In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.

           
Modulation
Immunity
Acupuncture anesthesia may enhance the body's immune response, reducing the risk of postoperative infections.
Blood Flow
Acupuncture anesthesia can optimize blood flow to tissues, aiding in wound healing and tissue recovery.
Endocrinology
Acupuncture anesthesia can influence endocrine function, helping maintain hormonal balance during surgery.
Circulation
Acupuncture anesthesia supports overall circulatory health, ensuring adequate oxygen and nutrient delivery to tissues.
Microcirculation
Acupuncture anesthesia positively affects microcirculation, benefiting tissue perfusion and healing.
Blood Pressure
Acupuncture anesthesia can help stabilize blood pressure, reducing perioperative hypertension risks.
Heart Rate
Acupuncture anesthesia can regulate heart rate, promoting cardiovascular stability during surgery.
Hemodynamics
Acupuncture anesthesia optimizes hemodynamic parameters, contributing to surgical safety.
Bleeding
Acupuncture anesthesia may reduce intraoperative bleeding, enhancing surgical outcomes.
Skin Temperature
Acupuncture anesthesia can help maintain stable skin temperature during surgery, preventing hypothermia.

Acupuncture anesthesia for Modulation-Bleeding


PMID Evidence Source Keyword Type
21717784 Progress of researches on mechanism of acupuncture therapy underlying improvement of acute cerebral hemorrhage. Zhen Ci Yan Jiu. 2011 Apr;36(2):145-9. Bleeding Review
21717784 In the present paper, the authors review the progress of researches on the mechanism of acupuncture therapy underlying improvement of acute cerebral hemorrhage from experimental studies and research methods. Zhen Ci Yan Jiu. 2011 Apr;36(2):145-9. Bleeding Review
22404527 This study seeks to identify: (i) effects of acupuncture use for persons with haemophilia who experience persistent joint pain as a result of repeated haemarthrosis and (ii) document no reported increased bleeding risk as a result of acupuncture use. Haemophilia. 2012 Jul;18(4):613-7. doi: 10.1111/j.1365-2516.2012.02766.x. Epub 2012 Mar 8. Bleeding Review
23227705 It turned out that in the area of clinical research, the main usage of acupuncture was assist treatment of artificial abortion and drug-induced abortion: in artificial abortion, acupuncture can play a role in analgesia, artificial abortion syndrome relieving, and cervix dilating, while in the drug induced abortion, acupuncture can play a role in improving completed abortion rate, accelerating foetal sac release, decreasing side effects and regulating postoperative bleeding. Zhongguo Zhen Jiu. 2012 Sep;32(9):860-4. Side Effects Bleeding Review
32744860 Objectives: This study was aimed at evaluating the efficacy of acupuncture in regulating BP in stroke patients, including both cerebral infarction and hemorrhage. J Altern Complement Med. 2020 Dec;26(12):1105-1116. doi: 10.1089/acm.2019.0454. Epub 2020 Jul 31. Bleeding Blood Pressure Review
33197658 Common adverse effects reported with topical capsaicin included mild burning sensations (50.0-88.2 %) or erythema (6.7-22.7%) while that of acupuncture included soreness (7.5 %), bleeding (6.0-7.5%) and hematoma (1.9 %). Complement Ther Med. 2021 Jan;56:102609. doi: 10.1016/j.ctim.2020.102609. Epub 2020 Nov 5. Adverse Reactions Bleeding Review
33350223 As for the occurrence of adverse reactions, the adverse reactions reported in the acupuncture group included in the study were all mild adverse reactions, like drowsiness, subcutaneous bleeding, local pain, subcutaneous hematoma and dizziness needle. Zhongguo Zhong Yao Za Zhi. 2020 Nov;45(21):5083-5092. doi: 10.19540/j.cnki.cjcmm.20200521.502. Adverse Reactions Bleeding Review
34581072 Systematic review and Meta-analysis of efficacy and safety of acupuncture therapy on hypertensive intracerebral hemorrhage. Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(18):4644-4653. doi: 10.19540/j.cnki.cjcmm.20210429.501. Bleeding Review
34581072 To systematically review the efficacy and safety of acupuncture combined with minimally invasive surgery or basic the-rapy in treating hypertensive intracerebral hemorrhage(HICH) patients compared with minimally invasive surgery or basic treatment. Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(18):4644-4653. doi: 10.19540/j.cnki.cjcmm.20210429.501. Bleeding Review
35439704 Common adverse reactions associated with acupressure included intradialytic hypotension (20.4%) and dizziness (11.1%) while that of acupuncture included elbow soreness (7.5%) and bleeding (7.5%). Complement Ther Clin Pract. 2022 Aug;48:101593. doi: 10.1016/j.ctcp.2022.101593. Epub 2022 Apr 15. Adverse Reactions Bleeding Review
23067573 As such, we chose to include the following criterion, which was created to ensure that treatment effects were attributable only to acupuncture rather than to other interventions: acupuncture administered (a) alone; (b) with a co-intervention, defined as an intervention that was provided additionally to both treatment and control groups; or (c) with one of the following interventions, often considered to be part of acupuncture treatment: (i) techniques commonly used with acupuncture (for example, tui na, acupressure, cupping, moxibustion, herbs, tai qi, qi gung, gua sha, bleeding, Ah Shi points), and/or (ii) self-management techniques (for example, stretching exercises, meditation, tai chi, breathing exercises, suggested dietary/lifestyle changes). Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. Bleeding Review
23067573 Expected, likely risks reported from acupuncture include localized discomfort and infection, slight bleeding and bruising at needle insertion sites. Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. Bleeding Review
24073009 In a more recent RCT, we further determined ovulation frequency in PCOS women, during a 3-month long acupuncture or attention control treatment period, by weekly progesterone measurement as well as menstrual bleeding registrations. Evid Based Complement Alternat Med. 2013;2013:762615. doi: 10.1155/2013/762615. Epub 2013 Sep 2. Bleeding Review
24349293 An inventory concerning 32,000 acupuncture consultations in UK revealed the most common adverse events of bleeding, needle pain and aggravation of symptoms, but none were serious. PLoS One. 2013 Dec 13;8(12):e82474. doi: 10.1371/journal.pone.0082474. eCollection 2013. Bleeding Review
24716183 Severe adverse effects of acupuncture are rare and easily handled, such as a small hemorrhage, fainting, or syncope, bruising, dizziness, needle breakage, pneumothorax, or nerve damage. J Tradit Complement Med. 2013 Oct;3(4):234-9. doi: 10.4103/2225-4110.119733. Adverse Reactions Bleeding Review
25435890 For auricular acupuncture, the most frequently reported adverse events were tenderness or pain at insertion, dizziness, local discomfort, minor bleeding and nausea, and so forth. Evid Based Complement Alternat Med. 2014;2014:506758. doi: 10.1155/2014/506758. Epub 2014 Nov 10. Bleeding Nausea and Vomiting Review
25435890 However, for the adverse events, cases of local pain and dizziness were much less in auricular acupressure studies compared with those identified in studies on auricular acupuncture, and there were no bleeding and infection reports related to auricular acupressure. Evid Based Complement Alternat Med. 2014;2014:506758. doi: 10.1155/2014/506758. Epub 2014 Nov 10. Bleeding Review
26608664 A wide range of minor adverse events was reported, which including bleeding at the acupuncture site, skin irritation, discomfort, transient rash, electrical shock sensation and tingling. Sci Rep. 2015 Nov 26;5:16776. doi: 10.1038/srep16776. Bleeding Review
26945382 However, only 2 RCTs reported acupuncture induced side effects, including dizziness during needle insertion (5/30), subcutaneous bleeding (3/30), and mild burn, which was observed in few cases when moxibustion was inappropriately conducted, which was judged by the original RCT. Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. Side Effects Bleeding Review
26977172 One trial reported adverse effects such as subcutaneous hemorrhage and fainting during acupuncture, with an incident rate of 8%. Evid Based Complement Alternat Med. 2016;2016:1720239. doi: 10.1155/2016/1720239. Epub 2016 Feb 10. Adverse Reactions Bleeding Review
27217981 It is effective treatment for dysfunctional bleeding and chronic pelvic inflammatory disease and dysmenorrhoea (see Table 2 for acupuncture points used in the treatment of heavy periods). Curr Obstet Gynecol Rep. 2016;5:110-118. doi: 10.1007/s13669-016-0156-0. Epub 2016 Apr 25. Bleeding Review
27417472 The type of acupuncture is explained to both the parent and child, along with possible complications, which may include bleeding, infection, or increased pain. Children (Basel). 2014 Aug 21;1(2):134-48. doi: 10.3390/children1020134. Bleeding Review
27531549 The other RCT reported 2 mild adverse events, including pain and bleeding in the acupuncture group and 2 in the drug group, whereas 1 RCT showed no adverse events. Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. Bleeding Review
28664077 Intracerebral hemorrhage-induced Fos expression and cell proliferation in the dentate gyrus of rats following acupuncture treatment at the ST36 acupoint has also been investigated. Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. Bleeding Review
29729027 Two RCTs reported minor side effects of acupuncture, which were primarily minor bruising, bleeding, or pain at needle insertion sites. Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. Side Effects Bleeding Review
29729027 Possible side effects of acupuncture treatment included minor bruising and bleeding at the site of needle insertion, which were reported in 2 trials. Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. Side Effects Bleeding Review
29729027 Additionally, some patients experience the minor side effects of bruising and bleeding at needle insertion points, and thus acupuncture should be used cautiously by patients on anticoagulant therapy, or by patients who have a bleeding disorder. Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. Side Effects Bleeding Review
29729027 Two RCTs reported minor side effects of acupuncture, which were primarily minor bruising, bleeding, or pain at needle insertion sites. Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. Side Effects Bleeding Review
30050856 Rats treated with electroacupuncture following cerebral hemorrhage showed improved clinical outcomes. Vet Med (Auckl). 2017 Aug 24;8:53-58. doi: 10.2147/VMRR.S125609. eCollection 2017. Bleeding Review
30557187 Level Vevidence reports on the risk of bleeding in gingko and kelp use and the risk of infection in acupuncture use. Ann Plast Surg. 2019 Apr;82(4):459-468. doi: 10.1097/SAP.0000000000001676. Bleeding Review
30584456 Adverse events such as acupuncture fainting, needle twisting and breaking, bleeding, and organ injury were also taken into account as safety measurement. Evid Based Complement Alternat Med. 2018 Nov 21;2018:8791538. doi: 10.1155/2018/8791538. eCollection 2018. Bleeding Review
30809158 Serious and potentially life-threatening acupuncture-related complications, including transmission of infections, pneumothorax, cardiovascular lesions, and hemorrhage or hematomas in the central nervous system (CNS), are very rarely reported. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Cardiovascular Bleeding Review
31304087 (TX = System Review OR Meta-analysis OR META) [AND] (TX = Acupuncture OR Acupuncture OR Electroacupuncture OR Auricular acupuncture OR scalp acupuncture OR aqua acupuncture) [AND] (TX = Stroke OR Stroke OR Cerebral Infarction OR Cerebral Hemorrhage OR Cerebral embolism OR cerebrovascular disease OR cerebrovascular accident OR acute phase OR TCM combined stroke unit OR TCM stroke unit) Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Bleeding Review
31304087 We include patients diagnosed with any type of stroke by World Health Organization stroke criteria [11] (ischemic stroke, acute ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, acute stroke, progressive cerebral infarction, acute cerebral infarction, cerebral hemorrhage, and cerebral ischemic stroke), or American Stroke Association criteria [12] (ischemic, hemorrhagic, transient ischemic) and received acupuncture along with conventional intervention (cognitive rehabilitation and conventional therapy) in post-stroke management. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Bleeding Review
31379957 Thus, some studies have reported that acupuncture is beneficial for treating cerebral hemorrhage because it results in functional improvements. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Bleeding Review
31565065 Two trials reported minor bleeding in the acupuncture group, but the spirit was good; the western medicine group had poor mentality during the day. Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. Bleeding Review
32051687 The main adverse effects following acupuncture include subcutaneous bleeding and pain following the piercing. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Adverse Reactions Bleeding Review
32718258 Participants were excluded if they (1) did not meet the diagnostic criteria of breast cancer; (2) had postoperative lymphatic drainage of breast cancer; (3) the body function could not tolerate acupuncture therapy; (4) had mental disorders or taking psychoactive drugs with a definite clinical diagnosis; (5) receiving blood transfusion or steroid treatment; (6) with a second solid tumor; (7) with contraindications of acupuncture therapy: those with bleeding tendency, severe allergic and infectious skin diseases, thyroid dysfunction, epilepsy, cerebral cortex damage, and a cardiac pacemaker installed. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420940394. doi: 10.1177/1534735420940394. Bleeding Review
32996339 Among the 9 RCTs, 2 studies have reported the occurrence of minor adverse effects (spot bleeding and bruising) related to acupuncture treatment. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420949679. doi: 10.1177/1534735420949679. Adverse Reactions Bleeding Review
33005199 The number, distribution, intensity, depth, and repetition of acupuncture and bleeding therapy on the sublingual veins were considered as manipulation types. Evid Based Complement Alternat Med. 2020 Sep 14;2020:4981945. doi: 10.1155/2020/4981945. eCollection 2020. Bleeding Review
33005199 Together with the acupuncture intervention type, it is generally accepted that some acupuncture manipulation skills, including intensity, depth, repetition, and distribution of needling, and bleeding therapy using needle pricking affect the clinical efficacy of AT. Evid Based Complement Alternat Med. 2020 Sep 14;2020:4981945. doi: 10.1155/2020/4981945. eCollection 2020. Bleeding Review
33005199 The search keywords used were dysarthria, acupuncture, acupuncture therapy, acupoint, electroacupuncture, auricular acupuncture, ear acupuncture, pharmacopuncture, randomized controlled trial, random allocation, clinical trial, placebo, stroke, apoplexy, brain infarction, cerebral infarction, and cerebral hemorrhage. Evid Based Complement Alternat Med. 2020 Sep 14;2020:4981945. doi: 10.1155/2020/4981945. eCollection 2020. Bleeding Review
33157947 Zhang et al reported 5 events, including subcutaneous hemorrhage (3 events), faint during acupuncture needling (1 event), and marasmus during acupuncture (1 event). Medicine (Baltimore). 2020 Nov 6;99(45):e23014. doi: 10.1097/MD.0000000000023014. Bleeding Review
33299403 The more adverse effect occurred in the acupuncture group when comparing with the dicetel group (RR = 11.86, 95% CI [1.58, 89.07]) and loperamide group (RR = 4.42, 95% CI [0.57, 33.97]), but most of the adverse reactions were mild hypodermic hemorrhage. Neural Plast. 2020 Nov 22;2020:8892184. doi: 10.1155/2020/8892184. eCollection 2020. Adverse Reactions Bleeding Review
33299403 Although the number of adverse events in the acupuncture group was similar to that in the control group, the majority of adverse events in the acupuncture group were subcutaneous hemorrhage. Neural Plast. 2020 Nov 22;2020:8892184. doi: 10.1155/2020/8892184. eCollection 2020. Bleeding Review
33757500 The choice of eye-acupuncture needle and needling techniques are more important to consider in terms of safety rather than regarding the effectiveness of the intervention There is a rich blood capillary network around the orbit and withdrawing the needle there may be the possibility of slight bleeding. BMC Complement Med Ther. 2021 Mar 23;21(1):101. doi: 10.1186/s12906-021-03272-8. Bleeding Review
33859714 The process of acupuncture treatment can be divided into seven stages: diagnosis and prescription, acupoint positioning, topical disinfection, needle insertion, manipulation, and needle withdrawing, sometimes it is needed to stop bleeding by applying pressure to the acupoint. Evid Based Complement Alternat Med. 2021 Mar 31;2021:8883598. doi: 10.1155/2021/8883598. eCollection 2021. Bleeding Review
33859714 Prudent acupuncture techniques are commonly practiced with the intent to avoid large neurovascular structures, thereby minimizing potential excessive bleeding and neural injury. Evid Based Complement Alternat Med. 2021 Mar 31;2021:8883598. doi: 10.1155/2021/8883598. eCollection 2021. Bleeding Review
33896475 Several studies reported only minor acupuncture-related adverse events (elbow soreness, minimal bleeding), but as the remaining studies did not report adverse events, conclusions cannot be made regarding safety. Semin Nephrol. 2021 Jan;41(1):68-81. doi: 10.1016/j.semnephrol.2021.02.007. Bleeding Review
33936242 Auricular acupuncture is a traditional Chinese meridian therapy, including ear embedding therapy, ear sticking therapy, auricular bleeding, and automatic ear acupuncture therapy equipment. Evid Based Complement Alternat Med. 2021 Apr 15;2021:6677767. doi: 10.1155/2021/6677767. eCollection 2021. Bleeding Review
34336626 In a study that investigated retrospective studies, case reports, and surveys of medical providers, they concluded the following to be the most common adverse effects of acupuncture: bruising, needle site bleeding, diarrhea, increased pain, nausea, vomiting, fainting, psychiatric disturbances, headaches, sweating, dizziness, and aggravation of symptoms. Anesth Pain Med. 2021 Apr 3;11(2):e113627. doi: 10.5812/aapm.113627. eCollection 2021 Apr. Adverse Reactions Bleeding Nausea and Vomiting Review
34336626 More specifically, a systemic review on acupuncture safety that looked at nine different studies found that the most common side effects were: needle pain, tiredness, and bleeding. Anesth Pain Med. 2021 Apr 3;11(2):e113627. doi: 10.5812/aapm.113627. eCollection 2021 Apr. Side Effects Bleeding Review
34336626 The most common adverse events associated with acupuncture included minor bleeding, bruising, soreness, pain at the needling site, lightheadedness, dizziness, and headache. Anesth Pain Med. 2021 Apr 3;11(2):e113627. doi: 10.5812/aapm.113627. eCollection 2021 Apr. Bleeding Review
34489268 Half of the AEs were bleeding, pain or flare at the needle site that are argued to represent intended acupuncture reaction. BMJ Open. 2021 Sep 6;11(9):e045961. doi: 10.1136/bmjopen-2020-045961. Bleeding Review
34489268 Most frequent and commonly occurring minor AEs with summary risk estimates between 1% and 5% of patients undergoing an acupuncture series were bleeding events, pain at the needling site, other local AEs, vegetative reactions, aggravation of symptoms, and events related to the central nervous system. BMJ Open. 2021 Sep 6;11(9):e045961. doi: 10.1136/bmjopen-2020-045961. Bleeding Review
34489268 Summary risk estimates for bleeding events, needle site pain, vegetative reactions, and aggravation of symptoms also ranged from 1% to 5% of treatments, while the meta-analysis of symptoms related to the central nervous system per acupuncture treatment resulted in a risk of 2 in 1000 treatments. BMJ Open. 2021 Sep 6;11(9):e045961. doi: 10.1136/bmjopen-2020-045961. Bleeding Review
34489268 About half of the reported minor AEs are usually mild and transient or might even be regarded as part of the acupuncture treatment or therapeutically intended reactions (bleeding, needle site pain, and flare around the needle site). BMJ Open. 2021 Sep 6;11(9):e045961. doi: 10.1136/bmjopen-2020-045961. Bleeding Review
34489268 Local reactions such as bleeding, pain, and flare at the needling site, which represented half of the AEs reported, are referred to as beneficial signs in standard acupuncture textbooks and by authors themselves. BMJ Open. 2021 Sep 6;11(9):e045961. doi: 10.1136/bmjopen-2020-045961. Bleeding Review
34646653 One of the most common side effects of acupuncture is micro bleeding which is defined as bleeding that took from 10 to 30 seconds to resolve. Cureus. 2021 Aug 31;13(8):e17601. doi: 10.7759/cureus.17601. eCollection 2021 Aug. Side Effects Bleeding Review
34646653 However, this and other studies related to bleeding in acupuncture have been limited by a small sample size, and larger double-blinded studies are needed to further assess the safety profile of acupuncture. Cureus. 2021 Aug 31;13(8):e17601. doi: 10.7759/cureus.17601. eCollection 2021 Aug. Bleeding Review
34667434 The most common side effects resulting from acupuncture needling is local pain (3.3% patients), bruising (3.2%), minor bleeding (1.4%), and orthostatic problems (0.5%). Contemp Oncol (Pozn). 2021;25(2):88-94. doi: 10.5114/wo.2021.105969. Epub 2021 May 7. Side Effects Bleeding Review
34667434 patients may be prone to infections and bleeding, so acupuncture should be avoided in patients with low neutrophil count, low platelet count, and international normalized ratio > 4, Contemp Oncol (Pozn). 2021;25(2):88-94. doi: 10.5114/wo.2021.105969. Epub 2021 May 7. Bleeding Review
34675729 Several prospective surveys with large sample sizes have suggested that acupuncture-related AEs mainly involve minor local reactions at the site of needling, such as bruising, pain, or minor bleeding, and the incidence of these events is generally very low (no more than 3%). Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Bleeding Review
34675729 Given its non-pharmacological basis, acupuncture also obviates the concerns with respect to toxicity and AEs that commonly occur when using hypnotics/sedatives, such as hangover, tolerance, increased alertness, and even endocrinological, hematological or cardiovascular events, and concerns regarding common side effects of contemporary antidepressive agents, such as dry mouth, cardiovascular/gastrointestinal side effects, seizure, bleeding, sexual dysfunction, weight gain, and even suicidality. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Cardiovascular Endocrinology Toxic Side Effects Side Effects Bleeding Review
35090456 In recent years, few adverse events related to acupuncture treatment have been reported, among which hematoma, bleeding and dizziness are the main manifestations. BMC Complement Med Ther. 2022 Jan 28;22(1):28. doi: 10.1186/s12906-021-03484-y. Bleeding Review
35090456 In terms of safety, although they are not common, some adverse events (AEs)-such as pneumothorax, central nervous system injury, syncope, infection, bleeding, allergy-do occur during acupuncture treatment. BMC Complement Med Ther. 2022 Jan 28;22(1):28. doi: 10.1186/s12906-021-03484-y. Bleeding Review
35462893 Previous studies showed that electroacupuncture could ameliorate early brain injury after subarachnoid hemorrhage by inhibiting the PARP-1/AIF pathway. Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. Bleeding Review
35462893 In addition, the BNIP3 expression is elevated in rats after SCI, and electroacupuncture at GV20-GB7 reduced BNIP3 after intracerebral hemorrhage. Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. Bleeding Review
35462893 Moreover, studies conducted in intracerebral hemorrhage rat models show the effect of ferroptosis inhibition by acupuncture. Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. Bleeding Review
35462893 In animal experiments, acupuncture can also improve the blood flow within the brain after hemorrhage or ischemia. Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. Bleeding Blood Flow Review
35726681 Among the studies that reported adverse effects, they were mostly considered as direct risk, as 13% reported mainly bleeding and bruising upon acupuncture treatment, and dizziness with yoga treatment. Integr Cancer Ther. 2022 Jan-Dec;21:15347354221105563. doi: 10.1177/15347354221105563. Adverse Reactions Bleeding Review
35726681 Choksi et al reported 15 cases of bleeding with acupuncture treatment (out of 252 sessions, 6%) and 5 cases of bruising (2%). Integr Cancer Ther. 2022 Jan-Dec;21:15347354221105563. doi: 10.1177/15347354221105563. Bleeding Review
35884060 They found that mild and non-worrisome adverse events during or after an acupuncture session included bruising, bleeding, mild pain upon needle insertion, and fatigue. Children (Basel). 2022 Jul 19;9(7):1076. doi: 10.3390/children9071076. Bleeding Review
36017012 The remaining studies reported seven cases of subcutaneous hemorrhage after acupuncture therapy. Front Med (Lausanne). 2022 Aug 9;9:940328. doi: 10.3389/fmed.2022.940328. eCollection 2022. Bleeding Review
36230606 Acupuncture was associated with needle pain, tingling and numbness, subcutaneous hemorrhage, bruising, and mild swelling. Cancers (Basel). 2022 Sep 26;14(19):4683. doi: 10.3390/cancers14194683. Bleeding Inflammatory Pain Review
36475060 However, pregnant migraine patients and people with bleeding problems should be careful about using acupuncture and should discuss it with their doctor. Open Med (Wars). 2022 Nov 23;17(1):1869-1882. doi: 10.1515/med-2022-0598. eCollection 2022. Bleeding Review
36482537 Bleeding at the stimulated site during acupuncture therapy and slight contusion of the skin tissue during massage therapy are common adverse reactions. Medicine (Baltimore). 2022 Dec 2;101(48):e32058. doi: 10.1097/MD.0000000000032058. Adverse Reactions Bleeding Review
36530891 used acupuncture at SP6, SP10, ST36, and LI11 in 40 patients and could report that 2 patients (one in acupuncture group, another in control group) complained about elbow soreness and 3 patients in the control group complained about minimal bleeding induced by acupuncture. Front Med (Lausanne). 2022 Dec 1;9:1036072. doi: 10.3389/fmed.2022.1036072. eCollection 2022. Bleeding Review
36532179 And the remaining eight cases had adverse effects such as subcutaneous bleeding, acupuncture pain, and insomnia. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Adverse Reactions Insomnia Bleeding Review
36532179 The adverse events in experimental groups included subcutaneous hemorrhage, pain or numbness from acupuncture, rapid heartbeat, dizziness, diarrhea, nausea, insomnia, and fainting from acupuncture. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Insomnia Bleeding Nausea and Vomiting Review
36607887 Notably, unlike electroacupuncture, transcutaneous electrical acupoint stimulation should not implement the piercing of the needle into the body, which reduces pain, bleeding, needle breakage, and other adverse reactions. Medicine (Baltimore). 2023 Jan 6;102(1):e32582. doi: 10.1097/MD.0000000000032582. Adverse Reactions Bleeding Review
36698826 Compared to the well-known side effects of NSAIDs such as gastrointestinal complications (e.g., bleeding, ulcer perforation), the relative safety of acupuncture and its association with few serious adverse events render it a promising option for patients with pain not responding to regular medications and those experiencing serious drug-related side effects. Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. Side Effects Bleeding Review
36845439 Although subcutaneous hematoma and pinhole hemorrhage appeared occasionally in the process of acupuncture therapy, there was no statistically significant difference between real acupuncture and SA based on the two studies (Huang et al.,; Li et al.,) (RR = 5.91, 95%CI [0.73, 47.72]) (Figure 6). Front Neurosci. 2023 Feb 9;17:1097830. doi: 10.3389/fnins.2023.1097830. eCollection 2023. Bleeding Review
36862907 In terms of safety, drug adverse reactions as dizziness, dry mouth, drowsiness, gastrointestinal symptoms, and adverse reactions of acupuncture for subcutaneous bleeding, strong sense of needle legacy, at the end of the withdrawal or acupuncture treatment can obviously relieve or disappear, never reported left side effects. Medicine (Baltimore). 2023 Mar 3;102(9):e33006. doi: 10.1097/MD.0000000000033006. Side Effects Adverse Reactions Bleeding Review
36960418 In acupuncture and sham acupuncture groups, specific skin symptoms including mild subcutaneous bleeding and pain were reported, while in the western medicine groups, gastrointestinal symptoms including nausea, abdominal pain, dizziness, and low blood pressure were recorded. Pain Res Manag. 2023 Mar 14;2023:7754876. doi: 10.1155/2023/7754876. eCollection 2023. Bleeding Nausea and Vomiting Blood Pressure Review
37038228 This may be attributed to excessive stress and fear of acupuncture in patients, especially those new to acupuncture, frail, seriously ill, with excessive blood loss, with a history of dizziness from acupuncture, or in an improper posture. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Bleeding Review
37038228 A total of 233 SRs reported tissue or organ injury caused by acupuncture, mainly including pain (11.79%, 144 SRs), bleeding or bruising (9.83%, 120 SRs), haematoma (5.73%, 70 SRs), headache (2.21%, 27 SRs), pruritus (1.88%, 23 SRs), erythema (1.56%, 19 SRs), neuromuscular disease (1.31%, 16 SRs), aggravation of symptoms (1.15%, 14 SRs), skin allergy reaction (1.15%, 14 SRs), minor swelling (1.06%, 13 SRs), numbness (1.06%, 13 SRs), induration (0.90%, 11 SRs), palpitations (0.82%, 10 SRs), menoxenia (0.41%, 5 SRs), mild edema (0.25%, 3 SRs), blisters (0.25%, 3 SRs), and motor disorders (0.16%, 2 SRs). Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Bleeding Inflammatory Pain Review
37038228 Local bleeding during acupuncture was reported in 120 studies. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Bleeding Review
37038228 It is worth noting that bleeding during acupuncture is relatively common because many blood vessels are under the skin. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Bleeding Review
37038228 Although acupuncturists avoid large and thick blood vessels when performing acupuncture, the tiny capillaries are difficult to see with the naked eye, and thus the needle may break the small blood vessel resulting in bleeding. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Bleeding Review
37038228 Heamatoma, a swelling and pain caused by bleeding under the skin at the acupuncture site, was reported in 70 studies. Chin Med. 2023 Apr 10;18(1):38. doi: 10.1186/s13020-023-00743-7. Bleeding Inflammatory Pain Review
37046882 Yang reported that among participants who received electro-acupuncture, bleeding and hematoma around the site of the needling occurred as adverse reactions in 12.5% (4/32) of cases. Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. Adverse Reactions Bleeding Review
37200784 The acupuncture group experienced mild needle pain, small amounts of superficial bleeding, small amounts of hematoma, headache, night sweats, nausea, and fatigue. Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Bleeding Nausea and Vomiting Review
37289799 Acupuncture-related adverse events were generally mild and temporary, such as mild bleeding and hematoma, and syncope was a rare but potentially serious adverse event (1/48 patients and 1/864 sessions over a treatment period of 4 weeks). PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Bleeding Review
37289799 Five studies reported adverse events related to acupuncture, including mild bleeding, hematoma, pain, and syncope. PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Bleeding Review
37289799 Nevertheless, considering the reports from five studies, acupuncture-related adverse events were generally mild and temporary, such as mild bleeding, hematoma, and local pain. PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Bleeding Review
37297763 In one study of acupuncture, side effects such as minor local bleeding or hematoma, pain at the site of needle insertion, and vegetative symptoms were reported in the experimental acupuncture group. Healthcare (Basel). 2023 Jun 1;11(11):1624. doi: 10.3390/healthcare11111624. Side Effects Bleeding Review
37441610 Out of these two studies reported that no adverse events associated with acupuncture treatment occurred, and four reported acupuncture-related adverse events which were mild and did not require treatment, including bleeding at the needle site, perspiration, dizziness, and nausea. Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. Bleeding Nausea and Vomiting Review
37644765 The second study included one case of hematoma, one of bleeding, and two of pain in the acupuncture group, with the control group having five cases of nausea, tiredness, and sleepiness. Libyan J Med. 2023 Dec;18(1):2251640. doi: 10.1080/19932820.2023.2251640. Bleeding Nausea and Vomiting Review
37675019 A prospective observational study on acupuncture for chronic pain in Germany included 454920 patients, of whom more than 30% were over 60 years old, and reported mild side-effects (pain, hematoma, and bleeding) in 7.9% of patients. Front Nephrol. 2022 Nov 9;2:1006506. doi: 10.3389/fneph.2022.1006506. eCollection 2022. Side Effects Bleeding Review
37795371 Reported AEs include mild ecchymosis, bleeding, pain upon needle insertion,dizziness caused by acupuncture and EA and mild skin burns caused by moxibustion. Front Endocrinol (Lausanne). 2023 Sep 18;14:1236370. doi: 10.3389/fendo.2023.1236370. eCollection 2023. Bleeding Review
2487311 In acupuncture anesthesia, blood pressure, pulse rate and respiration were stable during operation, and blood loss was less than in epidural or local anesthesia. Fukushima J Med Sci. 1989 Dec;35(2):45-52. Heart Rate Bleeding Blood Pressure Clinic
25797640 With acupuncture anesthesia there is less bleeding during surgery and there is also quicker post-operative recovery. J Integr Med. 2015 Mar;13(2):99-104. doi: 10.1016/S2095-4964(15)60159-5. Bleeding Clinic
28254101 We performed a computed tomography brain scan, which revealed a left-sided acute on chronic subdural hemorrhage. J Acupunct Meridian Stud. 2017 Jan;10(1):45-48. doi: 10.1016/j.jams.2016.06.005. Epub 2016 Sep 15. Bleeding Clinic
32188223 The rates of oxytocin use (4.70%), urinary retention (4.70%), and postpartum hemorrhage [(273.7 +/- 53.6) mL] in the AA group were significantly lower than in the CSEA group [46.70%, 24.20%, and (320.0 +/- 85.6) mL, respectively]. J Tradit Chin Med. 2017 Oct;37(5):629-635. Bleeding Urinary Retention Clinic
24621826 The continuous response variables like age, weight, duration of surgery, duration of anesthesia, urine volume, blood loss, and crystalloid and colloid requirements are presented as mean ±SD. Med Sci Monit. 2014 Mar 12;20:406-12. doi: 10.12659/MSM.890111. Bleeding Clinic
24621826 There were no significant differences in age, weight, duration of surgery, duration of anesthesia, urine volume, blood loss, or crystalloid and colloid requirements among the 4 groups (all p>0.05). Med Sci Monit. 2014 Mar 12;20:406-12. doi: 10.12659/MSM.890111. Bleeding Clinic
25047046 This in particular seems to be of interest when taking into account patient populations that are at higher risk of suffering from side effects from local bleeding. Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. Side Effects Bleeding Clinic
22611431 In animal studies, electroacupuncture at the Neiguan (PC-6) and Jianshi (PC-5) points affects the circulatory and sympathetic nervous system, especially electroacupuncture at the PC-6 point increases haemodynamics and makes bleeding-induced hypotension less severe. Evid Based Complement Alternat Med. 2012;2012:727121. doi: 10.1155/2012/727121. Epub 2012 Jan 31. Bleeding Circulation Clinic
22611431 Electroacupuncture at the PC-5 increases stroke volume and cardiac output and furthermore reduces the severity of bleeding-induced hypotension. Evid Based Complement Alternat Med. 2012;2012:727121. doi: 10.1155/2012/727121. Epub 2012 Jan 31. Bleeding Clinic
22611431 Some studies showed that electroacupuncture on the PC-5 at 40xe2x80x89Hz enhances myocardial function and prevents bleeding-induced hypotension, which are consistent with the present study. Evid Based Complement Alternat Med. 2012;2012:727121. doi: 10.1155/2012/727121. Epub 2012 Jan 31. Bleeding Clinic
27688791 A case reported resection cerebellar vermis and right cerebellum hemisphere in a cerebellum hemorrhage patient could cause transient orthostatic hypotension, indicating that the cerebellum was involved in blood pressure regulation. Evid Based Complement Alternat Med. 2016;2016:6908710. doi: 10.1155/2016/6908710. Epub 2016 Sep 4. Bleeding Blood Pressure Clinic
27688791 suggested that microcapillary hemorrhage or inflammation may be associated with mild cognitive impairment in hypertensive rats, and the frontal lobe was closely related to cognitive function. Evid Based Complement Alternat Med. 2016;2016:6908710. doi: 10.1155/2016/6908710. Epub 2016 Sep 4. Cognitive Function Bleeding Clinic
28105066 The exclusion criteria were as follows: participants undergoing endovascular surgery; participants with a history of hypothyroidism, hyperthyroidism, cardiopulmonary disease, diabetes, or psychological disorder; participants with a history of EA treatment; participants with a cardiac pacemaker; participants in the menstruating phase of the menstrual cycle; participants who refused to accept acupuncture; participants who were unconscious before surgery; participants with inability to communicate; participants participating in another clinical trial that could interfere with the primary endpoint of the study; participants with a bleeding disorder (hemophilia or fibrinogenemia); participants with serious systemic disease (AIDS or sepsis); participants with initial body temperature of above 38.0xc2xa0xc2xb0C or below 36.0xc2xa0xc2xb0C; participants with a known history of alcohol or substance abuse; participants requiring systemic sedation for other reasons; participants needing emergency procedures; participants who were pregnant or lactating women. Chin Med. 2017 Jan 16;12:5. doi: 10.1186/s13020-016-0122-9. eCollection 2017. Bleeding Sedation Clinic
28658163 As shown in Figure 1, because of noncooperation, excessive intraoperative blood loss and nonreceiving surgery, 17 patients were lost. Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. Bleeding Clinic
28658163 If the operation time is greater than 3xe2x80x8ahours, the intraoperative blood loss is more than 800xe2x80x8amL, or the patients did not undergo surgery, they will be excluded from this study. Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. Bleeding Clinic
28658163 In all, 107 patients were enrolled, and assigned to 2 groups (11 patients were lost because of nonreceiving, 5 patients were lost because of noncooperation, and 1 patient was lost because of intraoperative blood loss >800xe2x80x8amL). Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. Bleeding Clinic
28658163 Because of major trauma, long operation and anesthesia time, and excessive intraoperative blood loss, the patients receiving spine surgery easily suffer POCD. Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. Bleeding Clinic
31915045 The advantages of laparoscopy over laparotomy include less postoperative pain, shorter hospital stays, and reduced blood loss. Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. Bleeding Clinic
31915045 Surgical information recorded included anesthesia duration, surgery duration, estimated blood loss and all other intraoperative medications. Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. Bleeding Clinic
31915045 The characteristics of patients such as age, height, BMI, ASA physical status, anesthesia duration, surgery duration, estimated blood loss and fluid balance did not differ between the groups (Tablexc2xa01). Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. Bleeding Clinic
33154688 There were no statistically significant differences between the two groups in terms of patient gender (P = 0.595), age (P = 0.152), total dose of sufentanil consumption (P = 0.322), duration of surgery (P = 0.125), intraoperative fluid input volume (P = 0.424), bleeding volume (P = 0.515), urine volume (P = 0.689), and type of surgeries (P = 0.808) (Table 1). Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. Bleeding Clinic
33154688 Surgical trauma, general anesthetics, operation time, and intraoperative bleeding volume are important surgical factors that may cause POSD in patients, such as decreased REM sleep and slow-wave sleep, changes in sleep structure, and sleep fragmentation. Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. Bleeding Clinic
33488793 The anesthesia time, operation time, volume of blood loss and urine were recorded. Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. Bleeding Clinic
33488793 There were no significant differences between the two groups regarding the details of anesthesia and operation, in terms of duration, operation site, blood loss, infusion volume and urine volume (Table I). Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. Bleeding Clinic
26238027 The effects of acupuncture and traditional Chinese medicines on apoptosis of brain tissue in a rat intracerebral hemorrhage model. Physiol Behav. 2015 Nov 1;151:421-5. doi: 10.1016/j.physbeh.2015.07.036. Epub 2015 Aug 1. Bleeding Mechanism
26238027 OBJECTIVE: This study aimed to evaluate the effects of Chinese herbs and acupuncture on the neuronal apoptosis and the expression of apoptosis-related genes in the brain tissue of rats following intracerebral hemorrhage (ICH). Physiol Behav. 2015 Nov 1;151:421-5. doi: 10.1016/j.physbeh.2015.07.036. Epub 2015 Aug 1. Bleeding Mechanism
28395933 Electroacupuncture improves neurobehavioral function and brain injury in rat model of intracerebral hemorrhage. Brain Res Bull. 2017 May;131:123-132. doi: 10.1016/j.brainresbull.2017.04.003. Epub 2017 Apr 7. Bleeding Mechanism
28395933 Recently, studies have demonstrated that electroacupuncture (EA) can accelerate intracerebral hemorrhage (ICH)-induced angiogenesis in rats. Brain Res Bull. 2017 May;131:123-132. doi: 10.1016/j.brainresbull.2017.04.003. Epub 2017 Apr 7. Bleeding Mechanism
28395933 The hemorrhage volume and glucose metabolism of hemorrhagic foci were detected by PET/CT. Brain Res Bull. 2017 May;131:123-132. doi: 10.1016/j.brainresbull.2017.04.003. Epub 2017 Apr 7. Bleeding Mechanism
28395933 Hemorrhage volume reduced in EA group at day 14 when compared with MC and non-acupoint EA groups. Brain Res Bull. 2017 May;131:123-132. doi: 10.1016/j.brainresbull.2017.04.003. Epub 2017 Apr 7. Bleeding Mechanism
33403590 Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats. J Mol Neurosci. 2021 Sep;71(9):1863-1875. doi: 10.1007/s12031-020-01770-x. Epub 2021 Jan 5. Bleeding Mechanism
33403590 Baihui-penetrating-Qubin acupuncture is frequently used to treat intracerebral hemorrhage (ICH) in China. J Mol Neurosci. 2021 Sep;71(9):1863-1875. doi: 10.1007/s12031-020-01770-x. Epub 2021 Jan 5. Bleeding Mechanism
28619309 Limited human studies suggested that scalp acupuncture could facilitate functional recovery after cerebral hemorrhage. Complement Ther Med. 2017 Jun;32:85-90. doi: 10.1016/j.ctim.2017.03.014. Epub 2017 Apr 19. Bleeding Mechanism
28619309 In the current study, we used an animal model of cerebral hemorrhage to examine the potential effects of scalp acupuncture. Complement Ther Med. 2017 Jun;32:85-90. doi: 10.1016/j.ctim.2017.03.014. Epub 2017 Apr 19. Bleeding Mechanism
34284645 BACKGROUND: Intracerebral hemorrhage (ICH) accounts for approximately 15% of all stroke cases. Acupunct Med. 2022 Feb;40(1):59-67. doi: 10.1177/09645284211028873. Epub 2021 Jul 20. Bleeding Mechanism
36484920 METHODS: Seventy-five rats were randomly divided into 5 groups by a random number table: a control group (n=15), a model group (n=15), a BAJP group (n=15), a BAJP+3-methyladenine (3-MA) group (n=15), and a BANA (bloodletting at nonacupoint; tail bleeding, n=15) group. Chin J Integr Med. 2023 Feb;29(2):170-178. doi: 10.1007/s11655-022-3626-4. Epub 2022 Dec 9. Bleeding Mechanism
26419631 Five rats (one in CAS rats with EA, two each in CAS and ISC rats without EA) developed macro- or micro- intestinal bleeding, and were not included in data analysis. BMC Complement Altern Med. 2015 Sep 29;15:340. doi: 10.1186/s12906-015-0863-5. Bleeding Mechanism
25139460 Few infiltrating neutrophils were observed and there was no evidence of hemorrhage or edema in the lungs of groups C and PD (Figure 2 (C and PD)). Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. Bleeding Mechanism
25139460 In groups M, SEAM and EAMPD, histologic examination showed typical pathologic traits of lung injury, such as diffuse edema and severe inflammatory cell (predominantly neutrophils) infiltration in the alveoli and interstitium of the lungs, hemorrhage, and thickened interlobular septa (Figure 2 (M, SEAM and EAMPD)), whereas that of group EAM showed minimal lung injury with a mild degree of neutrophil infiltration and thickening of the alveolar walls (Figure 2 (EAM)). Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. Bleeding Mechanism
25139460 Microphotographs of morphological changes of lung tissues (×200): Few infiltrating neutrophils were observed and there was no evidence of hemorrhage or edema in the lungs of the control group rabbits (C and PD). Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. Bleeding Mechanism
25139460 In the models of the lung injury induced by endotoxic shock, whether given non-acupoint treatment or given PDTC, histologic examination showed typical pathologic traits of lung injury, such as diffuse edema and severe inflammatory cell (predominantly neutrophils) infiltration in alveoli and interstitium of the lung, hemorrhage, and thickened interlobular septa (M, SEAM and EAMPD), whereas the model with electro-acupuncture treatment showed minimal lung injury, with a mild degree of neutrophil infiltration and thickening of the alveolar walls (EAM). Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. Toxic Side Effects Bleeding Mechanism
24828425 MMPs/gelatinases can activate numerous proinflammatory agents, disrupt the BBB, and provoke encephaledema and cerebral hemorrhage. PLoS One. 2014 May 14;9(5):e97488. doi: 10.1371/journal.pone.0097488. eCollection 2014. Bleeding Mechanism
24828425 Unfortunately, the use of thrombolytic agents is controversial due to the increased risk of hemorrhage and neuronal death, prompting a search for safer and more efficacious ways to manage ischemic stroke. PLoS One. 2014 May 14;9(5):e97488. doi: 10.1371/journal.pone.0097488. eCollection 2014. Bleeding Mechanism
34659396 However, some patients cannot get timely access to effective treatment because the window for vascular recanalization is very short and often results in intracranial hemorrhage. Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. Bleeding Mechanism
25302705 Another study also provided evidence, by using an ischemia-reperfusion injury model through hemorrhage and a supraceliac cross-clamp followed by 6h resuscitation, that Tnfrsf12a was involved in apoptosis/cell death and angiogenesis/vascular development. Molecules. 2014 Oct 9;19(10):16158-78. doi: 10.3390/molecules191016158. Bleeding Mechanism
28913350 However, rt-PA is associated with the risk of bleeding and thus has both favorable and unfavorable consequences. Biomed Res Int. 2017;2017:3178014. doi: 10.1155/2017/3178014. Epub 2017 Aug 24. Bleeding Mechanism
25206407 Rats dying within 24 hours after surgery, or displaying a neurological score of 0 or subarachnoid hemorrhage (as macroscopically assessed), were excluded from the final analysis. Neural Regen Res. 2013 Apr 25;8(12):1132-8. doi: 10.3969/j.issn.1673-5374.2013.12.008. Bleeding Mechanism
26623337 Study of literature showed that the stimulation of acupuncture points and balance in the Yin and Yan energy in kidney meridians and maintaining this balance and the use of Qi energy on fracture site can activate Bone growth factors in the bleeding to establish the ossifying procedure (Hayashi et al., 2008). Open Vet J. 2014;4(1):44-50. Epub 2014 Apr 25. Bleeding Kidney Mechanism
24803946 Boundaries in the control group became obscured and broad hemorrhages were found in both gray and white matters. Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. Bleeding Mechanism
24803946 Spinal cord lacked clear infrastructures and cellular boundaries, while the degree of hemorrhage, necrosis, and peripheral tissue edema was mild compared with the control group. Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. Bleeding Mechanism
24803946 In the control group, impacted spinal cord exhibited typical necrosis showing as broad hemorrhage, edema, and neuronal apoptosis with condensed nuclei. Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. Bleeding Mechanism
24803946 Compared with the control group, hemorrhage and edema occurred in the EA, MA, and TAES groups. Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. Bleeding Mechanism
26487031 There is some aggravation of discomfort during the first two weeks after treatment as well as bleeding and synovial leakage during treatment. Animals (Basel). 2012 Sep 4;2(3):426-36. doi: 10.3390/ani2030426. Bleeding Mechanism
23983780 Under the anesthesia, the abdominal wall was carefully dissected along the linea alba without any bleeding into the abdomen because the coagulation thread was easily regarded as the primo vessel. Evid Based Complement Alternat Med. 2013;2013:438079. doi: 10.1155/2013/438079. Epub 2013 Jul 31. Bleeding Mechanism
37096024 Acupuncture can also significantly improve the symptoms of various animal models, such as animal model of COPD, animal model of cerebra hemorrhage, animal model of PCOS and animal model of ASD. Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. Bleeding Mechanism
33269744 In the MCAO group, three rats died due to excessive hemorrhage. Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. Bleeding Mechanism
24841896 Every 4 weeks (sometimes, 9 weeks), rats were fasted for 20 h. Each rat was then immobilized by pushing it into a small cage made of metal mesh and the tail vein was cut for bleeding. Med Sci Monit Basic Res. 2014 May 19;20:70-5. doi: 10.12659/MSMBR.890773. Bleeding Mechanism
34405366 The long-term advantages of tranexamic acid for the control of bleeding are not fully elucidated, and chronic utilisation of VII chain A (RF chain A) may increase the likelihood of thrombotic events (Mayer et al. ). J Mol Neurosci. 2022 Jan;72(1):82-96. doi: 10.1007/s12031-021-01890-y. Epub 2021 Aug 17. Bleeding Mechanism
30127121 Baihui (DU20)-penetrating-Qubin (GB7) acupuncture can inhibit inflammatory reactions and activate signaling pathways related to proliferation after intracerebral hemorrhage. Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. Bleeding Mechanism
30127121 Rat models of intracerebral hemorrhage were established by injecting 60 μL of autologous blood into the right side of the caudate-putamen. Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. Bleeding Mechanism
30127121 We conclude that Baihui-penetrating-Qubin acupuncture can mitigate hemorrhage and promote functional recovery of the brain in a rat model of intracerebral hemorrhage, possibly by activating the Sonic hedgehog pathway. Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. Bleeding Mechanism
30127121 Intracerebral hemorrhage (ICH) has one of the highest frequencies of mortality and morbidity in humans (Li et al., 2017; Ostrowski et al., 2017). Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. Bleeding Mechanism
30127121 Location of intracerebral hemorrhage site. Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. Bleeding Mechanism
30127121 The red circle shows the intracerebral hemorrhage site, which is located at the right caudate-putamen. Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. Bleeding Mechanism
30127121 ICH: Intracerebral hemorrhage; Ag: agonist; Ac: acupuncture; SAc: sham acupuncture. Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. Bleeding Mechanism
30127121 ICH: Intracerebral hemorrhage; Ag: agonist; Ac: acupuncture; SAc: sham acupuncture. Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. Bleeding Mechanism
30127121 TUNEL: Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling; ICH: intracerebral hemorrhage; Ag: agonist; Ac: acupuncture; SAc: sham acupuncture. Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. Bleeding Mechanism
30127121 ICH: Intracerebral hemorrhage; Ag: agonist; Ac: acupuncture; SAc: sham acupuncture; Smo: Smoothened; Gli1: Glioma-associated homolog 1; GAPDH: glyceraldehyde-3-phosphate. Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. Bleeding Mechanism
35722406 Although there are some common adverse events, such as bleeding, pain at the acupuncture site and fainting during acupuncture, both of them can clear the mind, lift the spirits. Ann Transl Med. 2022 May;10(10):540. doi: 10.21037/atm-22-2068. Bleeding Mechanism
25878596 Acupuncture inhibits Notch1 and Hes1 protein expression in the basal ganglia of rats with cerebral hemorrhage Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 To date, studies have rarely focused on changes or damage to signal transduction pathways during cerebral hemorrhage. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 Here, we examined the effect of acupuncture in a rat model of cerebral hemorrhage. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 In the model group, cerebral hemorrhage models were established by infusing non-heparinized blood into the brain. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 Our results suggest that acupuncture has a neuroprotective effect on cerebral hemorrhage by inhibiting Notch-Hes signaling pathway transduction in rat basal ganglia after cerebral hemorrhage. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Neuroprotection Bleeding Mechanism
25878596 Cerebral hemorrhage is non-traumatic, and caused by rupture of blood vessels in brain parenchyma. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 Cerebral hemorrhage is often induced by exertion and emotion, and most patients show sudden onset during activity. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mood Mechanism
25878596 A large number of studies have shown that cerebral hemorrhage causes neuronal apoptosis (Chamnanvanakij et al., 2002; Riggs et al., 2005; Gao et al., 2009), which aggravates the brain damage and causes contralateral limb dysfunction. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 Thus, in this study, we used a rat model of cerebral hemorrhage to investigate the effect of acupuncture on Notch1 and Hes1 expression in brain tissue. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 Our aim was to determine if acupuncture promotes restoration of brain injury after cerebral hemorrhage by increasing Notch1 and Hes1 expression, which may provide a theoretical foundation for acupuncture treatment during cerebral hemorrhage. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 Establishment of a cerebral hemorrhage model Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 In accordance with Berderson's score (Berderson et al., 1986), the specific method for assessing cerebral hemorrhage models was: rats were lifted by their tails, until they were 10 cm higher than the desktop; the paw of a normal rat will be straight. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 After model establishment, the rats had regained consciousness, according to appropriate signs and symptoms, rats with intracranial hematoma were considered successful models of cerebral hemorrhage. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 Notch1 protein expression in the basal ganglia of rats with intracerebral hemorrhage (western blot assay). Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Bleeding Mechanism
25878596 Notch1 immunoreactivity in the basal ganglia of rats with cerebral hemorrhage and acupuncture treatment (immunohistochemical staining, × 400 magnification). Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Immunity Bleeding Mechanism
25878596 Notch1-immunoreactive cell number was higher in the model group than the control group at various time points after cerebral hemorrhage induction. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Immunity Bleeding Mechanism
25878596 Hes1 immunoreactivity in the basal ganglia of rats with cerebral hemorrhage (immunohistochemical staining, × 400). Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Immunity Bleeding Mechanism
25878596 Hes1-immunoreactive cell number was higher in the model group than the control group at various time points after cerebral hemorrhage induction. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Immunity Bleeding Mechanism
25878596 DAPT, a Notch inhibitor, suppressed Hes1 immunoreactivity at various time points after cerebral hemorrhage induction. Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. Immunity Bleeding Mechanism
33478541 The incisions healed well after the operation, without obvious swelling and bleeding, infection, or death. J Orthop Surg Res. 2021 Jan 21;16(1):74. doi: 10.1186/s13018-021-02220-z. Bleeding Inflammatory Pain Mechanism
26889195 After successful compression, hemorrhage and swelling were seen at the injury site, and the rat twitched its tail. Neural Regen Res. 2015 Dec;10(12):2033-9. doi: 10.4103/1673-5374.172323. Bleeding Inflammatory Pain Mechanism
26889195 Hematoxylin-eosin-stained sections were used to observe nerve tissue swelling, hemorrhage and necrosis, cellular swelling, capsular spaces and vacuolar degeneration. Neural Regen Res. 2015 Dec;10(12):2033-9. doi: 10.4103/1673-5374.172323. Bleeding Inflammatory Pain Mechanism
26889195 At the injury site, swelling, hemorrhage, necrotic foci, cellular swelling, vacuoles, and vacuolar degeneration were visible in the gray matter. Neural Regen Res. 2015 Dec;10(12):2033-9. doi: 10.4103/1673-5374.172323. Bleeding Inflammatory Pain Mechanism
26889195 (A) Control group: spinal cord edema with multifocal hemorrhage, indicating successful model establishment. Neural Regen Res. 2015 Dec;10(12):2033-9. doi: 10.4103/1673-5374.172323. Bleeding Mechanism
28357997 Effects of Acupuncture on mRNA Levels of Apoptotic Factors in Perihematomal Brain Tissue During the Acute Phase of Cerebral Hemorrhage Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 To explore the time-dependent effects of acupuncture on mRNA levels of the apoptotic factors BCL-2 and BAX in a rat cerebral hemorrhage model, slow injection of autologous blood to the caudate nucleus was used to generate the cerebral hemorrhage model. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 The number of BCL-2 and BAX mRNA-positive cells significantly increased during the acute phase of cerebral hemorrhage. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 Acupuncture ameliorated changes in expression of apoptotic factors in the brain induced by acute cerebral hemorrhage and may thus protect the brain, with greater efficacy when the delay before acupuncture was minimized. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Brain Protection Bleeding Mechanism
28357997 Acupuncture therapy can influence the ratio between BCL-2 and BAX, suppress apoptosis, and exert a neuroprotective function in perihematomal brain tissue upon acute cerebral hemorrhage. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Neuroprotection Bleeding Mechanism
28357997 In the acute phase of cerebral hemorrhage, neural cells enter the initial stage of apoptosis by both intrinsic and extrinsic pathways. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 The mechanisms by which brain hemorrhage induces apoptosis are unclear, but many studies have demonstrated that the occurrence of oxidative stress could generate a large amount of superoxide radicals, which are the main inducers of apoptosis. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 This study explored the effects of acupuncture on apoptosis in perihematomal brain tissues at different times after the formation of hematoma in a rat cerebral hemorrhage model by evaluating the expression of BCL-2 and BAX mRNA and determining the BCL-2/BAX mRNA ratio. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 The study investigated the theoretical basis for the application of acupuncture therapy in the clinical treatment of acute cerebral hemorrhage. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 Slow injection of autologous blood to the caudate nucleus was used to generate the cerebral hemorrhage model in Wistar rats. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 When the rats recovered from anesthesia, the generation of a cerebral hemorrhage model was considered to be successful based on pilot experiments in which the Bederson and Longa scores were used to assess behavioral changes. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 Animals in the model group and acupuncture group underwent the cerebral hemorrhage model surgery, and the same volume of saline was injected into the caudate nucleus of the sham surgery group to mimic the surgical injury. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 BCL-2 mRNA was expressed at different levels in the cytoplasm in perihematomal brain tissues of rats with acute cerebral hemorrhage, and cytoplasm positive for BCL-2 mRNA exhibited a brown or tan color (Figure 2). Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 As shown in Figure 4, BAX mRNA was expressed at different levels in the cytoplasm in perihematomal brain tissues after acute cerebral hemorrhage, and the cytoplasm was stained brown or tan. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 The results of the present study showed that the number of cells positive for BCL-2 and BAX mRNA was significantly increased after acute cerebral hemorrhage, and that acupuncture resulted in a significant increase in the levels of BCL-2 mRNA and a decrease in the levels of BAX mRNA, even when compared to the sham surgery group. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 Apoptosis might be an important mechanism of delayed injury in neurocytes surrounding the hematoma, and it has a close relationship to the inflammatory reaction of hemorrhagic tissue after intracerebral hemorrhage. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 Therefore, this finding is of great significance to the early treatment of intracerebral hemorrhage by acupuncture. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
28357997 This study indicates that by ameliorating the changes in the mRNA expression of the apoptotic factors BCL-2 and BAX caused by acute cerebral hemorrhage, acupuncture therapy exerts a neuroprotective function in perihematomal brain tissue upon acute cerebral hemorrhage. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Neuroprotection Bleeding Mechanism
28357997 The most significant effects were observed when treatment was started 3 hours or 9 hours after cerebral hemorrhage, i.e., efficacy was highest when the interval between cerebral hemorrhage and acupuncture therapy was minimized. Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. Bleeding Mechanism
30106055 Acupuncture through Baihui (DU20) to Qubin (GB7) mitigates neurological impairment after intracerebral hemorrhage Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Inflammation plays an important role in nerve defects caused by intracerebral hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Repairing brain damage by inhibiting the macrophage-inducible C-type lectin/spleen tyrosine kinase (Mincle/Syk) signaling pathway is a potential new target for treating cerebral hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 In this study, we aimed to determine whether acupuncture through Baihui (DU20) to Qubin (GB7) is an effective treatment for intracerebral hemorrhage through the Mincle/Syk signaling pathway. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 An intracerebral hemorrhage rat model was established by autologous blood infusion into the caudate nucleus. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 These findings suggest that acupuncture through Baihui to Qubin can improve neurological impairment after cerebral hemorrhage by inhibiting the Mincle/Syk signaling pathway. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Approximately 2 million individuals worldwide are diagnosed with intracerebral hemorrhage (ICH) each year (Sudlow and Warlow, 1997; Broderick et al., 2007; Lloyd-Jones et al., 2009; Qureshi et al., 2009). Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Acupuncture can also antagonize inflammatory brain injury generated by cerebral hemorrhage by suppressing the classical nuclear factor-κB pathway (Liu et al., 2017). Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Altogether, these studies show that acupuncture has great potential for treating cerebral hemorrhage by inhibiting inflammation. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 The Mincle/Syk pathway plays a role in traumatic brain injury (de Rivero Vaccari et al., 2015), subarachnoid hemorrhage, and ischemic stroke (Suzuki et al., 2013; He et al., 2015; Xie et al., 2017). Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 However, the regulatory mechanism of the Mincle/Syk pathway in cerebral hemorrhage remains unclear. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Furthermore, it is also not known whether acupuncture can treat cerebral hemorrhage by regulating the Mincle/Syk pathway. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 In this study, we first used an autohemic blood infusion method to establish a rat model of cerebral hemorrhage for studying the effectiveness of acupuncture through Baihui to Qubin. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Rats were randomly divided into four groups: sham (n = 72), intracerebral hemorrhage (ICH) (n = 72), piceatannol (a Syk inhibitor) (n = 72), and acupuncture (n = 72). Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Establishment of a cerebral hemorrhage rat model Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Effect of acupuncture through Baihui (DU20) to Qubin (GB7) on mNSS in a rat model of intracerebral hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 mNSS: Modified neurological severity score; ICH: intracerebral hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Effect of acupuncture through Baihui (DU20) to Qubin (GB7) on brain water content in a rat model of intracerebral hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 ICH: Intracerebral hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Effect of acupuncture through Baihui (DU20) to Qubin (GB7) on brain histopathology of rats after intracerebral hemorrhage (hematoxylin and eosin staining, original magnification, 200×). Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 ICH: Intracerebral hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Effect of acupuncture through Baihui (DU20) to Qubin (GB7) on immunoreactivity of Mincle, Syk, and CARD9 in the brain of rats at 6, 12, 24, and 72 hours after intracerebral hemorrhage (immunohistochemistry). Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Immunity Bleeding Mechanism
30106055 S: Sham group; M: model group; P: piceatannol group; A: acupuncture group; ICH: intracerebral hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Effect of acupuncture through Baihui (DU20) to Qubin (GB7) on protein expression of CARD9, Syk, and Mincle in the brain of rats at 6, 12, 24, and 72 hours after intracerebral hemorrhage (western blot assay). Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 (A) Western immunoblotting analysis of proteins relevant to intracerebral hemorrhage in rats. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Immunity Bleeding Mechanism
30106055 S: Sham group; M: model group; P: piceatannol group; A: acupuncture group; ICH: intracerebral hemorrhage; Mincle: macrophage-inducible C-type lectin; Syk: spleen tyrosine kinase. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Effect of acupuncture through Baihui (DU20) to Qubin (GB7) on mRNA expression of IL-1β at 6, 12, 24, and 72 hours in the brain of rats after intracerebral hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 ICH: Intracerebral hemorrhage; IL: interleukin. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Meanwhile, previous studies have shown that acupuncture can reduce neural inflammation (Liu et al., 2016), suppress cell apoptosis, and alleviate nerve dysfunction (Ma et al., 2016) after stroke, but it remains unclear whether acupuncture is effective for treating cerebral hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Consequently, in this study, we first examined the protective effects of acupuncture through Baihui (DU20) to Qubin (GB7) in a cerebral hemorrhage animal model. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Our results show that acupuncture through Baihui (DU20) to Qubin (GB7) can decrease mNSS and reduce BWC in a cerebral hemorrhage animal model. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 As a mediator of the immune response and activation point of inflammation, IL-1β expression levels directly reflect grades of inflammation after cerebral hemorrhage (Gross et al., 2009). Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Immunity Bleeding Mechanism
30106055 Previous studies have shown that the Mincle/Syk signaling pathway is involved in many innate immune responses including ischemic stroke, traumatic brain injury, and subarachnoid hemorrhage (Suzuki et al., 2013; de Rivero Vaccari et al., 2015; He et al., 2015; Arumugam et al., 2017; Xie et al., 2017). Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Immunity Bleeding Mechanism
30106055 Our study found that acupuncture markedly suppressed protein expression in the Mincle/Syk pathway and decreased IL-1β expression in rat brain tissue following hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 These results suggest that acupuncture through Baihui (DU20) to Qubin (GB7) may mitigate cerebral hemorrhage injury neuritis and improve neural function by suppressing the Mincle/Syk pathway, which further downregulates expression levels of downstream inflammatory cytokines. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 Piceatannol, a Syk inhibitor, suppresses Syk/CARD9 expression during ischemic stroke and subarachnoid hemorrhage, reduces IL-1β levels, improves neural function, and facilitates brain edema therapy (Suzuki et al., 2013; He et al., 2015; Xie et al., 2017). Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
30106055 In summary, acupuncture through Baihui (DU20) to Qubin (GB7) may suppress the Mincle/Syk pathway and reduce the release of proinflammatory cytokines, thereby mitigating neurological damage after cerebral hemorrhage. Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. Bleeding Mechanism
21799685 Frequently used medications such as non-steroidal anti-inflammatory drugs have serious and even dangerous side effects, including bleeding and perforated ulcers. Evid Based Complement Alternat Med. 2011;2011:619650. doi: 10.1093/ecam/neq016. Epub 2011 Jan 9. Side Effects Bleeding Mechanism
26279808 The HE examination of brain tissue from LPS group newborn pups showed significant inflammatory changes, such as loose white matter structure, disordered turbulence, glial cell aggregation, nerve cell karyopyknosis, periventricular capillary dilatation, congestion or bleeding, intraventricular hemorrhage. J Korean Neurosurg Soc. 2015 Jul;58(1):14-21. doi: 10.3340/jkns.2015.58.1.14. Epub 2015 Jul 31. Bleeding Mechanism
34108361 Baihui (DU20)-penetrating-Qubin (GB7) acupuncture regulates microglia polarization through miR-34a-5p/Klf4 signaling in intracerebral hemorrhage rats Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. Bleeding Mechanism
34108361 Intracerebral hemorrhage (ICH) is the most devastating subtype of stroke with high morbidity and mortality. Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. Bleeding Mechanism
34108361 Intracerebral hemorrhage (ICH) is a life-threatening neurologic injury accounting for 10% to 20% of stroke cases globally. Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. Bleeding Mechanism
34108361 MiR-34a-5p counteracted the therapeutical effects of Baihui-penetrating-Qubin acupuncture in intracerebral hemorrhage (ICH) rats. Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. Bleeding Mechanism
34108361 Effects of miR-34a-5p on Klf4 expression in the perihemorrhagic penumbra of intracerebral hemorrhage (ICH) rats with Baihui-penetrating-Qubin acupuncture treatment. Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. Bleeding Mechanism
34108361 MiR-34a-5p crippled the anti-apoptotic effects of Baihui-penetrating-Qubin acupuncture in the perihemorrhagic penumbra of intracerebral hemorrhage (ICH) rats. Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. Bleeding Mechanism
34108361 Effects of miR-34a-5p on microglia polarization in the perihemorrhagic penumbra of intracerebral hemorrhage (ICH) rats with Baihui-penetrating-Qubin acupuncture treatment. Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. Bleeding Mechanism
28761425 Chaos of qi and blood leads to the paralysis and hemorrhage of the vein, and brings about pathogenic factors that invade the brain. Neural Regen Res. 2017 Jun;12(6):925-930. doi: 10.4103/1673-5374.208574. Bleeding Mechanism
36116306 During 7 days of using the treatment regimen, there were 3.3 % of patients with dizziness, 3.3 % of patients with vomiting/nausea, 3.3 % of patients with bleeding at the injection site. Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. Bleeding Nausea and Vomiting Mechanism
36116306 In the study group, we recorded 1 case of dizziness, 1 case of bleeding at acupuncture site, 1 case of anorexia. Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. Bleeding Mechanism
36116306 Similar to the results of author Tran Thien An and colleagues when studying the method of spinal manipulation combined with electroacupuncture in the treatment of low back pain due to spondylolisthesis, the authors showed no cases who suffers from unwanted clinical effects such as pricking, bleeding, broken needles, pricking nerves.. Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. Bleeding Mechanism