | Acupuncture can promote the release of anti-inflammatory and analgesic substances (opioid peptides, adenosine, dopamine, and endogenous Cannabinoids) and inhibit the release of proinflammatory factors (5-hydroxytryptamine, histamine, substance P, nerve growth factor, CGRP, and TRPV1) to produce analgesic effect. | Evid Based Complement Alternat Med. 2019 Feb 24;2019:2326867. doi: 10.1155/2019/2326867. eCollection 2019. | Analgesic Effect | Review |
| 30915143 | Ji-Yeun Park used gene chip technology to find that there are at least 7 neuroimmunological pathways involved in the analgesic and anti-inflammatory process of acupuncture at GB34 for inflammatory pain model, and ERK activation in the skin layer which contributes to the analgesic effect. | Evid Based Complement Alternat Med. 2019 Feb 24;2019:2326867. doi: 10.1155/2019/2326867. eCollection 2019. | Analgesic Effect Inflammatory Pain | Review |
| 30984277 | Many reports have showed acupuncture has an analgesic effect. | Evid Based Complement Alternat Med. 2019 Mar 7;2019:6173412. doi: 10.1155/2019/6173412. eCollection 2019. | Analgesic Effect | Review |
| 30984277 | The possible mechanisms underlying the analgesic effects of acupuncture include segmental inhibition and the activation of the endogenous opioid, adrenergic, 5-hydroxytryptamine, and N-methyl-D-aspartic acid, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate pathways. | Evid Based Complement Alternat Med. 2019 Mar 7;2019:6173412. doi: 10.1155/2019/6173412. eCollection 2019. | Analgesic Effect | Review |
| 30984277 | The mechanisms underlying the analgesic effects of acupuncture might be mediated by the inhibition of the NF-κB signaling pathway in primary sensory neurons and substance P, as seen in rat models. | Evid Based Complement Alternat Med. 2019 Mar 7;2019:6173412. doi: 10.1155/2019/6173412. eCollection 2019. | Analgesic Effect | Review |
| 30984277 | In a functional magnetic resonance imaging survey, acupuncture stimulation was shown to activate the limbic system, including the parahippocampal gyrus and anterior cingulate cortex, thus causing a central analgesic effect. | Evid Based Complement Alternat Med. 2019 Mar 7;2019:6173412. doi: 10.1155/2019/6173412. eCollection 2019. | Analgesic Effect | Review |
| 30984277 | In summary, acupuncture acts through multiple pathways to produce analgesic effects and reduce central sensitization. | Evid Based Complement Alternat Med. 2019 Mar 7;2019:6173412. doi: 10.1155/2019/6173412. eCollection 2019. | Analgesic Effect | Review |
| 31186654 | Acupuncture treatment showed significantly greater analgesic effects based on subjective pain ratings than sham acupuncture, and the maximum tolerable rectal sensation and distention pressure in IBS patients were significantly increased by acu-TENS compared to sham TENS (Tables 2 and 5). | Evid Based Complement Alternat Med. 2019 May 2;2019:1304152. doi: 10.1155/2019/1304152. eCollection 2019. | Analgesic Effect | Review |
| 31186654 | Based on these results, we found that acupuncture induces analgesic effects on visceral pain via multiple pathways from the peripheral organs (gut) to the CNS (brain). | Evid Based Complement Alternat Med. 2019 May 2;2019:1304152. doi: 10.1155/2019/1304152. eCollection 2019. | Analgesic Effect Visceral Pain | Review |
| 31379957 | The widely known mechanism of acupuncture is that it results in the secretion of endorphins that exert an analgesic effect. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Analgesic Effect | Review |
| 31467579 | At present, the correlation between electroacupuncture regulation and MAPK-related signaling pathways is mainly focused on the anti-inflammatory and analgesic effects, protection against injury, regulation of gastrointestinal functions, and prevention and treatment of cardiovascular and cerebrovascular diseases, skin diseases, and knee joint diseases. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Analgesic Effect Cardiovascular | Review |
| 31467579 | Analgesic Effects of Electroacupuncture Based on MAPK Signal Transduction Pathway | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Analgesic Effect | Review |
| 31467579 | Anti-Inflammatory and Analgesic Effects of Electroacupuncture | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Analgesic Effect | Review |
| 31467579 | Electroacupuncture may exert its analgesic effects by regulating the expression of phosphorylated ERK (p-ERK) in the spinal dorsal horn of adjuvant arthritis rats. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Analgesic Effect | Review |
| 31467579 | The combination of different parameters of electroacupuncture has the same analgesic effects in the early stage of inflammatory pain, while electroacupuncture of 2/100hz or 2/120hz frequency has better effects in the later stage. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Analgesic Effect Inflammatory Pain | Review |
| 31467579 | For chronic neuropathic pain, multiple electroacupuncture can increase the activity of Ras/Raf/ERK signaling pathway and the expression of p38MAPK, which indicates that the cumulative effect of electroacupuncture may be associated with the changes in the Ras/Raf/ERK signaling pathway and the expression of p38MAPK to achieve the analgesic effects. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Analgesic Effect Neuropathic Pain | Review |
| 31467579 | Analgesic Effects of Electroacupuncture against Labor Pain | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Analgesic Effect | Review |
| 31467579 | Although studies have found that β-endorphin secretion may be a causative factor in the analgesic effects of electroacupuncture against labor pain, the mechanism at this stage is not yet clear. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Analgesic Effect | Review |
| 31467579 | (1) In terms of electroacupuncture analgesia, the anti-inflammatory and analgesic mechanisms of electroacupuncture may include the following: analgesic effect was achieved by inhibiting of the activation of the p38 MAPK/ATF-2/VR-1 pathway, inhibiting both the PAG-RVM-SCDH p38MAPK level in the central nervous descending pathway and the PAG-ACB-AMY-Hb p-p38MAPK level and regulating the expression of phosphorylated ERK (p-ERK) in the spinal dorsal horn. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Analgesic Effect | Review |
| 31467579 | And the mechanism of electroacupuncture may inhibit the expression of Ras/Raf/ERK signaling pathway and p38MAPK to achieve the analgesic effects. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Analgesic Effect | Review |
| 31534469 | Despite the significant analgesic effect of verum acupuncture versus sham acupuncture, the high heterogeneity downgraded the level of evidence. | Evid Based Complement Alternat Med. 2019 Aug 25;2019:8757685. doi: 10.1155/2019/8757685. eCollection 2019. | Analgesic Effect | Review |
| 31567462 | In a meta-analysis of 20,827 patients from 39 RCTs, the analgesic effect size of acupuncture was 0.5 SDs compared with no acupuncture control and close to 0.2 SDs compared with sham. | Cancer J. 2019 Sep/Oct;25(5):343-348. doi: 10.1097/PPO.0000000000000399. | Analgesic Effect | Review |
| 31680841 | The aim was to explore the analgesic effect of acupuncture and sham acupuncture and to ascertain whether the type of the placebo acupuncture applied is associated with the estimated effect of acupuncture. | Front Neurosci. 2019 Oct 17;13:1110. doi: 10.3389/fnins.2019.01110. eCollection 2019. | Analgesic Effect | Review |
| 32050990 | proposed that the analgesic effects of auricular acupuncture could be explained by stimulation of the auricular branch of the vagus nerve. | J Neuroinflammation. 2020 Feb 12;17(1):54. doi: 10.1186/s12974-020-01732-5. | Analgesic Effect | Review |
| 32375775 | This mechanism has been usually accepted to explain acupuncture analgesic effects, but could also be used to explain acupuncture effects on dyspnoea, since endogenous opioids modulate dyspnoea in patients with COPD. | BMC Complement Med Ther. 2020 May 6;20(1):138. doi: 10.1186/s12906-020-02899-3. | Analgesic Effect | Review |
| 32493452 | There have already been many studies reporting that acupuncture stimulates secretion of opioid peptides such as β-endorphins, enkephalins, and dynorphins, and that these have an analgesic effect via their actions in the central nervous system. | BMC Complement Med Ther. 2020 Jun 3;20(1):171. doi: 10.1186/s12906-020-02955-y. | Analgesic Effect | Review |
| 32577957 | More recently Geoffrey Burnstock advanced the hypothesis that ATP released by acupuncture needling may stimulate sensory nerve terminals and thereby complement the analgesic effect of opioid peptides. | Purinergic Signal. 2020 Sep;16(3):297-304. doi: 10.1007/s11302-020-09708-z. Epub 2020 Jun 23. | Analgesic Effect | Review |
| 32630156 | Moreover, acupuncture exerts analgesic effects through the interference of both the ascending and descending pain signaling pathway. | Int J Mol Sci. 2020 Jun 30;21(13):4693. doi: 10.3390/ijms21134693. | Analgesic Effect | Review |
| 32630156 | Schematic of the potential mechanism underlying the electroacupuncture (EA)-mediated analgesic effect. | Int J Mol Sci. 2020 Jun 30;21(13):4693. doi: 10.3390/ijms21134693. | Analgesic Effect | Review |
| 32714410 | Three of the included articles supported the analgesic effect of acupuncture on DOMS, suggesting that acupuncture is effective in managing pain in DOMS. | Evid Based Complement Alternat Med. 2020 Jun 27;2020:5864057. doi: 10.1155/2020/5864057. eCollection 2020. | Analgesic Effect | Review |
| 32714410 | Although the mechanism of acupuncture on DOMS remains unknown, the neurostimulation and Chinese meridian theory were used to explain the analgesic effect. | Evid Based Complement Alternat Med. 2020 Jun 27;2020:5864057. doi: 10.1155/2020/5864057. eCollection 2020. | Analgesic Effect | Review |
| 32714410 | Wang supported that acupuncture for DOMS could relax muscles and have an analgesic effect. | Evid Based Complement Alternat Med. 2020 Jun 27;2020:5864057. doi: 10.1155/2020/5864057. eCollection 2020. | Analgesic Effect | Review |
| 32714410 | Whilst the included studies demonstrated that the analgesic effect occurred during acupuncture treatment sessions after inducing DOMS, the very-small-small effect sizes found in the meta-analysis for pain relief limited our confidence on the benefits of acupuncture for DOMS. | Evid Based Complement Alternat Med. 2020 Jun 27;2020:5864057. doi: 10.1155/2020/5864057. eCollection 2020. | Analgesic Effect Pain Relief | Review |
| 32714410 | thought that a number of acupuncture treatment sessions were required to achieve analgesic effects, and suitable treatment parameters for DOMS were needed to warrant more investigations. | Evid Based Complement Alternat Med. 2020 Jun 27;2020:5864057. doi: 10.1155/2020/5864057. eCollection 2020. | Analgesic Effect | Review |
| 32978666 | The majority of studies concluded the superiority of short-term analgesic effects over various controls and suggested that acupuncture may be efficacious for CMP. | Curr Rheumatol Rep. 2020 Sep 25;22(11):80. doi: 10.1007/s11926-020-00954-z. | Analgesic Effect | Review |
| 32978666 | Modern acupuncture research on pain mechanisms indicates that the analgesic effects of acupuncture activate peripheral and central pain control systems by releasing various endogenous opioids or non-opioid compounds. | Curr Rheumatol Rep. 2020 Sep 25;22(11):80. doi: 10.1007/s11926-020-00954-z. | Analgesic Effect | Review |
| 33014115 | The most commonly studied acupuncture points are LI 4, ST 36, and SP 6, because they are considered to have good analgesic effects. | Evid Based Complement Alternat Med. 2020 Sep 21;2020:8502530. doi: 10.1155/2020/8502530. eCollection 2020. | Analgesic Effect | Review |
| 33014115 | Deqi is believed to be closely related to the efficacy of acupuncture, especially its analgesic effect. | Evid Based Complement Alternat Med. 2020 Sep 21;2020:8502530. doi: 10.1155/2020/8502530. eCollection 2020. | Analgesic Effect | Review |
| 33441387 | Although the exact analgesic mechanism is uncertain, it is speculated that the analgesic effect of acupuncture may be mediated by the release of opioid peptides and serotonin. | BMJ Support Palliat Care. 2021 Sep;11(3):264-270. doi: 10.1136/bmjspcare-2020-002638. Epub 2021 Jan 13. | Analgesic Effect | Review |
| 33531894 | At present, many clinical randomized controlled trials (RCTs) have demonstrated the analgesic effect of acupuncture. | Neural Plast. 2021 Jan 18;2021:8881557. doi: 10.1155/2021/8881557. eCollection 2021. | Analgesic Effect | Review |
| 33531894 | Previous results observed that the acupuncture analgesic effect is related to spinal cytokines and neurotrophic factors released by glial cells. | Neural Plast. 2021 Jan 18;2021:8881557. doi: 10.1155/2021/8881557. eCollection 2021. | Analgesic Effect | Review |
| 33531894 | CXCL1 neutralizing antibodies reduced the acupuncture analgesic effect by 20%. | Neural Plast. 2021 Jan 18;2021:8881557. doi: 10.1155/2021/8881557. eCollection 2021. | Analgesic Effect | Review |
| 33757500 | For 57 conditions (52.8%), patients acquired an immediate analgesic effect after acupuncture, however, 38 (66.7%) of these conditions were from case series studies. | BMC Complement Med Ther. 2021 Mar 23;21(1):101. doi: 10.1186/s12906-021-03272-8. | Analgesic Effect | Review |
| 33883931 | Acupuncture has been proven to be an effective analgesic intervention in management of diverse types of pain, such as inflammatory pain, visceral pain, cancer pain, and neuropathic pain, including chemotherapy-induced neuropathic pain. | J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. | Analgesic Effect Visceral Pain Neuropathic Pain Cancer Pain Inflammatory Pain | Review |
| 34040901 | Acupuncture has various possible mechanism of action, however, the most supported theory is the release endogenous opioids, causing an analgesic effect. | Cureus. 2021 Apr 21;13(4):e14600. doi: 10.7759/cureus.14600. | Analgesic Effect | Review |
| 34054306 | A recent review indicated that acupuncture, moxibustion, and herbal medicine have important analgesic effects and are safe to use, in contrast to drugs that have adverse effects, for the treatment of knee OA. | J Pain Res. 2021 May 21;14:1345-1351. doi: 10.2147/JPR.S311557. eCollection 2021. | Analgesic Effect Adverse Reactions | Review |
| 34069357 | Segmental inhibitory mechanisms in the dorsal horn explain the analgesic effects of acupuncture and dry needling. | J Clin Med. 2021 May 19;10(10):2189. doi: 10.3390/jcm10102189. | Analgesic Effect | Review |
| 34306150 | Auricular acupuncture is easy and convenient, has good analgesic effects, and is long lasting. | Evid Based Complement Alternat Med. 2021 Jul 2;2021:6663602. doi: 10.1155/2021/6663602. eCollection 2021. | Analgesic Effect | Review |
| 34307076 | The analgesic effects of acupuncture can be conceptually divided into local, segmental (spinal), and suprasegmental (brain) effects (Fig. | Open Vet J. 2021 Apr-Jun;11(2):203-209. doi: 10.5455/OVJ.2021.v11.i2.3. Epub 2021 Apr 15. | Analgesic Effect | Review |
| 34307076 | Acupuncture stimulation leads to upregulation of TRPV-1 receptors in peripheral nerve endings, which has been associated with an analgesic effect. | Open Vet J. 2021 Apr-Jun;11(2):203-209. doi: 10.5455/OVJ.2021.v11.i2.3. Epub 2021 Apr 15. | Analgesic Effect | Review |
| 34307076 | Local tissue release of purine neurotransmitters ATP and adenosine via acupuncture stimulation has both direct and indirect analgesic effects. | Open Vet J. 2021 Apr-Jun;11(2):203-209. doi: 10.5455/OVJ.2021.v11.i2.3. Epub 2021 Apr 15. | Analgesic Effect | Review |
| 34307076 | However, there is some rationale for combining modes of acupuncture (DN and EA) and different frequencies of EA to produce a greater analgesic effect than would be possible with only one modality or one frequency. | Open Vet J. 2021 Apr-Jun;11(2):203-209. doi: 10.5455/OVJ.2021.v11.i2.3. Epub 2021 Apr 15. | Analgesic Effect | Review |
| 34349826 | The exact mechanism of acupuncture's analgesic effect has not yet been elucidated. | Evid Based Complement Alternat Med. 2021 Jul 26;2021:5558590. doi: 10.1155/2021/5558590. eCollection 2021. | Analgesic Effect | Review |
| 34349826 | Based on the meta-analysis of 19 studies, compared with the treatment of cancer pain with three-step analgesic drug treatment alone, the response rates of pain relief from acupuncture combined with three-step analgesic drug treatment were higher, the NRS scores were lower, the incidence of adverse reactions such as nausea and vomiting was less frequent, the incidence of times of burst pain was also less frequent, the onset time to analgesic effect was shorter, and the duration of pain response was longer. | Evid Based Complement Alternat Med. 2021 Jul 26;2021:5558590. doi: 10.1155/2021/5558590. eCollection 2021. | Analgesic Effect Cancer Pain Pain Relief Adverse Reactions Nausea and Vomiting | Review |
| 34397828 | The mechanism of acupuncture and moxibustion combined with cupping in the treatment of PHN may be to regulate the function of local blood vessels and muscles by stimulating local nerves, reducing the symptoms of local smooth muscle spasm, and then exerting a good analgesic effect. | Medicine (Baltimore). 2021 Aug 6;100(31):e26785. doi: 10.1097/MD.0000000000026785. | Analgesic Effect | Review |
| 34408622 | Role of Neuroimmune Crosstalk in Mediating the Anti-inflammatory and Analgesic Effects of Acupuncture on Inflammatory Pain | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Inflammatory Pain | Review |
| 34408622 | Studies in recent years have shown that acupuncture can exert anti-inflammatory and analgesic effects by regulating peripheral (i.e., involving local acupoints and inflamed regions) and central neuroimmune interactions. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect | Review |
| 34408622 | At sites of inflammation, acupuncture enables the recruitment of immune cells, causing the release of opioid peptides, while also exerting direct analgesic effects via nerve endings. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Immunity | Review |
| 34408622 | In conclusion, the regulation of neuroimmune crosstalk at the peripheral and central levels mediates the anti-inflammatory and analgesic effects of acupuncture on inflammatory pain in an integrated manner. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Inflammatory Pain | Review |
| 34408622 | Recent studies have shown that acupuncture can provide both anti-inflammatory and analgesic effects by regulating neuron and immune cell activity in the central and peripheral systems. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Immunity | Review |
| 34408622 | The injection of capsaicin, a TRPV1 agonist, can recapitulate the analgesic effect of acupuncture when injected at ST36. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect | Review |
| 34408622 | Role of neuroimmune crosstalk at the acupoint in mediating the anti-inflammatory and analgesic effects of acupuncture on inflammatory pain. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Inflammatory Pain | Review |
| 34408622 | Interestingly, the long-term analgesic effect of EA is antagonized by β-END and enkephalin (ENK) antagonists, but not by dynorphin A (DYN) antagonists, indicating that the β-ENDs released due to acupuncture stimulation act on μ- and δ-opioid receptors and inhibit peripheral inflammatory pain. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Inflammatory Pain | Review |
| 34408622 | These studies show that acupuncture may promote the aggregation of immune cells containing opioid peptides in inflammatory tissues and promote the release of β-END and ENK, which may act on μ-, δ-, and κ-opioid receptors at peripheral sensory endings to exert peripheral analgesic effects. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Immunity | Review |
| 34408622 | In addition, cannabinoids and β-ENDs synergistically mediate the anti-inflammatory and analgesic effects of acupuncture. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect | Review |
| 34408622 | Role of neuroimmune crosstalk at the sites of inflammation in mediating the anti-inflammatory and analgesic effects of acupuncture on inflammatory pain. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Inflammatory Pain | Review |
| 34408622 | Therefore, acupuncture produces an analgesic effect by preventing the activation of the ERK1/2-COX-2 pathway and ERK1/2-CREB-NK-1 pathway at different stages of inflammatory pain progression. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Inflammatory Pain | Review |
| 34408622 | In carrageenan-induced inflammatory pain models, the analgesic effects of acupuncture are blocked by the intrathecal administration of a μ-opioid receptor antagonist but not by that of a δ- or κ-opioid receptor antagonist. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Inflammatory Pain | Review |
| 34408622 | The injection of CB1R antagonists reverses the analgesic effects of repeated EA stimulation, indicating that the endocannabinoid system contributes to acupuncture-induced inflammatory pain reduction via the regulation of dopamine release in the striatum. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Inflammatory Pain | Review |
| 34408622 | Role of neuroimmune crosstalk within the central nervous system in mediating the anti-inflammatory and analgesic effects of acupuncture on inflammatory pain. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Inflammatory Pain | Review |
| 34408622 | Acupuncture can also recruit immune cells that secrete analgesic neurotransmitters, which then act on receptors to produce analgesic effects. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Immunity | Review |
| 34408622 | Accordingly, the regulation of neuroimmune crosstalk at the peripheral and central levels mediates the anti-inflammatory and analgesic effects of acupuncture on inflammatory pain in an integrated manner. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Analgesic Effect Inflammatory Pain | Review |
| 34437474 | As previously mentioned in the treatment of patients with headache in the recovery phase of ischemic stroke, acupuncture, in addition to promoting the secretion of opioid peptides, can also reduce the contents of pain-related factors SP, DA and 5-HT in plasma, thus achieving an analgesic effect. | Vet Sci. 2021 Jul 30;8(8):149. doi: 10.3390/vetsci8080149. | Analgesic Effect | Review |
| 34437474 | At present, the analgesic effect of acupuncture by inhibiting the release of SP has been confirmed by several studies, such as in the treatment of ischioneuralgia, knee osteoarthritis, lumbar disc herniation and other diseases. | Vet Sci. 2021 Jul 30;8(8):149. doi: 10.3390/vetsci8080149. | Analgesic Effect Neuralgia | Review |
| 34489662 | To date, research on the expectation effect has mainly involved analgesia, which found that although the expectation and acupuncture could achieve similar analgesic effects, their brain activation responses were different (Kong et al.,). | Front Hum Neurosci. 2021 Aug 20;15:694919. doi: 10.3389/fnhum.2021.694919. eCollection 2021. | Analgesic Effect | Review |
| 34526816 | This review included RCTs that investigated the acupuncture analgesic effects during oocyte retrieval in women undergoing in vitro fertilization. | J Pain Res. 2021 Sep 9;14:2833-2849. doi: 10.2147/JPR.S319923. eCollection 2021. | Analgesic Effect | Review |
| 34526816 | Furthermore, there is no significant consensus on whether there is an analgesic effect of applying acupuncture alone during oocyte retrievals, which needs further research. | J Pain Res. 2021 Sep 9;14:2833-2849. doi: 10.2147/JPR.S319923. eCollection 2021. | Analgesic Effect | Review |
| 34526816 | There was a significantly higher analgesic effect in the acupuncture stimulation with NSAIDs than sham acupuncture stimulation with NSAIDs (MD=â1.76, 95% CI: â2.08 to â1.44, Figure 4B). | J Pain Res. 2021 Sep 9;14:2833-2849. doi: 10.2147/JPR.S319923. eCollection 2021. | Analgesic Effect | Review |
| 34526816 | An absolutely opposite result was that electroacupuncture with PCB showed the worse analgesic effect of PCB with CSA (SMD=0.30; 95% CI: 0.12 to 0.47, Figure 4D). | J Pain Res. 2021 Sep 9;14:2833-2849. doi: 10.2147/JPR.S319923. eCollection 2021. | Analgesic Effect | Review |
| 34526816 | This review included 14 studies and investigated the analgesic effects of acupuncture in women during OPU through meta-analysis. | J Pain Res. 2021 Sep 9;14:2833-2849. doi: 10.2147/JPR.S319923. eCollection 2021. | Analgesic Effect | Review |
| 34526816 | Although previous reviews have examined several aspects of acupuncture analgesia, only one of these studies examined the analgesic effect of acupuncture-based during OPU limitedly. | J Pain Res. 2021 Sep 9;14:2833-2849. doi: 10.2147/JPR.S319923. eCollection 2021. | Analgesic Effect | Review |
| 34526816 | In Stener-Victorin et al study, the analgesic effect of acupuncture combined with PCB was inferior to the analgesic effect of the combination of PCB and CSA. | J Pain Res. 2021 Sep 9;14:2833-2849. doi: 10.2147/JPR.S319923. eCollection 2021. | Analgesic Effect | Review |
| 34667434 | It has been confirmed that acupuncture decreases the level of proinflammatory cytokines and chemokines, and increases the level of neurotrophic factors, which may contribute to the analgesic effect of acupuncture. | Contemp Oncol (Pozn). 2021;25(2):88-94. doi: 10.5114/wo.2021.105969. Epub 2021 May 7. | Analgesic Effect | Review |
| 34667434 | Acupuncture in combination with standard pharmacotherapy reduced the onset time of pain relief and prolonged duration of analgesic effect in comparison to pharmacotherapy alone. | Contemp Oncol (Pozn). 2021;25(2):88-94. doi: 10.5114/wo.2021.105969. Epub 2021 May 7. | Analgesic Effect Pain Relief | Review |
| 34729102 | Recently, acupuncture and EA-induced analgesic effect has been reported in both experimental cancer models and cancer patients. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Analgesic Effect | Review |
| 34729102 | In addition to the analgesic effect on cancer pain, acupuncture and EA were also shown to improve pain caused by cancer treatments, such as surgery and chemotherapy. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Analgesic Effect Cancer Pain | Review |
| 34729102 | The main focus has been on investigating the mechanisms of the analgesic effects of acupuncture and EA. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Analgesic Effect | Review |
| 34729102 | In the early 1970s, Han's group, for the first time, strongly suggested the involvement of central chemical mediators in the analgesic effect by acupuncture. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Analgesic Effect | Review |
| 34729102 | They transferred the cerebrospinal fluid of acupunctured donor rabbits into recipient rabbits and achieved analgesic effects in recipients. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Analgesic Effect | Review |
| 34729102 | From then on, a series of studies have demonstrated that the analgesic effects may be attributed to the neurotransmitters induced by acupuncture and EA. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Analgesic Effect | Review |
| 34729102 | For example, naloxone, a specific opioid receptor antagonist, had been shown to partially reverse the analgesic effect of acupuncture on electrical stimulation-induced tooth pulp pain and chronic pain in humans and monkey subjects; poor EA-induced analgesia had been observed in CXBK mice that are deficient with opioid receptors; protection of endogenous opioid peptides by using peptidase inhibitors could potentiate acupuncture analgesia. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Analgesic Effect | Review |
| 34828543 | In traditional Chinese medicine, acupuncture is widely used in numerous musculoskeletal disorders, as it can induce analgesic effects with minimal and minor side effects. | Healthcare (Basel). 2021 Nov 2;9(11):1497. doi: 10.3390/healthcare9111497. | Analgesic Effect Side Effects | Review |
| 34828543 | Specifically, EA treatment, which involves both acupuncture and electrical stimuli, yields better analgesic effects. | Healthcare (Basel). 2021 Nov 2;9(11):1497. doi: 10.3390/healthcare9111497. | Analgesic Effect | Review |
| 34899943 | Acupuncture could thus have a significant effect on the treatment of CPPS, which could achieve anti-inflammatory and analgesic effects by reducing the levels of inflammatory factors. | Evid Based Complement Alternat Med. 2021 Dec 3;2021:1907009. doi: 10.1155/2021/1907009. eCollection 2021. | Analgesic Effect | Review |
| 34899943 | Acupuncture and its related therapies achieve satisfied analgesic effects on PD via the downregulation of a wide variety of inflammatory cells and cytokines (e.g., TNFα, IL-1, IL-2, IL-18, COX-2, NF-κB, NK cell activity, and MCs). | Evid Based Complement Alternat Med. 2021 Dec 3;2021:1907009. doi: 10.1155/2021/1907009. eCollection 2021. | Analgesic Effect | Review |
| 34916843 | Acupuncture acts on various parts of the central system, exerting analgesic effects through neurotransmitters, signaling pathways and immune responses. | J Pain Res. 2021 Dec 10;14:3773-3789. doi: 10.2147/JPR.S340961. eCollection 2021. | Analgesic Effect Immunity | Review |
| 34916843 | Although the analgesic effect of acupuncture is clinically effective, its specificity has been questioned. | J Pain Res. 2021 Dec 10;14:3773-3789. doi: 10.2147/JPR.S340961. eCollection 2021. | Analgesic Effect | Review |
| 34975571 | proposed that the analgesic effects of auricular acupuncture could be explained by stimulation of the auricular branch of the vagus nerve. | Front Psychiatry. 2021 Dec 15;12:765106. doi: 10.3389/fpsyt.2021.765106. eCollection 2021. | Analgesic Effect | Review |
| 34992414 | Alternately, NF-κB inhibitors suppress the acupuncture analgesic effect by reducing IL-6 levels and the proportion of CD68+ macrophages. | J Inflamm Res. 2021 Dec 21;14:7191-7224. doi: 10.2147/JIR.S341581. eCollection 2021. | Analgesic Effect | Review |
| 34992414 | In addition, the association of adenosine to adenylate A1 receptors in acupoints mediates the anti-inflammatory and analgesic effects of acupuncture in CFA models. | J Inflamm Res. 2021 Dec 21;14:7191-7224. doi: 10.2147/JIR.S341581. eCollection 2021. | Analgesic Effect | Review |
| 34992414 | Additionally, our unpublished work has shown that acupuncture increases HMGB1 protein content at acupoints, which mediates the analgesic effect of acupuncture. | J Inflamm Res. 2021 Dec 21;14:7191-7224. doi: 10.2147/JIR.S341581. eCollection 2021. | Analgesic Effect | Review |
| 35140516 | Overall meta-analysis showed that acupuncture had a short-term analgesic effect on FM (SMD: â0.42, 95% CI, â0.66, â0.17, P<0.001, I2=58%) (Table 2). | J Pain Res. 2022 Feb 3;15:315-329. doi: 10.2147/JPR.S351320. eCollection 2022. | Analgesic Effect | Review |
| 35140516 | In four studies included in the analysis, our results suggested that acupuncture for FM had a long-term analgesic effect. | J Pain Res. 2022 Feb 3;15:315-329. doi: 10.2147/JPR.S351320. eCollection 2022. | Analgesic Effect | Review |
| 35140516 | Forest plots of the analgesic effect of acupuncture in the post-treatment. | J Pain Res. 2022 Feb 3;15:315-329. doi: 10.2147/JPR.S351320. eCollection 2022. | Analgesic Effect | Review |
| 35140516 | The subgroup analysis indicated that the real acupuncture group produced more analgesic effects than the control group, with different number of sessions, types of acupuncture, and stimulation. | J Pain Res. 2022 Feb 3;15:315-329. doi: 10.2147/JPR.S351320. eCollection 2022. | Analgesic Effect | Review |
| 35140516 | Our results were in contradiction with those of our predecessor, suggesting that acupuncture showed analgesic effects only in the EA subgroup, the personalized treatment subgroup, or the subgroup less than 10 sessions. | J Pain Res. 2022 Feb 3;15:315-329. doi: 10.2147/JPR.S351320. eCollection 2022. | Analgesic Effect | Review |
| 35140516 | A high-quality systematic review of seven RCTs published in 2010 showed a small analgesic effect after acupuncture (SMD: 0.25, 95% CI, 0.49, 0.02, P = 0.04). | J Pain Res. 2022 Feb 3;15:315-329. doi: 10.2147/JPR.S351320. eCollection 2022. | Analgesic Effect | Review |
| 35140516 | Our results were consistent with recent reviews that acupuncture can produce analgesic effects in patients with FM. | J Pain Res. 2022 Feb 3;15:315-329. doi: 10.2147/JPR.S351320. eCollection 2022. | Analgesic Effect | Review |
| 35140516 | Furthermore, we believe that manual acupuncture with at least 10 sessions can achieve better analgesic effect. | J Pain Res. 2022 Feb 3;15:315-329. doi: 10.2147/JPR.S351320. eCollection 2022. | Analgesic Effect | Review |
| 35237333 | Furthermore, the acupuncture analgesic effect is associated with substance P (SP) and β-endorphin. | Evid Based Complement Alternat Med. 2022 Feb 21;2022:3178154. doi: 10.1155/2022/3178154. eCollection 2022. | Analgesic Effect | Review |
| 35269431 | Acupuncture points (acupoints) are characterized by a high density of subcutaneous mast cells (MCs); their activation has turned out to play a crucial role in the initiation of the analgesic effect (see Section 2). | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269431 | MCs in Acupuncture-Analgesic Effect | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269431 | The analgesic effect of acupuncture is produced by needle piercing and manipulation at acupoints. | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269431 | Moreover, a function test confirm that MC degranulation is an essential step towards an analgesic effect of acupuncture. | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269431 | However, using CRO to shield the degranulation of MCs in the treated acupoint can significantly weaken the acupuncture analgesic effect (Figure 6a). | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269431 | The critical findings are that in non-painful WsRCâ+/+ rats, although acupuncture (10 min, ST36) still can produce an analgesic effect for mechanical pain, the effect is substantially decreased compared with wild-type rats. | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269431 | Further study in ankle AA rats reveals that Ado accumulation in the needling-treated ST36 can be canceled by preventing MC degranulation with CRO administration (Figure 12a), which is accompanied by the suppression of the acupuncture analgesic effect, as mentioned above (Figure 6). | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269431 | In ankle AA rats, pharmacological inhibition of TRPV4 channels in treated ST36 in advance can suppress acupuncture-induced eATP increase (Figure 15), which is accompanied by reduced analgesic effect, as we demonstrated in Figure 9b. | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269431 | Further study in ankle AA rats reports that up- and downregulating eATP levels in treated ST36 can dampen and duplicate acupuncture analgesic effect, respectively (Figure 17), which further implies the contribution of ATP mobilization, including release and hydrolysis, to acupuncture analgesia. | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269431 | In ankle AA rats, an acupuncture analgesic effect can be duplicated by local activation of H1 receptors with 2-pyridineethanamine dihydrochloride (Pyrid.) | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269431 | In ankle AA rats, blocking peripheral nerves with lidocaine in the treated ST36 attenuates acupuncture analgesic effect, but does not markedly suppress the degranulation of MCs. | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269431 | Activation of subcutaneous MCs triggers acupuncture analgesic effect. | Cells. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809. | Analgesic Effect | Review |
| 35269483 | Using mast cells, acupuncture analgesia and acupoint as key words to search CNKI, PubMed, Web of Science and other databases, combining the representative articles in these databases with the published research papers of our group, we summarized: The enrichment of mast cells and the dense arrangement of collagen fibers, microvessels, and nerves form the basis for acupoints as the reaction sites of acupuncture; acupuncture can cause the deformation of collagen fibers and activate TRPV channels on mast cells membrane, so as to stimulate mast cells to release bioactive substances and activate nerve receptors to generate analgesic effect; system biology models are set up to explain the quantitative process of information initiation and transmission at acupuncture points, and indicate that the acupuncture effect depends on the local mast cells density. | Cells. 2022 Mar 2;11(5):860. doi: 10.3390/cells11050860. | Analgesic Effect | Review |
| 35269483 | Nowadays, it is found that acupuncture can activate mast cells and cause their degranulation (releasing biological substances), inducing an analgesic effect. | Cells. 2022 Mar 2;11(5):860. doi: 10.3390/cells11050860. | Analgesic Effect | Review |
| 35269483 | After reducing the mast cell degranulation with disodium cromolyn (DSCG, mast cell membrane stabilizer), the analgesic effect of acupuncture was inhabited. | Cells. 2022 Mar 2;11(5):860. doi: 10.3390/cells11050860. | Analgesic Effect | Review |
| 35269483 | found that the analgesic effect was closely related with the intensity of mechanical stimulation, and mast cell deficiency in rat attenuated the analgesic effect of acupuncture. | Cells. 2022 Mar 2;11(5):860. doi: 10.3390/cells11050860. | Analgesic Effect | Review |
| 35269483 | As discussed previously, the TRPV2 channel on mast cells also affects the analgesic effect of acupuncture. | Cells. 2022 Mar 2;11(5):860. doi: 10.3390/cells11050860. | Analgesic Effect | Review |
| 35269483 | observed a great reduction in mast cell degranulation rate at zusanli acupoint in the TRPV2 gene knockout mice (comparing with wild-type animals), as well as a suppression of acupuncture analgesic effect. | Cells. 2022 Mar 2;11(5):860. doi: 10.3390/cells11050860. | Analgesic Effect | Review |
| 35269483 | The pretreatment with clemastine (histamine H1 receptor antagonist) could suppress the analgesic effect of acupuncture and decrease the mast cell degranulation rate induced by histamine, while the degranulation rate induced by acupuncture was not affected. | Cells. 2022 Mar 2;11(5):860. doi: 10.3390/cells11050860. | Analgesic Effect | Review |
| 35269483 | destroyed the collagen at zusanli acupoint in rats by collagenase, and they found that acupuncture could not cause mast cell degranulation effectively, thus the analgesic effect was significantly weakened. | Cells. 2022 Mar 2;11(5):860. doi: 10.3390/cells11050860. | Analgesic Effect | Review |
| 35269483 | The acupuncture analgesic effect is significantly attenuated by either blocking the peripheral nerves at acupoints, or blocking the nerve pathways, or damaging part of the central nervous system. | Cells. 2022 Mar 2;11(5):860. doi: 10.3390/cells11050860. | Analgesic Effect | Review |
| 35313481 | From the theory of traditional Chinese medicine (TCM), the blocked meridian is the main cause of pain, and effective acupuncture can play a positive analgesic effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Today, many types of research have confirmed that acupuncture has a positive analgesic effect in treating pain. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Acupuncture mainly exerts an analgesic effect by activating acupoints with special anatomical locations. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Many clinical pain studies on acupuncture have shown that the analgesic effect of the acupuncture group is superior to the standard control group. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | The analgesic effects of the acupuncture and the placebo groups are superior to those of the no acupuncture groups, but placebo analgesia has only a tiny to moderate effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Although the analgesic effect of the acupuncture group was superior to the control groups, it cannot be neglected that on the management of some pain (pain in labor, migraine, and neuropathic pain), low-quality evidence suggests that acupuncture does not differ much from usual care. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Neuropathic Pain | Review |
| 35313481 | Studies have shown that different acupuncture methods (actually stimulating acupoints but with different intensities) also have an analgesic effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Twist ankle acupuncture (WAA) and auricular acupuncture (AA) have curative effects on cancer pain, and the combination of different acupuncture methods has a better analgesic effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Cancer Pain | Review |
| 35313481 | The analgesic effect of acupuncture in certain pain disorders is as effective as NSAIDs, even has a faster and longer-lasting action in acute pain analgesia. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | divided 46 patients with postoperative swallowing pain into three groups, each receiving NSAIDs, and showed that the analgesic effect of the acupuncture group was better than that of the drug treatment group. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Interestingly, acupuncture may be the best option for pain relief when a patient cannot take NSAIDs or other analgesic medications, exerting analgesic effects even faster than medication. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Pain Relief | Review |
| 35313481 | found that the analgesic effect of acupuncture in urolithiasis-driven renal colic pain relief was superior to that of diclofenac and acetaminophen after ten minutes, and there was no significant difference in the analgesic effect of the three types of therapy after 120 minutes. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Pain Relief Kidney | Review |
| 35313481 | When combined with drugs to treat pain diseases, acupuncture can enhance the analgesic effect and reduce patients' dependence on drugs and even reduce the side effects of drugs. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Side Effects | Review |
| 35313481 | These studies clearly show that serotonin is involved in acupuncture analgesia, but the corresponding matching points should be selected for better analgesic effects. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Acupuncture can achieve an analgesic effect by downregulating glutamate in the ascending excitation pathway. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Although the acupuncture method is different, it seems to play the same analgesic effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | The modulation of glutamate and its receptor content by acupuncture is beneficial for optimizing the analgesic effect of acupuncture. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | The analgesic effect is closely related to the quantity of acupuncture stimulation. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | But the analgesic effect of acupuncture still has limitations, for instance, placebo as mentioned above effect and the inadequacy of RCTs design such as the design of an effective control group. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | Heterogeneity among practitioners may bias the analgesic effect of acupuncture. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | In the formalin-induced pain rat model, acupunctures ST36, SP9, and BL60 had a better analgesic effect than the control group, and BL60 had the most significant effect. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | The use of acupuncture helps to increase the levels of neurotransmitters in the body, which can be targeted for the treatment of different pain disorders according to different activation mechanisms while maximizing the analgesic effect according to their quantity requirements. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35313481 | (b) Based on the superiority and safety of acupuncture, acupuncture is now also used extensively as an effective analgesic therapy for various diseases. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect | Review |
| 35449821 | (1) Electroacupuncture can inhibit glial cell activation by downregulating the chemokine CX3CL1 and increasing anti-inflammatory cells to achieve analgesic effects. | Evid Based Complement Alternat Med. 2022 Apr 11;2022:7705256. doi: 10.1155/2022/7705256. eCollection 2022. | Analgesic Effect | Review |
| 35449821 | (3) The production of analgesic effects of acupuncture may be correlated with the activation of certain chemicals by acupuncture stimulation. | Evid Based Complement Alternat Med. 2022 Apr 11;2022:7705256. doi: 10.1155/2022/7705256. eCollection 2022. | Analgesic Effect | Review |
| 35496051 | So, acupuncture analgesia and placebo analgesia have similar mechanisms, both of which can be mediated by opioids to comfort pain when it occurs both effect, and acupunctures have analgesic effects, so it is difficult to separate them.But in research, acupuncture has effect in patients improving function [n = 2408; SMD = â1.25, 95% CI (-1.97, -0.53); I2 = 0%. | Biomed Res Int. 2022 Apr 21;2022:6561633. doi: 10.1155/2022/6561633. eCollection 2022. | Analgesic Effect | Review |
| 35725779 | A study found that adenosine can mediate the analgesic effects of acupuncture. | Blood Rev. 2022 Nov;56:100985. doi: 10.1016/j.blre.2022.100985. Epub 2022 Jun 13. | Analgesic Effect | Review |
| 35725779 | In mice with adenosine receptor knocked-out, acupuncture lost its analgesic effects. | Blood Rev. 2022 Nov;56:100985. doi: 10.1016/j.blre.2022.100985. Epub 2022 Jun 13. | Analgesic Effect | Review |
| 35737304 | Analgesic Effects of Acupuncture | Vet Sci. 2022 May 26;9(6):252. doi: 10.3390/vetsci9060252. | Analgesic Effect | Review |
| 35737304 | Painful local clinical conditions such as burns, lick granulomas, chronic wounds and local soft tissue injuries can benefit from the local analgesic effects of acupuncture. | Vet Sci. 2022 May 26;9(6):252. doi: 10.3390/vetsci9060252. | Analgesic Effect | Review |
| 35768044 | Another review about acupuncture and its effect on pain could also not establish a clear relationship between the technique and the analgesics effects in humans. | J Pain. 2022 Nov;23(11):1833-1855. doi: 10.1016/j.jpain.2022.06.007. Epub 2022 Jun 26. | Analgesic Effect | Review |
| 35922617 | have shown that acupuncture may exert analgesic effects through the following three levels: (1) in the periphery, acupuncture stimulation promoted the release of endogenous opioids, and then inhibited the nociception of peripheral nerve endings; (2) at the spinal level, acupuncture blocked nociceptive transmission while increasing levels of opioids, norepinephrine, and 5-HT; (3) in the brain, acupuncture worked mainly by inhibiting the production of pain sensations and emotional components. | Pain Ther. 2022 Dec;11(4):1095-1112. doi: 10.1007/s40122-022-00415-8. Epub 2022 Aug 3. | Analgesic Effect Mood | Review |
| 35937886 | It was found that the post-effects of acupuncture can cause changes in functional connectivity between important brain regions in the pain matrix, exerting the analgesic effects of acupuncture by decreasing the thalamus-anterior cingulate pain upload pathway and strengthening the ventral medial prefrontal-anterior cingulate descending inhibitory pathway (Roy et al.,). | Front Neurosci. 2022 Jul 22;16:906875. doi: 10.3389/fnins.2022.906875. eCollection 2022. | Analgesic Effect | Review |
| 35968313 | A meta-analysis of acupuncture for low back pain revealed that the brain regions involved in acupuncture were located in the salience network, DMN, pain matrix, and descending pain modulatory system, demonstrating the analgesic effect of acupuncture. | Front Neurol. 2022 Jul 22;13:930753. doi: 10.3389/fneur.2022.930753. eCollection 2022. | Analgesic Effect | Review |
| 36203799 | Additionally, analgesic effect of acupuncture was mediated in part through inhibiting the activation of JNK and promoting the release of IL10 in astrocytes. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Analgesic Effect | Review |
| 36203799 | It was suggested that the analgesic effect of acupuncture was mediated in part through inhibition of JNK activation in astrocytes after SCI. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Analgesic Effect | Review |
| 36203799 | The spinal cord is an important center for mediating the analgesic effects of acupuncture. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Analgesic Effect | Review |
| 36203799 | Endogenous opioids were closely related to the analgesic effect of acupuncture. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Analgesic Effect | Review |
| 36203799 | Acupuncture reduced the SNL-induced hypersensitivity response, which blocked by naloxone, a non-selective opioid receptor antagonist, suggesting that the analgesic effect of acupuncture was dependent on the opioid system. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Analgesic Effect | Review |
| 36203799 | The infiltration of procaine, a local anesthetic, into the deep tissues around the point of acupuncture entirely abolished the analgesic effect, suggesting that nerves was mediators of this response. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Analgesic Effect | Review |
| 36203799 | However, the analgesic effect of acupuncture on neuropathic pain induced by spinal cord injury has an obvious selectivity, which depends on the location and type of pain, as well as the type of injury. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Analgesic Effect Neuropathic Pain | Review |
| 36203799 | Intensities, frequencies, and the course of treatment of acupuncture all affect analgesic effects. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Analgesic Effect | Review |
| 36267617 | From the perspective of traditional Chinese medicine, pain is caused by the blockage of the meridians and collaterals, and acupuncture uses metal needles to penetrate specific acupoints in the body to regulate the Qi in the meridians and achieve its analgesic effect by unblocking the meridians and collaterals. | Front Med (Lausanne). 2022 Oct 4;9:947285. doi: 10.3389/fmed.2022.947285. eCollection 2022. | Analgesic Effect | Review |
| 36314416 | To evaluate the analgesic effect of acupuncture, paw withdrawal latency (PWL), paw withdrawal pressure threshold (PWTs), and tail lick latency (TFL) were tested. | Integr Cancer Ther. 2022 Jan-Dec;21:15347354221123788. doi: 10.1177/15347354221123788. | Analgesic Effect | Review |
| 36340786 | Acupuncture has analgesic effects locally (scalp acupoints) and remotely (body acupoints), which may be mediated by different mechanisms. | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Analgesic Effect | Review |
| 36340786 | With the exception of adenosine and VN hypotheses, other hypotheses include remote anti-inflammatory and analgesic effects, such as diffuse noxious inhibitory control hypothesis, segmental nerve hypothesis, and gate control hypothesis (suppressing the transmission of thin fibers by activating thick fibers), which may be the basis of the body points in acupuncture for the treatment of migraines. | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Analgesic Effect | Review |
| 36388203 | Some studies have shown that for migraine patients who do not respond to acute drugs, acupuncture can achieve its analgesic effect by regulating AÏ-fibers, which may become an important complementary and alternative therapy for migraine. | Front Neurol. 2022 Oct 26;13:1010410. doi: 10.3389/fneur.2022.1010410. eCollection 2022. | Analgesic Effect | Review |
| 36408345 | This article reviewed the literature on the pain and reward/motivation loop and the effect of acupuncture on this loop to provide new ideas for the internal mechanism of acupuncture exerting multidimensional regulation to produce an analgesic effect. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Analgesic Effect | Review |
| 36408345 | Functional nuclear magnetic resonance studies have shown that acupuncture produces an analgesic effect by modulating the limbic lobe-limbiclobe-neocortex network system. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Analgesic Effect | Review |
| 36408345 | Electroacupuncture promotes the release of opioids from the central nervous system to exert its analgesic effect. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Analgesic Effect | Review |
| 36408345 | After the activity of opioid receptors in the NAc is blocked by opioid receptor antagonists, the analgesic effect of acupuncture is reduced, and rACC endogenous opioid signals are necessary for relieving pain aversion. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Analgesic Effect | Review |
| 36408345 | Recent studies have shown that repeated electroacupuncture has a pronounced analgesic effect on rats with chronic neuralgia and can significantly improve their pain aversion. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Analgesic Effect Neuralgia | Review |
| 36408345 | Acupuncture, including electroacupuncture, can significantly inhibit pain sensation with the immediate analgesic effect and improve pain-induced negative emotions, including anxiety and depression accompanied by pain and cognitive changes. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Analgesic Effect Anxiety Depression Mood | Review |
| 36408345 | The brain reward motivation system is activated simultaneously as acupuncture analgesia, which can relieve pain aversion by promoting the release of opioids and 5-HT in the brain reward/motivation circuit and upregulating the expression of AMY's (Glu)Al, mGluR1, and GABAB2 proteins, thus exerting its analgesic effect. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Analgesic Effect | Review |
| 36408345 | Second, whether different acupuncture treatment schemes, such as acupuncture frequency, manipulation, selection of acupuncture points, and different electroacupuncture frequencies and current intensities, have other effects on analgesic reward effect remains to be further studied. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Analgesic Effect | Review |
| 36482655 | Studies have shown that acupuncture stimulates the release of opioid peptides including -endorphins, enkephalins, and dynorphins, which have analgesic effects through acting on the central nervous system. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Analgesic Effect | Review |
| 36482655 | Besides, several hypotheses have been put out that stress the role of acupuncture in pain relief, such as its ability to induce an analgesic effect on the hypothalamic-pituitary-adrenal axis and the endogenous opioid system. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Analgesic Effect Pain Relief | Review |
| 36570846 | However, further studies are needed to determine whether acupuncture exerts its analgesic effect by affecting peripheral autonomic nerves through these brain regions. | Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. | Analgesic Effect | Review |
| 36570846 | It has been found that the analgesic effects of acupuncture are primarily related to the regulation of the ascending activating system and descending inhibition system. | Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. | Analgesic Effect | Review |
| 36570846 | Various animal models have demonstrated the anti-inflammatory and analgesic effects of vagus-mediated acupuncture. | Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. | Analgesic Effect | Review |
| 36570846 | In the periphery, acupuncture can improve organ function, control inflammation, and exert analgesic effects through the modulation of autonomic nerves. | Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. | Analgesic Effect | Review |
| 36607887 | However, AA, which is developed from the traditional Chinese acupuncture analgesia, has an optimal analgesic effect by affecting the production and release of neurotransmitters, significantly controlling the increase in blood pressure and heart rate during surgery and reduces the cardiovascular response after cervical plexus block. | Medicine (Baltimore). 2023 Jan 6;102(1):e32582. doi: 10.1097/MD.0000000000032582. | Analgesic Effect Heart Rate Cardiovascular Blood Pressure | Review |
| 36607887 | Acupuncture causes the brain to release opioid peptides and other substances that interact with specific opioid peptide receptors to produce analgesic effects via mediating non-neuronal pathways. | Medicine (Baltimore). 2023 Jan 6;102(1):e32582. doi: 10.1097/MD.0000000000032582. | Analgesic Effect | Review |
| 36607887 | However, simple acupuncture anesthesia has an insufficient analgesic effect and causes evident traction reaction and muscle tension. | Medicine (Baltimore). 2023 Jan 6;102(1):e32582. doi: 10.1097/MD.0000000000032582. | Analgesic Effect | Review |
| 36620460 | For example, a previous study found that the analgesic effect of acupuncture at Hegu is related to the pregenual anterior cingulate and hippocampal. | Front Neurosci. 2022 Dec 22;16:1084362. doi: 10.3389/fnins.2022.1084362. eCollection 2022. | Analgesic Effect | Review |
| 36628350 | Specifically, acupuncture is known for its antiinflammatory and analgesic effects and is used in patients with pain-related diseases. | J Pharmacopuncture. 2022 Dec 31;25(4):301-316. doi: 10.3831/KPI.2022.25.4.301. | Analgesic Effect | Review |
| 36698826 | Although the mechanism underlying acupuncture-induced analgesia is not clear, it has been shown to exert its analgesic effects though nervous system modulation, endocrine regulation, and smooth muscle relaxation on visceral pain. | Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. | Analgesic Effect Visceral Pain Endocrinology | Review |
| 36698826 | With respect to the analgesic effect of neuropathic pain, electroacupuncture might alleviate the hyperalgesia state through inhibition of prostaglandin E2 secretion after 1 week of intervention in a rat model. | Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. | Analgesic Effect Neuropathic Pain | Review |
| 36698826 | Our finding was consistent with that of a previous paired meta-analysis that supported the prompt analgesic effect of acupuncture for acute pain relief in a variety of settings with an onset ranging from 15 to 30 min. | Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. | Analgesic Effect Pain Relief | Review |
| 36698826 | Similarly, a 2021 meta-analysis of the immediate analgesic effect of acupuncture against acute low back pain reported a better immediate analgesic effect of acupuncture than conventional analgesics. | Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. | Analgesic Effect | Review |
| 36704010 | To compare the analgesic effects of various acupuncture therapies on PHN, we conducted a pairwise and network meta-analysis (NMA) to comprehensively and critically evaluate all available and eligible clinical evidence to provide evidence-based recommendations for selecting the best therapeutic acupuncture schedule. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Analgesic Effect | Review |
| 36704010 | We can assume that antiepileptics combined with acupuncture techniques enhance analgesic effects. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Analgesic Effect | Review |
| 36704010 | (2) Sodium channels are involved in the overexcitation of sensory neurons leading to neuropathic pain, and acupuncture can change sodium ion channel expression to produce analgesic effects. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Analgesic Effect Neuropathic Pain | Review |
| 36704010 | Acupuncture can inhibit central sensitization and the formation of synaptic plasticity, achieving analgesic effects. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Analgesic Effect | Review |
| 36704010 | (5) Acupuncture can regulate the entire brain area network of pain stimulation by adjusting the interaction between various brain functional areas and neurotransmitters, producing analgesic effects. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Analgesic Effect | Review |
| 36704010 | (6) Acupuncture exerts analgesic effects by mediating mitogen-activated protein kinase (MAPK) signaling pathways, including the spinal cord p38/MAPK, extracellular-signal-regulated kinase, c-Jun N-terminal kinase, and nuclear factor kappa-B pathways. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Analgesic Effect | Review |
| 36704010 | (7) Acupuncture exerts analgesic effects through epigenetic regulation of genes in tissues and cells, including DNA methylation, histone modification, and microRNA regulation. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Analgesic Effect | Review |
| 36756246 | Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect Neuropathic Pain | Review |
| 36756246 | However, previous studies on the analgesic effects of acupuncture for NP were scattered and did not form a whole. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect | Review |
| 36756246 | Acupuncture also inhibits neuronal glucose metabolism by downregulating mPFC's GLUT-3 and promotes metabolic alterations of the brain, thus exerting an analgesic effect. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect | Review |
| 36756246 | In conclusion, the regulation of nerve signal transduction and neuroimmune crosstalk at the peripheral and central levels mediates the analgesic effects of acupuncture for neuropathic pain in an integrated manner. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect Neuropathic Pain | Review |
| 36756246 | Of all the advantages associated with acupuncture, the analgesic effect is the most recognized. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect | Review |
| 36756246 | The analgesic effect of acupuncture is a comprehensive process that involves multiple pathways and levels, and is particularly associated with neuro-humoral regulation. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect | Review |
| 36756246 | Everyday new evidence confirms the analgesic effect of acupuncture on NP, this investigation summarizes the mechanisms associated with the analgesic effect of acupuncture in NP in terms of nerve signaling, neuro-immune crosstalk, and metabolic and oxidative stress regulation, to provide a reliable basis for better clinical acupuncture application for NP treatment. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect Immunity | Review |
| 36756246 | All the above studies suggest that acupuncture produces analgesic effects by downregulating neurotransmitters and receptors such as glutamate and its NMDA receptors, P2XR, SP, CGRP, and ion channels (TRPV1 and HCN), which inhibit the upstream excitatory system and weaken the neuronal transmission efficiency. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect | Review |
| 36756246 | In conclusion, acupuncture upregulates opioid peptides such as β-endorphin and MOR receptors, GABA and its receptors, and bi-directionally regulates 5-HT and its receptors (upregulates 5-HT 1A and downregulates 5-HT7R) to activate the downstream pain inhibitory pathway and produce analgesic effects. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect | Review |
| 36756246 | Recently it has been revealed that the analgesic effect of acupuncture for NP may be related to metabolic regulation. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect | Review |
| 36756246 | Role of nerve signal transduction and neuroimmune crosstalk in mediating the analgesic effects of acupuncture for neuropathic pain. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Analgesic Effect Neuropathic Pain | Review |
| 36778899 | revealed that the INS was activated to integrate sensory and affective information and to produce analgesic effects during acupuncture stimulation. | Front Neurosci. 2023 Jan 27;16:1097450. doi: 10.3389/fnins.2022.1097450. eCollection 2022. | Analgesic Effect | Review |
| 36778899 | Therefore, different parts of ACC may play different roles in the acupuncture-induced analgesic effect. | Front Neurosci. 2023 Jan 27;16:1097450. doi: 10.3389/fnins.2022.1097450. eCollection 2022. | Analgesic Effect | Review |
| 36778899 | Besides, the TTG, STG, IPL, HPG, IOG, PreCG, and posterior lobe of the cerebellum are also involved in the analgesic effect of acupuncture. | Front Neurosci. 2023 Jan 27;16:1097450. doi: 10.3389/fnins.2022.1097450. eCollection 2022. | Analgesic Effect | Review |
| 36845439 | Modern medical research indicates that acupuncture exerts analgesic effects by regualting the activation of microglia, inhibiting inflammatory response and modulating certain receptors along the pain pathways in the central or peripheral nervous systems (Coutaux,; Wang et al.,). | Front Neurosci. 2023 Feb 9;17:1097830. doi: 10.3389/fnins.2023.1097830. eCollection 2023. | Analgesic Effect | Review |
| 36852393 | The results suggest that the mechanism of acupuncture in the treatment of primary dysmenorrhea is the involvement of networks regulating different areas of the brain in the analgesic effects of acupuncture. | Pain Res Manag. 2023 Feb 18;2023:8307249. doi: 10.1155/2023/8307249. eCollection 2023. | Analgesic Effect | Review |
| 36852393 | In terms of brain alterations in patients with PD, both acupuncture and moxibustion have been shown to activate analgesia-related brain regions to exert analgesic effects. | Pain Res Manag. 2023 Feb 18;2023:8307249. doi: 10.1155/2023/8307249. eCollection 2023. | Analgesic Effect | Review |
| 36852393 | The limbic system is thought to be the system that processes motivational-emotional aspects, cognitive-evaluative aspects, and pain memory while mediating the analgesic effects of acupuncture. | Pain Res Manag. 2023 Feb 18;2023:8307249. doi: 10.1155/2023/8307249. eCollection 2023. | Analgesic Effect Mood | Review |
| 36862907 | Acupuncture can inhibit the pain signals of the dorsal horn of the spinal cord and the medial thalamic nucleus, so that they cannot be transmitted, and achieve analgesic effect. | Medicine (Baltimore). 2023 Mar 3;102(9):e33006. doi: 10.1097/MD.0000000000033006. | Analgesic Effect | Review |
| 36950556 | Acupuncture has been shown to have analgesic effects in studies of many other pain diseases, such as knee osteoarthritis, migraine, dysmenorrhea and low back pain. | Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. | Analgesic Effect | Review |
| 36960418 | The research on the central mechanism of acupuncture in the treatment of CP is still unclear, but there have been a large number of studies on the central analgesic effect of acupuncture. | Pain Res Manag. 2023 Mar 14;2023:7754876. doi: 10.1155/2023/7754876. eCollection 2023. | Analgesic Effect | Review |
| 36964825 | The effect of the therapy was observed to be similar in the region of the posterior and anterior buccal mucosa, mandibular body, chin, and lower lip, with a difference only in the region of the posterior mandibular body, where the effect of laser acupuncture occurred more slowly and gradually, which can be explained by the analgesic effect of this therapy. | Lasers Med Sci. 2023 Mar 25;38(1):92. doi: 10.1007/s10103-023-03754-w. | Analgesic Effect | Review |
| 37025199 | Acupuncture at the Hegu and Zusanli points can activate the hypothalamus and the nucleus accumbens and reduce the excitability of the pretuberous cortex, amygdala, and hippocampus; it can also activate the structure of the down-pass analgesic pathway and inactivate multiple limbic brain regions related to pain so as to achieve an analgesic effect and relieve patients' depression. | Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. | Analgesic Effect Depression | Review |
| 37025199 | In the study of acupuncture analgesia, acupuncture stimulation can inhibit the pain-activated brain network under the condition of Qi and transform the pain-activated brain area into an inhibited state to thereby achieve the analgesic effect of acupuncture. | Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. | Analgesic Effect | Review |
| 37297763 | The general mechanism of acupuncture treatment is to act on the central nervous system to stimulate the secretion of opioid peptides such as β-endorphin, enkephalin, and dynorphin, which produce analgesic effects. | Healthcare (Basel). 2023 Jun 1;11(11):1624. doi: 10.3390/healthcare11111624. | Analgesic Effect | Review |
| 37297763 | Studies have shown that acupuncture has an analgesic effect by stimulating the secretion of opioid peptides such as β-endorphins, enkephalins, and dynorphins, which act in the central nervous system to produce analgesic effects. | Healthcare (Basel). 2023 Jun 1;11(11):1624. doi: 10.3390/healthcare11111624. | Analgesic Effect | Review |
| 37297763 | Auricular acupuncture is known to enhance the analgesic effect through continuous stimulation and is used for various types of pain treatment in clinical practice. | Healthcare (Basel). 2023 Jun 1;11(11):1624. doi: 10.3390/healthcare11111624. | Analgesic Effect | Review |
| 37332744 | Therefore, our results suggested that acupuncture may be an effective analgesic strategy for patients receiving ESWL. | Front Med (Lausanne). 2023 Jun 2;10:1114485. doi: 10.3389/fmed.2023.1114485. eCollection 2023. | Analgesic Effect | Review |
| 37332744 | A previous experimental study suggested that the analgesic effect of low frequency (2 Hz) electroacupuncture stimulation in the rat spinal cord may be mediated by met-enkephalin and dynorphin acting simultaneously on the μ-, δ-, and κ-receptors, while that of high frequency (l00 Hz) electroacupuncture stimulation is mediated by dynorphin acting on the κ-receptor. | Front Med (Lausanne). 2023 Jun 2;10:1114485. doi: 10.3389/fmed.2023.1114485. eCollection 2023. | Analgesic Effect | Review |
| 37397275 | Acupuncture has obvious anti-inflammatory and analgesic effects on various diseases, which could regulate inflammatory cytokines and immune function and treat inflammatory pain with significant anti-inflammatory and antioxidant effects. | J Pain Res. 2023 Jun 27;16:2189-2204. doi: 10.2147/JPR.S415998. eCollection 2023. | Analgesic Effect Immunity Inflammatory Pain | Review |
| 37397439 | On the other hand, at-VNS and electro-acupuncture have analgesic effects with low frequency in various pain models in humans and rodents. | Front Neurosci. 2023 Jun 15;17:1151892. doi: 10.3389/fnins.2023.1151892. eCollection 2023. | Analgesic Effect | Review |
| 37478239 | The analgesic effect of acupuncture is also association with the release of neurotransmitters (e.g., endogenous opioid drugs, 5-hydroxytryptamine, and norepinephrine). | Medicine (Baltimore). 2023 Jul 21;102(29):e34266. doi: 10.1097/MD.0000000000034266. | Analgesic Effect | Review |
| 37521010 | The Analgesic Effect and Potential Mechanisms of Acupuncture for Migraine Rats: A Systematic Review and Meta-Analysis | J Pain Res. 2023 Jul 24;16:2525-2542. doi: 10.2147/JPR.S422050. eCollection 2023. | Analgesic Effect | Review |
| 37521010 | All the above results suggested that acupuncture could suppress pain symptoms in a rat model of migraine and exerted effective analgesic effects. | J Pain Res. 2023 Jul 24;16:2525-2542. doi: 10.2147/JPR.S422050. eCollection 2023. | Analgesic Effect | Review |
| 37521010 | Acupuncture can inhibit the expression of CGRP, SP, IL-1, IL-6 and TNF-α, reduce the release of inflammatory substances, inhibit neurogenic inflammation, and thus exert analgesic effect. | J Pain Res. 2023 Jul 24;16:2525-2542. doi: 10.2147/JPR.S422050. eCollection 2023. | Analgesic Effect | Review |
| 37521010 | In conclusion, acupuncture can exert analgesic effects by improving pain sensitization, regulating the expression of related neurotransmitters, and reducing inflammatory factor levels, thereby improving pain symptoms in migraine rats. | J Pain Res. 2023 Jul 24;16:2525-2542. doi: 10.2147/JPR.S422050. eCollection 2023. | Analgesic Effect | Review |
| 37551854 | Studies have depicted that acupuncture can relieve cancer pain and reduce the dose and side effects of analgesics. | Integr Cancer Ther. 2023 Jan-Dec;22:15347354231192017. doi: 10.1177/15347354231192017. | Analgesic Effect Cancer Pain Side Effects | Review |
| 37655096 | The analgesic effect of acupuncture has been widely demonstrated, and this effect may even be sustained over a longer period of time. | Front Oncol. 2023 Aug 15;13:1232754. doi: 10.3389/fonc.2023.1232754. eCollection 2023. | Analgesic Effect | Review |
| 37678839 | As a combination of traditional acupuncture and modern electrotherapy, electroacupuncture (EA) has satisfactory analgesic effects on various acute and chronic pain. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect | Review |
| 37678839 | Because of its good analgesic effects and no side effects, acupuncture has been widely accepted all over the world. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect Side Effects | Review |
| 37678839 | Despite the increase in the number of studies, the mechanisms via which acupuncture exerts its analgesic effects have not been conclusively established. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect | Review |
| 37678839 | Due to its good analgesic effects and minimal side effects, acupuncture is a viable option for treatment of inflammatory pain. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect Side Effects Inflammatory Pain | Review |
| 37678839 | As a combination of traditional acupuncture and modern electrotherapy, electroacupuncture (EA) can have satisfactory analgesic effect on various acute and chronic pain. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect | Review |
| 37678839 | Therefore, the stimulation frequency of acupuncture is particularly important for its analgesic effects, and there is an optimal frequency preference for different inflammatory pain models. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect Inflammatory Pain | Review |
| 37678839 | For instance, in CFA-induced chronic inflammatory pain, 100Â Hz electroacupuncture and high-frequency acupuncture have the best analgesic effects, while in acute gout arthritis and muscle inflammatory pain, 2/100Â Hz electroacupuncture can achieve better effects. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect Inflammatory Pain | Review |
| 37678839 | Different needles may exert profound analgesic effects of acupuncture, which need to be further elucidated. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect | Review |
| 37678839 | Acupuncture mediates interactions between immune cells and nociceptors to regulate the peripheral purinergic pathways, endogenous cannabinoid systems, opioid peptide systems and nociceptive ion channels to regulate the above inflammatory factors to achieve analgesic effects. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect Immunity | Review |
| 37678839 | The key cells that mediate the effects of joint acupuncture are monocytes/macrophages, which can inhibit macrophage maturation towards the M1 phenotypes, implying that acupuncture promotes macrophage differentiation at the inflammatory site into the M2 phenotypes, so as to achieve the anti-inflammatory and analgesic effects. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect | Review |
| 37678839 | The mechanisms underlying the analgesic effects of acupuncture and recombinant chemokine ligand 1 (CXCL1) may both be associated with a peripheral opioid-mediated pathway. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect | Review |
| 37678839 | They further investigated the role of CXCL1 in EA analgesia and revealed that serum CXCL1 has analgesic effects and may be a key anti-nociceptive medium in acupuncture-mediated treatment of inflammatory pain. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect Inflammatory Pain | Review |
| 37678839 | The analgesic effects of acupuncture and recombinant CXCL1 were alleviated by an i.pl. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect | Review |
| 37678839 | While some studies have confirmed the specificity of acupoint selection in the analgesic effect of acupuncture, there is limited research exploring the therapeutic differences and mechanisms between various acupoints. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect | Review |
| 37712096 | However, literature on the analgesic effects of NP mediated by acupuncture in specific key brain nuclei or circuits is relatively heterogeneous and fragmented, lacking systematic generalization. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect | Review |
| 37712096 | The results showed that acupuncture could exert analgesic effects and regulate pain emotion and cognitive pain effects by affecting functional activities in different brain regions (e.g., synaptic plasticity, the release of different neurotransmitters), which explains the modulatory effects and mechanisms of acupuncture analgesia and further deepens the implication and extension of acupuncture analgesia. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect Mood | Review |
| 37712096 | Acupuncture can exert analgesic effects by modulating glucose metabolism in brain regions. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect | Review |
| 37712096 | Studies have confirmed that acupuncture can mediate different signal transduction pathways or signal transduction molecules to exert analgesic effects, mainly including the mitogen-activated protein kinase (MAPK) signaling pathway, nitric oxide (NO) signaling pathway, and other pathways. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect | Review |
| 37712096 | One study analyzed the overall changes in relevant proteins in the hippocampus after acupuncture (ST36 and GB34) interventions in NP conditions, and differential protein enrichment analyzes suggested that the analgesic effect of EA was mediated through the modulation of hippocampal amino acid metabolism-related proteins and activation of the MAPK signaling pathway. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect | Review |
| 37712096 | However, the expression of iNOS did not change significantly, and the expression of nNOS and PKG genes was reduced considerably after EA stimulation at different frequencies, suggesting that the hippocampal nNOS/PKG signaling pathway may be involved in the cumulative analgesic effect produced by acupuncture in a chronic pain rat model. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect | Review |
| 37712096 | In addition to the analgesic effects, acupuncture may improve neuropathic pain-induced mood/cognitive dysfunction by restoring overall DNA methylation in the PFC. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect Neuropathic Pain Cognitive Function Mood | Review |
| 37712096 | In conclusion, these findings suggest that acupuncture can also affect miRNA expression in different brain regions, DNA methylation, microglia proliferation, ion channels, and other multiple pathways to exert their analgesic effects. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect | Review |
| 37712096 | Moreover, research on the analgesic mechanism of acupuncture is more inclined to longitudinal refinements, such as acupuncture as it can regulate a variety of neurotransmitters and receptors in the brain tissue to play an analgesic effect. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect | Review |
| 37732301 | Therefore, this systematic review aims to comprehensively summarize the existing mechanism through which acupuncture and moxibustion exert an analgesic effect on IBS animal models. | Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. | Analgesic Effect | Review |
| 37849245 | Both animal and human studies have revealed that preoperative electroacupuncture facilitates an elevation in enkephalin and β-endorphin levels, thereby conferring beneficial analgesic effects. | Med Sci Monit. 2023 Oct 18;29:e941262. doi: 10.12659/MSM.941262. | Analgesic Effect | Review |
| 37861487 | Modern research has proved that acupuncture can increase the pain threshold and activate enkephalin neurons to inhibit pain stimulation and achieve analgesic effects. | Medicine (Baltimore). 2023 Oct 20;102(42):e35000. doi: 10.1097/MD.0000000000035000. | Analgesic Effect | Review |
| 37904453 | Analgesic effects of perioperative acupuncture methods: A narrative review | Medicine (Baltimore). 2023 Oct 27;102(43):e35759. doi: 10.1097/MD.0000000000035759. | Analgesic Effect | Review |
| 37904453 | This study aimed to confirm the analgesic effect of perioperative acupuncture by reviewing studies on the different methods of perioperative acupuncture and their analgesic effects. | Medicine (Baltimore). 2023 Oct 27;102(43):e35759. doi: 10.1097/MD.0000000000035759. | Analgesic Effect | Review |
| 37904453 | This review aimed to describe the postoperative analgesic effects of different perioperative acupuncture methods in recent years and to suggest a multimodal approach for perioperative pain management by using acupuncture for further research. | Medicine (Baltimore). 2023 Oct 27;102(43):e35759. doi: 10.1097/MD.0000000000035759. | Analgesic Effect | Review |
| 37904453 | In all the typical cases analyzed, 22 studies confirmed that perioperative acupuncture had a significant analgesic effect, fifteen studies stated that it reduced or delayed the need for analgesic drugs, and 5 studies concluded that there was no significant pain reduction in the acupuncture group compared with the control group. | Medicine (Baltimore). 2023 Oct 27;102(43):e35759. doi: 10.1097/MD.0000000000035759. | Analgesic Effect | Review |
| 37904453 | Therefore, we only classified acupuncture methods in this review to explore the analgesic effect of the different perioperative acupuncture methods. | Medicine (Baltimore). 2023 Oct 27;102(43):e35759. doi: 10.1097/MD.0000000000035759. | Analgesic Effect | Review |
| 37990288 | Acupuncture exerts analgesic effects on visceral pain through various mechanisms, including signal interaction and integration at neurons, ion channels, activation of central descending inhibitory pathways, gene regulation, and the recruitment of various biochemicals, such as opioids, 5-HT, and NMDA (Zhang et al. | Bioelectron Med. 2023 Nov 22;9(1):27. doi: 10.1186/s42234-023-00130-5. | Analgesic Effect Visceral Pain | Review |
| 37990288 | These studies have suggested that acupuncture and EA may have analgesic effects by modulating the default mode network and sensorimotor network (Zhao et al.). | Bioelectron Med. 2023 Nov 22;9(1):27. doi: 10.1186/s42234-023-00130-5. | Analgesic Effect | Review |
| 38027491 | Acupuncture can exert analgesic effects by integrating and interacting input signals from acupuncture points and the sites of pain in the central nervous system. | Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. | Analgesic Effect | Review |
| 38027491 | Acupuncture can induce analgesic effects by integrating and interacting input signals from acupuncture points and the sites of pain in the central nervous system. | Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. | Analgesic Effect | Review |
| 38027491 | Correspondingly, signals induced by acupuncture can modulate multiple links in the transmission pathway, thus inducing analgesic effects. | Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. | Analgesic Effect | Review |
| 38027491 | EA at the ST36 acupoint in the cat was shown to inhibit its nociceptive neurons; this may represent a possible mechanism for acupuncture-induced analgesic effects on visceral pain. | Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. | Analgesic Effect Visceral Pain | Review |
| 38027491 | These findings were also confirmed by another study who also suggested that acupuncture may enhance the levels of β-EP in the hypothalamus, thus inducing analgesic effects. | Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. | Analgesic Effect | Review |
| 38027491 | Previous studies have shown that abnormalities in the FC of the brain may represent the basis of visceral pain and that acupuncture can exert analgesic effects by regulating abnormal functional networks in the brain. | Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. | Analgesic Effect Visceral Pain | Review |
| 38027491 | By utilizing different animal models of visceral pain, researchers have concluded that acupuncture information and visceral nociceptive signals can reach different brain regions at the same time and create an analgesic effect by influencing the secretion and release of neurotransmitters and receptors in different brain regions. | Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. | Analgesic Effect Visceral Pain | Review |
| 38027491 | The brain mechanisms responsible for the analgesic effects of acupuncture | Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. | Analgesic Effect | Review |
| 38027491 | Furthermore, few researchers have focused on such mechanisms concerning the analgesic effects of acupuncture. | Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. | Analgesic Effect | Review |
| 2904213 | If so, it might be possible to enhance the analgesic effect of acupuncture by the administration of endorphins. | Acupunct Electrother Res. 1988;13(2-3):87-97. doi: 10.3727/036012988816358705. | Analgesic Effect | Clinic |
| 2904213 | If D-phenylalanine (DPA), an inhibitor of the endorphin degrading enzyme, is administered, the analgesic effect of acupuncture should be prolonged due to the increased level of endorphins. | Acupunct Electrother Res. 1988;13(2-3):87-97. doi: 10.3727/036012988816358705. | Analgesic Effect | Clinic |
| 2904213 | From the changes of the pain threshold (PT), we investigated whether or not the pre-administration of DPA can enhance the analgesic effect of acupuncture in humans. | Acupunct Electrother Res. 1988;13(2-3):87-97. doi: 10.3727/036012988816358705. | Analgesic Effect | Clinic |
| 2904213 | 5) These findings show that DPA enhances the analgesic effect of acupuncture by the ""endorphin mechanism. | Acupunct Electrother Res. 1988;13(2-3):87-97. doi: 10.3727/036012988816358705. | Analgesic Effect | Clinic |
| 16419716 | OBJECTIVE: To observe analgesic effect of acupuncture anesthesia. | Zhongguo Zhen Jiu. 2005 Dec;25(12):876-8. | Analgesic Effect | Clinic |
| 19127921 | OBJECTIVE: To probe into peripheral nervous mechanisms of analgesic effect of electroacupuncture (EA) at Hegu (LI 4) and Neiguan (PC 6) on cervical region. | Zhongguo Zhen Jiu. 2008 Dec;28(12):910-2. | Analgesic Effect | Clinic |
| 19127921 | CONCLUSION: EA at Hegu (LI 4) and Neiguan (PC 6) can produce a better analgesic effect on cervical region; EA at Hegu (LI 4) and Neiguan (PC 6) induces electro-physio logic changes of the nerve innervating the cervical region, showing increase of excitability; the nerves innervating Hegu (LI 4) and Neiguan (PC 6) and the nerves of cervical region possibly are homologous nerves. | Zhongguo Zhen Jiu. 2008 Dec;28(12):910-2. | Analgesic Effect | Clinic |
| 20209977 | RESULTS: Of the 20 cases in AAA and control groups, 16 and 18 cases had a striking analgesic effect, 4 and 2 were effective, respectively. | Zhen Ci Yan Jiu. 2009 Dec;34(6):403-5. | Analgesic Effect | Clinic |
| 23072093 | OBJECTIVE: To explore different frequency electroacupuncture in acupuncture-drug compound anesthesia on analgesic effect and immune function in the pulmonary resection patients in order to recommend the best electroacupuncture frequency in acupuncture-drug compound anesthesia. | Zhongguo Zhen Jiu. 2012 Aug;32(8):715-9. | Analgesic Effect Immunity | Clinic |
| 23072093 | CONCLUSION: Acupuncture-drug compound anesthesia with 2 Hz and 100 Hz electroacupuncture together with 2 Hz/100 Hz transcetaneous acupoints electrical stimulation have the best analgesic effect, and 2 Hz/100 Hz transcetaneous acupoints electrical stimulation and 2 Hz/100 Hz electroacupuncture have the best regulation of immune function. | Zhongguo Zhen Jiu. 2012 Aug;32(8):715-9. | Analgesic Effect Immunity | Clinic |
| 23163146 | CONCLUSION: Patients undergoing AA had less fluctuation of the BP and the HR, indicating AA had better analgesic effects. | Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Oct;32(10):1358-60. | Analgesic Effect Heart Rate Blood Pressure | Clinic |
| 23227690 | [Analgesic effect of acupuncture compound anesthesia in functionality nasal endoscopic sinus surgery]. | Zhongguo Zhen Jiu. 2012 Sep;32(9):815-8. | Analgesic Effect | Clinic |
| 23227690 | OBJECTIVE: To verify the analgesic effect of acupuncture compound anesthesia in functionality nasal endoscopic sinus surgery (FNES). | Zhongguo Zhen Jiu. 2012 Sep;32(9):815-8. | Analgesic Effect | Clinic |
| 33415861 | The two groups were compared in terms of the sedative and analgesic effects of anesthesia, amount of anesthetics used, incidence rate of intraoperative snore and respiratory depression, and change in serum beta-endorphin level before anesthesia, before surgery, and after the surgery. | Zhen Ci Yan Jiu. 2020 Dec 25;45(12):1006-9. doi: 10.13702/j.1000-0607.200116. | Analgesic Effect Depression Acupuncture Anesthesia Effect | Clinic |
| 33415861 | CONCLUSION: In microwave ablation of benign thyroid nodules, combined acupuncture-medicine anesthesia has good sedative and analgesic effects and can reduce the amounts of anesthetics used as well as the incidence rates of intraoperative snore and respiratory depression. | Zhen Ci Yan Jiu. 2020 Dec 25;45(12):1006-9. doi: 10.13702/j.1000-0607.200116. | Analgesic Effect Depression | Clinic |
| 33415861 | The analgesic effect of acupuncture anesthesia is associated with increased beta-endorphin secretion. | Zhen Ci Yan Jiu. 2020 Dec 25;45(12):1006-9. doi: 10.13702/j.1000-0607.200116. | Analgesic Effect | Clinic |
| 15385352 | Stimulation at P6 also has analgesic effects. | Anesth Analg. 2004 Oct;99(4):1070-1075. doi: 10.1213/01.ANE.0000130355.91214.9E. | Analgesic Effect | Clinic |
| 18679598 | CONCLUSION: Transcutaneous electroacupoint stimulation at P6 with the TOF mode could reduce the incidence and severity of nausea and vomiting with analgesic effects. | Chin J Integr Med. 2008 Jun;14(2):94-7. doi: 10.1007/s11655-008-0094-4. Epub 2008 Aug 6. | Analgesic Effect Nausea and Vomiting | Clinic |
| 22330010 | Chinese studies have found that acupuncture may have an analgesic effect in posthaemorrhoidectomy patients. | Colorectal Dis. 2012 Aug;14(8):e486-91. doi: 10.1111/j.1463-1318.2012.02984.x. | Analgesic Effect | Clinic |
| 24024321 | Analgesic effect of acupuncture at hegu (LI 4) on transvaginal oocyte retrieval with ultrasonography. | J Tradit Chin Med. 2013 Jun;33(3):294-7. doi: 10.1016/s0254-6272(13)60167-3. | Analgesic Effect | Clinic |
| 24024321 | OBJECTIVE: To observe the analgesic effect of acupuncture at Hegu (LI 4) in vitro fertilization-embryo transfer (IVF-ET) transvaginal oocyte retrieval using ultrasonography and explore its mechanism. | J Tradit Chin Med. 2013 Jun;33(3):294-7. doi: 10.1016/s0254-6272(13)60167-3. | Analgesic Effect | Clinic |
| 24024321 | CONCLUSION: The analgesic effect of acupuncture at Hegu in transvaginal oocyte retrieval using ultrasonography may be related to the increase in the NPY level of the follicular fluid. | J Tradit Chin Med. 2013 Jun;33(3):294-7. doi: 10.1016/s0254-6272(13)60167-3. | Analgesic Effect | Clinic |
| 25926298 | Intraoperative and postoperative anaesthetic and analgesic effect of multipoint transcutaneous electrical acupuncture stimulation combined with sufentanil anaesthesia in patients undergoing supratentorial craniotomy. | Acupunct Med. 2015 Aug;33(4):270-6. doi: 10.1136/acupmed-2014-010749. Epub 2015 Apr 29. | Analgesic Effect | Clinic |
| 25926298 | OBJECTIVES: To investigate the anaesthetic and analgesic effect of multipoint transcutaneous electrical acupuncture stimulation (TEAS) during supratentorial tumour resection for postoperative recovery and side effects. | Acupunct Med. 2015 Aug;33(4):270-6. doi: 10.1136/acupmed-2014-010749. Epub 2015 Apr 29. | Analgesic Effect Side Effects | Clinic |
| 16820123 | Electro-acupuncture has previously proven its analgesic effect in oocyte retrieval for IVF. | Reprod Biomed Online. 2006 Jul;13(1):120-5. doi: 10.1016/s1472-6483(10)62025-1. | Analgesic Effect | Clinic |
| 16820123 | Contrary to previous reports on acute and chronic pain, the analgesic effect of the mixed frequency and the fixed frequency was similar when used for short duration electro-acupuncture. | Reprod Biomed Online. 2006 Jul;13(1):120-5. doi: 10.1016/s1472-6483(10)62025-1. | Analgesic Effect | Clinic |
| 2904213 | If so, it might be possible to enhance the analgesic effect of acupuncture by the administration of endorphins. | Acupunct Electrother Res. 1988;13(2-3):87-97. doi: 10.3727/036012988816358705. | Analgesic Effect | Clinic |
| 2904213 | If D-phenylalanine (DPA), an inhibitor of the endorphin degrading enzyme, is administered, the analgesic effect of acupuncture should be prolonged due to the increased level of endorphins. | Acupunct Electrother Res. 1988;13(2-3):87-97. doi: 10.3727/036012988816358705. | Analgesic Effect | Clinic |
| 2904213 | From the changes of the pain threshold (PT), we investigated whether or not the pre-administration of DPA can enhance the analgesic effect of acupuncture in humans. | Acupunct Electrother Res. 1988;13(2-3):87-97. doi: 10.3727/036012988816358705. | Analgesic Effect | Clinic |
| 2904213 | 5) These findings show that DPA enhances the analgesic effect of acupuncture by the ""endorphin mechanism. | Acupunct Electrother Res. 1988;13(2-3):87-97. doi: 10.3727/036012988816358705. | Analgesic Effect | Clinic |
| 25047046 | Soon, Bruce Pomeranz revealed that an analgesic effect of acupuncture is mediated by the release of endorphins and can therefore be abolished by the administration of naloxone in humans. | Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. | Analgesic Effect | Clinic |
| 25152761 | However, it is still unclear how the placebo effect of EA contributes to analgesic effect in the present study since sham-EA was also effective. | Evid Based Complement Alternat Med. 2014;2014:592319. doi: 10.1155/2014/592319. Epub 2014 Jul 23. | Analgesic Effect | Clinic |
| 35647012 | With the development of acupuncture technology and the emergence of electro-acupuncture (EA) apparatus, its analgesic effect is stronger. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Analgesic Effect | Clinic |
| 35647012 | The analgesic effects of EA are mainly manifested as alleviation of diabetic neuropathic pain, postherpetic neuralgia, tactile sensation-induced pain, paclitaxel chemotherapy pain, reduction of cold and heat sensitive pain threshold, and other various types of pain. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Analgesic Effect Neuropathic Pain Neuralgia | Clinic |
| 35647012 | Compared with conventional acupuncture, EA is more effective and convenient, so EA is often used to assist anesthesia and analgesia in various surgical procedures.. It has been reported that in a variety of local anesthesia surgerys, EA can significantly enhance the perioperative analgesic effect, improve hemodynamic abnormalities, and reduce the incidence of adverse reactions after anesthesia. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Analgesic Effect Adverse Reactions | Clinic |
| 35647012 | It was analyzed that EA could stimulate the central nervous system to up-regulate the secretion of morphine-like neurotransmitters with endogenous analgesic effects, such as β -endorphin and at the same time, the signal from acupuncture points could inhibit the transmission of pain signals at nearby spinal stages to the central nervous system, thus increasing the pain threshold of the body. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Analgesic Effect | Clinic |
| 35647012 | However, acupuncture at Hegu (LI 4) exerts analgesic effect and remarkably reduces the sensitivity of the throat to exert a sedative effect. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Analgesic Effect | Clinic |
| 36034956 | Multimode analgesia is a kind of analgesic program that combines the application of drugs with different methods or mechanisms to make them have synergistic effects, so as to reduce the dosage of analgesics and improve the analgesic effect, and has achieved remarkable effects in clinical application. | Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. | Analgesic Effect | Clinic |
| 36034956 | Studies have found that multimode analgesia can not only improve the analgesic effect but also reduce the side effects of anesthesia to maximize the effect/side effects ratio, so as to achieve balanced analgesia. | Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. | Analgesic Effect Side Effects Acupuncture Anesthesia Effect | Clinic |
| 36034956 | In order to further strengthen the analgesic effect and reduce the physical and mental stress caused by pain and surgery, this study combined with the traditional Chinese medicine treatment of auricular acupoint pressing beans, sticking the medicine beans on the auricular acupoint through adhesive tape for moderate stimulation, so as to achieve the purpose of external treatment. | Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. | Analgesic Effect | Clinic |
| 36034956 | Therefore, the combined plan adopted in this study had a significant analgesic effect and was widely recognized and satisfied by patients. | Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. | Analgesic Effect | Clinic |
| 36034956 | This study for the first time found that the first exhaust, get out of bed time, and hospital stay in the observation group were shorter than that of the control group (P < 0.05), indicating that multimodal analgesia combined with auricular application therapy could achieve good analgesia effect through a variety of analgesic effect mechanism and reduce the adverse effects of traumatic stimulation on patients' body and mind. | Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. | Analgesic Effect Adverse Reactions | Clinic |
| 36034956 | However, this study showed that there was no statistical significance in the incidence of postoperative complications between the two groups (P > 0.05), suggesting that in addition to strengthening the analgesic effect, complications prevention and management should be done to further reduce the risk of complications in clinical. | Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. | Analgesic Effect Postoperative Complications | Clinic |
| 23573118 | Primary endpoint analysis revealed a statistically significant analgesic effect for both acupuncture treatments. | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Analgesic Effect | Clinic |
| 23573118 | Acupuncture revealed specific analgesic effects after sternotomy. | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Analgesic Effect | Clinic |
| 23573118 | Patients were informed that the study aimed to compare two different acupuncture treatments with respect to their analgesic effect after sternotomy. | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Analgesic Effect | Clinic |
| 23573118 | Primary endpoint analysis revealed a statistically significant analgesic effect for both acupuncture treatmentsxe2x80x94acupuncture in Group 1 resulted in a mean PPR of 18% (SD 19, P < 0.001), and acupuncture treatment in Group 2 yielded a mean PPR of 71% (SD 13, P < 0.001). | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Analgesic Effect | Clinic |
| 23573118 | Interestingly, only clinically significant analgesic effects (PPR xe2x89xa5 60%) led to functional improvements in lung function. | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Analgesic Effect | Clinic |
| 23573118 | The study period was short with no repeated acupuncture treatments, and the results only mirror immediate analgesic effects. | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Analgesic Effect | Clinic |
| 23573118 | The fact that the acupuncture treatment of Groups 1 and 2 differ in their analgesic effects in the present study indicates that it considerably matters which acupoints are used and contradicts the view that acupuncture might only mediate nonspecific skin stimulation, which may or may not exceed placebo effects. | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Analgesic Effect | Clinic |
| 23573118 | As imaging studies have delivered evidence of acupoint-specific functional magnetic resonance imaging patterns and the selection of acupoints presented the only systematic difference between acupuncture treatment in Groups 1 and 2, the observable difference in analgesic effects can be attributed to the summation effect of all twelve individual acupoint-specific reactions. | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Analgesic Effect | Clinic |
| 23573118 | However, it is also imaginable that psychological confounders may have distorted post-treatment pain assessment; minimal to moderate pain reductionsxe2x80x94as frequently observed in Group 1xe2x80x94are possibly underrated if patients were disappointed by the acupuncture treatment effect, while patients, who were positively surprised by the analgesic effect of acupuncture treatment, might tend to overrate its effect. | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Analgesic Effect | Clinic |
| 23342207 | Our results showed that electro-acupuncture alone had analgesic effects. | Korean J Pain. 2013 Jan;26(1):46-50. doi: 10.3344/kjp.2013.26.1.46. Epub 2013 Jan 4. | Analgesic Effect | Clinic |
| 15937559 | Reduced post-operative ibuprofen requirement and the decreasing trend of pain intensity the day following surgery compared with the sham procedure suggest an analgesic effect of AA applied to specific acupuncture points. | Evid Based Complement Alternat Med. 2005 Jun;2(2):185-189. doi: 10.1093/ecam/neh097. Epub 2005 May 11. | Analgesic Effect | Clinic |
| 15937559 | The unequal sex distribution between the two groups (female prevalence in the AA group and male prevalence in the control group) might only have diminished the difference between the groups in terms of ibuprofen requirement (suggested analgesic effect of AA), since women experience more acute pain than men and they also require more non-steroidal anti-inflammatory drugs. | Evid Based Complement Alternat Med. 2005 Jun;2(2):185-189. doi: 10.1093/ecam/neh097. Epub 2005 May 11. | Analgesic Effect | Clinic |
| 15937559 | We hesitate to make a final conclusion concerning the analgesic effects of AA based on the widely spread data of this initial study (Figure 2). | Evid Based Complement Alternat Med. 2005 Jun;2(2):185-189. doi: 10.1093/ecam/neh097. Epub 2005 May 11. | Analgesic Effect | Clinic |
| 15937559 | Indeed, it is well known that sham acupuncture produces an analgesic effect in 40xe2x80x9350% of patients, compared with 70% for true acupuncture. | Evid Based Complement Alternat Med. 2005 Jun;2(2):185-189. doi: 10.1093/ecam/neh097. Epub 2005 May 11. | Analgesic Effect | Clinic |
| 15937559 | Clearly, this weak analgesic effect of sham acupuncture may diminish the comparative effect of AA applied to specific points when only two groups (real AA and sham) are compared. | Evid Based Complement Alternat Med. 2005 Jun;2(2):185-189. doi: 10.1093/ecam/neh097. Epub 2005 May 11. | Analgesic Effect | Clinic |
| 24137250 | Our study indicated that EA, in addition to its analgesic effects, prevented the decrease of immunoglobulin after surgery. | Exp Ther Med. 2013 Sep;6(3):699-702. doi: 10.3892/etm.2013.1225. Epub 2013 Jul 16. | Analgesic Effect Immunity | Clinic |
| 26170873 | The underlying mechanisms of TEAS's analgesic effects have not been clearly clarified. | Evid Based Complement Alternat Med. 2015;2015:324360. doi: 10.1155/2015/324360. Epub 2015 Jun 11. | Analgesic Effect | Clinic |
| 28658163 | Acupuncture has an effect on the nervous system and immune system, which has analgesic effect, immune regulation, and regulation on the function of organs. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Analgesic Effect Immunity | Clinic |
| 32062864 | The acupuncturexe2x80x90drug compound anesthesia, referred to as transcutaneous electrical acupoint stimulation combined with general anesthesia, has been demonstrated to relieve perioperative anxiety, reduce intraoperative opioid consumption, and improve postoperative analgesic effect.3, 4 However, its application in modern lung surgery including videoxe2x80x90assisted thoracic surgery (VATS) has rarely been reported. | Thorac Cancer. 2020 Apr;11(4):928-934. doi: 10.1111/1759-7714.13343. Epub 2020 Feb 16. | Analgesic Effect Anxiety | Clinic |
| 32062864 | Lung surgery guidelines strongly recommend opioidxe2x80x90sparing analgesia and nausea and vomiting control to improve the quality of ERAS.12 There is a dosexe2x80x90response relationship between opioid use and adverse effects.13 Our data showed that TEAS reduced the postoperative sufentanil consumption by almost 16%, suggesting that TEAS may exert an analgesic effect. | Thorac Cancer. 2020 Apr;11(4):928-934. doi: 10.1111/1759-7714.13343. Epub 2020 Feb 16. | Analgesic Effect Adverse Reactions Nausea and Vomiting ERAS(Enhanced Recovery After Surgery) | Clinic |
| 32062864 | It is well known that the analgesic mechanism of acupuncture is related to endogenous opioid system activation.14 Laboratory studies have also shown that continuous electrical stimulation at one frequency could induce tolerance and weaken the analgesic effect.15, 16 Thus, dilatational wave stimulation has been popularly used in recent years, since it can promote the release of all three endogenous opioid peptides and delay analgesia tolerance under continuous electroacupuncture (EA) or TEAS.17 Highxe2x80x90intensity EA produces more extensive and enduring analgesic effect than lowxe2x80x90intensity EA due to the activation of brainstem negative feedback system by Axcexb4 fibers and also by C fibers under noxious stimulation. | Thorac Cancer. 2020 Apr;11(4):928-934. doi: 10.1111/1759-7714.13343. Epub 2020 Feb 16. | Analgesic Effect | Clinic |
| 32062864 | The human sensory threshold is about 5 mA and to promote the release of endogenous analgesic substances, the intensity of stimulation should be at least 2xe2x80x933 times the threshold.18 The acupoints Hegu and Houxi have a general analgesic effect according to the main and collateral channels theory in Traditional Chinese Medicine. | Thorac Cancer. 2020 Apr;11(4):928-934. doi: 10.1111/1759-7714.13343. Epub 2020 Feb 16. | Analgesic Effect | Clinic |
| 33154688 | Undergoing TEAS treatment perioperatively can improve sleep quality, and effectively promote the postoperative analgesic effect and alleviate postoperative complications. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Analgesic Effect Postoperative Complications Sleep Quality | Clinic |
| 33154688 | However, patients who underwent TEAS before and after the surgery had better perioperative sleep efficiency and subjective sleep quality, and TEAS promoted the postoperative analgesic effect and alleviated postoperative complications, as compared with patients in the control group. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Analgesic Effect Postoperative Complications Sleep Quality | Clinic |
| 33154688 | According to previous studies about the analgesic effect of stimulation at ST-36 (Zusanli) and LI-4 (Hegu) acupoints, we used these two acupoints in combination with PC6 (Neiguan) and HT7 (Shenmen) acupoints after surgery in our study. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Analgesic Effect | Clinic |
| 33488793 | Although weak opioids (for example, tramadol) and non-steroidal anti-inflammatory drugs cannot inhibit immune function, they are rarely used alone for postoperative pain control, given their weak analgesic effects and side effects. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Analgesic Effect Immunity Side Effects | Clinic |
| 33488793 | The results suggested that patients in the TEAS group displayed significantly lower VAS scores at 12 and 24 h post-operation, as well as reduced consumption of PCA within 48 h post-surgery, indicating that TEAS displayed potent analgesic effects, which was consistent with a previous study. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Analgesic Effect | Clinic |
| 33488793 | TEAS can also generate an action potential to activate nerve fibers as signals are transmitted to the central nervous system to induce corresponding analgesic effects by modulating the release of neurotransmitters, such as endorphins and enkephalins, and blocking pain signaling pathways. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Analgesic Effect | Clinic |
| 34682857 | Acupuncture on specific acupoints can produce an analgesic effect through descending pain modulation, especially by modulating PAG activity. | J Clin Med. 2021 Oct 15;10(20):4731. doi: 10.3390/jcm10204731. | Analgesic Effect | Clinic |
| 36749304 | Neuroimaging studies have shown that acupuncture can achieve analgesic effect by restoring the pain processing, regulating pain perception, improving abnormal structure, and functional activities of patients (Tian etxc2xa0al.,; Wen etxc2xa0al.,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Analgesic Effect | Clinic |
| 36749304 | The EA's analgesic effect on neuropathic pain may rely on the activation the brain functional connectivity between bilateral hemispheres and the sensorimotor cortex (Hou etxc2xa0al.,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Analgesic Effect Neuropathic Pain | Clinic |
| 36749304 | The descending pain modulation systems, including the anterior cingulated cortex, the periaqueductal gray, and the rostral ventromedial medulla, play an important role in the analgesic effect of EA (Chen etxc2xa0al.,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Analgesic Effect | Clinic |
| 36749304 | This may be attributed to the fact, the patients tended to limit their limb movement on the operative side to reduce the pain sensation due to the poor analgesic effect of SA. | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Analgesic Effect | Clinic |
| 34622872 | Our group preliminarily found that plum-blossom needle percussion, one of the acupuncture therapies in traditional Chinese medicine, combined with analgesic could significantly relieve CPSP in NSCLC patients and reduce the side effects of analgesic. | Medicine (Baltimore). 2021 Oct 8;100(40):e27461. doi: 10.1097/MD.0000000000027461. | Analgesic Effect Side Effects | Clinic |
| 17005164 | However, the underlying mechanisms of the analgesic effect of acupuncture are not fully understood. | Brain Res. 2006 Nov 20;1120(1):46-53. doi: 10.1016/j.brainres.2006.08.077. Epub 2006 Sep 26. | Analgesic Effect | Mechanism |
| 21680256 | Here, the involvement of spinal neurotrophin-3 (NT-3) in EA's analgesic effects on complete Freund's adjuvant (CFA)-induced inflammatory pain was examined. | J Pain. 2011 Sep;12(9):974-84. doi: 10.1016/j.jpain.2011.03.002. Epub 2011 Jun 15. | Analgesic Effect Inflammatory Pain | Mechanism |
| 21680256 | These results suggested that endogenous NT-3 may be involved in the analgesic effect of EA on inflammatory pain in rats, mediated through the inhibition of spinal glial activity as well as proinflammatory cytokine production. | J Pain. 2011 Sep;12(9):974-84. doi: 10.1016/j.jpain.2011.03.002. Epub 2011 Jun 15. | Analgesic Effect Inflammatory Pain | Mechanism |
| 21680256 | PERSPECTIVE: The present study may initiate a discussion on the possible roles of NT-3/glia/cytokines in the therapeutic effects of acupuncture and provide insight on the mechanism underlie the analgesic effects of acupuncture on pain associated with arthritis. | J Pain. 2011 Sep;12(9):974-84. doi: 10.1016/j.jpain.2011.03.002. Epub 2011 Jun 15. | Analgesic Effect | Mechanism |
| 10688051 | This study was performed to investigate the possibility of an increase in analgesic effect by adding manipulation to EA. | Neurosci Lett. 2000 Feb 4;279(3):149-52. doi: 10.1016/s0304-3940(99)00994-5. | Analgesic Effect | Mechanism |
| 20654703 | The results demonstrate that electroacupuncture (EA) had a long lasting and better analgesic effect than celecoxib in reducing neuropathic hypersensitivity. | Neuroscience. 2010 Oct 13;170(2):655-61. doi: 10.1016/j.neuroscience.2010.07.031. Epub 2010 Jul 25. | Analgesic Effect | Mechanism |
| 12406517 | The magnitude of this improvement was equivalent to that obtained after a systemic injection of 2mg/kg of morphine and this improvement of stepping pressure was interpreted as an analgesic effect. | Pain. 2002 Oct;99(3):423-431. doi: 10.1016/S0304-3959(02)00164-1. | Analgesic Effect | Mechanism |
| 12406517 | The analgesic effect was specific to the acupuncture point since (1). | Pain. 2002 Oct;99(3):423-431. doi: 10.1016/S0304-3959(02)00164-1. | Analgesic Effect | Mechanism |
| 12406517 | the analgesic effect on the ankle sprain pain model could not be mimicked by EA applied to a nearby point, LI-4 and (2). | Pain. 2002 Oct;99(3):423-431. doi: 10.1016/S0304-3959(02)00164-1. | Analgesic Effect | Mechanism |
| 12406517 | The analgesic effect could not be blocked by systemic injection of opioid antagonists naloxone or naltrexone. | Pain. 2002 Oct;99(3):423-431. doi: 10.1016/S0304-3959(02)00164-1. | Analgesic Effect | Mechanism |
| 12406517 | These data suggest that EA produces a potent analgesic effect on the ankle sprain pain model in the rat. | Pain. 2002 Oct;99(3):423-431. doi: 10.1016/S0304-3959(02)00164-1. | Analgesic Effect | Mechanism |
| 12406517 | This analgesic effect is produced by applying EA to a site remote from the painful area in a stimulus point-specific way. | Pain. 2002 Oct;99(3):423-431. doi: 10.1016/S0304-3959(02)00164-1. | Analgesic Effect | Mechanism |
| 19577620 | Prolonged analgesic effect of PLGA-encapsulated bee venom on formalin-induced pain in rats. | Int J Pharm. 2009 Oct 1;380(1-2):62-6. doi: 10.1016/j.ijpharm.2009.06.034. Epub 2009 Jul 3. | Analgesic Effect | Mechanism |
| 19577620 | BV-PLGA-NPs treatment showed comparable analgesic activity to typical BV acupuncture during the late phase, compared with saline-treated controls, and the analgesic effect lasted for 12h. | Int J Pharm. 2009 Oct 1;380(1-2):62-6. doi: 10.1016/j.ijpharm.2009.06.034. Epub 2009 Jul 3. | Analgesic Effect | Mechanism |
| 12297003 | Although the mechanism of neuropathic pain and analgesic effects of electroacupuncture (EA) have been studied in a rat model system, its detailed mechanism at the molecular level remains unclear. | J Biochem Mol Biol. 2002 Jul 31;35(4):420-7. doi: 10.5483/bmbrep.2002.35.4.420. | Analgesic Effect Neuropathic Pain | Mechanism |
| 12297003 | This indicates that opioid-signaling events are involved in neuropathic pain and the analgesic effects of EA. | J Biochem Mol Biol. 2002 Jul 31;35(4):420-7. doi: 10.5483/bmbrep.2002.35.4.420. | Analgesic Effect Neuropathic Pain | Mechanism |
| 26338695 | CONCLUSIONS: The up-regulation of TRPV1 and HSP70 expression in bone marrow cells may be involved in visceral pain development and the analgesic effect of moxibustion on VH may be mediated through down-regulation of TRPV1 and HSP70 expression in bone marrow cells. | Acupunct Med. 2016 Apr;34(2):114-9. doi: 10.1136/acupmed-2015-010788. Epub 2015 Sep 3. | Analgesic Effect Visceral Pain | Mechanism |
| 7345921 | These facts suggest that the analgesic effect induced by weak stimulation is not the result of direct excitation of afferent fibers but the result of subsequent activation of receptors provoked by tetanic muscular contraction. | Am J Chin Med. 1981 Summer;9(2):164-70. doi: 10.1142/s0192415x81000202. | Analgesic Effect | Mechanism |
| 19013506 | Warm needle acupuncture at Pungsi (GB31) has an enhanced analgesic effect on formalin-induced pain in rats. | Brain Res Bull. 2009 Mar 16;78(4-5):164-9. doi: 10.1016/j.brainresbull.2008.10.006. Epub 2008 Nov 14. | Analgesic Effect | Mechanism |
| 19013506 | We evaluated the analgesic effect of WNA treatment on formalin-induced pain behavior and c-Fos expression in the spinal cord of rats. | Brain Res Bull. 2009 Mar 16;78(4-5):164-9. doi: 10.1016/j.brainresbull.2008.10.006. Epub 2008 Nov 14. | Analgesic Effect | Mechanism |
| 20130880 | To investigate the analgesic effect of electroacupuncture (EA) pretreatment on carrageenan-induced inflammatory pain, we studied on the effect of EA parameters on an animal model of acute arthritic pain. | Rheumatol Int. 2011 Jun;31(6):725-30. doi: 10.1007/s00296-010-1364-y. Epub 2010 Feb 4. | Analgesic Effect Inflammatory Pain | Mechanism |
| 20130880 | These results suggested that the analgesic effect mediated by the mu OR during low-frequency contralateral EA pretreatment has an anti-nociceptive action against inflammatory pain and that it may provide a potential strategy to treat inflammatory arthritic pain. | Rheumatol Int. 2011 Jun;31(6):725-30. doi: 10.1007/s00296-010-1364-y. Epub 2010 Feb 4. | Analgesic Effect Inflammatory Pain | Mechanism |
| 19151301 | BACKGROUND: Acupuncture stimulation and phototherapy have been reported to have analgesic effects and improve the microcirculation. | Anesth Analg. 2009 Feb;108(2):635-40. doi: 10.1213/ane.0b013e31819317bc. | Analgesic Effect Microcirculation | Mechanism |
| 26846282 | Acupuncture tolerance is the gradual decrease in analgesic effect due to its prolonged application. | Mol Neurobiol. 2017 Mar;54(2):1429-1439. doi: 10.1007/s12035-016-9759-8. Epub 2016 Feb 4. | Analgesic Effect | Mechanism |
| 25074385 | Since excessive release of interferon-gamma (IFN-gamma) after nerve injury transforms quiescent spinal microglia into an activated state with more neuropathic pain, associated with purinergic receptor P2X4 expression, it is possible that EA may mediate its analgesic effect by attenuating IFN-gamma release and subsequent generation of P2X4R(+) microglia. | Br J Anaesth. 2015 Jan;114(1):150-7. doi: 10.1093/bja/aeu199. Epub 2014 Jul 29. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25074385 | However, EA did not exert the same analgesic effect after intrathecal IFN-gamma injection. | Br J Anaesth. 2015 Jan;114(1):150-7. doi: 10.1093/bja/aeu199. Epub 2014 Jul 29. | Analgesic Effect | Mechanism |
| 19409856 | In this report, we determined the effect of electroacupuncture (EA) on the level of anandamide in the skin tissue and the role of cannabinoid CB1 and CB2 receptors in the analgesic effect of EA in an animal model of inflammatory pain. | J Pain. 2009 Jul;10(7):732-9. doi: 10.1016/j.jpain.2008.12.012. Epub 2009 May 5. | Analgesic Effect Inflammatory Pain | Mechanism |
| 19409856 | Activation of peripheral CB2 receptors contributes to the analgesic effect of EA on inflammatory pain. | J Pain. 2009 Jul;10(7):732-9. doi: 10.1016/j.jpain.2008.12.012. Epub 2009 May 5. | Analgesic Effect Inflammatory Pain | Mechanism |
| 19409856 | PERSPECTIVE: This study shows that electroacupuncture increases the anandamide level in inflammatory skin tissues, and CB2 receptors contribute to the analgesic effect of electroacupuncture in a rat model of inflammatory pain. | J Pain. 2009 Jul;10(7):732-9. doi: 10.1016/j.jpain.2008.12.012. Epub 2009 May 5. | Analgesic Effect Inflammatory Pain | Mechanism |
| 19409856 | This information improves our understanding of the mechanisms involved in the analgesic effect of acupuncture. | J Pain. 2009 Jul;10(7):732-9. doi: 10.1016/j.jpain.2008.12.012. Epub 2009 May 5. | Analgesic Effect | Mechanism |
| 11849761 | The analgesic effects of acupuncture on the mechanical allodynia in the rat model of neuropathic pain have not yet been studied. | Neurosci Lett. 2002 Mar 1;320(1-2):49-52. doi: 10.1016/s0304-3940(02)00027-7. | Analgesic Effect Neuropathic Pain | Mechanism |
| 19010737 | Acupoint stimulation with diluted bee venom (apipuncture) potentiates the analgesic effect of intrathecal clonidine in the rodent formalin test and in a neuropathic pain model. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect Neuropathic Pain | Mechanism |
| 19010737 | administration of the alpha(2)-adrenoceptor agonist clonidine has a pronounced analgesic effect, the clinical use of clonidine is limited by its side effects. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect Side Effects | Mechanism |
| 19010737 | Previously, our laboratory has demonstrated that the subcutaneous injection of diluted bee venom (DBV) into an acupoint (termed apipuncture) produces significant analgesic effect in various pain animal models. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect | Mechanism |
| 19010737 | The present study was designed to examine whether DBV injection into the Zusanli acupoint (ST-36) could enhance lower-dose clonidine-induced analgesic effects without the development of hypotension, bradycardia, or sedation. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect Sedation | Mechanism |
| 19010737 | clonidine dose dependently suppressed chronic constriction injury (CCI)-induced mechanical allodynia and thermal hyperalgesia, and this clonidine-induced analgesic effect was significantly potentiated by apipuncture pretreatment. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect | Mechanism |
| 19010737 | clonidine produced an analgesic effect similar to that of the high dose of clonidine, but without significant side effects. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect Side Effects | Mechanism |
| 19010737 | The analgesic effect produced by the combination of i.t. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect | Mechanism |
| 19010737 | The administration of low-dose clonidine in combination with acupuncture produced a potent analgesic effect without significant side effects and thus represents a potential novel strategy for the management of chronic pain. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect Side Effects | Mechanism |
| 16376128 | Single EA on day 8 after inoculation showed significant analgesic effect immediately after the treatment, the analgesic effect reached its maximum within 15-30min and declined to its minimum at 50min after EA treatment. | Eur J Pain. 2006 Nov;10(8):689-94. doi: 10.1016/j.ejpain.2005.11.001. Epub 2005 Dec 22. | Analgesic Effect | Mechanism |
| 16376128 | Single EA treatment on day 20 showed no significant analgesic effect; Repeated EA treatments (started from day 8, once every other day) showed therapeutic analgesic effect, while it showed no therapeutic effect when started from day 16, a relatively late stage of this cancer pain model. | Eur J Pain. 2006 Nov;10(8):689-94. doi: 10.1016/j.ejpain.2005.11.001. Epub 2005 Dec 22. | Analgesic Effect Cancer Pain | Mechanism |
| 22269805 | Analgesic effect of electroacupuncture on chronic neuropathic pain mediated by P2X3 receptors in rat dorsal root ganglion neurons. | Neurochem Int. 2012 Mar;60(4):379-86. doi: 10.1016/j.neuint.2012.01.006. Epub 2012 Jan 18. | Analgesic Effect Neuropathic Pain | Mechanism |
| 22269805 | EA may be expected to induce an apparent induce analgesic effect by decreasing expression and inhibiting P2X(3) receptors in DRG neurons of CCI rats. | Neurochem Int. 2012 Mar;60(4):379-86. doi: 10.1016/j.neuint.2012.01.006. Epub 2012 Jan 18. | Analgesic Effect | Mechanism |
| 22269805 | There is a similar effect on analgesic effect between rats with contralateral EA and those with ipsilateral EA. | Neurochem Int. 2012 Mar;60(4):379-86. doi: 10.1016/j.neuint.2012.01.006. Epub 2012 Jan 18. | Analgesic Effect | Mechanism |
| 35138669 | PAP protein but not mRNA increased in L4-L5 DRGs, and inhibition of PAP expression via AAV microinjection reversed the analgesic effect of EA. | Eur J Pain. 2022 May;26(5):991-1005. doi: 10.1002/ejp.1923. Epub 2022 Feb 17. | Analgesic Effect | Mechanism |
| 16356296 | Analgesic effect of electroacupuncture on complete Freund's adjuvant-induced inflammatory pain in mice: a model of antipain treatment by acupuncture in mice. | Jpn J Physiol. 2005 Dec;55(6):339-44. doi: 10.2170/jjphysiol.RP001505. Epub 2005 Dec 17. | Analgesic Effect Inflammatory Pain | Mechanism |
| 31219313 | CONCLUSION: TEAS treatment may produce an analgesic effect, probably by inhibiting the expression of p-JNK in the DRG of rats with MPS. | Acupunct Med. 2019 Oct;37(5):312-318. doi: 10.1136/acupmed-2017-011536. Epub 2019 Jun 20. | Analgesic Effect | Mechanism |
| 6978757 | Sixteen dogs were used to study the analgesic effects of electroacupuncture. | Can Anaesth Soc J. 1982 May;29(3):231-5. doi: 10.1007/BF03007122. | Analgesic Effect | Mechanism |
| 24513344 | In conclusion, EA can provide general analgesia with a considerable analgesic effect for a rabbit undergoing an ovariohysterectomy, resulting in a short postoperative recovery time. | J Acupunct Meridian Stud. 2014 Feb;7(1):15-24. doi: 10.1016/j.jams.2013.05.004. Epub 2013 Jun 19. | Analgesic Effect | Mechanism |
| 2872776 | These effects might explain some part of the analgesic effect of acupuncture. | Acupunct Electrother Res. 1986;11(1):15-23. doi: 10.3727/036012986816359247. | Analgesic Effect | Mechanism |
| 26104377 | CONCLUSIONS: TENS at both local (BL23) and distant (ST36) acupuncture points had a pain-relieving effect in rats with the third lumbar vertebrae transverse process syndrome, and LAS appeared to have greater anti-inflammatory and analgesic effects than DAS. | Acupunct Med. 2015 Oct;33(5):400-5. doi: 10.1136/acupmed-2014-010752. Epub 2015 Jun 23. | Analgesic Effect | Mechanism |
| 37519181 | The analgesic effect of ACE through the TRPV1 pathway may reflect its potential as a therapeutic target for FM treatment. | J Integr Neurosci. 2023 Jul 17;22(4):97. doi: 10.31083/j.jin2204097. | Analgesic Effect | Mechanism |
| 484537 | The analgesic effect in both the donor and recipient was abolished by the pretreatment of naloxone. | Am J Chin Med. 1979 Summer;7(2):143-8. doi: 10.1142/s0192415x79000118. | Analgesic Effect | Mechanism |
| 29436370 | Isoflurane and the Analgesic Effect of Acupuncture and Electroacupuncture in an Animal Model of Neuropathic Pain. | J Acupunct Meridian Stud. 2018 Jun;11(3):97-106. doi: 10.1016/j.jams.2018.01.004. Epub 2018 Feb 6. | Analgesic Effect Neuropathic Pain | Mechanism |
| 29436370 | The present study aimed to determine whether isoflurane interferes with the analgesic effects of acupuncture (Ac) and electroacupuncture (EA), using a neuropathic pain (NP) rat model. | J Acupunct Meridian Stud. 2018 Jun;11(3):97-106. doi: 10.1016/j.jams.2018.01.004. Epub 2018 Feb 6. | Analgesic Effect Neuropathic Pain | Mechanism |
| 29436370 | Isoflurane enhanced the analgesic effects of Ac and EA and altered serum S100beta and left sciatic nerve NGF levels in rats with NP. | J Acupunct Meridian Stud. 2018 Jun;11(3):97-106. doi: 10.1016/j.jams.2018.01.004. Epub 2018 Feb 6. | Analgesic Effect | Mechanism |
| 34562596 | Adiponectin regulates electroacupuncture-produced analgesic effects in association with a crosstalk between the peripheral circulation and the spinal cord. | Brain Behav Immun. 2022 Jan;99:43-52. doi: 10.1016/j.bbi.2021.09.010. Epub 2021 Sep 22. | Analgesic Effect Circulation | Mechanism |
| 34562596 | Adiponectin (APN), a circulating adipokine, shows analgesic effects. | Brain Behav Immun. 2022 Jan;99:43-52. doi: 10.1016/j.bbi.2021.09.010. Epub 2021 Sep 22. | Analgesic Effect Circulation | Mechanism |
| 34562596 | The study aimed to examine whether APN regulates analgesic effects of electroacupuncture (EA) in the complete Freund's adjuvant (CFA)-induced mouse model. | Brain Behav Immun. 2022 Jan;99:43-52. doi: 10.1016/j.bbi.2021.09.010. Epub 2021 Sep 22. | Analgesic Effect | Mechanism |
| 34562596 | The deletion of APN significantly reduced the acupuncture analgesia in the CFA-treated APN KO mice while the intrathecal administration of APN mimicked the analgesic effects of EA. | Brain Behav Immun. 2022 Jan;99:43-52. doi: 10.1016/j.bbi.2021.09.010. Epub 2021 Sep 22. | Analgesic Effect | Mechanism |
| 34562596 | We further revealed that EA produced analgesic effects mainly via APN/AdipoR2-mediated AMPK pathway by the siRNA inhibitions of APN receptors (adipoR1/2) in the spinal cord. | Brain Behav Immun. 2022 Jan;99:43-52. doi: 10.1016/j.bbi.2021.09.010. Epub 2021 Sep 22. | Analgesic Effect | Mechanism |
| 34562596 | In conclusion, the study indicates a novel mechanism that acupuncture produces analgesic effects at least partially via APN/AdipoR2-AMPK pathway in the spinal cord. | Brain Behav Immun. 2022 Jan;99:43-52. doi: 10.1016/j.bbi.2021.09.010. Epub 2021 Sep 22. | Analgesic Effect | Mechanism |
| 27707699 | CONCLUSIONS: The use of low frequency TEAS significantly mitigated neuropathic pain in this rat model, and its analgesic effect is likely mediated by upregulation of MOR expression in the DRG. | Acupunct Med. 2017 Apr;35(2):142-147. doi: 10.1136/acupmed-2016-011063. Epub 2016 Oct 4. | Analgesic Effect Neuropathic Pain | Mechanism |
| 37548586 | Our group has previously found that electroacupuncture (EA) has a good analgesic effect on CSR. | Brain Behav. 2023 Oct;13(10):e3177. doi: 10.1002/brb3.3177. Epub 2023 Aug 7. | Analgesic Effect | Mechanism |
| 37548586 | EA mediates central sensitization and exerts analgesic effects on CSR by modulating spinal synaptic plasticity, which may be related to the inhibition of CaMKII/CREB/BDNF signaling pathway. | Brain Behav. 2023 Oct;13(10):e3177. doi: 10.1002/brb3.3177. Epub 2023 Aug 7. | Analgesic Effect | Mechanism |
| 37548586 | Electroacupuncture mediates central sensitization and exerts analgesic effects on CSR by modulating spinal synaptic plasticity, which may be related to the inhibition of CaMKII/CREB/BDNF signaling pathway. | Brain Behav. 2023 Oct;13(10):e3177. doi: 10.1002/brb3.3177. Epub 2023 Aug 7. | Analgesic Effect | Mechanism |
| 30883553 | The analgesic effect of LA on chronic pain has been proven by photobiomodulation through acupuncture points and it is an alternative to low-level laser therapy. | PLoS One. 2019 Mar 18;14(3):e0211341. doi: 10.1371/journal.pone.0211341. eCollection 2019. | Analgesic Effect | Mechanism |
| 30883553 | Among all the proposed mechanisms by which acupuncture works, the anti-inflammatory effect has been the most often mentioned and is supposed to provide nonanalgesic effects via suppression of the inflammatory response, improved blood flow, or relaxation of muscle tone, but they are still largely conjectural. | PLoS One. 2019 Mar 18;14(3):e0211341. doi: 10.1371/journal.pone.0211341. eCollection 2019. | Analgesic Effect Blood Flow | Mechanism |
| 30883553 | In our study, LA significantly reduced ankle edema and inflammation-induced hyperalgesia in AIA rats, which is consistent with the results of previous research, indicating the analgesic effects of LA in the AIA model. | PLoS One. 2019 Mar 18;14(3):e0211341. doi: 10.1371/journal.pone.0211341. eCollection 2019. | Analgesic Effect | Mechanism |
| 32796318 | Overall, the results showed that the acupoints had an analgesic effect. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Analgesic Effect | Mechanism |
| 32796318 | These pathway genes play important roles in the analgesic effect of acupuncture. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Analgesic Effect | Mechanism |
| 34564665 | Bee venom (BV) acupuncture has anti-inflammatory and analgesic effects; therefore, it was used as a traditional Korean medicine for various musculoskeletal disorders, especially arthritis. | Toxins (Basel). 2021 Sep 16;13(9):661. doi: 10.3390/toxins13090661. | Analgesic Effect | Mechanism |
| 25481535 | Several animal studies have demonstrated that the analgesic effects of BVA are mediated mainly by activation of α2-adrenergic and/or serotonergic receptors in various pain models, such as nerve injury-induced neuropathic pain, acetic acid-induced visceral pain and inflammatory pain. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Analgesic Effect Visceral Pain Neuropathic Pain Inflammatory Pain | Mechanism |
| 25481535 | These results suggest that the serotonergic system plays a major role in mediating the analgesic effect of BVA on oxaliplatin-induced cold allodynia. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Analgesic Effect | Mechanism |
| 25481535 | Unlike the EA-induced analgesia mainly involving the endogenous opioid system, the analgesic effects of BVA are known to be mediated by the non-opioid, descending noradrenergic system. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Analgesic Effect | Mechanism |
| 25481535 | This implies that BVA exerts a potent analgesic effect on oxaliplatin-induced cold allodynia by activating the spinal serotonergic inhibitory system. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Analgesic Effect | Mechanism |
| 25481535 | It has been known that spinal administration of 5-HT produces analgesic effects, depending on the receptor type activated and dosage use. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Analgesic Effect | Mechanism |
| 25481535 | And the analgesic effect of serotonin is reported to be mediated by the descending pain inhibitory system from periaqueductal grey, nucleus raphe magnus and finally spinal serotonergic receptors. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Analgesic Effect | Mechanism |
| 26184310 | One of the pain therapies is the use of chemical stimulation into an acupuncture point to produce an analgesic effect and to reduce pain severity. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Analgesic Effect | Mechanism |
| 26184310 | In this regard, the injection of diluted bee venom (DBV) into an acupuncture point, termed apipuncture, has been used clinically in traditional Korean medicine to produce a significant analgesic effect in human patients. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Analgesic Effect | Mechanism |
| 26184310 | Thus, the present study was designed to examine the following: (1) whether repetitive DBV acupuncture point treatment for five days during the induction and maintenance phases following thoracic 13 (T13) spinal cord hemisection would produce a more potent and prolonged analgesic effect compared to controls that received repetitive injections of vehicle; (2) whether the anti-nociceptive effect of DBV is mediated by the modulation of spinal astrocyte and microglia activation; and (3) whether repetitive DBV treatment affects motor functional recovery in SCI rats. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Analgesic Effect Motor Function | Mechanism |
| 26184310 | Collectively, these findings, including the present results, imply that repetitive DBV acupuncture therapy during the induction phase is able to produce a powerful analgesic effect on chronic central neuropathic pain and suggest the clinical use of repetitive DBV treatment as a potential novel strategy in the early management of SCI-induced neuropathic pain. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25158599 | NK cells mediate the cumulative analgesic effect of electroacupuncture in a rat model of neuropathic pain | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25158599 | Repeated EA interventions have a time-dependent cumulative analgesic effect in neuropathic pain rats, which is closely associated with its regulatory effects on NK cells, splenic IL-2, β-EP, and plasma IL-2, IL-1β, IFN-γ and TGF-β levels. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25158599 | The analgesic effect of EA peaked after several successive sessions of treatment. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Analgesic Effect | Mechanism |
| 25158599 | It suggests an apparent cumulative analgesic effect of repeated EA intervention. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Analgesic Effect | Mechanism |
| 25158599 | These results suggest that splenic and plasma NK cells participated in the repeated EA intervention-induced cumulative analgesic effect in CCI rats. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Analgesic Effect | Mechanism |
| 25158599 | Successive EA interventions have a time-dependent cumulative analgesic effect in neuropathic pain rats, which is closely associated with its regulatory effects on NK cells, splenic IL-2, β-EP, and plasma IL-2, IL-1β, IFN-γ and TGF-β levels. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25158599 | As an effect cell involving this cumulative analgesic effect, NK cell may be a functional bridge between the cumulative analgesic effect of EA and the immune activity and may be a target for EA analgesia. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Analgesic Effect Immunity | Mechanism |
| 24612851 | Third, agonist of the channels were injected into ST36 and tested in a mouse inflammatory pain model to seek if agonist injection could replicate acupuncture-like analgesic effect. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect Inflammatory Pain | Mechanism |
| 24612851 | However, only capsaicin, a TRPV1 agonist, replicated the analgesic effect of acupuncture when injected into ST36. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | This was first demonstrated by the abundant mechanosensitive channels expression at neural and non-neural tissues of Zusanli acupoint (ST36) followed by the replication of the acupuncture analgesic effect after injecting agonist of the channels into ST36. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | Manual acupuncture had an analgesic effect at ST36 but not at the sham point | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | Manual acupuncture (MA) at ST36 yielded an analgesic effect in mouse CFA inflammatory pain model. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect Inflammatory Pain | Mechanism |
| 24612851 | The observation that the analgesic effect was only observed in the MA group implies that acupuncture analgesia can only be induced on acupoints and that manipulation is vital for the effect. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | Injection of the TRPV1 agonist capsaicin into ST36 replicated the acupuncture-like analgesic effect | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | Next, we aimed to determine whether the activation of these channels would produce an acupuncture-like analgesic effect. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | TRPV1 agonist (capsaicin) injection at ST36 replicated the analgesic effect of acupuncture. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | TRPV4 agonist (GSK1016790A) injection at ST36 yielded no analgesic effect. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | ASIC3 agonist (acidified saline) injection at ST36 yielded no analgesic effect. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | As only capsaicin produced an analgesic effect similar to that of MA, the change of ratio between MA and 0.5% capsaicin injection were then compared. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | This study also demonstrated an acupuncture-like analgesic effect of capsaicin injection at ST36. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | Also, it has been proven that stimulation but not inhibition of peroneal nerve would result in analgesic effect to nociception. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | Capsaicin stimulation releases glutamate and substance P at the spinal dorsal horn, activating NMDA, AMPA/kainate, mGluR5, and NK1 receptors on inhibitory interneurons and releases GABA or glycine to provide an analgesic effect. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | However, capsaicin was also injected into the sham point, but with no analgesic effect. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | As acids can also activate TRPV1, it is worth asking why the acidified saline injection did not activate TRPV1 and provide analgesic effects, similar to capsaicin. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | One may ask why TRPV4 and ASIC3 injections did not yield analgesic effects similar to TRPV1. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | Moreover, directly block of the MA analgesic effect with antagonists of mechanosensitive channels was not performed. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 24612851 | Nonetheless, replicating the MA analgesic effect by injecting capsaicin into acupoint ST36 may provide knowledge on the functional role of TRPV1 at acupoints. | BMC Complement Altern Med. 2014 Mar 11;14:96. doi: 10.1186/1472-6882-14-96. | Analgesic Effect | Mechanism |
| 26438555 | Nevertheless, the exact mechanisms underlying the analgesic effect of acupuncture (including pretreatment) on migraine have not yet been determined. | Acupunct Med. 2016 Apr;34(2):127-35. doi: 10.1136/acupmed-2015-010840. Epub 2015 Oct 5. | Analgesic Effect | Mechanism |
| 23173601 | OXA at 0.3 nmol and EA at 2/15 Hz produced respective analgesic effects on the model (P<0.05). | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Pre-surgical intrathecal administered of SB-334867 30 nmol antagonized OXA analgesia and attenuated the analgesic effect of EA (P<0.05). | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Although the opioid system is definitely involved in acupuncture analgesia, naloxone, an opioid receptor antagonist, can only partially block the analgesic effect of acupuncture. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | orphanin FQ, cholecystokinin, neuropeptide Y, neurokinin A, and substance P, to achieve therapeutic as well as analgesic effects. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Using a modified post-laparotomy pain model, which is more closely related to clinical use, the present study was intended to (1) examine the change in OXA levels both in the rat model of post-laparotomy pain and after EA treatment of the model; (2) evaluate the modified rat model of post-laparotomy pain and observe the analgesic effect of intrathecal injected OXA and EA application on the model; (3) test the inhibitory effect of the selective OX1R antagonist, SB-334867, on OXA and EA analgesia; and (4) further verify whether OXA analgesia was independent of the opioid system in the rat model of post-laparotomy pain. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Acupuncture and OXA were separately employed in the pain model to test whether they had an analgesic effect. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | To verify whether OXA has an analgesic effect on the model, rats received intrathecally administered OXA (0.1, 0.3 and 1.0 nmol, n=8 per group) or drug-vehicle (normal saline 10 μL, n=6) after surgery at time 0. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | To explore the EA analgesic effect on the rat model, EA was applied perioperatively for 30 min, i.e., EA stimulation (2/15 Hz or 2/100 Hz) begun 10 min before surgery and ended 10 min after surgery. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | To explore whether OXA produces its analgesic effect via OX1R, the selective OX1R antagonist SB-334867 (30 nmol, n=7) or drug-vehicle (DMSO, 10 μL, n=8) was intrathecally administered prior to surgery OXA with the minimum effective dose selected from (c) was intrathecally administered post-surgery. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Figure 3A shows that 0.1 nmol OXA did not have an analgesic effect after surgery, whereas OXA at 0.3 and 1.0 nmol increased ACT significantly at 0.5 h compared with the saline group (P<0.05). | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Pre-surgical treatment with SB-334867 (SB-pr) significantly decreased EA analgesia (P<0.05 by one way ANOVA with LSD test) (Figure 3D), while post-surgical administration of SB-334867 (SB-ps) did not decrease the EA analgesic effect. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | The OXA analgesic effect was not blocked by intrathecal administration of naloxone (A). | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | The fentanyl-induced analgesic effect was not blocked by intrathecal administration of SB-334867 (B). | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | The allodynia could be relieved by fentanyl in a dose-dependent manner with a limited time course of 2 h. OXA at 0.3 nmol and EA at 2/15 Hz both showed analgesic effects in the rat model. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Among these factors, frequency is a key factor affecting the analgesic effect of EA. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | We selected 2/15 Hz and 2/100 Hz for EA administration and compared the analgesic effects of these two frequencies. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Our results show that 2/15 Hz produced a better analgesic effect in the rat model. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Therefore, this frequency of EA can produce a strong analgesic effect. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | We can infer it is because EA activated OXA release to achieve the analgesic effect, which was proven by the ELISA. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Because EA mainly achieves its analgesic effect by stimulating the release of opioid peptides, whether SB-334867 blocked EA in an opioid-dependent way was also studied. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Therefore, naloxone mainly antagonizes the analgesic effect of endorphins, as well as part of the effects of dynorphin and enkephalin. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | This result has shown that EA can regulate the descending inhibitory system to achieve an analgesic effect. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 23173601 | Intrathecal administered of OX1R antagonist SB-334867 antagonized OXA analgesia and attenuated the analgesic effect of EA, but did not block fentanyl-induced analgesia. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Analgesic Effect | Mechanism |
| 36510338 | In the present study, EA reduced mechanical allodynia and the degree of joint swelling in KOA rats, suggesting that EA has an analgesic effect and improves functional mobility impairment. | Mol Pain. 2023 Jan-Dec;19:17448069221147792. doi: 10.1177/17448069221147792. | Analgesic Effect Inflammatory Pain | Mechanism |
| 24980520 | Sprague-Dawley (SD) rats were divided into the responder and the non-responder groups, based on EA-induced analgesic effects in the tail flick latency (TFL) test, which measures the latency of the tail flick response elicited by radiant heat applied to the tail. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect | Mechanism |
| 24980520 | Electroacupuncture (EA) is a modified technique that utilizes electrical stimulation to enhance the analgesic effects of acupuncture. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect | Mechanism |
| 24980520 | The analgesic effects of EA on acute thermal pain were quantified using the TFL test, which measures the latency of the tail flick response elicited by radiant heat applied to the proximal third of the tail. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect | Mechanism |
| 24980520 | The analgesic effects are expressed as percent changes from the pre-EA TFL. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect | Mechanism |
| 24980520 | To see whether WT AMPK virus and DN AMPK virus gene expression in the hypothalamus alter EA-induced analgesic effects, we compared the TFL increase ratio between the WT AMPK virus-injected and DN AMPK virus-injected rats. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect | Mechanism |
| 24980520 | In consistent with the role of DN AMPK virus transfection in inhibiting AMPK activity, EA-induced analgesic effects were markedly decreased in a time dependent manner after microinjection of DN AMPK virus into the hypothalamus (Figure 4). | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect | Mechanism |
| 24980520 | The analgesic effects of EA also show marked individual differences in acute, inflammatory and neuropathic pain rats. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect Neuropathic Pain | Mechanism |
| 24980520 | EA-induced analgesic effects were gradually decreased and slightly increased after injection of DN AMPK virus and WT AMPK virus, respectively, producing a significant difference between the two groups at 7 and 14Â days post-injection. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect | Mechanism |
| 24980520 | Consistent with these reports, there was no significant increase in EA-induced analgesic effect after WT AMPK virus injection. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect | Mechanism |
| 24980520 | Also, it would be interesting to examine the analgesic effects of EA on pathological pain, such as neuropathic pain, the mechanism of which is somewhat different from acute pain (e.g. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Analgesic Effect Neuropathic Pain | Mechanism |
| 27301303 | It is well known that analgesic effects of acupuncture are systemic. | Sci Rep. 2016 Jun 15;6:28018. doi: 10.1038/srep28018. | Analgesic Effect | Mechanism |
| 29981376 | Results from preclinical studies of neuropathic and inflammatory pain disorders suggest that the analgesic effects of acupuncture are due, in large part, to reducing the activity of glial cells involved in neuroinflammation. | J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. | Analgesic Effect Inflammatory Pain | Mechanism |
| 29981376 | Stimulation of ST36 has a systemic analgesic effect, suppressing pain in patients with conditions that affect many different body sites. | J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. | Analgesic Effect | Mechanism |
| 29981376 | The analgesic effect of acupuncture on persistent pain is greater in MRL/MpJ mice compared to C57BL/6 mice | J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. | Analgesic Effect | Mechanism |
| 29981376 | Pre-clinical studies in animal models of nerve injury and inflammation have demonstrated that the analgesic effects of acupuncture are mediated, in large part, through the resolution of inflammation in the periphery and CNS. | J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. | Analgesic Effect | Mechanism |
| 29981376 | The mechanisms underlying the analgesic effects of acupuncture for COPCs, however, have remained unknown. | J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. | Analgesic Effect | Mechanism |
| 29981376 | While these findings seem inconsistent with the ability of antidepressants to alleviate persistent pain by increasing synaptic levels of catecholamines, it is important to note that the analgesic effect of antidepressants is associated with descending inhibition of pain via actions at α2ARs or D2DARs in the spinal dorsal horn, while COMT-dependent pain is mediated by peripheral β2- and β3ARs. | J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. | Analgesic Effect | Mechanism |
| 29981376 | Studies of patients with painful inflammatory conditions such as rheumatoid arthritis and prostatitis have also demonstrated that the analgesic effects of acupuncture are associated with reduced plasma levels of TNFα and other pro-inflammatory cytokines following treatment. | J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. | Analgesic Effect Inflammatory Pain | Mechanism |
| 29981376 | Acupuncture may produce its analgesic effects through dynamic alterations in the tissue and extracellular milieu which directly or indirectly influence the activity of innervating nociceptors. | J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. | Analgesic Effect | Mechanism |
| 29981376 | The analgesic effect of acupuncture varies among patients and mouse strains, such that some respond better than others. | J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. | Analgesic Effect | Mechanism |
| 24524846 | To determine possible bio-candidates involved in the mechanisms of acupuncture and investigate the role of such bio-candidates in the analgesic effects of acupuncture, we conducted 2 stepwise experiments. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | This article presents the novel evidence of the local molecular signaling in acupuncture analgesia by demonstrating that ERK activation in the skin layer contributes to the analgesic effect of acupuncture in a mouse pain model. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | Although previous studies have provided important information about the local changes around acupuncture points, few studies have investigated the local molecular and cellular mechanisms that are responsible for the analgesic effects of acupuncture. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | To test this hypothesis, the aims of this study were 1) to identify molecular entities following acupuncture needling at the local skin level and 2) to investigate the role of such identified molecules on the analgesic effects of acupuncture. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | To our knowledge, this is the first study to report molecular changes related to acupuncture needling and to suggest that they are biochemical hallmarks that initiate the effects of acupuncture, including analgesic effects. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | In our pilot experiment, this acupoint showed more significant analgesic effect than adjacent points in the formalin test (Supplementary Fig S1). | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | The Involvement of Local Molecular Changes in the Analgesic Effects of Acupuncture | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | To examine whether acupuncture-induced ERK activation is involved in the analgesic effects of acupuncture, we used the MEK/MAPK inhibitor U0126 in the formalin-induced and CFA-induced mouse pain model. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | We confirmed the analgesic effect of acupuncture and the blocking effect of U0126 on CFA-induced mechanical allodynia (Fig 8A). | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | The analgesic effect of acupuncture in the CFA-induced mechanical allodynia was attenuated by the U0126 injection into the skin layer (P < .05 at 10 minutes, P < .001 at 20 and 30 minutes). | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | In this study, we found that acupuncture needling provoked ERK activation in the fibroblasts and keratinocytes of the skin layer and that the analgesic effect of acupuncture was blocked by the MEK/MAPK inhibitor U0126. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | These results suggest that ERK activation in the skin layer is a key inducer of the analgesic effect of acupuncture. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | To our knowledge, this is the first study to explore the molecular changes around the acupuncture point in relation to the analgesic effects of acupuncture. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | These factors might influence the extracellular environment surrounding the skin tissue and then trigger subsequent processes to produce analgesic effects. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | Recently, Goldman et al reported that ATP and adenosine are released after acupuncture needling around the local muscle or subcutis of the acupuncture point and determined that the analgesic effect of acupuncture requires the adenosine A1 receptor. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | Zylka et al also confirmed the analgesic effect of acupuncture by injecting phosphatidic acid phosphatase, which is known to induce a local adenosine release. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | Several lines of research proposed that acupuncture can produce analgesic effects by both central and peripheral mechanisms. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | Release of these substances influences the extracellular environments surrounding skin tissue cells and may participate in local analgesic effects in part. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | U0126 administration reversed the analgesic effect of acupuncture needling in the formalin-induced pain model. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 24524846 | U0126 administration reversed the analgesic effect of acupuncture needling on the CFA-induced mechanical threshold. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Analgesic Effect | Mechanism |
| 29034548 | It has also been shown that the 5-HT1A receptor antagonists blocked EA-induced analgesic effects in formalin-induced and collagen-induced arthritis pain model. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Analgesic Effect | Mechanism |
| 36003380 | The analgesic effect of EA stimulation is well documented, and a recent study demonstrated that EA stimulation ameliorated cognitive impairment via inhibition of synaptic degeneration and neuroinflammation in a mouse model of AD. | Front Immunol. 2022 Aug 8;13:955581. doi: 10.3389/fimmu.2022.955581. eCollection 2022. | Analgesic Effect | Mechanism |
| 22524543 | Notably, transcutaneous electrical nerve stimulation (TENS) is used clinically to reduce the intensity and unpleasantness of pain in humans, and caffeine (but not placebo) at a dose equivalent to two to three cups of coffee can block these analgesic effects of TENS. | Mol Pain. 2012 Apr 23;8:28. doi: 10.1186/1744-8069-8-28. | Analgesic Effect | Mechanism |
| 38026466 | Local acupuncture has been found to have a good analgesic effect in rats with cervical spondylosis radiculopathy (CSR), but it lacks a regulatory effect on traditional Chinese medicine syndrome types of CSR. | J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. | Analgesic Effect | Mechanism |
| 38026466 | Previous studies have shown that ibuprofen mainly exerts analgesic effects by inhibiting the synthesis of prostaglandins, but also downregulating of systemic inflammatory biomarkers such as IL-6 in serum of NP patients. | J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. | Analgesic Effect | Mechanism |
| 38026466 | Recent studies have found that electroacupuncture at ST36 could produce analgesic effects by reducing tyrosine kinase B receptor and microglial activation-induced BDNF in the spinal cord of rats with chronic constrictive injury. | J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. | Analgesic Effect | Mechanism |
| 33398365 | Furthermore, a previous study has demonstrated that DRG P2X3R is involved in the analgesic effect of EA in rat models of chronic constriction injury. | Mol Med Rep. 2021 Mar;23(3):175. doi: 10.3892/mmr.2020.11814. Epub 2021 Jan 5. | Analgesic Effect | Mechanism |
| 33398365 | In light of the downregulated P2X4R mRNA and protein expression levels in the EA group, the present study demonstrated that the analgesic effects of EA analgesia may be mediated in part by P2X4R. | Mol Med Rep. 2021 Mar;23(3):175. doi: 10.3892/mmr.2020.11814. Epub 2021 Jan 5. | Analgesic Effect | Mechanism |
| 33398365 | In future, pharmacological, chemogenic and optogenetic methods may be used to further characterize the analgesic effects of EA mediated by P2X4R. | Mol Med Rep. 2021 Mar;23(3):175. doi: 10.3892/mmr.2020.11814. Epub 2021 Jan 5. | Analgesic Effect | Mechanism |
| 33398365 | In conclusion, the present study demonstrated that mechanical allodynia and thermal hyperalgesia may be attenuated by the analgesic effects of EA. | Mol Med Rep. 2021 Mar;23(3):175. doi: 10.3892/mmr.2020.11814. Epub 2021 Jan 5. | Analgesic Effect | Mechanism |
| 33398365 | EA may exert analgesic effects by inhibiting P2X4R-mediated activation of spinal microglia and decreasing the excitability of neurons in the SG region of SNL rats. | Mol Med Rep. 2021 Mar;23(3):175. doi: 10.3892/mmr.2020.11814. Epub 2021 Jan 5. | Analgesic Effect | Mechanism |
| 33398365 | Treatment with EA results in a significant analgesic effect. | Mol Med Rep. 2021 Mar;23(3):175. doi: 10.3892/mmr.2020.11814. Epub 2021 Jan 5. | Analgesic Effect | Mechanism |
| 25206406 | Different electroacupuncture parameters produce varying effects and different frequencies of electroacupuncture cause various analgesic effects. | Neural Regen Res. 2013 Apr 25;8(12):1122-31. doi: 10.3969/j.issn.1673-5374.2013.12.007. | Analgesic Effect | Mechanism |
| 25206406 | For example, 2/100 Hz of alternating dilatational wave could increase the release of four kinds of opioid peptides, which created an analgesic effect. | Neural Regen Res. 2013 Apr 25;8(12):1122-31. doi: 10.3969/j.issn.1673-5374.2013.12.007. | Analgesic Effect | Mechanism |
| 25206406 | Whereas in 100 Hz electroacupuncture, the analgesic effect was poor, and multiple stimuli did not produce a cumulative effect. | Neural Regen Res. 2013 Apr 25;8(12):1122-31. doi: 10.3969/j.issn.1673-5374.2013.12.007. | Analgesic Effect | Mechanism |
| 27978835 | Following subsequent daily EA interventions, CCI-induced ipsilateral hyperalgesia was markedly improved from day 4 and the analgesic effect of EA lasted 3Â days after cessation of EA. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect | Mechanism |
| 27978835 | However, EA did not exert the same analgesic effect after microinjection of PD98059 into the contralateral hippocampus during the first 3Â days of EA intervention. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect | Mechanism |
| 27978835 | Clinical practice demonstrates that multiple sessions of acupuncture treatment (not a single session) may induce an obvious analgesic effect. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect | Mechanism |
| 27978835 | Our previous study showed that the cumulative analgesic effect of repeated electroacupuncture (EA) intervention in neuropathic pain rats is closely associated with its regulatory effects on natural killer cells as well as some splenic and plasma cytokines. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect Neuropathic Pain | Mechanism |
| 27978835 | However, the central regulation mechanism of the cumulative analgesic effect of multiple sessions of EA intervention remains unknown, particularly under chronic pain conditions. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect | Mechanism |
| 27978835 | Our previous study demonstrated that in chronic constriction injury (CCI)-induced neuropathic pain rats, the cumulative analgesic effect of repeated EA stimulation of Zusanli (ST36)-Yanglingquan (GB34) is closely associated with its effects in upregulating the decreased hippocampal synaptophysin immunoreactivity and improving synaptic plasticity in the hippocampus. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect Immunity Neuropathic Pain | Mechanism |
| 27978835 | Our initial work showed that the hippocampus participated in the cumulative analgesic effect of multiple sessions of EA intervention, and many molecules in this brain region were implicated in this process. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect | Mechanism |
| 27978835 | In addition, we assessed the involvement of MEK1 in the cumulative analgesic effect of multiple sessions of EA intervention by intra-hippocampal injection of a MEK1 inhibitor in neuropathic pain rats. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect Neuropathic Pain | Mechanism |
| 27978835 | Furthermore, after four successive sessions of EA intervention, the analgesic effect of EA lasted at least 3Â days after cessation of EA. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect | Mechanism |
| 27978835 | After the cumulative analgesic effect of EA was present, hippocampal pMEK1 levels decreased gradually. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect | Mechanism |
| 27978835 | Particularly, the present study does not focus on the specificity of the analgesic effect of the acupoint. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect | Mechanism |
| 27978835 | Our data showed that four successive sessions of daily EA treatment induced a time-dependent cumulative analgesic effect, which persists for at least 3Â days in a rat model of neuropathic pain. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect Neuropathic Pain | Mechanism |
| 27978835 | This cumulative analgesic effect may depend on the activation of the MEK1 signaling pathways in the contralateral hippocampus following peripheral nerve injury. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Analgesic Effect | Mechanism |
| 34646326 | ST37 and LI11 are two the most effective acupoints for treating intestinal diseases; however, they showed different analgesic effects in the model of zymosan-induced colorectal hypersensitivity. | Evid Based Complement Alternat Med. 2021 Oct 4;2021:5561999. doi: 10.1155/2021/5561999. eCollection 2021. | Analgesic Effect | Mechanism |
| 34646326 | The analgesic effect of ST37 is better than LI11 and may be associated with the different nerve segments of them. | Evid Based Complement Alternat Med. 2021 Oct 4;2021:5561999. doi: 10.1155/2021/5561999. eCollection 2021. | Analgesic Effect | Mechanism |
| 34646326 | Therefore, MA at ST 37 gets a better analgesic effect than LI11. | Evid Based Complement Alternat Med. 2021 Oct 4;2021:5561999. doi: 10.1155/2021/5561999. eCollection 2021. | Analgesic Effect | Mechanism |
| 34646326 | The dose-effect of the analgesic effect of these two acupoints for visceral pain is unknown. | Evid Based Complement Alternat Med. 2021 Oct 4;2021:5561999. doi: 10.1155/2021/5561999. eCollection 2021. | Analgesic Effect Visceral Pain | Mechanism |
| 34646326 | And it is still not known how acupuncture signals are transmitted and cause changes in the PI3K/Akt pathway of target organs to achieve analgesic effect. | Evid Based Complement Alternat Med. 2021 Oct 4;2021:5561999. doi: 10.1155/2021/5561999. eCollection 2021. | Analgesic Effect | Mechanism |
| 34646326 | Our results indicate that the mechanism underlying the analgesic effects of acupuncture at ST37 on acute visceral hyperalgesia likely involves a reduction in TRPV1 expression, which is regulated by the PI3K/Akt pathway, induced by NGF. | Evid Based Complement Alternat Med. 2021 Oct 4;2021:5561999. doi: 10.1155/2021/5561999. eCollection 2021. | Analgesic Effect | Mechanism |
| 31447579 | Results: In EA poor-responders, combined treatment with EA and netupitant signiï¬cantly enhanced the analgesic effects of EA in poor-responders on mechanical, heat, cold, and deep tissue pain, and decreased phosphorylation of p38 MAPK in lumbar spinal cords and its nuclear translocation in the spinal dorsal horn. | J Pain Res. 2019 Aug 1;12:2419-2426. doi: 10.2147/JPR.S210196. eCollection 2019. | Analgesic Effect | Mechanism |
| 31447579 | Furthermore, combined treatment with EA and SB203580 significantly improved analgesic effects of EA on mechanical and heat hyperalgesia, but not cold or deep tissue hyperalgesia. | J Pain Res. 2019 Aug 1;12:2419-2426. doi: 10.2147/JPR.S210196. eCollection 2019. | Analgesic Effect | Mechanism |
| 31447579 | However, additional EA treatment only, or administration of either netupitant or SB203580 alone did not lead to analgesic effects. | J Pain Res. 2019 Aug 1;12:2419-2426. doi: 10.2147/JPR.S210196. eCollection 2019. | Analgesic Effect | Mechanism |
| 31447579 | These findings suggest that the inadequate analgesic effect of EA in moderate- and non-responders might be attributed to the hypersensitivity resulting from the higher levels of inflammatory signaling via SP and p38 MAPK. | J Pain Res. 2019 Aug 1;12:2419-2426. doi: 10.2147/JPR.S210196. eCollection 2019. | Analgesic Effect | Mechanism |
| 31447579 | There was a gradual decrease in mechanical hyperalgesia starting on day 3 after the co-treatment with EA and netupitant in EA-treated moderate- and non-responders (Moderate/Non-responders + EA + Netupitant); this analgesic effect reached significance on day 9 as compared to untreated controls (Moderate/Non-responders untreated) or treatment with only EA (Moderate/Non-responders + EA) or netupitant (Moderate/Non-responders + Netupitant) and was sustained until day 12, lasted for the period of observation (Figure 1A). | J Pain Res. 2019 Aug 1;12:2419-2426. doi: 10.2147/JPR.S210196. eCollection 2019. | Analgesic Effect | Mechanism |
| 31447579 | Inhibition of p38 MAPK potentiates the analgesic effect of EA. | J Pain Res. 2019 Aug 1;12:2419-2426. doi: 10.2147/JPR.S210196. eCollection 2019. | Analgesic Effect | Mechanism |
| 31447579 | Similar to the effect of netupitant and EA co-treatment, the analgesic effect of EA and SB203580 co-treatment was sustained and remained progressively greater in attenuating mechanical and heat hyperalgesia with successive treatments. | J Pain Res. 2019 Aug 1;12:2419-2426. doi: 10.2147/JPR.S210196. eCollection 2019. | Analgesic Effect | Mechanism |
| 31447579 | Preclinical data support the analgesic effect of NK1R blockade, but it has not been validated in clinical trials. | J Pain Res. 2019 Aug 1;12:2419-2426. doi: 10.2147/JPR.S210196. eCollection 2019. | Analgesic Effect | Mechanism |
| 31447579 | Observations above evince treatable targets to potentiate the analgesic effect of EA in sickle mice with chronic pain. | J Pain Res. 2019 Aug 1;12:2419-2426. doi: 10.2147/JPR.S210196. eCollection 2019. | Analgesic Effect | Mechanism |
| 26623337 | The analgesic effects of acupuncture are better well understood than its ability to improved impaired function. | Open Vet J. 2014;4(1):44-50. Epub 2014 Apr 25. | Analgesic Effect | Mechanism |
| 34472492 | These findings suggest that electroacupuncture treatment has positive analgesic effects on pain sensitivity caused by long-term chronic nicotine exposure. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | The results indicate that short-term acute nicotine exposure produced an analgesic effect, and long-term chronic nicotine exposure led to an increase in pain sensitivity. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | The results indicate that electroacupuncture treatment had positive analgesic effects on pain sensitivity in the nicotine exposed rats. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | This analgesic effect was maintained for at least 24 hours after each electroacupuncture treatment. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | This study demonstrated that short-term nicotine exposure had an analgesic effect, and long-term nicotine exposure increased pain sensitivity. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | In this trial, the mechanical sensory behavioral testing results indicate that electroacupuncture treatment had significant analgesic effects on nicotine-induced hyperalgesia in rats. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | The increased β-EP combined with the increased MOR appears to produce improved analgesic effects. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | The increased levels of GAD67 and GAD65 lead to an increase in GABA synthesis, promoting the release of GABA and apparently producing increased analgesic effects. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | Electroacupuncture treatment significantly increased the expression of GAD65 in the spinal cord and midbrain PAG in nicotine-induced hyperalgesic rats, producing analgesic effects. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | Simultaneously, electroacupuncture treatment increased the release of β-EP and improved the expression of MOR in the midbrain PAG and appeared to increase analgesic effects. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | The increased β-EP combines with the increased MOR, producing enhanced analgesic effects. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | Electroacupuncture treatment can also improve the expression of GAD67 and GAD65 in the spinal cord, and improve the expression of GAD65 in the midbrain PAG, promoting the release of GABA and again, produced analgesic effects. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | In condition, short-term acute nicotine exposure can induce analgesic effects, and long-term chronic nicotine exposure can cause pain hypersensitivity. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | Electroacupuncture treatment has positive analgesic effects on the increased pain sensitivity noted in the nicotine-exposed rats. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 34472492 | The enhancing analgesic effects of electroacupuncture treatment appear to be related to the increased expression of β-EP, MOR, GAD67, and GAD65 in the spinal cord, and the increased expression of β-EP, MOR, and GAD65 in the midbrain PAG. | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Analgesic Effect | Mechanism |
| 24803946 | The recent study reported that EA had a better analgesic effect than MA, while a sustained effect was better produced by MA. | Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 34675986 | To compare the analgesic effects of different frequencies of twirling-rotating MA on rats with complete Freund's adjuvant- (CFA-) induced pain and explore the underlying mechanism via peripheral sensory nerves. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | The ipsilateral nociceptive thresholds (paw withdrawal latency; PWL) were tested to evaluate the analgesic effects. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | PWL was evaluated to investigate the analgesic effect. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | The acupuncture-induced analgesic effect has been valuable in alleviating diverse pains, including headache, muscle pain, joint pain, visceral pain, and postoperative pain. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect Visceral Pain | Mechanism |
| 34675986 | In EA, it was reported that strong current intensity is superior to weak current intensity in inducing the analgesic effect, However, the intensity-analgesic effect relationship in MA requires further investigation. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | It is unclear if the types and degrees of nerve fibers activated by acupuncture are affected by the diverse frequency of MA and whether the nerve fibers mediating the analgesic effect demands further study. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | In this study, we postulated that different frequencies of MA resulted in variable analgesic effects, and the underlying mechanism was related to the types and degrees of activated primary sensory afferent nerve fibers. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | Rats with pain induced by complete Freund's adjuvant (CFA) were used to compare the analgesic effect produced by two frequencies of twirling-rotating MA. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | Resiniferatoxin (RTX) was used to explore whether C-fibers mediated the analgesic effect of two frequencies of twirling-rotating MA. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | The third experiment was conducted to ascertain if the inhibition of C-fiber affected the analgesic effect of the two forms of MA. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | PWL was evaluated to determine the analgesic effect of acupuncture after injecting the RTX to the corresponding acupoints, and the duration of the third experiment was the same as the first experiment. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | The Analgesic Effects of Twirling-Rotating MA with Different Frequencies | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | The Analgesic Effect of MA after Injecting RTX to the Acupoints | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | In the present study using the CFA-induced pain rat model, the analgesic effects of MA with two forms of twirling frequency were explored. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | and Liu et al., demonstrating the analgesic effect by MA. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | In this study, RTX was used to inhibit the activation of C-fiber in order to investigate the contribution of the peripheral afferent fibers to the analgesic effect following the application of twirling-rotating MA. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | However, the relationship between the acupuncture parameters, the type of nerve fibers activation, and the analgesic effects remains unclear. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | In our study, two forms of twirling frequency of MA had been standardized to compare the analgesic effect, and we discovered differences in the analgesic effects that may be mediated by different peripheral afferent nerve fibers. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | Twirling-rotating MA with different intensities (frequency) produce diverse analgesic effects. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | The analgesic effect of strong MA is superior to that of gentle MA, which is mediated differentially by peripheral afferent fibers. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 34675986 | The analgesic effects of 2 forms of MA affected by RTX. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:5528780. doi: 10.1155/2021/5528780. eCollection 2021. | Analgesic Effect | Mechanism |
| 22550540 | Studies indicated that the BL60 acupoint has analgesic effects on chronic low back pain as well as hind limb pain. | Evid Based Complement Alternat Med. 2012;2012:324039. doi: 10.1155/2012/324039. Epub 2012 Apr 5. | Analgesic Effect | Mechanism |
| 22550540 | However, there have been no reports that electroacupuncture at BL60 by itself has an analgesic effect on inflammatory pain. | Evid Based Complement Alternat Med. 2012;2012:324039. doi: 10.1155/2012/324039. Epub 2012 Apr 5. | Analgesic Effect Inflammatory Pain | Mechanism |
| 22550540 | In electroacupuncture treatment, it has been shown that low-frequency stimulation produces prolonged analgesic effects relatively late in electroacupuncture; however, high-frequency stimulation produces short-lasting analgesic effects immediately after initiation of electroacupuncture. | Evid Based Complement Alternat Med. 2012;2012:324039. doi: 10.1155/2012/324039. Epub 2012 Apr 5. | Analgesic Effect | Mechanism |
| 22550540 | However, our behavioral results herein are not fully consistent with other studies that observed analgesic effects of EA in both early and late phases. | Evid Based Complement Alternat Med. 2012;2012:324039. doi: 10.1155/2012/324039. Epub 2012 Apr 5. | Analgesic Effect | Mechanism |
| 22550540 | did not find any analgesic effect with acupuncture at BL60. | Evid Based Complement Alternat Med. 2012;2012:324039. doi: 10.1155/2012/324039. Epub 2012 Apr 5. | Analgesic Effect | Mechanism |
| 22550540 | Therefore, our study may be the first to show the analgesic effects of electroacupuncture at BL60 acupoint in inflammatory pain. | Evid Based Complement Alternat Med. 2012;2012:324039. doi: 10.1155/2012/324039. Epub 2012 Apr 5. | Analgesic Effect Inflammatory Pain | Mechanism |
| 22550540 | However, the mechanisms of analgesic effects of electroacupuncture treatment on formalin-induced pain are uncertain. | Evid Based Complement Alternat Med. 2012;2012:324039. doi: 10.1155/2012/324039. Epub 2012 Apr 5. | Analgesic Effect | Mechanism |
| 22550540 | Otherwise, electroacupuncture stimulation may induce diffuse noxious inhibitory controls (DNICs) in which analgesic effects by electroacupuncture treatment can be diffuse and unspecific, as the pain-relieving effect of electroacupuncture depends on the intensity of stimulation rather than the precise location thereof. | Evid Based Complement Alternat Med. 2012;2012:324039. doi: 10.1155/2012/324039. Epub 2012 Apr 5. | Analgesic Effect | Mechanism |
| 22550540 | Nevertheless, the detailed mechanisms of the analgesic effects of electroacupuncture treatment still remain to be determined. | Evid Based Complement Alternat Med. 2012;2012:324039. doi: 10.1155/2012/324039. Epub 2012 Apr 5. | Analgesic Effect | Mechanism |
| 30872987 | (Kim G. H. et al.,) reported that manual twisting is more effective than the lifting-thrusting technique in producing analgesic effects on formalin-induced pain in rats. | Front Neurosci. 2019 Feb 20;13:110. doi: 10.3389/fnins.2019.00110. eCollection 2019. | Analgesic Effect | Mechanism |
| 30872987 | Similarly, a previous study attempted to determine the analgesic effects of acupuncture in 4 different stimulation conditions (angle and frequency of rotation: 90° + 1 Hz, 90° + 1/4 Hz, 360° + 1 Hz, and 360° + 1/4 Hz) by using a computer-controlled rotational device in rats. | Front Neurosci. 2019 Feb 20;13:110. doi: 10.3389/fnins.2019.00110. eCollection 2019. | Analgesic Effect | Mechanism |
| 28299842 | EA activated sensory ganglia and SNS centers to mediate the release of MSC that can enhance tissue repair, increase anti-inflammatory cytokine production and provide pronounced analgesic relief. | Stem Cells. 2017 May;35(5):1303-1315. doi: 10.1002/stem.2613. | Analgesic Effect | Mechanism |
| 28299842 | To address the possible anti-inflammatory and analgesic effects of EA-mobilization of circulating MSC, we analyzed the contribution of an EA treatment paradigm on injury-induced hyperalgesia in rats in the presence and absence of a β-blocker, propranolol. | Stem Cells. 2017 May;35(5):1303-1315. doi: 10.1002/stem.2613. | Analgesic Effect Circulation | Mechanism |
| 28299842 | EA has been reported to have long-lasting and powerful analgesic effects in models of both acute and chronic pain. | Stem Cells. 2017 May;35(5):1303-1315. doi: 10.1002/stem.2613. | Analgesic Effect | Mechanism |
| 26064171 | A good body of evidence suggests that acupuncture therapy helps with anti-inflammatory and analgesic effects. | Evid Based Complement Alternat Med. 2015;2015:687196. doi: 10.1155/2015/687196. Epub 2015 May 3. | Analgesic Effect | Mechanism |
| 25206591 | Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciaticaâ | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect | Mechanism |
| 25206591 | In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanli (ST36) and Yanglingquan (GB34). | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect Neuropathic Pain Learning and Memory Ability | Mechanism |
| 25206591 | Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect | Mechanism |
| 25206591 | These findings indicate that repeated electroacupuncture at bilateral Zusanli and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25206591 | (2) Hypothalamic paraventricular nucleus neural plasticity was associated with the cumulative analgesic effects of electroacupuncture. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect | Mechanism |
| 25206591 | In comparison, in ovariectomized (OVX) + CCI (estrogen-deprived) rats, the repeated EA intervention-induced analgesic effect was substantially weakened, suggesting an intimate association between the analgesic effect and the estrogen level. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect | Mechanism |
| 25206591 | However, the correlation between the analgesic effect of EA and plastic changes in hypothalamic neurons has not been fully investigated. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect | Mechanism |
| 25206591 | Therefore, the present study was designed to analyze the relationship between the cumulative analgesic effect of repeated EA intervention and hypothalamic neuronal synaptic structural plasticity in CCI and OVX + CCI rats. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect | Mechanism |
| 25206591 | In comparison with the CCI + EA 2W group, the pain scores in the OVX + CCI + EA 2W group were significantly higher (P < 0.05), suggesting an attenuation of analgesic effect of EA intervention in OVX rats compared with simple CCI rats (Table 1). | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect | Mechanism |
| 25206591 | After EA intervention, the pain threshold was increased significantly in EA-2W rats, being markedly higher than in EA-2D rats, suggesting a cumulative analgesic effect of repeated EA stimulation of Zusanli and Yanglingquan in rats with neuropathic pain. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25206591 | Moreover, when the cumulative analgesic effect of EA was induced, the increase in synaptic cleft width was considerably diminished, and the reductions in postsynaptic density size, active zone length and synaptic interface curvature were substantially mitigated in EA-2W (both CCI and OVX + CCI) rats. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect | Mechanism |
| 25206591 | However, a systematic study on the mechanisms underlying the analgesic effect of repeated EA intervention has been lacking. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect | Mechanism |
| 25206591 | The present study suggests that hypothalamic PVN neural plasticity mediates the cumulative analgesic effect of EA and provides insight into the underlying synaptic ultrastructural changes. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect | Mechanism |
| 25206591 | It is possible that repeated EA intervention promotes the storage of pain-relief information in the brain, which is consolidated gradually after multiple treatments, resulting in the establishment of the cumulative analgesic effect. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect Pain Relief | Mechanism |
| 25206591 | In conclusion, repeated EA intervention of Zusanli and Yanglingquan has a cumulative analgesic effect in rats with chronic neuropathic pain. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25206545 | The present study demonstrated that electroacupuncture treatment was superior to manual acupuncture treatment in terms of improvements after chronic constriction injury and an overall analgesic effect. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Analgesic Effect | Mechanism |
| 31775332 | These two acupoints were frequently used in our previous studies and showed reliable analgesic effects on hind limbs upon EA stimulation. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Analgesic Effect | Mechanism |
| 31775332 | We then investigated the mechanisms underlying EA-induced analgesic effects on paclitaxel-treated rats. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Analgesic Effect | Mechanism |
| 31775332 | Capsaicin significantly reversed the analgesic effects of EA on paclitaxel-induced mechanical allodynia (Figure 7C) and thermal hyperalgesia (Figure 7E) in rats. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Analgesic Effect | Mechanism |
| 31775332 | AUC analysis further demonstrated an overall reversal of the analgesic effects of EA on paclitaxel-treated rats by capsaicin (Figure 7D,F). | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Analgesic Effect | Mechanism |
| 25206515 | The analgesic effect of acupuncture may relate to binding of adenosine triphosphate with purinergic receptors of sensory nerve endings of the skin, causing activation of a signal conduction pathway and regulated pain perception in the cerebral cortex. | Neural Regen Res. 2013 Aug 5;8(22):2069-77. doi: 10.3969/j.issn.1673-5374.2013.22.006. | Analgesic Effect | Mechanism |
| 25206515 | Research frontiers: We hypothesized that the analgesic effect of acupuncture relates to adenosine triphosphate signaling via a purinergic receptor on sensory nerve endings of the skin, and subsequent activation of a signal conduction pathway resulting in adjustment of pain sensation in the cerebral cortex. | Neural Regen Res. 2013 Aug 5;8(22):2069-77. doi: 10.3969/j.issn.1673-5374.2013.22.006. | Analgesic Effect | Mechanism |
| 28600329 | Accordingly, the present study was designed to examine the analgesic effects of EA in relation to the balance between CGRP/SP and GABA expression in cervical DRGs, in order to explore the peripheral mechanisms involved in the relief of thyroid surgery-induced pain by EA. | Acupunct Med. 2017 Aug;35(4):276-283. doi: 10.1136/acupmed-2016-011177. Epub 2017 Jun 9. | Analgesic Effect | Mechanism |
| 28600329 | Clearly, segmental needling in the neck had a much greater effect on thermal PT and expression of SP, CGRP and GABA in DRGs than distal needling; however, differences in thermal PT in the ST36-GB34 group came close to significance compared with the model group, suggesting an analgesic effect that may reflect central (supraspinal) mechanisms. | Acupunct Med. 2017 Aug;35(4):276-283. doi: 10.1136/acupmed-2016-011177. Epub 2017 Jun 9. | Analgesic Effect | Mechanism |
| 28600329 | After application of selective GABAA (but not GABAB) receptor agonists, an analgesic effect is seen in rat models of inflammatory and neuropathic pain. | Acupunct Med. 2017 Aug;35(4):276-283. doi: 10.1136/acupmed-2016-011177. Epub 2017 Jun 9. | Analgesic Effect Neuropathic Pain | Mechanism |
| 28600329 | Thus, upregulation of GABA induced by the EA intervention may contribute to its analgesic effect by downregulating the expression of both SP and CGRP in the DRG of rats with incisional neck pain. | Acupunct Med. 2017 Aug;35(4):276-283. doi: 10.1136/acupmed-2016-011177. Epub 2017 Jun 9. | Analgesic Effect | Mechanism |
| 29033603 | Electroacupuncture (EA) was performed at GB30 to study the analgesic effects on neuropathic pain and the underlying mechanisms. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Analgesic Effect Neuropathic Pain | Mechanism |
| 37143500 | Analgesic effects and metabolome analyses of laser- and electro-acupuncture combined therapies in paclitaxel-induced neuropathic pain model | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Analgesic Effect Neuropathic Pain | Mechanism |
| 37143500 | Although pain-related diseases are relatively common, few studies have analyzed the analgesic effects and mechanisms of LA combined with EA. | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Analgesic Effect | Mechanism |
| 37143500 | These are closely related to analgesic effects by the inhibition of presynaptic neurotransmitter and neuropeptide release, modulation of postsynaptic neuron, and reductions in neuroinflammatory signaling. | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Analgesic Effect | Mechanism |
| 37143500 | The objective of this study was to evaluate the analgesic effect and mechanism of manual acupuncture (MA), EA, LA, and the combination therapy of LA and EA by assessing pathological pain through von Frey filaments and analyses of mRNA and protein expression as well as metabolomes in a paclitaxel-induced allodynia rat model. | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Analgesic Effect | Mechanism |
| 37143500 | The von Frey index on day 8, when administration of paclitaxel was terminated, can be interpreted as indicating an analgesic effect, and the index on day 15, when the 9th treatment intervention was completed, seems to demonstrate an effect of damage repair and regeneration. | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Analgesic Effect | Mechanism |
| 37143500 | However, nociceptive and analgesic effects are affected by complex mechanisms including nociceptive, inflammatory, and neuropathic etiology and chemical and mechanical modality, it is important to comprehensively evaluate mechanical threshold values along with various factors related to pain in the body. | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Analgesic Effect | Mechanism |
| 22369266 | This study aims to examine whether the intensity and duration of the analgesic effect of electroacupuncture (EA) at the Zusanli (ST36) and Sanynjiao acupoints (SP6) change according to the depth of the stimulation. | Chin Med. 2012 Feb 27;7:3. doi: 10.1186/1749-8546-7-3. | Analgesic Effect | Mechanism |
| 22369266 | The analgesic effects were measured by the rat tail-flick test. | Chin Med. 2012 Feb 27;7:3. doi: 10.1186/1749-8546-7-3. | Analgesic Effect | Mechanism |
| 22369266 | Slow analgesic effect also occurred after formalin injection at 1 mm or 5 mm below ST36 by inserting the needle at 45° to the skin surface. | Chin Med. 2012 Feb 27;7:3. doi: 10.1186/1749-8546-7-3. | Analgesic Effect | Mechanism |
| 22369266 | The analgesic effect of acupuncture was replicated by the direct injection of 2-chloro-N(6)-cyclopentyladenosine (CCPA), an adenosine A1 receptor agonist into the acupoint. | Chin Med. 2012 Feb 27;7:3. doi: 10.1186/1749-8546-7-3. | Analgesic Effect | Mechanism |
| 22369266 | This study used the rat tail-flick test to examine whether the intensity and duration of the analgesic effect of EA at ST36 and the Sanynjiao acupoints (SP6) or the injection of formalin into ST36 change according to the depth of the stimulation. | Chin Med. 2012 Feb 27;7:3. doi: 10.1186/1749-8546-7-3. | Analgesic Effect | Mechanism |
| 22369266 | The analgesic effect of acupuncture was subject to individual differences that were reported in human and rodents, classifiable as responders or non-responders. | Chin Med. 2012 Feb 27;7:3. doi: 10.1186/1749-8546-7-3. | Analgesic Effect | Mechanism |
| 24757373 | In the present study, the effects of acupuncture on behavioral responses and c-Fos expression were evaluated using a formalin test in male Sprague-Dawley rats in order to clarify the analgesic effects of three different acupoints. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 24757373 | To date, however, no research has assessed the analgesic effect of manual acupuncture on a formalin-induced pain. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 24757373 | According to previous studies, analgesic effects of manual acupuncture and electroacupuncture may be somewhat different. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 24757373 | They found that manual acupuncture and electroacupuncture can induce analgesia and suggested that the collagen fibers may contribute to the analgesic effect of manual acupuncture and the peripheral nerve receptors may contribute to the electroacupuncture-induced analgesia. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 24757373 | And they found that the neurons responded to manual acupuncture and electroacupuncture but the extent of action of manual acupuncture was smaller than that of electroacupuncture, suggesting the difference of analgesic effects of manual acupuncture and electroacupuncture. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 24757373 | However, we observed the analgesic effect of manual acupuncture at BL60 in the present study similarly to our previous study in which electroacupuncture at BL60 produced the analgesic effect. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 24757373 | The difference between the analgesic effect of BL60 stimulation and that of ST36 or SP9 is of interest. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 24757373 | Even though there is no direct evidence regarding the analgesic effect of BL60 stimulation, the pain-relieving effect of acupuncture stimulation at acupoints on biphasic pain behavior in formalin test may be limited and mainly suppress the late phase in formalin test which reflects the injury-induced spinal sensitization. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 24757373 | Other reports have implied that the analgesic effects of acupuncture are related with the endogenous opioid system as well as monoamine secretion in the midbrain and the activity of the autonomic nervous system. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 24757373 | In addition, the analgesic effects of acupuncture stimulation at ST36 and SP9 acupoints cannot be excluded even though behavioral analgesia produced by acupuncture at ST36 and SP9 was less than analgesia by acupuncture at BL60. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 24757373 | Acupuncture at ST36 or SP9 acupoint tended to inhibit flinching behavior, but the analgesic effect was not statistically significant while it significantly inhibited c-Fos expression. | Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. | Analgesic Effect | Mechanism |
| 35069759 | A variety of studies affirmed that SP6 is one of the most common used points for PD, with satisfactory analgesic effect. | Evid Based Complement Alternat Med. 2022 Jan 13;2022:4571981. doi: 10.1155/2022/4571981. eCollection 2022. | Analgesic Effect | Mechanism |
| 35069759 | CCR3 Agonist Blocked TN-Induced Analgesic Effect | Evid Based Complement Alternat Med. 2022 Jan 13;2022:4571981. doi: 10.1155/2022/4571981. eCollection 2022. | Analgesic Effect | Mechanism |
| 35069759 | Moreover, the CCR3 agonist CCL11 significantly abolished a TN-induced analgesic effect and related benefits, while CCR3 antagonist SB328437 could mimic the analgesic effect, supporting this contention. | Evid Based Complement Alternat Med. 2022 Jan 13;2022:4571981. doi: 10.1155/2022/4571981. eCollection 2022. | Analgesic Effect | Mechanism |
| 35069759 | To investigate the influence of needling techniques on SP6's analgesic effect is crucial for acupuncture clinical practice. | Evid Based Complement Alternat Med. 2022 Jan 13;2022:4571981. doi: 10.1155/2022/4571981. eCollection 2022. | Analgesic Effect | Mechanism |
| 30510442 | Moreover, we also found that knockout of CB2 receptor can block the analgesic effect of EA and that EA had no effect on the expression of IL-1β in CB2â/â mice. | J Pain Res. 2018 Nov 8;11:2797-2808. doi: 10.2147/JPR.S171664. eCollection 2018. | Analgesic Effect | Mechanism |
| 35416841 | Our previous studies showed that the adenosine content in the spinal cord of rats with chronic constriction injuries (CCIs) can significantly rise 60 min after electroacupuncture (EA), thus producing analgesic effects in these rats. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | Therefore, this study investigated whether EA produces analgesic effects on CCI rats via promotion of increased spinal adenosine, through upregulating 5'-NT expression. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | AOPCP reversed the analgesic effect of EA on CCI rats | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | In the EA group, compared with the MWT and TPT of the rats on the seventh day after modeling, they were significantly higher 60 min after EA (P = 0.003 for MWT; P < 0.0001 for TPT), thus indicating that EA had an analgesic effect on CCI rats. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | AOPCP can reverse the analgesic effect of EA in CCI rats. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | CCPA restored the analgesic effect of EA on CCI rats | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | CCPA can restore the analgesic effect of EA in CCI rats. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | Among these, adenosine A1 receptors are widely distributed in the spinal dorsal horn neurons, and activation of adenosine A1 receptors can inhibit the excitability of spinal neurons and achieve analgesic effects. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | It claimed that the increase in adenosine content around the Zusanli acupoint in mice after EA was the main mechanism of acupuncture analgesia and that the analgesic effect of acupuncture was eliminated in adenosine A1 receptor knockout mice14. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | Moreover, our own previous studies showed that adenosine content in the spinal cord of CCI rats can increase 60 min after EA, while silencing the adenosine A1 receptors can reverse the analgesic effect of EA. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | At the same time, the MWT and TPT levels in the EA + AOPCP group were significantly lower than those in the EA and EA + NS groups, which provided strong evidence that AOPCP could reverse the analgesic effect of EA on CCI rats. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | Therefore, we hypothesized that EA may increase the level of adenosine and produce analgesic effects through upregulating the expression of 5'-NT in the spinal cord of CCI rats. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | However, our study had some shortcomings: we only used AOPCP to inhibit the activity of 5'-NT; this could only demonstrate the involvement of 5'-NT in the analgesic effect of EA at the pharmacological level. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | In conclusion, we believe that EA can upregulate the expression of 5'-NT in the spinal cord of CCI rats and that AOPCP can significantly reverse the upregulation of adenosine content in the spinal cord of CCI rats and the analgesic effect of EA on CCI rats, while exogenous adenosine supplementation can restore the analgesic effect of EA. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 35416841 | Therefore, we hypothesize that 5'-NT mediates the analgesic effect of EA in CCI rats. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Analgesic Effect | Mechanism |
| 28860844 | In this study, we used behavioral testing to confirm the analgesic effects of EA and pregabalin in a rat model of trigeminal neuralgia induced by cobra venom. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Analgesic Effect Neuralgia | Mechanism |
| 28860844 | The analgesic effects of EA stimulation and pregabalin | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Analgesic Effect | Mechanism |
| 28860844 | The results of this study are consistent with these previous findings, indicating similar analgesic effects of EA stimulation and pregabalin in treating trigeminal neuralgia. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Analgesic Effect Neuralgia | Mechanism |
| 28860844 | Although pregabalin demonstrated a dramatic behavioral analgesic effect on chronic trigeminal pain in this study, it did not suppress the development of deficits in the abilities of spatial learning and memory. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Analgesic Effect Learning and Memory Ability | Mechanism |
| 25767502 | Results indicated that repeated electroacupuncture has a cumulative analgesic effect, which is closely associated with upregulation of acetylcholinesterase and vesicular acetylcholine transporter activity, as well as M1 receptor mRNA expression and memory. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Analgesic Effect | Mechanism |
| 25767502 | When ACh receptors are activated, the analgesic effect of acupuncture is significantly increased. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Analgesic Effect | Mechanism |
| 25767502 | Our previous studies have demonstrated that protein kinase A and synaptophysin expression in hippocampal cells induces a repeated electroacupuncture (EA)-induced analgesic effect; when learning and memory ability are impaired by ovariotomy (OVX), the cumulative analgesic effect is decreased. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Analgesic Effect Learning and Memory Ability | Mechanism |
| 25767502 | We hypothesized that a repeated, EA-induced, cumulative, analgesic effect could be closely associated with memory and information storage in central nervous system neurons. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Analgesic Effect | Mechanism |
| 25767502 | The present study was designed to analyze the relationship between the cumulative analgesic effect of repeated EA and hippocampal cholinergic nerve activity in a rat model of chronic constriction injury (CCI) to the sciatic nerve and OVX. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Analgesic Effect | Mechanism |
| 25767502 | However, pain scores were significantly less in the CCI + EA 2W group than in the OVX + CCI + EA 2W group (P < 0.05), suggesting a weakened analgesic effect of repeated EA in OVX rats compared with simple CCI rats (Figure 4). | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Analgesic Effect | Mechanism |
| 25767502 | The pain threshold evaluation on day 18 after CCI demonstrated that all the increased pain scores were significantly reduced in the rats undergoing 2-week EA treatment compared with those undergoing 2-day EA treatment, suggesting a cumulative analgesic effect after repeated EA. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Analgesic Effect | Mechanism |
| 25767502 | These results suggested an increased synthesis and degradation of ACh in the hippocampal CA1 region as a result of the cumulative analgesic effect of repeated EA intervention. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Analgesic Effect | Mechanism |
| 25767502 | In summary, hippocampal CA1 acetylcholine and the M1 muscarinic receptor are involved in the cumulative analgesic effect of repeated EA, which suggests a role for repeated EA in learning and memory. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Analgesic Effect Learning and Memory Ability | Mechanism |
| 25657670 | The cumulative analgesic effect of repeated electroacupuncture involves synaptic remodeling in the hippocampal CA3 regionâ | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect | Mechanism |
| 25657670 | In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25657670 | In ovariectomized rats with chronic constriction injury, the analgesic effect was significantly reduced. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect | Mechanism |
| 25657670 | Repeated electroacupuncture intervention had a cumulative analgesic effect on injury-induced neuropathic pain reactions, and it led to synaptic remodeling of hippocampal neurons and upregulated calcium/calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25657670 | In ovariectomized (OVX) + CCI rats, the analgesic effect of repeated electroacupuncture was significantly weakened, suggesting a close association between analgesic effect and estrogen levels. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect | Mechanism |
| 25657670 | However, the relationship between the analgesic effects of electroacupuncture and changes in neuronal plasticity in the hippocampus remains poorly understood. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect | Mechanism |
| 25657670 | The present study was designed to analyze the relationship between the analgesic effect of repeated electroacupuncture and hippocampal synaptic plasticity in ovariectomized rats with CCI of the sciatic nerve. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect | Mechanism |
| 25657670 | Our present results indicate that the cumulative analgesic effect of electroacupuncture is associated with the following: (1) significant increases in CaMKII expression, postsynaptic density area and active zone length in the hippocampal CA3 region; and (2) a significant reduction in synaptic cleft width. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect | Mechanism |
| 25657670 | Our present study is the first attempt to reveal the mechanisms behind the analgesic effect of repeated electroacupuncture on hippocampal synaptic plasticity and CaMKII protein expression. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect | Mechanism |
| 25657670 | It is possible that electroacupuncture intervention induces synaptic changes associated with pain-relief which are gradually consolidated with repeated treatment, eventually establishing the observed cumulative analgesic effect. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect Pain Relief | Mechanism |
| 25657670 | In conclusion, repeated electroacupuncture at Zusanli and Yanglingquan has a cumulative analgesic effect on chronic neuropathic pain in rats. | Neural Regen Res. 2012 Jun 25;7(18):1378-85. doi: 10.3969/j.issn.1673-5374.2012.18.003. | Analgesic Effect Neuropathic Pain | Mechanism |
| 23573158 | In this paper, we determined the role of spinal dynorphin and orphanin-FQ system in analgesic effect of warming moxibustion (WM) on chronic visceral hyperalgesia (CVH) in IBS-like rat model. | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23573158 | Our previous studies also revealed the analgesic effects of moxibustion in reducing abdominal pain in IBS patients and IBS rat models. | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23573158 | We also reported that WM treatment could alleviate CVH in IBS-like rats by suppressing hypothalamic corticotrophin-releasing-hormone level, which provides the evidence that the analgesic effect of moxibustion may be associated with the central nervous system (CNS). | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23573158 | The spinal dorsal horn is the first integration center in CNS, and then what role does the spinal cord play in the analgesic effect of moxibustion? | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23573158 | What are the kinds of chemicals that participate in the process of CVH and the analgesic effect of moxibustion in IBS-like rats? | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23573158 | A variety of pain assays in rodents have shown the effect of intrathecally administered orphanin-FQ (OFQ) to be antinociceptive, and it was also reported that acupuncture could exert an analgesic effect by activating spinal OFQ-OFQ receptor system in inflammatory pain model. | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect Inflammatory Pain | Mechanism |
| 23573158 | Experiment 1: Analgesic Effects of Moxibustion on CVH in IBS-Like Rat Model | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23573158 | Experiment 2: Moxibustion Exert Analgesic Effect by Activating Spinal Dynorphin-κ System | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23573158 | κ antagonist could attenuate the analgesic effect of moxibustion and i.t. | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23573158 | Experiment 3: Moxibustion Exert Analgesic Effect by Activating Spinal OFQ-OFQ Receptor System | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23573158 | [Nphe1]NC(1-13)NH2 could attenuate the analgesic effect of moxibustion on CVH and i.t. | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23573158 | We also found that WM's analgesic effects in CVH rats were enhanced by i.t. | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23573158 | The present study provides the convincing evidence for our presumption, and we found that WM's analgesic effects in CVH rats were enhanced by intrathecal administration of OFQ and partly attenuated following OFQ receptor antagonist, indicating the involvement of spinal OFQ-OFQ receptor system in moxibustion analgesia. | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Analgesic Effect | Mechanism |
| 23970928 | These observations suggest that ERK may be involved in signal transduction in the EA stimulation at acupoints of stomach meridian of foot yangming, repairing gastric mucosal injury, and that EA had an analgesic effect by downregulating p-ERK expression levels in the dorsal horn of the spinal cord of rats with adjuvant arthritis. | Evid Based Complement Alternat Med. 2013;2013:198282. doi: 10.1155/2013/198282. Epub 2013 Jul 22. | Analgesic Effect | Mechanism |
| 32967614 | This suggested for a significant analgesic effect of acupuncture in the DPN rats. | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Analgesic Effect | Mechanism |
| 23097675 | Moreover, the effectiveness of acupuncture analgesia increases with the increase in number of times of acupuncture (Figure 3 CRD4, CRD5, and CRD6), indicating that EA had an analgesic effect in this model. | Evid Based Complement Alternat Med. 2012;2012:483123. doi: 10.1155/2012/483123. Epub 2012 Oct 11. | Analgesic Effect | Mechanism |
| 32042305 | However, WAA produced a quicker analgesic effect than EA, the mechanisms of which need further investigation. | Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. | Analgesic Effect | Mechanism |
| 32042305 | Due to its wide range of analgesic effects for various pain states, WAA is easily accepted by patients with cancer-related pain. | Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. | Analgesic Effect | Mechanism |
| 32042305 | Electroacupuncture (EA) has been found to be effective for relieving various pain states including cancer pain, and its analgesic effect on animal with CIBP has been examined in recent studies. | Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. | Analgesic Effect Cancer Pain | Mechanism |
| 32042305 | Analysis of the difference in analgesic effects between EA and WAA demonstrated that WAA produced a fast analgesic effect while EA (2/100 Hz) showed a comparatively slow analgesic potency (Fig. 3b). | Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. | Analgesic Effect | Mechanism |
| 32042305 | The body produces β-EP, a peptide with a stronger analgesic effect than morphine, to suppress early pain, but as the pain continues the secretion of β-EP decreases gradually. | Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. | Analgesic Effect | Mechanism |
| 32042305 | However, an increase in EM-1 in both the RVM and spinal cord was observed after WAA and EA treatment, contributing to the analgesic effects of WAA and EA. | Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. | Analgesic Effect | Mechanism |
| 32042305 | Furthermore, WAA produced a quicker analgesic effect than EA, the mechanisms of which may be related to retaining needle of WAA but require further investigation. | Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. | Analgesic Effect | Mechanism |
| 27411565 | The electroacupuncture-induced analgesic effect mediated by 5-HT1, 5-HT3 receptor and muscarinic cholinergic receptors in rat model of collagenase-induced osteoarthritis | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | The analgesic effect of EA was evaluated by the tail flick latency (TFL) and paw pressure threshold (PPT) tests. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | EA on Zusanli (ST 36) demonstrated an analgesic effect in the CIOA rat model. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | The 2Â Hz EA treatment showed a significantly greater analgesic effect than the 100Â Hz treatment. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | The analgesic effect of 2Â Hz EA was not strengthened by 5-HT1, 5-HT2, 5-HT3, and muscarinic cholinergic receptor agonist pretreatment, was blocked by 5-HT1, 5-HT3, and muscarinic cholinergic receptor antagonist pretreatment, but not blocked by 5-HT2 receptor antagonist pretreatment. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | In the CIOA rat model, EA on Zusanli (ST 36) exhibited analgesic effects, and 2Â Hz EA resulted in a significantly greater analgesic effect than 100Â Hz EA. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | The analgesic effect of 2Â Hz EA was reduced by pretreatment of 5-HT1 receptor, 5-HT3 receptor and muscarinic cholinergic receptor antagonists. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | The analgesic effects of EA have also been established through many studies. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | The analgesic effects and its adrenergic or opioidergic mechanisms of EA in CIOA in vivo study was reported, but the serotonergic and cholinergic roles in EA analgesia have not been fully clarified. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | Current study was designed to investigate which receptors agonists and antagonists were involved in the analgesic effect of EA in CIOA in vivo model. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | To evaluate the analgesic effect on the thermal stimuli, the TFL test was performed using the tail flick unit (Ugo Basile Model 7360, Comrio, Italy). | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | The increase in the degree of TFL change represents the analgesic effect on the thermal stimuli. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | For evaluation of the analgesic effect on the mechanical stimuli, a PPT test was performed. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | The increase in the mean pressure represents the analgesic effect on the mechanical stimuli. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | At first, EA was performed at 2Â Hz and 100Â Hz to compare analgesic effects at different frequencies. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | The frequency that showed a better analgesic effect was selected when conducting experiments on the analgesic mechanism of EA. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | The analgesic effect of EA and comparison according to latency (2, 100Â Hz) | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | Several studies have been performed to prove the analgesic effect and mechanism of EA in various animal models, considering EA stimulation parameters such as frequency, intensity, and wave form. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | TFL and PPT tests are appropriate to evaluate analgesic effects on thermal and mechanical stimuli in the CIOA, in accordance with other painful condition experiments. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | Our results demonstrated that both 2Â Hz and 100Â Hz EA showed analgesic effect, evidenced in the TFL and PPT tests. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | Recent studies also showed that 2Â Hz EA provides better and longer-lasting analgesic effects on mechanical allodynia. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | With respect to the serotonergic mechanism, our study showed that the analgesic effect of 2Â Hz EA was not strengthened by the 5-HT1, 5-HT2, and 5-HT3 receptor agonists. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | In experiments with antagonists, the analgesic effect of 2Â Hz EA was blocked by the 5-HT1 and 5-HT3 receptor antagonists, but not blocked by the 5-HT2 receptor antagonist. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | conducted experiments on the analgesic effects and mechanism of 2Â Hz EA in the collagen-induced arthritis (CIA) model using 5-HT1A, 5-HT1B, and 5-HT4 receptor antagonists, and demonstrated that the analgesic effect of EA was blocked by 5-HT1A, 5-HT1B, and 5-HT4 receptor antagonists. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | conducted experiments on the analgesic effects and mechanism of 2Â Hz EA in a CIA model using 5-HT1A, 5-HT2, and 5-HT3 receptor agonists and antagonists, and demonstrated that the analgesic effect of EA was blocked by the 5-HT1A and 5-HT3 receptor antagonists, but not blocked by the 5-HT2 receptor antagonist. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | In this regard, 2Â Hz EA induces an analgesic effect through 5-HT1 and 5-HT3 receptors. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | With respect to the cholinergic mechanism, our study showed that the analgesic effect of 2Â Hz EA was not strengthened by the muscarinic cholinergic receptor agonist and blocked by muscarinic cholinergic receptor antagonist. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | also conducted experiments on the analgesic effects and mechanism of 2Â Hz EA in the CIA model using a muscarinic cholinergic receptor agonist and antagonist, and demonstrated that the analgesic effect of EA was blocked by the muscarinic cholinergic receptor antagonist. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | In this regard, 2Â Hz EA induces analgesic effect through muscarinic cholinergic receptor. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | suggested that ondansetron could have an analgesic effect in neuropathic pain in a double-blind study and Ali Z et al. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect Neuropathic Pain | Mechanism |
| 27411565 | Houde RW showed the analgesic effectiveness of narcotic agonists and antagonists. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 27411565 | In summary, these observation suggest that 5-HT1, 5-HT3 and muscarinic cholinergic receptors partially mediate the analgesic effects of EA in CIOA. | BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10.1186/s12906-016-1204-z. | Analgesic Effect | Mechanism |
| 35656078 | Recent studies have implicated release of adenosine, dopamine, and endogenous opiates in the analgesic effects of acupuncture as evidenced by elevated levels of these molecules in serum or cerebrospinal fluid. | Iran J Basic Med Sci. 2022 Apr;25(4):451-459. doi: 10.22038/IJBMS.2022.60121.13327. | Analgesic Effect | Mechanism |
| 33193035 | In our recent study, we screened the optimal EA frequency for CPIP treatment and found that daily 100 Hz EA treatment showed effective and reliable analgesic effect on mechanical allodynia of CPIP model rats. | Front Neurol. 2020 Oct 30;11:580997. doi: 10.3389/fneur.2020.580997. eCollection 2020. | Analgesic Effect | Mechanism |
| 33193035 | Repetitive SCS produced robust analgesic effect on chronic constriction injury (CCI) and paclitaxel-induced chronic pain model rats in these two studies. | Front Neurol. 2020 Oct 30;11:580997. doi: 10.3389/fneur.2020.580997. eCollection 2020. | Analgesic Effect | Mechanism |
| 22110373 | Moreover, we tested the hypothesis that synergic treatment with an NMDA antagonist along with electroacupuncture produces analgesic effects greater than either agent alone in a maintained diabetic neuropathic pain phase, and we identified alterations in p35 level in response to analgesic effects. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Analgesic Effect Neuropathic Pain | Mechanism |
| 22110373 | EA-induced analgesic effects on DNP | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Analgesic Effect | Mechanism |
| 22110373 | The analgesic effects of EA treatment were at the maximum in the 2 hours after EA treatment. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Analgesic Effect | Mechanism |
| 22110373 | Activation of p35 contributes to analgesic effects by EA combined with MK-801 treatment in DNP | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Analgesic Effect | Mechanism |
| 22110373 | The analgesic effects of the EA and sub-effective MK-801 dose combination treatment were significantly sustained to 4 hours after treatments and showed as much analgesia as the effective dose (0.01 mg MK-801). | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Analgesic Effect | Mechanism |
| 22110373 | It has been well defined that acupuncture induces general analgesic effects in experimental studies, and the participation of various endogenous opioids and their receptors has been widely accepted. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Analgesic Effect | Mechanism |
| 21799685 | Ketanserin pretreatment blocked the analgesic effect of EA but did not influence weight bearing in sham EA control rats. | Evid Based Complement Alternat Med. 2011;2011:619650. doi: 10.1093/ecam/neq016. Epub 2011 Jan 9. | Analgesic Effect | Mechanism |
| 21799685 | However, the analgesic effect of EA on the osteoarthritis rat model was blocked by systemic ketanserin (Figure 2), indicating that EA treatment induced the release of serotonin, which activated 5-HT2A/2C receptors to alleviate pain. | Evid Based Complement Alternat Med. 2011;2011:619650. doi: 10.1093/ecam/neq016. Epub 2011 Jan 9. | Analgesic Effect | Mechanism |
| 21799685 | Ketanserin pretreatment blocked the analgesic effect of EA but did not influence weight bearing in sham EA control rats. | Evid Based Complement Alternat Med. 2011;2011:619650. doi: 10.1093/ecam/neq016. Epub 2011 Jan 9. | Analgesic Effect | Mechanism |
| 27381504 | Interestingly, peripheral injection of prostatic acid phosphatase induced a longer lasting A1R-dependent analgesic effect than agonist injection. | Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. | Analgesic Effect | Mechanism |
| 27381504 | ST36 is one of the most commonly used acupuncture points in Traditional Chinese Medicine and its analgesic effects are well established. | Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. | Analgesic Effect | Mechanism |
| 27381504 | Low frequency EA administered immediately following the second acid saline injection reduced mechanical hyperalgesia on days 5 to 8 (p<0.05, FM+EA vs FM groups), while such analgesic effects were not observed in FM+MA mice (p>0.05, FM+MA vs FM groups), suggesting a specific effect of electrical stimulation on induced hyperalgesia rather than a general reduction in mechanical pain threshold. | Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. | Analgesic Effect | Mechanism |
| 27381504 | The analgesic effect of EA can be reversed by a serotonin synthesis inhibitor delivered to the descending serotonergic spinal pathway, suggesting a central effect. | Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. | Analgesic Effect | Mechanism |
| 27073385 | At least a 30-minute treatment period might be needed for the full expression of the analgesic effects of acupuncture, and no less than 15 minutes may be needed to produce the initial treatment effect (Jiang et al., 2014). | Neural Regen Res. 2016 Feb;11(2):305-11. doi: 10.4103/1673-5374.177740. | Analgesic Effect | Mechanism |
| 29311503 | They reported a short 4-day course of EA treatment and a rather strong analgesic effect that last for 3 days after EA treatment, shown as recovered weight bearing deficit. | Exp Anim. 2018 May 10;67(2):271-280. doi: 10.1538/expanim.17-0142. Epub 2018 Jan 1. | Analgesic Effect | Mechanism |
| 29311503 | Early-on EA treatment provides significant analgesic effects and reduces histological changes of the knee joint. | Exp Anim. 2018 May 10;67(2):271-280. doi: 10.1538/expanim.17-0142. Epub 2018 Jan 1. | Analgesic Effect | Mechanism |
| 37384285 | In a previous study, it was reported that high temperature stimulation at 47°C or 52°C produced a significant analgesic effect in mice with inflammation compared to low temperature stimulation at 37°C or 42°C. | Front Neurol. 2023 Jun 13;14:1168012. doi: 10.3389/fneur.2023.1168012. eCollection 2023. | Analgesic Effect Hypothermia | Mechanism |
| 37384285 | found that TRPV1 was highly expressed at ST36 and participated in acupuncture-related analgesia, and capsaicin injection into ST36 replicated the analgesic effect of acupuncture. | Front Neurol. 2023 Jun 13;14:1168012. doi: 10.3389/fneur.2023.1168012. eCollection 2023. | Analgesic Effect | Mechanism |
| 29785197 | It indicated that MA had an analgesic effect on inflammatory pain in CFA rats. | Evid Based Complement Alternat Med. 2018 Jan 29;2018:9260630. doi: 10.1155/2018/9260630. eCollection 2018. | Analgesic Effect Inflammatory Pain | Mechanism |
| 29785197 | These indicate that the key signaling molecules we acquired were consistent with the pathogenesis of RA and the analgesic effect and anti-inflammatory mechanism of MA. | Evid Based Complement Alternat Med. 2018 Jan 29;2018:9260630. doi: 10.1155/2018/9260630. eCollection 2018. | Analgesic Effect | Mechanism |
| 29785197 | In conclusion, this study shows that MA has obvious analgesic and anti-inflammatory effects on CFA rats with inflammatory pain; the key signaling molecules of ST36 acupoint, serum, and hind footpad tissue acquired by statistical and complex network methods were all consistent with the pathogenesis of RA and the analgesic effect and anti-inflammatory mechanism of MA; these key signaling molecules in the three parts may play an important role in MA modulating NEI network; it still needs to be further studied in the future. | Evid Based Complement Alternat Med. 2018 Jan 29;2018:9260630. doi: 10.1155/2018/9260630. eCollection 2018. | Analgesic Effect Inflammatory Pain | Mechanism |
| 29785197 | It shows that analgesic effect of MA can be detected on day 7 and day 21 after treatment. | Evid Based Complement Alternat Med. 2018 Jan 29;2018:9260630. doi: 10.1155/2018/9260630. eCollection 2018. | Analgesic Effect | Mechanism |
| 26064176 | Acupuncture originated in ancient China has been proved to have a promising analgesic effect on several pain disorders, such as neuropathic pain, inflammatory pain, and cancer pain. | Evid Based Complement Alternat Med. 2015;2015:848603. doi: 10.1155/2015/848603. Epub 2015 Apr 29. | Analgesic Effect Neuropathic Pain Cancer Pain Inflammatory Pain | Mechanism |
| 27942989 | Low-level lasers have been used in laser acupuncture, and their analgesic effects have been reported. | Lasers Med Sci. 2017 Dec;32(9):2167-2171. doi: 10.1007/s10103-016-2124-3. Epub 2016 Dec 10. | Analgesic Effect | Mechanism |
| 38164490 | reported that ACE has analgesic effects in withdrawal levels and decreased paw edema in mice inflammatory pain model. | Iran J Basic Med Sci. 2024;27(1):66-73. doi: 10.22038/IJBMS.2023.71431.15534. | Analgesic Effect Inflammatory Pain | Mechanism |
| 36277498 | These results indicated that EA has an immediate analgesic effect on pT-ION mice. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Analgesic Effect | Mechanism |
| 36277498 | These findings demonstrated that EA has long-term analgesic effects on pT-ION model mice without disrupting their motor function. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Analgesic Effect Motor Function | Mechanism |
| 36277498 | On day 21 after pT-ION surgery (day 14 after EA every 2 days), the analgesic effect of EA is shown as an increased primary mechanical pain threshold (D) and secondary mechanical pain threshold (E) in response to von Frey stimulation and a decreased wiping duration in response to acetone stimulation (F). | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Analgesic Effect | Mechanism |
| 36277498 | Studies have demonstrated that EA has an analgesic effect on chronic pain and can modulate mood changes and cognitive dysfunction through central and peripheral mechanisms. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Analgesic Effect Cognitive Function Mood | Mechanism |
| 36277498 | Importantly, the mechanical pain threshold of the EA group on day 21 was higher than that on day 7, suggesting EA may have cumulative analgesic effects on pT-ION-induced orofacial pain. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Analgesic Effect | Mechanism |
| 25368638 | Direct injection of an adenosine A1 receptor agonist enhanced the analgesic effect of acupuncture. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 25368638 | The analgesic effect of acupuncture appears to be mediated by activation of A1 receptors located on ascending nerves. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 25368638 | Electroacupuncture may act via purinergic A1 and P2X3 receptors simultaneously to induce an analgesic effect on neuropathic pain. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25368638 | Previous studies addressing the analgesic effect of acupuncture mainly focused on purine and a single purine receptor; no studies have examined the possible influence of synergism or antagonism with other receptors. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 25368638 | Electroacupuncture may induce an analgesic effect in neuropathic pain by influencing both purinergic A1 and P2X purinoceptor 3 (P2X3) receptors simultaneously. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25368638 | Electroacupuncture can inhibit purinergic A1 and P2X3 receptors and exert an analgesic effect on neuropathic pain. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25368638 | Whereas the stimulation of A1 receptors results in analgesic effects in a wide range of animal models, in rats lacking the A1 receptor there is an enhanced response to nociceptive stimuli. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 25368638 | Electroacupuncture treatment produces a long-lasting analgesic effect on neuropathic pain and increases expression of P2X3 receptors in the midbrain periaqueductal gray matter, which potentiates the function of the purinergic signaling system at the supraspinal level and provides a rational basis for explaining the analgesic effect of electroacupuncture. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25368638 | The analgesic effects of peripheral, spinal and supraspinal A1 receptors are well established, and an A1 receptor agonist has been found to substantially reduce inflammatory and neurogenic pain; also, the suppression of pain mediated by electroacupuncture requires adenosine A1 receptor expression. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 25368638 | Although the analgesic effect of electroacupuncture is well documented, little is understood about its biological basis. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 25368638 | The primary mechanism implicated in the analgesic effect of electroacupuncture involves release of endogenous opioid peptides in response to the long-lasting activation of ascending sensory tracts during stimulation. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 25368638 | Also, it has been suggested that the analgesic effects of electroacupuncture are associated with its ability to counter-regulate spinal glial activation. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 25368638 | The analgesic effect of electroacupuncture has been used widely to alleviate diverse pains in clinical practice, particularly chronic pain. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 25368638 | Moreover, there is a long-lasting analgesic effect after acupuncture stimulation has been completed. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 25368638 | Therefore, the ATP release induced by electroacupuncture does not activate P2X3 receptors and so does not exert an anti-analgesic effect. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 25368638 | In patients with chronic neuropathic pain, adenosine compounds appear to mediate their analgesic effects through A1 receptor-related modulation of central sensitization at spinal or supraspinal levels. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect Neuropathic Pain | Mechanism |
| 25368638 | The analgesic effect of adenosine and ATP is slow in onset and long-lasting. | Neural Regen Res. 2012 Nov 25;7(33):2618-23. doi: 10.3969/j.issn.1673-5374.2012.33.007. | Analgesic Effect | Mechanism |
| 28473863 | As found by Yu et al., the destruction of the collagen structure at Zusanli acupoint area of AA rat with type I collagenase significantly inhibited the degranulation of the mast cells at this acupoint area, and the manipulation of lifting, thrusting, and twisting showed significantly weakened analgesic effect. | Evid Based Complement Alternat Med. 2017;2017:2813437. doi: 10.1155/2017/2813437. Epub 2017 Apr 4. | Analgesic Effect | Mechanism |
| 23737830 | However, these two EA methods have never been directly compared regarding their analgesic effects and other features such as stress. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 23737830 | In the present study, we reported similar analgesic effects between restrained and unrestrained EA in rats of acute inflammatory pain induced by intraplantar injection of CFA. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect Inflammatory Pain | Mechanism |
| 23737830 | These advantages suggest that this unrestrained EA method can replace the traditional restrained procedure with similar analgesic effects and allow for more choices of stimulating intensities and locations. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 23737830 | This restrained EA method had been suggested to cause stress, and its analgesic effects might hardly be differentiated from stress-induced analgesia (SIA). | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 23737830 | In addition, accumulating evidence suggests that different stimulating parameters, such as current intensity, frequency, and location, all significantly affect the analgesic effects of EA. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 23737830 | However, the analgesic effects, intensity tolerance, and stress-like behaviors have never been directly compared between these two EA methods. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 23737830 | To obtain strong analgesic effects, each rat received two EA sessions, one immediately after CFA injection and one 2 hours after injection as previously described. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 23737830 | In both human volunteers and anaesthetized rodents, there is evidence that EA of different intensities exerts analgesic effects through distinct mechanisms. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 23737830 | Acupoint specificity has raised lots of attention, not only that different acupoints show distinct analgesic effects under pathological conditions but also that the underlying mechanisms vary as well. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 23737830 | Our experiment in CFA-induced inflammatory pain revealed similar analgesic effects between the restrained and the unrestrained EA methods. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect Inflammatory Pain | Mechanism |
| 23737830 | showed that restraining mice in clothing holders alone was sufficient to produce mild anti-nociception, but EA stimulation showed an additional analgesic effect. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 23737830 | Thus, restraint becomes a confounding factor in evaluating the real analgesic effects of EA and explaining its mechanisms. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 23737830 | These advantages, combined with similar analgesic effects compared with the traditional restrained EA, suggest that the unrestrained EA method can replace the restrained EA procedure in future research. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 23737830 | Restrained and unrestrained EA produced significant and similar analgesic effects 2.5 and 5 but not 24 hours after intraplantar CFA injection, indicated by decreased changes of PWL from preinjection baseline. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Analgesic Effect | Mechanism |
| 36116306 | Electro-acupuncture has a significant analgesic effect in 24-48 hours after surgery. | Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. | Analgesic Effect | Mechanism |
| 36116306 | So far, there have been many studies on the analgesic effect of electro-acupuncture after surgery and found a significant therapeutic effect. | Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. | Analgesic Effect | Mechanism |
| 36116306 | The results of our study on the analgesic effect of electroacupuncture showed that, 24 h after surgery, the pain level in the study group decreased to 4.12 ± 1.32, in the control group to 4.81 ± 1.29. | Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. | Analgesic Effect | Mechanism |